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Cell BiologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Mohammed Akaaboune, Ph.D. Regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to observe the structure of synapses in living animals. Many studies take advantage of our in vivo imaging techniques to follow the dynamics of synaptic proteins over time in the same animal. Molecular, Cellular & Developmental Biology, Neuroscience. Anuska Andjelkovic-Zochowska, M.D., Ph.D. Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of glioma associated angiogenesis. Pathology. Neuroscience. Molecular & Cellular Pathology.
Philip C. Andrews, Ph.D. Bioactive
peptides--structure and function; development of new
technologies in proteome analysis and functional genomics
for identifying gene function and characterizing gene
products, including analysis of posttranslational
modifications. Biological Chemistry.
Bioinformatics. Radha Ayyagari, Ph.D Molecular genetics of retinal and macular degenerations and understanding the mechanism underlying the degeneration process. Cell and Developmental Biology. Ophthalmology and visual sciences. Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology.
James Bardwell, Ph.D. Protein folding catalysts,
from genetics to 3-D structures: role of molecular
chaperones and disulfide catalysts. Biology. Biophysics. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Robert A. Bender, Ph.D. Metabolic regulation in microorganisms. Molecular, Cellular & Developmental Biology. Robert M. Bradley, Ph.D. Neurophysiology of the taste system; mechanisms of sensory processing in the gustatory system. Molecular & Integrative Physiology. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Christine Canman, Ph.D. Understanding how DNA repair and cell cycle checkpoint pathways interact in human cells exposed to chemotherapy or ionizing radiation and how these interactions might collaborate to preserve genomic instability in unchallenged cells. Pharmacology. Thomas Carey, Ph.D. Genetic mechanisms in head and neck cancer progression; genetic mechanisms affecting response to therapy; and mechanisms of autoimmune hearing loss mediated by antibodies to inner ear antigens. Cellular & Molecular Biology. Pharmacology. Vern Carruthers, Ph.D. Pathogenesis of parasitic infections: Mechanisms of cell invasion and survival during infection. Microbiology and Immunology.
Christin Carter-Su, Ph.D. Signal transduction used by
cytokine receptors via JAK tyrosine kinases; regulation
of gene transcription by tyrosine kinases; cellular and
molecular actions of growth hormone and cytokines.
Molecular & Integrative Physiology. Cellular & Molecular Biology. Raymond Chan , Ph.D. Studies the packaging of chromosome in preparation for cellular division in mitosis and meiosis in the nematode C. elegans. My primary focus is on the Structural Maintenance of Chromosomes (SMC) protein family and TIM-1, a novel regulator of SMC proteins that I had previously identified. Human Genetics. http://www.umich.edu/~mmgmed/faculty/bios/Chan.htm Amy Chang, Ph.D. Genetics and cell biology of protein folding, sorting, and transport in the yeast secretory pathway; membrane biogenesis. Molecular, Cellular, and Developmental Biology. Kathleen
Collins, M.D., Ph.D. Molecular Mechanisms of HIV
Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology. Stephen Cooper, Ph.D. Analysis of the mammalian cell cycle, analysis of the bacterial cell cycle, the logic and chemistry of cell cycle control. Microbiology & Immunology. Mark Day, Ph.D. Cell-cycle regulation of epithelial programmed cell death. Cellular & Molecular Biology. Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology. Gregory Dressler, Ph.D. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue. Cellular & Molecular Biology. Molecular and Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. R.
Keith Duncan, Ph.D. Early stages of signal processing
in the auditory periphery, particularly in the context of
hair cell physiology. Neuroscience
David R. Engelke, Ph.D. Regulation of eukaryotic gene
expression at the levels of transcription and RNA
processing; catalytic and therapeutic RNA. Cellular & Molecular Biology. Biological
Chemistry. James T. Elder, M.D., Ph.D. Genetics of psoriasis; regulation of keratinocyte growth and differentiation. Cellular & Molecular Biology. José
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience.
Eric R. Fearon, MD, Ph.D. Molecular genetics of
cancer; tumor suppressor gene function. Cellular & Molecular Biology. Human Genetics.
Molecular and
Cellular Pathology. Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience. Diane Fingar, Ph.D. Signal transduction by the kinase mTOR, the mammalian target of rapamycin, using molecular, biochemical, and cell biological approaches. Cell and Developmental Biology. Stephen
K. Fisher, Ph.D. Role of inositol phospholipids in
neuronal signal transduction at cell-surface receptors.
Pharmacology.
Neuroscience. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry.
Robert S. Fuller, Ph.D. Proteolytic processing,
protein localization, and macromolecular transport in the
secretory pathway; yeast cell biology; structure,
mechanism, and specificity of proteases. Biological Chemistry. Cellular & Molecular Biology. Sonja Gerrard, Ph.D. Replication and assembly of RNA viruses; molecular pathogenesis and evasion of host innate immune systems. Microbiology & Immunology. Cellular & Molecular Biology. Epidemiology. David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics. Margaret
E. Gnegy, Ph.D. Neuropharmacology; mechanism of
amphetamine action; adaptive responses after repeated
amphetamine. Pharmacology.
Neuroscience.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Jun-Lin Guan, Ph.D. Signal transduction in cell migration. FAK signaling pathways in angiogenesis and metastasis. Role of a putative tumor suppressor FIP200 in development and cancer. Cellular & Developmental Biology. Internal Medicine.
Deborah L. Gumucio, Ph.D. Understanding the cell biology of familial Mediterranean fever; linking
Gary D. Hammer, MD, Ph.D. Molecular mechanisms of
stress. Adrenal cortical growth and differentiation.
Transcriptional regulation by adrenal-specific nuclear
receptors-transcription factors. Adrenal cortical
carcinogenesis. Transgenic models of adrenal development
and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Kurt D. Hankenson, D.V.M., Ph.D. Influence of the ECM on skeletal cells, and determining how the ECM modulates skeletal growth, remodeling, and healing. Cellular & Molecular Biology, Cell & Developmental Biology. Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/ Marc Hershenson, M.D. Signal transduction mechanisms underlying airway smooth muscle cell proliferation and differentiation; biochemical signaling pathways regulating pro-inflammatory molecule expression in airway epithelial cells. Molecular & Integrative Physiology Peter
F. Hitchcock, Ph.D. Developmental neurobiology;
retinal neurobiology; vision research; neuronal
regeneration in retina and ocular morphogenesis.
Cell & Developmental Biology.
Neuroscience. Joseph Holoshitz, MD Signal transduction; MHC and DNA repair in autoimmunity. Immunology. Microbiology. Cellular & Molecular Biology. Ronald
W. Holz, MD, Ph.D. Molecular mechanisms of underlying neurotransmitter and hormone secretion; development and use of novel optical techniques based upon total internal reflection microscopy to study the biochemistry of events at the plasma membrane. Pharmacology. Neuroscience. Cellular & Molecular Biology. Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Alan Hunt, Ph.D. Among the most fundamental processes of life is the ability to move, at the cellular level these forces are generated by proteins knows as molecular motors. Two broad classes of molecular motors: 1) those that use energy derived from ATP to exert force against filaments, such as myosin, kinesin, and dynein, and 2) those that use energy stored in an electrochemical gradient across a membrane to drive rotational movements, such as the motors that drive bacterial flagella. Biophysics. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Ursula Jakob, Ph.D. Oxidative stress and aging - Analysis of redox regulated proteins using biochemical, cell biological and proteomic tools. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology. Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry. Biophysics. Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology.
Daniel J. Klionsky, Ph.D. Molecular and cellular
biology of protein targeting and degradation, and
organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological
Chemistry. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology. Daniel Lawrence, Ph.D How basic binary interactions such as protein:protein interactions regulate complex physiologic processes. Studies focus on protease inhibitors and their targets in systems such as vascular cell migration, and in models of stroke and seizure. Internal Medicine. Cellular & Molecular Biology. Angel W.
Lee, M.D., Ph.D. Tyrosine kinase-based signal transduction mechanisms
that regulate Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Jiandie Lin, Ph.D. - Genome-wide mapping and functional analysis of transcriptional networks in the control metabolism in cells and in vivo. Metabolic basis of diseases including obesity, type 2 diabetes, neurodegeneration and cancer. Cell & Developmental Biology. Life Sciences Institute. Xiaoxia (Nina) Lin, Ph.D. The research goal of our lab is to unearth fundamental mechanisms underlying the diverse and complex functions of biological systems, and to engineer them for the development of beneficial biotechnologies, through a multidisciplinary approach integrating mathematical modeling, computer simulation and wet-lab experiments. More specifically, one part of our lab focuses on the quantitative investigation of the mechanisms for biological switching, which is a widespread feature of biological systems and is crucial for the regulation of numerous biological processes, such as cell cycle progression and cell fate decision. The other research area of our lab is the study and engineering of microorganisms with the goal of developing new biotechnologies for important applications such as bio-energy and bio-remediation. Examples of interesting projects in this broad direction include system-level modeling of metabolic networks, design and construction of genetic circuits, and laboratory evolution of microbial consortia. Biomedical Engineering. Medical Engineering. Bioinformatics. Jennifer J. Linderman, Ph.D. Digital imaging of single cells; signal transduction; mathematical modeling of receptor-mediated cell behavior. Biophysics. Chemical Engineering. Mats Ljungman, Ph.D. Cellular responses induced by DNA-damaging agents and other cellular stresses. Cellular & Molecular Biology. Jill A. Macoska, Ph.D. Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology.
Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly.
Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry. Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology. Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease. Molecular & Integrative Physiology.
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Molecular and
Cellular Pathology.
Cellular & Molecular Biology. Immunology. Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology. Kentaro Nabeshima, Ph.D. Mechanisms of the chromosome dynamics in meiosis with the primary focus on the establishment of the association between homologous chromosomes. Lab: http://www.med.umich.edu/cdb/sub_pages/People/nabeshima.html Cell and Developmental Biology Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Gabriel Nuñez, MD Molecular regulation of programmed cell death (apoptosis); identification and characterization of apoptosis regulatory genes. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology. Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology. Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology. K. Sue O'Shea, Ph.D. Developmental neurobiology; extracellular matrix; epithelial polarity. Cell & Developmental Biology. Jack Parent, M.D. Neural stem cells, plasticity and regeneration after brain injury; epileptogenesis. Neuroscience. Elizabeth M. Petty, MD Molecular genetics of solid tumor development; translation of molecular genetic discoveries to clinical applications; medical ethics. Cellular & Molecular Biology. Human Genetics.
Sem H. Phan, MD, Ph.D. Mechanisms of fibrosis;
myofibroblast biology; regulation of þ-smooth
muscle actin gene expression; eosinophils and cytokines
in pulmonary fibrosis. Molecular and
Cellular Pathology.
Immunology. Donald G. Puro, MD, Ph.D. Physiology of ion channels in retinal cells and pathophysiology of glial cells. Molecular & Integrative Physiology. Neuroscience. Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology. Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs. Neuroscience. Pamela A.
Raymond, Ph.D.Development and regeneration in the
central nervous system of zebrafish, using genetics with
molecular and embryological tools to uncover the
molecular basis of cell-cell interactions that regulate
retinal neurogenesis (the formation of neurons) and
neuronal specificity (the expression of differentiated
cellular features) during development and regeneration.
Mechanisms of pattern formation and formation of precise
arrays of cone photoreceptors in the zebrafish retina. Cell & Developmental Biology. Alnawaz Rehemtulla, Ph.D. Non-invasive detection of molecular events in live animals (Molecular Imaging). Development of mouse models of cancer wherein activation of apoptosis, carcinogenesis, cellular siginalling cascades, etc.can be imaged quantitatively thus facilitating studies on the molecular basis of cancer and the development and testing of novel therapeutics. Cellular & Molecular Biology Gus Rosania, Ph.D. We study the transport of small molecules at the cellular and subcellular levels, and develop chemical, biological, and mathematical/computational tools to understand the transport of nutrients and drugs. Bioinformatics. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Richard H. Sands, Ph.D. Spin-label studies on keratinocyte membranes and structure and function of redox proteins using various physical-chemical techniques including EPR, ENDOR, and Mossbauer. Biophysics. Physics. Maria Sandkvist, Ph.D. Protein trafficking in bacterial pathogens. Microbiology & Immunology.
Jochen H. Schacht, Ph.D. Neurochemistry; biochemical
mechanisms of hearing processes and drug-induced hearing
loss. Biological Chemistry.
Neuroscience. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. James A. Shayman, MD Mechanisms of cellular signaling by sphingolipid development of inhibitors for treating sphingolipid storage disorders. Pharmacology. Internal Medicine. JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics. Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Molecular & Integrative Physiology. Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology. Lloyd M. Stoolman, MD Lymphocyte recirculation and migration; functional characterization of the lymphocyte and endothelial receptors that mediate migration into lymphoid organs and sites of chronic inflammation; role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; role of lymphocyte-extracellular matrix interactions in lymphocyte migration. Immunology. Molecular and Cellular Pathology. Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Michael A. Sutton, Ph.D. My lab studies mechanisms that control synapse development and plasticity. Molecular and Behavioral Neuroscience Institute. Molecular and Integrative Physiology. Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology. Biophysics. Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry. Bill Tsai, Ph.D. Our overall goal is to clarify the cellular entry mechanism of both cholera toxin and polyoma/SV40 virus. Insights into these mechanisms will not only lead to a better understanding of how certain toxins and viruses infect their host cell, but will also clarify important aspects of basic cellular processes. Cell & Developmental Biology. R.
Scott Turner, MD, Ph.D. Molecular mechanisms of
Alzheimer's disease using cells and neurons in
culture and transgenic mouse models; (beta) amyloid
precursor protein and Alzheimer's disease. Molecular and
Chemical Neuroscience. Neuroscience. Michael D. Uhler, Ph.D. Regulation and specificity of serine-threonine protein kinase structures; regulation of calcium channels and neurotransmitter secretion; function and regulation of neuronal activity; Cyclic nucleotides and phosphorylation in neuronal plasticity. Cellular & Molecular Biology. Biological Chemistry. Molecular and Chemical Neuroscience. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience Kristen Verhey, Ph.D. Motor proteins and the cytoskeleton in neurons; axonal transport of signaling complexes; protein trafficking. Cell & Developmental Biology. Anne Vojtek, Ph.D. Regulation of cell growth and differentiation by signal transduction pathways. Biological Chemistry. Nils G.
Walter, Ph.D. Folding and function of non-coding RNA; structural and single molecule RNA enzymology; ribosome and spliceosome function by single molecule microscopy; single molecule systems biology. Biophysics. Cellular & Molecular Biology. Peter A. Ward, MD Mechanisms of the inflammatory response and its regulation; role of oxidants in tissue injury; mechanisms and participation of cytokines and chemokines; role of complement activation products in the inflammatory response. Molecular and Cellular Pathology. Immunology. Jeffrey S. Warren, MD Role of cellular redox status in modulating chemokine expression; pathogenesis of granulomatous vasculitis. Molecular and Cellular Pathology. Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute. Steve J. Weiss, MD Regulation, expression, and function of proteinases in cell movement through the extracellular matrix. Cellular & Molecular Biology. Deneen M. Wellik, Ph. D. The developmental and genetic role of the Hox genes during embryogenesis with a primary focus on kidney development and patterning of the axial skeleton. Internal Medicine-Molecular Medicine and Genetics, Cell and Developmental Biology. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology. Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology. Max S. Wicha, M.D. Regulation of cell growth and death pathways in mammary cells. Cellular & Molecular Biology. John A. Williams, MD, Ph.D. Membrane receptor regulation of cell function; cellular mechanisms of pancreatic secretion; regulation of intracellular Ca2+. Molecular & Integrative Physiology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology. X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. Yanzhuang Wang, Ph.D. Molecular organization and biogenesis of the Golgi apparatus during the cell cycle. Molecular, Cellular & Developmental Biology Christiane Wobus, Ph.D. Entry of enteric murine norovirus into macrophages and dendritic cells in vitro and in vivo. Microbiology and Immunology. Yukiko Yamashita Mechanisms of asymmetric stem cell division, control of stem cell behavior in their natural environment (in vivo), cell polarity, spindle orientation. Cell & Developmental Biology.
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