Cardiovascular Biology

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Molecular & Integrative Physiology. Surgery.

Daniel Eitzman, M.D. Our lab studies genetic determinants of thrombosis and atherosclerosis using murine models. Cellular & Molecular Biology.

Doug Engel, Ph.D. Molecular genetics of mammalian organ specification and differentiation. Cell & Developmental Biology. Cellular & Molecular Biology.
http://www-personal.umich.edu/~engel/

David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology.

Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics.

Daniel Lawrence, Ph.D How basic binary interactions such as protein:protein interactions regulate complex physiologic processes. Studies focus on protease inhibitors and their targets in systems such as vascular cell migration, and in models of stroke and seizure. Internal Medicine. Cellular & Molecular Biology.

Anatoli Lopatin, Ph.D. Regulation of potassium channels by polyamines. Neuroscience. Molecular & Integrative Physiology.

Benedict R. Lucchesi, MD, Ph.D. Cardiovascular pharmacology. Biological Chemistry.

Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology.

Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.

Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease. Molecular & Integrative Physiology.

Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine.

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.
Biophysics Lab

Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics.

David J. Pinsky, Ph.D. To elucidate mechanisms driving ischemic modulation of the vascular phenotype, to understand endogenous mechanisms of ischemic vascular injury and protection at the intersection of thrombotic, fibrinolytic, and inflammatory axes. Molecular & Integrative Physiology.

Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology.

Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology.