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BiotechnologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. J. Wayne Aldridge, Ph.D. Neuronal activity in basal ganglia and motor cortex in movement. Neuroscience. Philip
C. Andrews, Ph.D. Bioactive peptides--structure and function;
development of new technologies in proteome analysis and functional
genomics for identifying gene function and characterizing gene
products, including analysis of posttranslational modifications.
Biological Chemistry. Bioinformatics. James R. Baker Jr., MD Determining why autoantigens are recognized in autoimmune disease; epitope mapping thyroid autoantigens from patients with autoimmune thyroid disease. Immunology. Molecular and Cellular Pathology. David P. Ballou, Ph.D. Mechanisms of biological redox reactions and reactions with oxygen, especially metalloproteins and flavoproteins; physical and chemical studies, including rapid reaction techniques and instrumentation development. Biological Chemistry. Biophysics. Sanford Bledsoe, Ph.D. Neuropharmacology and neurochemistry of peripheral and central auditory systems. Otolaryngology. Sensory Neurobiology. Kresge Hearing Research Institute. Neuroscience. David T. Burke, Ph.D. Mammalian genetics; genetics of aging in the mouse; quantitative genetic analysis. Human Genetics. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience.
Arul M. Chinnaiyan, M.D., Ph.D. Focus on high-throughput genomic
and proteomic technologies to analyze human disease. Lab projects
include molecular profiling of prostate cancer, profiling cancer
with protein microarrays, and molecular signatures of sepsis. Bioinformatics.
Molecular and
Cellular Pathology. Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Molecular & Integrative Physiology. Surgery. David
R. Engelke, Ph.D. Regulation of eukaryotic gene expression
at the levels of transcription and RNA processing; catalytic and
therapeutic RNA. Cellular & Molecular Biology. Biological
Chemistry. John A. Faulkner, Ph.D. Muscle mechanics and mechanisms involved in injury, degeneration, and regeneration of skeletal muscle fibers. Molecular & Integrative Physiology. Carol
A. Fierke, Ph.D. RNA Processing. Protein Prenylation. Structure,
Mechanism and Inhibition of metalloenzymes and ribozymes. Protein
engineering of biosensors and biocatalysts. Biological Chemistry.
Biophysics. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry. Alan Hunt, Ph.D. Among the most fundamental processes of life is the ability to move, at the cellular level these forces are generated by proteins knows as molecular motors. Two broad classes of molecular motors: 1) those that use energy derived from ATP to exert force against filaments, such as myosin, kinesin, and dynein, and 2) those that use energy stored in an electrochemical gradient across a membrane to drive rotational movements, such as the motors that drive bacterial flagella. Biophysics. Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology. Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry. Robert Kennedy, Ph.D. Mechanisms and regulation of neurotransmitter and hormone secretion. Chemical basis of behavior and regulation by drugs. Novel technology for in vivo and single cell studies. Pharmacology. Tom
Kerppola, Ph.D. Regulation of gene expression by proto-oncogene
transcription factors; protein interactions in living cells and
organisms; and nucleoprotein complex architecture. Biological
Chemistry. Biophysics. Raoul Kopelmann, Ph.D. Biomedical nanosensors embedded in single cells and fiber-optic biochemical nanosensors; novel supermicroscopy techniques via Near-Field optics, laser fluorescence, and energy transfer. Biophysics. Jun Li, Ph.D. Genetic studies of complex human diseases, including psychiatric disorders, heart disease, and cancer, with emphases on genetic influence of gene expression, population structure, DNA copy number variation (either inherited or somatic), and application of next-generation sequencing methods to related problems. Human Genetics. Cellular & Molecular Biology. Bioinformatics. Xiaoxia (Nina) Lin, Ph.D. The research goal of our lab is to unearth fundamental mechanisms underlying the diverse and complex functions of biological systems, and to engineer them for the development of beneficial biotechnologies, through a multidisciplinary approach integrating mathematical modeling, computer simulation and wet-lab experiments. More specifically, one part of our lab focuses on the quantitative investigation of the mechanisms for biological switching, which is a widespread feature of biological systems and is crucial for the regulation of numerous biological processes, such as cell cycle progression and cell fate decision. The other research area of our lab is the study and engineering of microorganisms with the goal of developing new biotechnologies for important applications such as bio-energy and bio-remediation. Examples of interesting projects in this broad direction include system-level modeling of metabolic networks, design and construction of genetic circuits, and laboratory evolution of microbial consortia. Biomedical Engineering. Medical Engineering. Bioinformatics. Jennifer J. Linderman, Ph.D. Digital imaging of single cells; signal transduction; mathematical modeling of receptor-mediated cell behavior. Biophysics. Chemical Engineering. David Lubman, Ph.D. The use of proteomics and glycoproteomics to study cancer biomarkers and the progression of disease. Our methods include protein fractionation techniques, liquid separations, mass spectrometry, protein microarrays and spectroscopic methods. We are also developing microproteomic methods to study stem cells and the tumor microenvironment. Surgery. Bioinformatics. Molecular and Cellular Pathology. Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. Neil Marsh, Ph.D. Enzymology: Structure and mechanism of coenzyme B12 and S-adenosylmethionine-dependent radical enzymes. Protein Design: synthesis of "Teflon" proteins - introducing new properties into proteins using fluorinated amino acids. Biophysics. Biological Chemistry. John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics. Richard Neubig, MD, Ph.D. Molecular
mechanisms of signal transduction; spectroscopic and rapid kinetic
studies of receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of alpha-adrenergic
receptors. Bioinformatics. Biophysics. Pharmacology. Bryan Pfingst, Ph.D. Perception and processing of auditory information. Neuroscience. Gina Poe, Ph.D. Basic sleep processes, development, learning and memory, and optimization of cognitive performance. Molecular & Integrative Physiology. Neuroscience. Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology. Stephen W. Ragsdale, Ph.D. We are studying the microbial metabolism of one-carbon compounds (CO, CO 2 , methane) and xenobiotics (e.g., PCBs); oxygen sensing in the human carotid body; and the roles of metal ions in biology, including the mechanisms of nickel, B 12 , heme, and iron-sulfur enzymes. We use transient and steady-state kinetics, spectroscopy, and molecular biology to uncover mechanistic information. Biological Chemistry. Chemical Biology. Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs. Neuroscience. Rudy J. Richardson,
ScD, DABT Mechanisms of neurological disorders, stroke and
autoimmune diseases and their modulation by xenobiotics, genetics
and age. Biomarkers of xenobiotic exposure or disease. Interactions
of ligands with macromolecules using kinetics, molecular modeling
and mass spectrometry. Environmental epidemiology. Scientific basis
of risk assessment and public health policy. Neuroscience. Mark A. Saper, Ph.D. Structural biology of components of the type III secretion system essential for bacterial pathogenesis. Other current projects include a novel bacterial tyrosine kinase and phosphatase important for pathogenesis, and a family of aminotransferases essential for plant photorespiration. Protein crystallography is the main technique employed in the lab. Biological Chemistry. Biophysics. Anand Swaroop, Ph.D. Molecular
genetics of inherited eye diseases; animal models for retinal degeneration;
regulation of development and tissue-specific gene expression; expression
mapping of human genome. Human Genetics. Cellular & Molecular Biology. Neuroscience. Alice Telesnitsky,
Ph.D. Retrovirus molecular genetics, reverse transcriptase
structure-function studies, HIV-1 and murine leukemia virus genetic
recombination and other mechanisms of genetic variation, virus-host
interactions on the cellular level. Microbiology & Immunology.
Cellular & Molecular Biology. Nils G. Walter, Ph.D. Folding
of catalytic RNA; structure and function; fluorescence spectroscopy;
atomic force microscopy. Biophysics. Cellular & Molecular Biology. |
