Bioinformatics Related Research

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Goncalo Abecasis, Ph.D Development and application of statistical methods for complex trait gene identification. Active research areas include mental disorders and aging-related diseases. Biostatistics. Bioinformatics.

James Bardwell, Ph.D. Protein folding catalysts, from genetics to 3-D structures: role of molecular chaperones and disulfide catalysts. Biophysics. Biology. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/bardwell.htm

Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology.

Dean E. Brenner, MD Pharmacodynamics of anticancer drugs in animal models and humans. Pharmacology.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine

Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience.

Heather Carlson, Ph.D. Computer modeling of protein-ligand complexes. Interested in the basic biophysics of the process as well as drug design; also mine protein-ligand databases for proteomic information about ligand recognition. Biophysics. Bioinformatics.

Arul M. Chinnaiyan, M.D., Ph.D. Focus on high-throughput genomic and proteomic technologies to analyze human disease. Lab projects include molecular profiling of prostate cancer, profiling cancer with protein microarrays, and molecular signatures of sepsis. Bioinformatics. Molecular and Cellular Pathology.
Lab: http://www.pathology.med.umich.edu/chinnaiyan/

Gordon M. Crippen, Ph.D. Novel methods in conformational analysis: distance geometry; computational studies of ligand binding; prediction of protein folding. Biophysics. Bioinformatics.

Julie A. Douglas, Ph.D. Statistical genetics. Statistical genetics. Genetic mapping of complex human diseases and traits with an emphasis on the development, application, and evaluation of statistical methods. Human Genetics. Bioinformatics.

Debashis Ghosh, Ph.D. Statistical and computational methods for analysis of high-throughput genomic and proteomic expression data, statistical modelling of transcription regulatory systems, protein modelling and cancer biology modelling. Bioinformatics.

Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/

Jay Hess, M.D., Ph.D. Mechanisms of transformation by the mixed lineage leukemia protein and its downstream targets, the clustered (Hox) genes. Molecular and Cellular Pathology. Cellular & Molecular Biology.

Xiaoxia (Nina) Lin, Ph.D. The research goal of our lab is to unearth fundamental mechanisms underlying the diverse and complex functions of biological systems, and to engineer them for the development of beneficial biotechnologies, through a multidisciplinary approach integrating mathematical modeling, computer simulation and wet-lab experiments. More specifically, one part of our lab focuses on the quantitative investigation of the mechanisms for biological switching, which is a widespread feature of biological systems and is crucial for the regulation of numerous biological processes, such as cell cycle progression and cell fate decision. The other research area of our lab is the study and engineering of microorganisms with the goal of developing new biotechnologies for important applications such as bio-energy and bio-remediation. Examples of interesting projects in this broad direction include system-level modeling of metabolic networks, design and construction of genetic circuits, and laboratory evolution of microbial consortia. Biomedical Engineering. Medical Engineering. Bioinformatics.

Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology.

Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene transcription factors; protein interactions in living cells and organisms; and nucleoprotein complex architecture. Biological Chemistry. Biophysics.
http://sitemaker.umich.edu/kerppola.lab

Denise E. Kirschner, Ph.D. Computational pathogenesis and host-pathogen interactions. Microbiology & Immunology. Bioinformatics. Immunology. Human Genetics.

Angel W. Lee, M.D., Ph.D. Tyrosine kinase-based signal transduction mechanisms that regulate
cell proliferation and differentiation in myeloid progenitors, embryonic and neural stem cells; identification of novel molecules in neurogenesis. Pharmacology. Cellular & molecular Biology. Bioinformatics.
http://sitemaker.umich.edu/awmlee

Jun Li, Ph.D. Genetic studies of complex human diseases, including psychiatric disorders, heart disease, and cancer, with emphases on genetic influence of gene expression, population structure, DNA copy number variation (either inherited or somatic), and application of next-generation sequencing methods to related problems. Human Genetics. Cellular & Molecular Biology. Bioinformatics.

David Lubman, Ph.D. The use of proteomics to study cancer biomarkers and the progression of disease. Our methods include protein fractionation techniques, liquid separations, mass spectrometry and spectroscopic methods. Surgery. Bioinformatics. Molecular and Cellular Pathology.

Jonathan Maybaum, Ph.D. Gene therapy approaches to protection of host tissues during chemotherapy; role of programmed and non-programmed cell death mechanisms in cancer chemotherapy. Pharmacology. Radiation Oncology.

Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology.

John Middlebrooks, Ph.D. Psychophysical and cortical physiological studies of directional hearing. Physiological stimulus of cochlear prosthesis. Neuroscience.

Richard A. Miller, MD, Ph.D. Signal transduction in T cells; aging and T-cell subsets; immunology of aging; genetics of longevity. Molecular and Cellular Pathology. Cellular & Molecular Biology. Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#millerr

David Mindell, Ph.D. Molecular evolution and phylogenetics of vertebrate genomes and of viruses. Bioinformatics. Ecology & Evolutionary Biology. University of Michigan Museum of Zoology.

Alexey Nesvizhskii, Ph.D. Functional and clinical proteomics, bioinformatics, computational and statistical methods for analysis of high throughput biological data, mass spectrometry data analysis. Molecular and Cellular Pathology. Bioinformatics.

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.

Gilbert Omenn, MD. Ph.D. Proteomics and bioinformatics for development of cancer biomarkers. Human Genetics. Bioinformatics. Internal Medicine.

Jignesh M. Patel, Ph.D. Ddesigning and implementing highly efficient, flexible, and intuitive methods for querying large biological data sets. Electrical Engineering & Computer Science. Bioinformatics.
http://www.eecs.umich.edu/~jignesh/periscope

Steve Qin, Ph.D. Statistical genetics, disease mapping, computational biology, comparative genomics, functional genomics. Biostatistics. Bioinformatics.

Dragomir Radev, Ph.D. Natural language processing and information retrieval, specifically information extraction, text summarization, graph-based methods. Applications to Bioinfomatics include protein interaction identification in the literature, summarization of biomedical papers. School of Information. Bioinformatics.

Rudy J. Richardson, ScD, DABT Mechanisms of neurological disorders, stroke and autoimmune diseases and their modulation by xenobiotics, genetics and age. Biomarkers of xenobiotic exposure or disease. Interactions of ligands with macromolecules using kinetics, molecular modeling and mass spectrometry. Environmental epidemiology. Scientific basis of risk assessment and public health policy. Neuroscience.
http://www.umich.edu/~neurosci/faculty/rjrich.htm

Gus Rosania, Ph.D. We study the transport of small molecules at the cellular and subcellular levels, and develop chemical, biological, and mathematical/computational tools to understand the transport of nutrients and drugs. Bioinformatics.

Noah Rosenberg, Ph.D. Mathematical models in genetics and evolution, human population genetics, statistical methods for inference of human genetic history, role of human genetic variation in disease-gene mapping, human statistical genetics, genetic variation in pathogens, gene trees and species trees, phylogenetics. Bioinformatics. Human Genetics.

Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology.

David States, MD, Ph.D. Current projects focus on the application of quantitative analytic methods and machine learning technology to problems of molecular biology and genome analysis. Computational techniques include simulation, classification, database construction and analysis, and parallel computation. Integration of statistical and heuristic techniques with algorithm development is viewed as critical to solving problems of biological interest. Bioinformatics. Human Genetics.

Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology

Matt Young, Ph.D. Regulatory mechanisms of the Cyclin Dependent Kinases and other protein kinases. Structural studies and computational modeling of molecular dynamics in signaling proteins.  Biological Chemistry.  Bioinformatics.

Jianzhi Zhang, Ph.D. Molecular and genomic evolution, with both experimental and computational approaches. Bioinformatics.