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Biological Chemistry Related ResearchPlease note: Words in italics are the official PIBS affiliations of the indicated faculty.
Philip C. Andrews, Ph.D. Bioactive
peptides--structure and function; development of new
technologies in proteome analysis and functional genomics
for identifying gene function and characterizing gene
products, including analysis of posttranslational
modifications. Biological Chemistry.
Bioinformatics. David P. Ballou, Ph.D. Mechanisms of biological redox reactions and reactions with oxygen, especially metalloproteins and flavoproteins; physical and chemical studies, including rapid reaction techniques and instrumentation development. Biological Chemistry. Biophysics.
James Bardwell, Ph.D. Protein folding catalysts, from
genetics to 3-D structures: role of molecular chaperones
and disulfide catalysts. Biology. Biophysics. Cellular & Molecular Biology. Daniel A. Bochar, Ph.D. Regulation of eukaryotic gene expression through the modulation of chromatin structure and the connection to developmental disorders and cancer. Biological Chemistry. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Vern Carruthers, Ph.D. Pathogenesis of parasitic infections: Mechanisms of cell invasion and survival during infection. Microbiology and Immunology. Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Molecular & Integrative Physiology. Surgery.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Yali Dou, Ph.D. Using a combination of biochemical, cellular and genetic analyses, we would like to: analyze the structure, function and regulation of MLL complex; study the cross-talks between MLL and other histone modifying activities such as histone acetyltransferase and histone ubiquitinase; elucidate the mechanism of MLL deregulation (deletion, amplification and translocation) in leukemogenesis. Molecular & Cellular Pathology. Gregory Dressler, Ph.D. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue. Cellular & Molecular Biology. Molecular and Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. David R. Engelke, Ph.D. Regulation of eukaryotic gene
expression at the levels of transcription and RNA
processing; catalytic and therapeutic RNA. Cellular & Molecular Biology. Biological
Chemistry. Josè
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience. Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience.
Carol A. Fierke, Ph.D. RNA Processing. Protein
Prenylation. Structure, Mechanism and Inhibition of
metalloenzymes and ribozymes. Protein engineering of
biosensors and biocatalysts. Biological Chemistry. Biophysics. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry.
Robert S. Fuller, Ph.D. Proteolytic processing,
protein localization, and macromolecular transport in the
secretory pathway; yeast cell biology; structure,
mechanism, and specificity of proteases. Biological Chemistry. Cellular & Molecular Biology. Jason Gestwicki, Ph.D. Use of organic chemistry to build new tools for exploring important biological questions. We are currently focused on generating new technologies for inhibiting protein-protein interactions in neurodegenerative diseases. Life Sciences Institute. Molecular & Cellular Pathology. Sid Gilman, MD Neurophysiological basis of motor control. Integrative and Systems Neurobiology. David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics.
Gary Glick, Ph.D. Developing new methods to study the
structure, folding, and dynamics of both DNA and RNA.
Defining binding properties of anti-DNA autoantibodies
that arise in the autoimmune disorder systemic lupus
erythematosus. Chemistry. Immunology. Cellular & Molecular Biology.
Biophysics. Biochemistry.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Marc Hershenson, M.D. Signal transduction mechanisms underlying airway smooth muscle cell proliferation and differentiation; biochemical signaling pathways regulating pro-inflammatory molecule expression in airway epithelial cells. Molecular & Integrative Physiology Paul F. Hollenberg, Ph.D. Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations. Pharmacology. Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Ursula Jakob, Ph.D. Oxidative stress and aging - Analysis of redox regulated proteins using biochemical, cell biological and proteomic tools. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry. Biophysics. Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology.
Daniel J. Klionsky, Ph.D. Molecular and cellular
biology of protein targeting and degradation, and
organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological
Chemistry. Roland Kwok, Ph.D. Hormonal regulation of cAMP-activated gene expression. Biological Chemistry. Obstetrics and Gynecology. Ming Lei, Ph.D. Structural and functional studies of the molecular mechanism of human telomere and its regulation. with an emphasis in a multi-subunit complex (telosome) which forms the protective cap of the telomere. Biological Chemistry. David Lubman, Ph.D. The use of proteomics to study cancer biomarkers and the progression of disease. Our methods include protein fractionation techniques, liquid separations, mass spectrometry and spectroscopic methods. Surgery. Bioinformatics. Molecular and Cellular Pathology. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry. Neil Marsh, Ph.D. Enzymology: Structure and mechanism of coenzyme B12 and S-adenosylmethionine-dependent radical enzymes. Protein Design: synthesis of "Teflon" proteins - introducing new properties into proteins using fluorinated amino acids. Biophysics. Biological Chemistry K. M. Jairam Menon, Ph.D. Signal transduction through G protein-coupled receptors; molecular aspects of hormone action. Biological Chemistry. Obstetrics & Gynecology. Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology. Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease. Molecular & Integrative Physiology John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Alexander J. Ninfa, Ph.D. Reconstitution of signal transduction systems from purified components, structure/function analysis of signal transduction enzymes, protein crystallography. Characterization of protein kinases, phosphatases, and nucleotidy/transferases involved in signal transduction. Organization of the gene cascade controlling nitrogen assimilation in bacteria. Development of synthetic systems that perform useful functions. Biological Chemistry. Microbiology & Immunology. Patrick O'Brien, Ph.D. Biochemical, biophysical, and structural approaches to understanding mechanisms of human DNA repair. Biological Chemistry. Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology. Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology. Yoichi Osawa, Ph.D. Formation of reactive intermediates such as nitric oxide, oxygen metabolites, and drug metabolites and their subsequent interactions with important cellular targets as potential mechanisms by which drugs, environmental pollutants, and certain pathological conditions lead to toxicity or disease. Pharmacology. Bruce Palfey, Ph.D. Mechanistic enzymology with a focus on flavoproteins involved in pyrimidine biosynthesis, tRNA maturation, inhibitor design, and structure/function relationships. Biological Chemistry. Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology. Stephen W. Ragsdale, Ph.D. We are studying the microbial metabolism of one-carbon compounds (CO, CO 2 , methane) and xenobiotics (e.g., PCBs); oxygen sensing in the human carotid body; and the roles of metal ions in biology, including the mechanisms of nickel, B 12 , heme, and iron-sulfur enzymes. We use transient and steady-state kinetics, spectroscopy, and molecular biology to uncover mechanistic information. Biological Chemistry. Chemical Biology. Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Brian D. Ross, Ph.D. Multinuclear NMR spectroscopy and imaging of intact biological systems, with an emphasis in experimental neuro-oncology, oxidative stress, and gene therapy. Biological Chemistry. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. Gabrielle Rudenko, Ph.D. Determining the three-dimensional structure of proteins with important functions in the brain using x-ray crystallography, augmented with biochemical, biophysical as well as mutagenesis studies. Pharmacology. Life Sciences Institute Maria Sandkvist, Ph.D. Protein trafficking in bacterial pathogens. Microbiology & Immunology. Mark A. Saper, Ph.D. Structural biology of components of the type III secretion system essential for bacterial pathogenesis. Other current projects include a novel bacterial tyrosine kinase and phosphatase important for pathogenesis, and a family of aminotransferases essential for plant photorespiration. Protein crystallography is the main technique employed in the lab. Biological Chemistry. Biophysics.
Jochen H. Schacht, Ph.D. Neurochemistry; biochemical
mechanisms of hearing processes and drug-induced hearing
loss. Biological Chemistry.
Neuroscience. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics. Donna S. Shewach, Ph.D. Metabolism and mechanism of action of nucleoside analog anticancer compounds. Pharmacology. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. Janet Smith, Ph.D. Structure-function studies of proteins using X-ray crystallography with an emphasis on complex enzymes and the replication proteins of flaviviruses and alphaviruses. Biological Chemistry. William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as "cyclooxygenases". Biological Chemistry. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Roger Sunahara, Ph.D. Structure/function of the G-protein-coupled signaling cascade; molecular mechanisms of hormone receptor-mediated activation of G proteins; molecular mechanisms of activation and regulation of adenylyl cyclase. Pharmacology. Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry. Raymond C. Trievel, Ph.D. Structural and functional studies of enzymes that catalyze post-translational modifications of proteins, especially those involved in transcriptional regulation and chromatin remodeling. Biological Chemistry. David Turner, Ph.D. Molecular mechanisms that regulate cell-fate decisions during the development of the vertebrate nervous system. Biological Chemistry. Neuroscience. Tetsufumi
Ueda, Ph.D. Protein phosphorylation in the nervous
system and neuropharmacology; Biochemistry and function
of synaptic vesicles. Neuroscience.
Pharmacology. Michael D. Uhler, Ph.D. Regulation and specificity of serine-threonine protein kinase structures; regulation of calcium channels and neurotransmitter secretion; function and regulation of neuronal activity; Cyclic nucleotides and phosphorylation in neuronal plasticity. Cellular & Molecular Biology. Biological Chemistry. Molecular and Chemical Neuroscience. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network and
synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience, Molecular & Behavioral Neuroscience
Institute. Anne Vojtek, Ph.D. Regulation of cell growth and differentiation by signal transduction pathways. Biological Chemistry. Nils G.
Walter, Ph.D. Folding and function of non-coding RNA; structural and single molecule RNA enzymology; ribosome and spliceosome function by single molecule microscopy; single molecule systems biology. Biophysics. Cellular & Molecular Biology. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute.
Thomas E. Wilson, MD, Ph.D. DNA double-strand break
repair mechanisms and their contribution to the
chromosomal instability of cancer. Molecular and
Cellular Pathology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology Zhaohui Xu, Ph.D. Protein-protein interaction and molecular recognition; structural biology of protein folding, protein translocation, and cellular signal transduction; x-ray crystallography. Biological Chemistry. Charles F. Yocum, Ph.D. Mechanisms of photosynthetic energy transduction. Molecular, Cellular & Developmental Biology. Biophysics. Matt Young, Ph.D. Regulatory mechanisms of the Cyclin Dependent Kinases and other protein kinases. Structural studies and computational modeling of molecular dynamics in signaling proteins. Biological Chemistry. Bioinformatics. Robert Zand, Ph.D. Studies of posttranslational modification in human normal and multiple sclerosis myelin basic protein. Also studies of demyelination in genetically modified mice. These studies involve spectroscopic methods such as UV-Vis, IR, CD, Mass Spectrometry, and NMR.. Biological Chemistry. Biophysics. Jon-Kar Zubieta, MD, Ph.D. Neurochemical and brain networks involved in the pathophysiology of the mood disorders, as well as their comorbidity with substance abuse. Monoaminergic synaptic density, brain volumes and brain proton spectroscopy in Bipolar Disorder. Psychiatry. Internal Medicine. Neuroscience. Mental Health Research Institute. Erik R. P. Zuiderweg, Ph.D. Determination of three-dimensional structures of biomolecules and complexes of biomolecules in solution, using multidimensional heteronuclear NMR spectroscopy; NMR studies of biomacromolecular conformation and dynamics in solution, concentrating on methodology developments and on applications involving domains of Hsp-70 chaperone and metal binding proteins such as matrix-metalloproteinase proteins. Biophysics. Biological Chemistry. Chemistry. |
