healthy children were randomized into one of 5 different treatment
groups to receive control syrup (n=165, mean age 2.2), xylitol
syrup (n=159, mean age 2.2), control chewing gum (n=178, mean
age 4.6), xylitol chewing gum (n=179, mean age 4.6), or xylitol
lozenges (n=176, mean age 4.7).1
3 month randomized, controlled trial, blinded within chewing gum
and syrup groups.
Comparison of xylitol syrup with control syrup showed an ARR of
12%, with an NNT of 8 to prevent one episode of AOM; ARR 26% and
an NNT of 4 in preventing any episode of AOM.
Comparison of xylitol chewing gum with control chewing gum showed
an ARR of 12%, with an NNT of 8 in preventing one episode of AOM.
To prevent any episode of AOM, the ARR=15% with an NNT of 7.
No statistically significant difference with xylitol lozenges
compared with control chewing gum.