patients were enrolled. Patients were 1-18 years old
drawn from 3 suburban St. Louis pediatric practices.
All patients had 10-28 days of persistent upper respiratory
symptoms and a clinical diagnosis of sinusitis.1
excluded if they had “fulminant sinusitis” (fever>39, facial
swelling/pain), were allergic to the study drug, had
concurrent illness requiring antibiotic, had complication
of sinus disease, chronic (>28 days) sinus disease, had received
antibiotics in the preceding 2 weeks, or had cystic fibrosis.
outcome measure was change insymptom score measured by S5
questionnaire (validated pediatric sinus severity scale).
outcomes included: adverse effects, recurrence or relapse,
functional status, lost time from school/day care, satisfaction
with treatment, compliance.
received either Amoxicillin (40mg/kg/D), Augmentin (45 mg/kg/D)
or placebo for 14 days.
interviews conducted at days 3, 7, 10, 14, 21, 28, 60.
patients improved over time with no differences in any outcomes
at any time.
treated with Amoxicillin had a higher incidence of abdominal
pain compared to the other groups. Otherwise no differences
in adverse effects.