is a randomized, double blinded, placebo controlled trial among
simethicone alone, loperamide alone, and combination loperamide-simethicone.1
- Patients received blinded identical chewable tablets and kept
ongoing records of timing and consistency of stools and degree
of abdominal pain for 48hrs.
- The groups were similar, except that there were more people
with more severe disease in the combination group.
- Combination loperamide-simethicone users had lower time to resolution
of diarrhea vs placebo (9.7 vs 39.0 hrs, p<.001) and shorter time
to resolution of abdominal pain (12.0 vs 48.0 hrs, p<.001). Users
of simethicone or loperamide alone had smaller but still statistically
significant reductions vs placebo.
- Compared to placebo, for every two patients treated with the
combination, one person will no longer have diarrhea at 24 hours
- No adverse events were reported, but the study was not powered
to detect these.