- Study is problematic due to problems with confounding variables and
- The confounding variable is the number of febrile episodes (107) is
less than the total number of children in the study (80).
- The study has problems with generalizability given that the study
involves a very specific patient population that is followed very closely
through St. Jude's research hospital and the fact that in addition to
stated exclusion criteria, study also excluded children that met "high
risk" criteria that were never defined.
et al. Outpatient treatment with ceftriaxone and oral cefixime of selected
febrile children with sickle cell disease. J Pediatric Hematology
Author: Sara Boblick, MD
CAT Appraisers: James
Date appraised: March
November 28, 2006
of Pediatrics and Communicable Diseases
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