- The study did a poor job accounting for all the evaluations and patients.
In addition, none of the sensitivity and specificity data for evaluations
performed after one day of life were revealed.
- No single criteria or group of criteria had the net effect of ruling
in or out a diagnosis.
- The organisms isolated from the blood cultures differed from the
"usual offenders" for neonatal sepsis, casting some doubt on the gold
- No long-term data (in terms of mortality outcomes) was reported.
J, Goldfarb J. Neonatal Infections, Chapter 13 in Care of the High-Risk
Neonate, 4th edition. MH Klaus and AA Fanaroff: editors. Philadelphia:
WB Saunders Company, 1993.
RL, Leslie AL, Tudehope DI. Early diagnosis of neonatal sepsis using
a hematologic scoring system. Journal of Pediatrics 1988; 112:
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Millar MR, Gorham P, Congdon P. Comparison of five tests used in diagnosis
of neonatal bacteremia. Archives of Diseases of Children 1988;
C, Uehlinger J, Ghelfi D, Blau N, Fanconi S. Comparison of C-reactive
protein and white blood cell count with differential in neonates at
risk for septicaemia. Journal of Pediatrics 1995;154:138-144.