- None of the above cited articles performed a power analysis, thus
they may contain type 2 errors.
- More research regarding the use of steroids in patients with severe
bronchiolitis requiring intubation is needed.1
- Both of the above cited studies were performed in northern European
countries. Perhaps findings would be different with patients from other
- More research is needed regarding the long-term effect of steroid
use. One study found that prednisolone during the acute phase of RSV
bronchiolitis does not prevent wheezing or the development of asthma
at the mean age of 5 years. However, this study was small, including
only 47 patients, and relied on parental self reporting.4
- No clinically significant adverse side effects were noted in any of
the studies mentioned; however, the sample sizes were small.
- van Woensel
JB, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL. Randomised double
blind placebo controlled trial of prednisolone in children admitted
to hospital with respiratory syncytial virus bronchiolitis. Thorax.
- De Boeck
K, Van der Aa N, Van Lierde S, Corbeel L, Eeckels R. Respiratory syncytial
virus bronchiolitis: a double-blind dexamethasone efficacy study. Journal
of Pediatrics. 131(6):919-21, 1997.
TP, Sutcliffe T, Watters LK, Wells GA, Allen UD, Li MM. Dexamethasone
in salbutamol-treated inpatients with acute bronchiolitis: a randomized,
controlled trial. Journal of Pediatrics. 130(2):191-6, 1997.
- van Woensel
JB, Kimpen JL, Sprikkelman AB, Ouwehand A, van Aalderen WM. Long-term
effects of prednisolone in the acute phase of bronchiolitis caused by
respiratory syncytial virus. Pediatric Pulmonology. 30(2):92-6,
C, Bar-Yishay E, Uwayyed K, Avital A, Vilozni D, Godfrey S. Corticosteroids
do not affect the clinical or physiological status of infants with bronchiolitis.
Pediatric Pulmonology. 9(3):181-5, 1990.
JH, Field CM, Glasgow JF, Slattery CM, MacLynn DM. A double blind trial
of prednisolone in epidemic bronchiolitis due to respiratory syncytial
virus. Acta Paediatrica Scandinavica. 58(2):116-20, 1969.