- Biological mechanisms in question are the absorption of the oral HRV
within the gut and whether this puts the patient at risk for future
development of intussusception, a condition of intestinal telescoping
and subsequent edema and possible incarceration.
- Instituting a broad clinical directive to add HRV to the already busy
standard immunization schedule recommended for U.S. children obviously
involves many different aspects of health care included cost benefit,
risk of illness vs. risk of HRV, societal perception of rotavirus, and
availability of safe, large scale vaccine production.
GM, Perez-Schael I, Velazquez FR, et al. Safety and efficacy of an attenuated
vaccine against severe rotavirus gastroenteritis. N Engl J Med
BP, Azimi PH, Staat MA, et al. Nonmedical costs associated with rotavirus
disease requiring hospitalization. Pediatr Inf Dis J 2005;