- Postductal pulse oximetry was measured in 11,281 infants with out
signs (cyanosis, tachypnea, grunting, flaring, retractions, murmur,
active precordium, or diminished pulses). If SpO2 measured was <95%,
an echocardiogram was done. If SpO2>95%, the infant was routinely
- The reference standard was reported diagnoses of CHD from a state-law
mandated birth defects registry, hospital discharge data, and death
certificates. SpO2<95% detected three cases of significant CHD; two
with total anomalous pulmonary venous return, one with truncus arteriosus.
Two infants with normal screen had delayed diagnosis of CHD, one with
aortic coarctation and one with hypoplastic left pulmonary artery with
aortopulmonary collaterals. There was one false positive, persistent
right to left shunting due to delayed fetal transition.
- Total number of CHD detected by screening was 1/3760. Hospital A
detection rate was 1/8642, hospital B detection rate was 1/1320. Hospital
A performed a higher percentage of fetal echos.
- The authors report that there was no cost incurred for equipment,
supplies, or personnel.