- Comparison in children younger than six months needs to be completed.
- Results may not be applicable to children younger than 6 months of
age; there has been at least one small study4 which showed
in children 2-28 months, there is bacterial eradication with azithromycin
after 3 and 5 day courses, but up to 20% of participants experienced
- To treat a 20kg child a full course of erythromycin (as per the study)
would cost $3.20 (based on hospital cost for drug) vs. for azithromycin
$19.60 (again based on hospital prices)
- When taking azithromycin, patients need to time doses to be 1 hour
before or 2 hours after eating for better absorption, whereas erythromycin
can be taken at any time.
JM, Halperin SA, Boucher FD, Smith B; Azithromycin is as effective as
tolerated than erythromycin estolate for the treatment of pertussis.
A, Zrnic T, Begovac J, Kuzmanovic N, Culig J. Short-term treatment of
with azithromycin in infants and young children. Eur J Clin Microbiol
Infect Dis. 1999 Apr;18(4):296-8.