yr olds recruited via advertisements on TV, in schools, and churches
initially responded, 329 eligible, 159 actually presented, 120 randomized
for treatment, with 53 actually completing the study.
if smoking >10 CPD, scoring high on Fagerstrom Test of Nicotine Dependence,
motivated to quit, and with consent of parent or legal guardian. Patients
excluded if with major health problem, pregnant, acute psychiatric illness.
randomly distributed to 3 groups: 21mg nicotine patch and placebo gum,
placebo patch and 4mg nicotine gum, placebo patch and placebo gum for
total of 12 weeks
follow up first 6 weeks with self report of cigarettes smoked per day,
measurement of exhaled CO and blood and saliva nicotine, thiocyanate
and cotinine levels and 45min of cognitive behavioral therapy. Bi-weekly
follow up for second 6 weeks with same parameters obtained and continued
f/u at 3months after study finish with same parameters measured and
self report of abstinence or cigarettes smoked per day
reduction in cigarettes smoked per day in all three treatment groups
with abstinence as noted above.
side effects noted with nicotine patch and gum over placebo, but none