- 94 patients at onset, 81 followed clinically over initial 2 week period.
Patients were computer randomized into placebo and treatment groups.
- This was a double blind study. Both groups with similar demographic
and laboratory features; EBV infection confirmed by serology.
- Treatment group given Acyclovir 800mg po 5x/d and prednisolone 0.7mg/kg/d
x 4d, then weaned by 0.1mg/kg per day until stopped at day 10.
Equivalent IV meds used in some hospitalized patients. Matching placebos
were provided for the control group.
- Groups examined clinically with assessment scale regarding symptoms.
34 patients also selected for virologic and immunologic assessments
to look at EBV replication, effects on EBV-specific immunity.
E. Aurelius E. Brandell A. Julander I. Wood M. Yao QY. Rickinson A.
Akerlund B. Andersson J. Acyclovir and prednisolone treatment of acute
infectious mononucleosis: a multicenter, double-blind, placebo-controlled
study. Journal of Infectious Diseases. 174(2):324-31, 1996.