- Amount of stool was not reported in the studies, and therefore not
- The methods in the included studies differed as to how diarrhea was
defined, how diarrhea intensity was measured, which strain of Lactobacillus
was used and how lactobacillus was administered.
- It included studies funded by pharmaceutical and food companies -
may have biased toward submission and publication of only those studies
that found therapy to be beneficial.
- No significant adverse reactions were reported; myoclonic jerks were
reported in 1 patient in the treatment group and 1 patient in the control
- 48-hour course of Lactobacillus product is available for approximately
- All studies were done on inpatients; Lactobacillus-effects might be
less pronounced in children who are not sick enough to require hospitalization;
however most of the patients required only oral rehydration solution.
therapy for acute infectious diarrhea in children: a meta-analysis.
et al. Lactobacillus GC administrationin oral rehydration solution to
children with acute diarrhea: a muticenter European trial. J Pediatr
Gastroenterol Nutr 2000;30:629- 634.
et al. Lactobacillus reuteri is a therapeutic agent in aute diarrhea
in young children. J Pediatr Gastroenterol Nutr 1997;24:399-404.
Author: Lina Boujaoude, MD
CAT Appraisers: Jonathan
Date appraised: June
October 27, 2002
of Pediatrics and Communicable Diseases
© 1998-2002 University of Michigan Health System