- This study was performed in Spain where there is more heterogeneity in IVF than in our hospital so a direct comparison is difficult.
- The dropout rate in the study was very high (~50%).
- While the 1° outcome (hyponatremia) was different between the groups at 24hrs, it is unclear how that trend would change over time. Both 1° and 2° endpoints beyond 24hrs would enhance the generalizability of the results.
- Montanana, et al. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med. 2008;9:589-97.
- Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19:823-32.
Author: Brian K. Jordan, MD, PhD
CAT Appraisers: Amanda Dempsey,
Date appraised: March 11, 2009
June 9, 2009
of Pediatrics and Communicable Diseases
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