is the first large study, since FDA black box warnings came out, to
address use of SSRIs in depressed adolescents.1
needed to harm was calculated for "harm-related events" defined
as events which include aggression, increased suicidal ideation, and
increased non-lethal suicidal behavior: Number Needed to Harm (NNH)=
16 patients treated to cause one more harm-related event (95% CI = 6
needed to harm was also calculated for "suicide-related events"'
defined as events which include suicide attempts or increases in suicidal
ideation, this is a subset of the events included in "harm-related"
events: NNH = 31, (95% CI = 8 to NNT 106). This can be interpreted as
31 patients treated to cause one more harm related event, but 95% CI
crosses from NNH of 8 to NNT of 106 (which would reflect a decrease
in these events on patients on fluoxetine).