amenorrheic patients with anorexia nervosa were studied.(1) 22
patients received estrogen and progesterone, and 26 patients acted
as control subjects.
Within the therapy group, the type of hormonal therapy varied;
some patients took oral contraceptive pills, and others received
Premarin (0.625mg) and Provera (5 mg).
Patients were followed every 6 months for an average of 18 months.
History and physical, spinal bone density, and serum studies were
performed at each visit.
All patients took at least 1500 mg of calcium per day (from diet
and/ or supplements).
The two groups were similar in all ways at the onset of the study,
including mean spinal bone mineral density.
There was no statistical difference in bone density between the
two groups at the end of the study period. (p=0.2)
There was a statistically significant increase in mean bone density
in the subset of the control group who regained menses and a more
normal body weight.
No mention of the power of this study is made and there are several
factors (e.g. different types of hormonal therapy) which could
bias the study in the direction of no results.