- Strengths of this paper lies in the analyses that can be done (i.e.
it can be assessed) from multiple points of view (i.e. length of hospital
stay, utilization of ancillary tests, use of IV antibiotics), and its
use of the test year round.
- Weaknesses of this study include not performing a detailed economic
analysis (i.e. it only states that economic benefits can be inferred
from the results), and that it does not separate the impact of the PCR
from that of the clinical presentation on the medical decision making.
- This article suggests that there may be savings by using EV-PCR as
a diagnostic test.
- Numerous variables will affect actual cost savings for my institution
that begins to use EV-PCR. A clinical decision algorithm and a prospective
study may be useful to confirm its effect here.
C, Billman G, Hartin M, Ho S, Sawyer MH. Impact of a diagnostic cerebrospinal
fluid enterovirus polymerase chain reaction test on patient management.
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MS, Jackson MA, Abel D. Clinical utility of polymerase chain reaction
testing for enteroviral meningitis. Pediatr Infect Dis J 1999;
SK, Heinl RE, Thornton LL, Opal SM. Clinical characteristics, management
strategies, and cost implications of a statewide outbreak of enterovirus
meningitis. Clin Infect Dis 1995; 20:931-7.
GS, Hauck MA, Buck G, Rabalais GP. Potential cost savings through rapid
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