- Physicians feel obligated to follow guidelines despite the lack of
evidence that antibiotic prophylaxis is effective.
- Because the incidence of endocarditis is so low, a RCT done over 2
years would require inclusion of 60,000 patients with a cardiac risk
factor for endocarditis.
- The American Heart Association has published guidelines recommending
the use of prophylactic antibiotics when undergoing surgical or dental
procedures likely to cause bacteremia in those cardiac conditions associated
R; Roberts, GJ; Hooper, L. Penicillins for the prophylaxis of bacterial
endocarditis in dentistry. The Cochrane Database of Systematic Reviews