- It is important to note that the participants are those who were seen
by a physician for their cold symptoms. Whether the results would be
the same in those children who were not seen is unclear.
- The study did not report the number of patients who declined to participate,
nor did it report if any patients failed to complete the study.
- The blinding between placebo and medication was careful and had same
taste/appearance but did not mention if either contained alcohol in
- The increase in sleep may well have been due to the drowsiness from
the antihistamine's anticholinergic effect.
- There was no reporting of side effects or adverse reactions, but these
may be serious considerations when treating a minor illness such as
CJ, Taylor JA, Almquist JR, Quinn HC, Mehta A, Naylor GS. Is an antihistamine
-decongestant combination effective in temporarily relieving symptoms
of the common cold in preschool children? J Pediatr 1997;103,463-6.