- Cimetidine is an H2-receptor antagonist known to have immunomodulatory
effects including enhancement of T-cell-dependent responses. It has
been tested in the treatment of HSV, VZV & EBV infections as well as
several systemic and dermatologic diseases associated with immunosuppression.
- Ten studies of cimetidine treatment for warts have been done; only
three were double-blind, placebo-controlled; the remainder were either
open-label studies, comparison with standard therapy, or case reports.
Cure rates have ranged from 10%-82%. Results have suggested that younger
patients have a greater response rate.2
- Children with multiple recalcitrant warts remain a unique population
in whom effective, safe and painless systemic treatment would be advantageous.
A randomized controlled trial focusing on this group should be conducted.
- More than 50% of warts in children will resolve spontaneously within
2 years. Cure rates for warts in placebo treatments have ranged from
10%-35% in the literature.2
E, Alpsoy E, Basaran E. Cimetidine therapy for warts: A placebo-controlled,
double-blind study. J Am Acad Dermatol 1996; 34:1005-7.
CJ, Gibney MD, et al. Cimetidine therapy for recalcitrant warts in adults:
Is it any better than placebo? J Am Acad Dermatol 1999; 41:123-7.