- Literature evaluation reveals greater sepsis risk for study group
than for all newborns (baseline risk).1,2
- Altering practice guidelines would result in missing infants with
bacteremia and partially treated sepsis, which could produce serious
morbidity and/or additional mortality.
- Study performed in 1993, before guidelines for GBS screening and treatment
implemented. Etiology of early-onset neonatal sepsis has changed since
- A more recent cohort study is needed to ascertain current sepsis incidence
and etiology before current conservative approach to infants born to
mothers with chorioamnionitis can be altered.
RL, Wiswell TE. Hume RF. Outcome of term gestation neonates whose mothers
received intrapartum antibiotics for suspected chorioamnionitis. Am
J Perinatology 1993; 10:365-8.
J, Goldberg M, Kohelet D. Neonatal bacteremia. A 4-year prospective
study. Isr J Med Sci 1983; 19:963-6.
L, et al. Intrapartum treatment of acute chorioamnionitis: Impact on
neonatal sepsis. Am J Obstetrics Gynec 1988;159:579-83.
sepsis: Intraamniotic infection. Up-To-Date. 2004.