- Chronic fatigue syndrome likely represents at least several and likely
many distinct clinical entities; no causal etiology has been identified.
Therefore, individual patients with chronic fatigue syndrome may have
different responses to therapy.
- Medications studied in randomized controlled trials for CFS include
antidepressants, corticosteroids, dietary supplements, immunotherapy,
and oral NADH. None of these were proven efficacious in randomized,
placebo-controlled clinical trials.(3)
- Given the heterogeneous nature of patients with chronic fatigue syndrome,
the “n of 1” randomized, placebo-controlled trial may be a useful intervention
in individual patients to determine treatment efficacy.
- Vercoulen JH, et al. Randomised, double-blind, placebo-controlled
study of fluoxetine in chronic fatigue syndrome. Lancet,
- Mehta VK and Blume GB. A randomized trial of fluoxetine in
a patient with persistent fatigue. Journal of the American
Board of Family Practice, 1995; 8(3):230-232.
- Marshall GS. Report of a workshop on the epidemiology, natural
history, and pathogenesis of chronic fatigue syndrome in adolescents.
Journal of Pediatrics, 1999; 134(4):395-405.
- Reid S, et al. Chronic fatigue syndrome. BMJ, 2000;