collection of patients with DVT's had a significant rate of morbidity
and mortality.(1) However, the incidence of 3.5 per 10,000 admissions
was thought to be an underestimate.
A prospective study in the PICU setting showed a rate of clinically
evident thrombosis at 7.5% and a clinically silent rate of CA-DVT at
18.3%. (2) Although the study population was small there was no
symptomatic PE or mortality from CA-DVT in the group. Infection
in patients with DVT was not reported. 2/12 patients still had
symptoms at one month follow-up.
A prospective study of 156 children with cancer undergoing ECHOs for
anthracycline use systematically looked for and found that 8.8% had
right atrial thrombi.(3) Although no patients were symptomatic,
2 patients underwent thrombectomy, 3 were treated and 7 were observed.
They found a relationship between placement of catheter tip in atrium,
diagnosis of ALL (may have been selection bias) and possible trend toward
treatment with L-aspariginase.