of 24 randomized or quasi-randomized trials evaluating the efficacy
of fiberoptic phototherapy in a number of different clinical situations
and patient populations, of which nine included only preterm infants,
or contained some preterm infants and reported results for them separately.1
of phototherapy was not significantly different between the groups (WMD
2 hours, 95% CI -3.52, 7.52).
was no greater use of additional phototherapy in the fiberoptic group
(RR 1.07, 95% CI 0.27, 4.27).
percentage change in SBR after 24 hours of treatment was not significantly
different betaween the groups (WMD 1.7%, 95% CI -2.65, 6.05).
use of repeat phototherapy for rebound jaundice was no higher in the
fiberoptic group (RR 2, 95% CI 0.71, 5.63).
percentage change in SBR per hour and per day was significantly affected
by heterogeneity. Some factors that may have attributed to this include
different types of fiberoptic therapies, different irradiance settings
of the biliblanket, different lamp colors/types for conventional PT,
phototherapy instituted at different SBR levels.
review appeared to be valid as it appeared to be an exhaustive search,
methodological quality of both the index trials and review process was
high, and results were reproducible.
incidence of kernicterus was not included in any of the studies.
studies did not share a common primary outcome measure, making a meta-analysis
including all studies impossible without individual patient data.
water loss (WMD 17 ml/m2/hr, 95% CI 7.26, 26.74) and mesenteric blood
flow velocity (WMD 0.11m/s, 85% CI 0.1, 0.12) after feeding were significantly
higher in infants treated with fiberoptic devices.