control study of 696 patients utilized a multivariable predictive model
to identify 5 predictors of bacterial meningitis: CSF Gram stain positive
for organism, CSF protein >80, CSF absolute neutrophil count (ANC)
>1,000, peripheral ANC >10,000, and presence of seizure.1
Meningitis Score (BMS) constructed from analytical models was validated
through an independent data set separate from the derivation set.
the calculation of BMS (+2 for +CSF Gram stain, +1 for +CSF protein,
+1 for +CSF ANC, +1 for peripheral ANC, +1 for seizure), a score of
0/6 produces NPV of 100% and -LR ~0. A score of >2/6 produces PPV
of 87% and +LR of 33.