- Double-blind placebo randomized controlled trial.
- Reasonable study protocol, treatment intervention, and
- 11% population was less than 2 years of age.
- Dosage of ipratropium bromide was 250 mcg per dose.
- Corticosteroids were administered at different times within
the first hour depending on the physician.
- Eight patients in the control group received ipratropium
bromide outside the study protocol and were subsequently discharged
- Outcome measures (e.g., time to ER disposition; number
of treatments needed) are difficult to translate into clinical
- Double-blind randomized placebo controlled trial of children
with moderate to severe asthma.
- Reasonable patient population, protocol, and treatment
- Patients less than 2 years of age and those with mild
disease were excluded. Dosing of albuterol and Atrovent
was higher per kg body weight than most studies.
- More girls were present in the treatment group compared
to controls, p=0.04.
Zorc J, Pusic M, Ogborn J, Lebet R, Duggan A. Ipratropium bromide
added to asthma treatment in the pediatric emergency department.
Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized
ipratropium on the hospitalization rates of children with asthma.
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Brophy C, Ahmed B, Bayston S, Arnold A, McGivern D, Greenstone M.
How long should Atrovent be given in acute asthma. Thorax1998;
Stoodley RG, Aaron S, Dales R. The role of ipratropium bromide
in the emergency management of acute asthma exacerbation: A meta-analysis
of randomized clinical trials. Annals of Emergency Medicine
Rowe B, Travers A, Holroyd B, Kelly K, Bota G. Nebulized ipratropium
bromide in acute pediatric asthma: Does it reduce hospital admissions
among children presenting to the emergency department. Annals
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