- Increased amounts of particulate matter are associated with motor
vehicle exhaust fumes, incinerators, and other combustive processes.2
- There has long been a recognized association between increased symptom
severity, visits to emergency rooms, and mortality in patients with
chronic lung disease, when larger diameter particulate matter in increased.2
This paper examines the association between smaller diameter particulate
matter and severe asthma symptoms.1,2
- The proposed biologic mechanism is the induction of inflammation by
the deposition of particulate matter in the altered airways of patients
- This is an epidemiologic study; therefore, it is not randomized, there
is no control group, and there is potential for confounders not identified
in the analysis (e.g. indoor allergens).3
- Slaughter JC et. al. Effects of ambient air pollution on symptom severity
and medication use in children with asthma. Ann Allergy Asthma &
Imm 2003; 91: 346-353.
- Slavi S. Ambient particulate air pollution and childhood asthma exacerbations
(editorial). Ann Allergy Asthma & Imm 2003; 91:321-323.
- Etzel R. How environmental exposures influence the development and
exacerbation of asthma. Pediatrics 2003; 112: 233-239.