- Mechanism of action of corticosteroids in the treatment of asthma
is not entirely clear, but includes interference with arachidonic acid
metabolism and synthesis of leukotrienes; prevention of activation and
migration of inflammatory cells, and increased responsiveness of B-receptors
of airway smooth muscle.
- AAP and University of Michigan Clinical Guidelines recommend the use
of systemic corticosteroids in the treatment of moderate to severe asthma
exacerbation, but acknowledge the controversy surrounding the route
PLJ, et al. Intravenous versus oral corticosteroids in the management
of acute asthma in children. Annals of Emergency Medicine 1997;
- Cada DJ.
Drug Facts and Comparison. St. Louis, MO: Drug Facts and Comparison,
- Lacy CF.
Drug Information Handbook, 9th Edition. Lexicomp Publishing: Hudson,
K. Oral versus IV steroids for asthma. The Journal of Family Practice
Asthma Education Report, expert panel report. Guidelines for the
Diagnosis and Management of Asthma. Bethesda, MD: National Institutes
of Health, 1991:NIH publication no. 91-3042A, 1991.
- Amy Skyles,
pharmacy student, University of Michigan Drug Information Services.