Research PECARN has over 21 projects in various stages from the data collection phase to complete with published results.  Studies are currently enrolling at GLEMSCRN sites include: A study on the application of diagnostic biosignatures that will allow accurate discrimination between febrile infants evaluated in the ED with bacterial infections and those infected with non-bacterial infections (see below) A study comparing the use of lorazepam versus diazepam for the treatment of pediatric status epilepticus A study to evaluate whether regulating the body temperature will improve the outcome for children after cardiac arrest (see below) A planning grant to prepare for a randomized controlled trial of progesterone for traumatic brain injury in children.  (see below) A study of  intravenous magnesium sulfate for treatment of acute painful vaso-occlusive crisis in sickle cell disease        A study  comparing two fluid regimens for management of diabetic ketoacidosis A study to assess whether implementation of  the PECARN traumatic brain injury (TBI) prediction rules using computerized clinical decision support decreases CT use in those at very low risk of TBI   GLEMSCRN Federally Funded Research Projects The following studies are led by investigators from GLEMSCRN: Therapeutic Hypothermia After Cardiac Arrest in Children (THAPCA) Trials Funded by the National Heart, Lung and Blood InstitutePrincipal Investigator:  Frank Moler, M.D., M.S., C.S. Mott Children’s Hospital, University of Michigan The study will evaluate whether regulating the body temperature will improve the outcome for children after cardiac arrest. There is a separate study for children who arrest in the hospital (THAPCA-IH) and children who arrest out of the hospital (THAPCA-OH). The goal of these two trials is to determine if therapeutic hypothermia improves survival with good neurobehavioral outcome in children who have had a cardiac arrest. http://www.thapca.org/ http://clinicaltrials.gov/ct2/results?term=THAPCA Progesterone for the Traumatic Brain Injury in Children:  Planning for a Safety and Efficacy Trial Funded by HRSA Grant # H34MC19353 Principal Investigators:  Rachel Stanley, M.D., M.H.S.A., University of Michigan and Nathan Kuppermann, M.D., M.P.H., University of California at Davis  Planning grant to complete all planning work necessary to conduct a future safety and efficacy trial of progesterone for pediatric traumatic brain injury including developing detailed inclusion/exclusion criteria and study outcomes. RNA Biosignatures in the Emergency Evaluation of Young Febrile Infants Funded by National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health & Human Development, Grant #1R01HD062477-01A1 Principal Investigators:  Prashant Mahajan, M.D., M.P.H., M.B.A., Wayne State University and Children’s Hospital of Michigan, Octavio Ramilo, M.D., Nationwide Children’s Hospital, The Ohio State University and Nathan Kuppermann, M.D., M.P.H., University of California at Davis  The main aim of this study is to evaluate the application of diagnostic biosignatures that will allow accurate discrimination between young febrile infants evaluated in the ED with bacterial infections and those infected with non-bacterial pathogens. The long term goal is to provide the clinician with a tool that can be used in the ED setting and reduce the need for unnecessary invasive procedures, empiric antibiotics and hospitalizations. Please see the PECARN website for the current list of projects.

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Great Lakes EMS-C Research Network University of Michigan Emergency Medicine Research 24 Frank Lloyd Wright Drive, Suite H-3200 PO Box 443 Ann Arbor MI 48106 (734) 936-1724   FAX (734) 936-2706 This study is supported by grant U03 MC 00003 from the Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, Department of Health and Human Services.