Search press releases
Search entire Web site Go
UMHS Home/Logo

April 30, 2007

Nobel-winning pioneer in understanding cholesterol to give annual James V. Neel lecture at U-M

ANN ARBOR, MIJoseph L. Goldstein, M.D., a noted molecular genetics pioneer at the University of Texas Southwestern Medical Center whose discoveries two decades ago laid the groundwork for the development of statin drugs to lower cholesterol and prevent heart attacks, will give the seventh annual James V. Neel Lecture at the University of Michigan on Thursday, May 17 at 3 p.m.

Joseph GoldsteinThe talk, sponsored by the U-M Department of Human Genetics, takes place at the Biomedical Science Research Building Auditorium, located at 109 Zina Pitcher Place on the University of Michigan medical campus. A reception and poster session will follow the lecture. For information, call 734-764-5491.

The annual event honors James V. Neel, M.D., Ph.D., who founded the nation’s first human genetics department at U-M in 1956. Neel was among the first to foresee the role of genetics in the diagnosis and treatment of medical conditions. Goldstein continues to explore that role today.

“Dr. Goldstein is one of America’s most prominent cardiovascular scientists,” says Kim Eagle, M.D., a director of the U-M Cardiovascular Center.

U-M Medical School Chief of Cardiovascular Medicine David Pinsky, M.D., also a director of the Cardiovascular Center, calls Goldstein “one of the great scientific-medical thinkers of our time who has made a difference.”

Goldstein and his longtime collaborator Michael S. Brown won a 1985 Nobel Prize for discovering a key protein on cell surfaces, the LDL receptor, that regulates how cholesterol is taken up in cells. Their work sparked a new understanding of heart disease and paved the way for drugs to treat it.

At the University of Texas Southwestern Medical Center, the two men continue to collaborate in laboratory research on a group of gene-activating proteins key to the normal process of lipid synthesis, work that sheds light on several diseases ranging from heart disease to obesity to diabetes. Goldstein’s U-M talk, “The SREBP Pathway: From Cholesterol Homeostasis in Cells to Neural Crest Defects in Embryos,” will explore aspects of his current research.

Goldstein is a past president of the American Society for Clinical Investigation and was a member of the Governing Council of the U.S. National Academy of Sciences. He also chaired the Howard Hughes Medical Institute’s Medical Advisory Board and the Lasker Awards jury.

Goldstein is an outstanding figure in the dwindling ranks of physician-scientists who both see patients and conduct basic laboratory research that focuses on discoveries and treatments relevant to real diseases, says Pinsky. “It is important to have role models such as Dr. Goldstein to inspire the next generation of physician scientists.”   

Written by: Anne Rueter


E-mail this information to a friend

Recent Press Releases


Newsroom HOME

Contact Media Team

Join the Media List

Search Releases & Clips

UMHS Facts & Figures

Background Info


Our Publications

FAQs for Media

Medical School | Hospitals and Health Centers | School of Nursing | U-M

University of Michigan Health System
1500 E. Medical Center Drive  Ann Arbor, MI 48109  734-936-4000
(c) copyright Regents of the University of Michigan
Developed & maintained by: Public Relations & Marketing Communications
Contact UMHS


The University of Michigan Health System web site does not provide specific medical advice and does not endorse any medical or professional service obtained through information provided on this site or any links to this site.
Complete Disclaimer and Privacy Statement


Health Topics A-Z

For Patients & Families

For Health Professionals

Search Tools & Index