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January 3, 2003

A University of Michigan Health Minute update on important health issues

Watching your kids for the signs of eye disease

When detected early, strabismus and amblyopia can be successfully treated to prevent childhood vision loss

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ANN ARBOR, MI - Infants are not born with normal vision. Over the first six to nine years of life, children actually learn how to see properly. If a serious eye condition such as strabismus (a misalignment of the eye) or amblyopia (poor vision in one eye from disuse) - both often called 'lazy eye' - occurs, a child's brain will never learn to see correctly and vision in the affected eye will be permanently lost if not treated.

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Pediatric ophthalmologists (doctors who are eye specialists) at the Kellogg Eye Center in the University of Michigan Health System advise parents on what to look for to ensure proper eye and vision development for their young children.

According to Monte Del Monte, M.D., director of U-M Pediatric Ophthalmology at the Kellogg Eye Center, vision is a skill that children develop. The brain's learning process requires two things during early childhood:


  • The eyes must be aligned at the same target.
  • The target must be brought into focus on the retina of each eye.

Experts believe that between four and five percent of children under 12 years old develop a significant eye problem. Among the serious problems, the most common is called amblyopia, which is a failure for the brain to connect properly to one of the eyes. In other words, it is poor vision in one eye caused by disuse.

Amblyopia most often occurs when asymmetrical refraction (near-sightedness or far-sightedness) prevents both eyes from focusing at the same time.

"The brain sends signals to the eyes to focus. When just one eye comes into focus and the child sees adequately, the brain stops trying to make both eyes work together to focus," Del Monte says. "In that situation, that one eye will always be in focus and its connection to the brain will develop. The other eye will remain out of focus throughout childhood and will not develop the needed connections to the brain."

This type of amblyopia is the most difficult to diagnose and treat, because there are no symptoms for parents to see and discuss with their pediatrician. Frequently, it isn't diagnosed until a child receives routine vision screenings at school, usually around four, five or six years of age. At this point, it is often too late to treat.

A second type of amblyopia occurs when the eyes are misaligned. This is called strabismus and it can sometimes be noticed by parents. Symptoms include:

  • Eyes that are not aligned, either cross-eyed or turn outward;
  • Eyes that don't work together to follow a target;
  • Eyes that don't look in the same direction all the time.

If not identified and treated early, the child will experience double vision for awhile, until the brain turns off one of the eyes in order to eliminate the double vision.

"This is called suppression. If the same eye is suppressed over a long period of time, it won't connect to the brain properly, resulting in permanent loss of vision," says Del Monte, who is also the Skillman Professor in the U-M departments of Ophthalmology, and Pediatric & Communicable Diseases.

The last cause of amblyopia, and the one that is least common, is a blockage of vision in one eye. This type of amblyopia, called deprivation amblyopia, may develop because of an eyelid tumor, swelling, or drooping that covers the eye. It can also result from a problem which blocks the light path into the eye, such as a scar on the cornea (which is like a window at the front of the eye) or a cataract or bleeding within the eye.

Since vision is developed from birth until a child is between six and nine years of age and this development requires continuous focused images in both eyes, if amblyopia develops, the condition must be diagnosed and treated as early as possible for the best result. Once the child reaches the age of visual maturity, roughly six to nine years of age, the brain can no longer make new connections with the eye and good vision is permanently lost.

Treatment options depend on the cause of the amblyopia. If the problem is an abnormal or asymmetrical refraction, then the treatment involves proper glasses therapy, generally to be worn full time. If the problem is related to difficulty with alignment of the eyes, then the eyes must be straightened, either by wearing glasses, a patch on one eye, medicine in the form of eye drops, or surgery.

A common treatment for amblyopia involves patching, or occlusion therapy, in which the child must wear a patch over the strong eye so that the weaker one can grow stronger through use, according to Del Monte.

In cases of deprivation amblyopia, the blockage of the light path must be cleared by raising a drooping eyelid, shrinking an eyelid tumor or removing a cataract or hemorrhage that is inside the eye.

Del Monte says that by six or eight weeks of age, a child's eyes should be aligned, focusing properly, looking in the same direction and tracking together. If parents suspect these are not happening, they should follow up with a visit to their pediatrician or an eye specialist for diagnosis and treatment of the suspected eye problem.

The American Academy of Ophthalmology and the American Academy of Pediatrics both have recommendations on when vision screenings should occur. The first should be at the hospital as part of a newborn baby's discharge examination. Screenings should also take place in the doctor's office at two, four and six months of age. Later amblyopia screenings should take place at three years of age, and each year after school starts. These can take place at the doctor's office, with an eye specialist, or at school.

Elizabeth Coffey is the mother of a lively five-year-old named Alexander.

"He loves school and he's very smart. He's very mechanical and he can make anything with blocks. I think he's going to be a scientist someday," she says.

Just before Alexander's third birthday, Coffey noticed one eye was beginning to cross. Sometimes it was very slight, and other times - usually toward the end of the day - it would be very noticeable.

"It seemed that a lot of times, we would notice it when looking at pictures of Alexander. It would be almost crossed all the way over to his nose. But, he didn't seem like he had a problem seeing," she says.

Upon taking Alexander to an eye specialist, Coffey was surprised when Alexander couldn't see with one eye covered up.

"He kept trying to push the little paddle away and he couldn't see the letters to read them. I was amazed. I had no idea he couldn't see - there were no other signs that he couldn't see," Coffey remembers.

After Del Monte diagnosed him with strabismus and amblyopia, Alexander began wearing eyeglasses and a patch over his good eye. He's also had surgery to adjust the strength the muscles of his eyes so they would be properly aligned.

According to Coffey, Alexander now has 20/20 vision when he wears his glasses, and he may not need to wear glasses at all in a few years.

"Alexander's doing great now. He wears his glasses and he is a happy little boy. If we had waited until he was older, it would have been too late and we wouldn't have been able to correct the problem," she says.

For more information, visit the following Web sites:

U-M Kellogg Eye Center: Amblyopia
www.kellogg.umich.edu/conditions/pediatric/amblyopia.htm.

U-M Kellogg Eye Center: Strabismus
www.kellogg.umich.edu/conditions/pediatric/strabismus.htm.

U-M Kellogg Eye Center: Eye Exams
www.kellogg.umich.edu/conditions/eyeexams/eyeexam.html

National Eye Institute: Amblyopia
www.nei.nih.gov/health/amblyopia/index.htm

National Eye Institute: Photos, Images and Videos
www.nei.nih.gov/photo/eye_exam/eye_exam.htm

American Academy of Pediatrics: Preschool Vision Screening
www.aap.org/advocacy/releases/article2.htm


Written by Mary Beth Reilly


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