Research
We conduct most of our research in the Crosby Neurosurgery Research Laboratories. Our research is broadly focused on cerebral vasculature, tumors and the application of this knowledge in the development of potential treatments.
See a list of publications.
The areas of research are:
- Amino acid and peptide transport
- Axonal injury and regeneration
- Blood-brain barrier function
- Choroid plexus function
- Gene therapy, particularly in relation to lysosomal storage disorders
- Induced tolerance to brain injury (preconditioning)
- Mechanisms responsible for formation and resolution of brain edema during ischemia or following an intracerebral hemorrhage
- Pathophysiology of cerebral ischemia with particular emphasis on inflammatory mediators and the effects of hyperglycemia
- Pathophysiology of intracerebral hemorrhage with an emphasis on thrombin and iron
- Spinal cord injury and mechanical stabilization and implants to promote regeneration
- Spinal cord stimulation for stroke
Clinical research projects focus on the following areas:
- Deep brain stimulation for movement disorders
- Drug trials for diabetic peripheral neuropathy
- Growth patterns in malignant brain tumors
- Hypothermic anesthesia during aneurysm surgery
- Immunotoxin treatment of brain tumors
- Outcomes following shunting for hydrocephalus
- Treatment protocols for acute spinal cord injury
