Recent Publications

Fink, D.J., Wechuck, J., Mata, M., Glorioso, J.C., Goss, J., Krisky, D., and Wolfe, D. Gene Therapy for Pain: Results of a Phase I Clinical Trial. Annals of Neurology, 2011 [In press]

Chattopadhyay, M., Mata, M., and Fink, D.J., Vector-mediated release of GABA attenuates pain-related behaviors and reduces NaV1.7 in DRG neurons. European Journal of Pain, 2011. [Epub ahead of print]

Hao, S., Liu, S., Zheng, X., Ouyang, H., Mata, M. and Fink, D.J. The role of TNFalpha in the periaqueductal gray during naolxone-precipitated morphine withdrawal in rats. Neuropsychopharmacology, 36:664-76, 2011

Wu Z., Mata M., Fink D.J. Prevention of Diabetic Neuropathy by Regulatable Expression of HSV-Mediated Erythropoietin. Molecular Therapy. 19:310-7, 2010

Zhou Z., Peng X., Hagshenas J., Insolera R., Fink D.J., Mata M. A novel cell-cell signaling by microglial transmembrane TNFalpha with implications for neuropathic pain. Pain. 51: 296-306, 2010

Zhou, Z., Peng, X., Hu, J., Fink, D.J. and Mata, M. Soluble NOGO receptor down-regulates expression of neuronal NOGO-A to enhance axonal regeneration. Journal of Biological Chemistry, 285:2783-95, 2010

Koelsch, A., Feng, Y., Fink, D.J., Mata, M. Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional recovery after spinal cord contusion. Journal of Neurochemistry. 113:143-52, 2010

Glorioso J.C. and Fink D.J., Gene therapy for pain: introduction to the special issue. Gene Therapy 16:453-4, 2009

Zhou, Z., Peng, X., Insolera, R., Fink, D.J. and Mata, M. IL-10 promotes neuronal survival following spinal cord injury.  Experimental Neurology 220:182-90, 2009  

Wolfe, D., Wechuck, J., Krisky, D., Mata, M., and Fink, D.J.  A human trial of gene therapy for chronic pain.  Pain Medicine 10:1325-30, 2009

Zhou, Z., Peng, X., Insolera, R., Fink, D.J., Mata, M.  Interleukin-10 provides direct trophic support to neurons. Journal of Neurochemistry 110:1617-27, 2009

Zhou, Z., Peng, X., Fink, D.J., Mata, M.  HSV-mediated transfer of artemin overcomes myelin inhibition to improve outcome after spinal cord injury.  Molecular Therapy 17:1173-9, 2009

Wolfe, D., Mata, M. and Fink D.J. A human trial of HSV mediated gene transfer for the treatment of chronic pain. Gene Therapy 16:455-60, 2009

Chattopadhyay, M., Walter, C., Mata, M. and Fink, D.J. Neuroprotective effect of HSV-mediated gene transfer of erythropoietin in hyperglycemic DRG neurons. Brain 132:879-88, 2009

Hao, S., Wolfe, D., Glorioso, J.C., Mata, M. and Fink, D.J. Effects of transgene-mediated endomorphin-2 in inflammatory pain. European Journal of Pain 13:380-386, 2009

Hao, S., Hu. J., Fink, D.J. Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.  Behavioral Brain Research 197:84-9, 2009

Glorioso, J.C., Fink, D.J. Herpes vector-mediated gene transfer in the treatment of chronic pain.  Molecular Therapy 17:13-18, 2009.

Hao, S., Wolfe, D., Glorioso, J.C., Mata, M. and Fink, D.J. Effects of transgene-mediated endomorphin-2 in inflammatory pain. European Journal of Pain 13:380-386, 2009

Chattopadhyay, M., Mata, M. and Fink, D.J. Continuous delta opioid receptor activation reduces neuronal voltage gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. Journal of Neuroscience 28:6652-58, 2008

Mata, M., Hao, S.H., Fink, D.J., Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNF alpha. Neuroscience Letters 437:209-13, 2008

Pohl, M. and Fink, D.J. A new player in gene therapy for pain? [Invited commentary]. Gene Therapy 15:953-54, 2008

Mata, M., Hao, S.H., Fink, D.J., Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNF alpha. Neuroscience Letters 437:209-13, 2008

Zhou, Z., Peng, X., Hao, S., Fink, D.J., Mata, M. HSV-mediated transfer of interleukin-10 reduces inflammatory paion through modulation of membrane tumor necrosis factor alpha in spinal cord microglia. Gene Therapy 15:183-90, 2008.

Fink, D.J. Applications of gene therapy to the treatment of chronic pain. Current Gene Therapy 1:42-8, 2008

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Tel. (734) 936-9070 | Fax (734) 763-5059 | djfink@umich.edu