Faculty Research

Andrea M. Vincent, Ph.D. ( jandreav@umich.edu )
Research Assistant Professor, Department of Neurology

Dr. Vincent has dedicated her research to understanding the mechanisms that lead to neuronal cell injury. Her current research is mainly in diabetic neuropathy, with a minor project in amyotrophic lateral sclerosis. Recent studies have demonstrated that oxidative stress resulting from metabolic changes in diabetes is a critical mediator of neuronal injury. Her current work is focused on preventing this stress in animal models by multiple strategies. In addition, Dr. Vincent has developed a drug screening strategy for the prevention of mitochondrial oxidative stress in acute hyperglycemia. This strategy is being used to screen FDA-approved compounds in order to design new drug applications and combinations for the treatment of diabetic neuropathy.

Recent publications

Vincent, A.M., Sullivan, K.A., Backus, C., Sastry, A.M., Lastoskie, C., Feldman, E.L. RAGE activation injures primary sensory neurons via oxidative stress, Endocrinology, 2007 Feb;148(2):548-58.

Vincent, A.M., Russell, J.W., Sullivan, K.A., Backus, C., Hayes, J.M., McLean, L.L., Feldman, E.L. SOD2 Protects Neurons from Injury in Cell Culture and Animal Models of Diabetic Neuropathy, Exp Neurol., in press. Pre-print available online doi:10.1016/j.expneurol.2007.07.017.

Vincent, A.M., Sakowski, S.A., Schuyler, A., Feldman, E.L. Strategic approaches to developing drug treatments for ALS, Drug Discovery Today, in press.

Vincent, A.M., Feldman, E.L. The Antioxidant Response as a Drug Target in Diabetic Neuropathy, Curr Drug Targets, in press.

Vincent, A.M., Feldman, E.L., Can Drug Screening Lead to Candidate Therapies for Testing in Diabetic Neuropathy?, Antioxidant and Redox Signaling in press.