Color image: Representative ΔR2* maps (sec-1) of the tumor tissue (color) overlaid onto a gradient-echo image for the four different formulations of PAM nanoparticles in four different 9L tumors of similar size. (a) PAM0, (b) PAM0.6, (c) PAM2, (d) PAM10. ΔR2* was calculated using Equation 1, where t = 2 min. Therefore, the color overlays can be viewed as rCBV maps.

Top graph: Scatter plot (n = 3) for signal intensity time courses in the vasculature shown over 80 min following intravenous injection of PAM0, PAM0.6, PAM2, PAM10 nanoparticles in the rat, plotted as % initial signal (S0) with fits to the data.

Bottom graph: Nonlinear least square fits to relative concentration time courses derived from the intensity data. (Molecular Imaging. Vol. 2, No. 4, October 2003, pp. 324 - 332)