Athey, Brian (Computational Medicine and Bioinformatics) bleu@umich.edu
Arvan, Peter (Internal Medicine - MEND) parvan@umich.edu
Insulin secretion, thyroid hormone secretion
Banerjee, Ruma (Biological Chemistry) rbanerje@umich.edu
Redox metabolism and redox signaling in cell-cell communication
Barkan, Ariel (Medical School) abarkan@umich.edu
Regulation of fuel homeostasis by growth hormone.
Beecher, Christopher (Translational Pathology) chrisbee@umich.edu
Metabolomics
Bitar, Khaliln (Medical School) bitar@umich.edu
The effects of obesity as it relates to motility of the GI tract, and as it relates to aging of the GI tract
Bodary, Peter F. (Kinesiology) pfbodary@umich.edu
Underlying mechanisms of enhanced vascular diease risk in obese individuals, effects of exercise on obseity-related diseases.
Boehnke, Michael (Biostatistics) boehnke@umich.edu
Mapping and positionally cloning genes for type 2 diabetes and obesity
Borer, Katarina T. (Division of Kinesiology - Movement Science) katarina@umich.edu
Examination of the effects of exercise and diet, particularly the timing of these interventions, on hormonal and metabolic responses in obese individuals
Britton, Steve (Anesthesiology) brittons@umich.edu
Obesity
Burant, Charles (Internal Medicine - MEND) burantc@umich.edu
Molecular and cell biology of insulin resistance, lipid and glucose metabolism, nuclear hormone receptors and stem cell biology
Burghardt, Paul (Molecular and Behavioral Neuroscience) pburghar@umich.edu
Interaction between energy management systems in the brain and interventions for mood disorders (e.g., antidepressant treatment, exercise)
Byun, Jaeman (Internal Medicine - Nephrology) jaemanb@umich.edu
Metabolomic approaches for understanding mechanism of obesity induced diabetic
Cartee, Gregory D. (Division of Kinesiology) gcartee@umich.edu
Skeletal muscle insulin resistance and metabolism, especially as influenced by exercise, diet (calorie restriction), and aging
Carter-Su, Christin (Molecular & Integrative Physiology) cartersu@umich.edu
Tyrosines in proteins are phosphorylated in JAK2 and GH receptor, what proteins are recruited to JAK2/GH receptor complexes in response to ligand activation, what signaling pathways and cell processes are limited or regulated as a consequence of the recruitment of these proteins to the JAK2/GH receptor complex, and how JAK2 is activated and subsequently inactivated by ligand binding.
Cavalcoli, James (CCMB) cavalcoli@umich.edu
Developing computational methods for integrating various experimental data to create models for human disease
Chang, Anne (Internal Medicine - MEND) annchang@umich.edu
Mechanisms of human age-related glucose intolerance, role of b-cell dysfunction in the development of type 2 diabetes, prevention and treatment of type 2 diabetes
Chen, Eugene (Internal Medicine - MEND) echenum@umich.edu
Obesity/diabetes-related cardiovascular complications
Chun, Tae-Hwa (Internal Medicine - MEND) taehwa@umich.edu
Coffey, Michael (Adult Pulmonary and Critical Care) coffeym@umich.edu
Leptin-induced excessive leukotiene generation in the pathogenesis of asthma in obese subjects
Conjeevaram, Hari (Internal Medicine - Gastroenterology) omsairam@umich.edu
Role of obesity and insulin resistance in hepatitis C infection.
Das, Arun (Internal Medicine - MEND) akudas@umich.edu
Studies on structural and functional aberration of membrane lipids, lipid metabolites and the enzymes involved for such alterations under the state of diabetes, obesity and related physiological dynsfunctions
Dempsey, Peter (Molecular and Integrative Physiology) petedemp@med.umich.edu
Characteristics of the phenotype of TNFa converting enzyme (TACE/ADAM17)-deficient mice
Diez Roux, Ana (School of Public Health - Epidemiology) adiezrou@umich.edu
Epidemiology of obesity, racial diferences, social factors
Djuric, Zora (Family Medicine - Cancer Prevention) zoralong@umich.edu
The impact of energy balance on cancer risk
Dolinoy, Dana (Environmental Health Sciences) ddolinoy@umich.edu
My primary research interests are in the emerging fields of nutritional and environmental epigenomics and the developmental origins of adult disease, including obesity.
Duvernoy, Claire S. (Internal Medicine - Cardiology) duvernoy@umich.edu
Vascular endothelial function, primarily in the coronary vasculature, as assessed by dynamic positron emission tomography, and the impairment in myocardial blood flow and flow reserve seen in obesity; whether weight loss and/or exercise can improve coronary vascular reactivity
Eagle, Kim (Internal Medicine - Cardiology) keagle@umich.edu
Developing school and community based interventions to reduce childhood obesity
Eitzman, Dan (Internal Medicine) deitzman@umich.edu
Inflammation and vascular disease triggered by adipose tissue
Ellingrod, Vicki (Pharmacy) vellingr@umich.edu
Pharmacogenetics of metabolic complications from antipsychotic use in children and adults, specifically development of the metabolic syndrome and insulin resistance; role of folic acid and the methylenetetrahydrofolate reductase polymorphism on occurance of metabolic complications from antipsychotic use
Evans, Charles (Internal Medicine - MEND) chevans@umich.edu
Evans, Simon J. (Psychiatry) evanssi@umich.edu
Nutritional neuroscience and how diet effects feeding behavior and body fat storage as regulated by gut and CNS signals
Fajans, Stefan (Internal Medicine-MEND) sfajans@umich.edu
Obesity in connection with diabetes; insulin secretion
Feldman, Eva L. (Neurology) efeldman@umich.edu
The cause of diabetic complications (specifically diabetic neuropathy) and developing novel therapeutic treatments; to accomplish these goals, type 1 and type 2 diabetic animal models, including obese strains, are utilized.
Finks, Jonathan (Department of Surgery) jfinks@umich.edu
Surgical outcomes from bariatric surgery; specifically, I am interested in identifying operative and performance measures which correlate with surgical outcomes.
Ford, Kathleen (Epidemiology) kford@umich.edu
Obesity and women's health at midlife
Gordon, Paul (Physical Medicine) gordonp@umich.edu
Han-Markey, Theresa (MCRU) hanmark@umich.edu
Holmes, Crystal (MEND - Podiatry/Diabetic Foot) crysholm@umich.edu
Obesity-related podiatric complications, including predisposing factors for soft tissue, arthritic and biomechanical lower extremity complications
Hornyak, Joseph E. (Medical School - Physical Medicine and Rehabilitation) jhornyak@umich.edu
Obesity and complications in children and adults with disabilities
Horowitz, Jeffrey (Division of Kinesiology) jeffhoro@umich.edu
Regulation of skeletal muscle insulin resistance and metabolic factors contributing to body weight regulation
Hu, Patrick J. (Internal Medicine/Life Sciences Institute) pathu@umich.edu
Mechanisms of insulin signaling and insulin resistance that pertain to type 2 diabetes
Hurvitz, Edward A. (Physical Medicine and Rehabilitation) ehurvitz@umich.edu
Involved with the Human Performance Laboratory in the Department of Physical Medicine and Rehabilitation; body composition, fitness, and activity in individuals with pediatric onset disability
Jiang, John Yebin (Radiology) johjiang@umich.edu
Osteoarthritis, biomechanics, and body composition
Kang, Sewon (Medical School - Dermatology) swkang@umich.edu
Diet and skin disease; mechanical tension, stretch marks
Kaplan, Mariana (Internal Medicine) makaplan@umich.edu
My lab studies mechanisms by which patients with autoimmune diseases develop premature vascular damage and atherosclerosis. We have an interest in assessing the role of PPAR-gamma agonists in improving cardiovascular risk and insulin resistence in individuals with inflammatory conditions.
Karnovsky, Alla (CCMB) akarnovs@umich.edu
Building computational tools for metabolomics, and integration and analysis of large scale molecular and phenotypic data
Kaufman, Randel J. (Biological Chemistry - Internal Medicine) kaufmanr@umich.edu
Protein folding in the endoplasmic reticulum and how the cell responds to the accumulation of misfolded protein, a response termed the Unfolded Protein Response (UPR); recent studies indicate that this signaling pathway may be a cause for insulin resistance associated with obesity and development of diabetes as a consequence of beta cell failure
Keller, Evan T. (Medical School - Urology Surgery & Pathology) etkeller@umich.edu
Understanding how obesity or metabolic syndrome may impact cancer etiology, pathophysiology and response to therapy. Metabolic syndromes' role on prostate cancer metastisis
Kennedy, Robert T. (Chemistry) rtkenn@umich.edu
We are interested in the interaction of obseity and islet cell function that leads to diabetes and the neurochemistry of feeding behavior
Koch, Lauren (Phys Medicine and Rehab) lgkoch@umich.edu
Our goal is to understand mechanistically the biological differences responsible for differences in exercise capacity to uncover the connection between metabolism and complex disease. To achieve this goal, we develop and study animal models that contrast for low and high aerobic exercise capacity.
Koenig, Ronald J. (Internal Medicine - MEND) rkoenig@umich.edu
Thyroid hormone regulation of metabolism. PPARg in the context of Pax8-PPARg fusion protein in thyroid cancer
Kretzler, Matthias (Internal Medicine - Nephrology) kretzler@umich.edu
Diabetic nephropathy, obesity and glomerulosclerosis
Leichtman, Alan (Internal Medicine - Transplantation) aleicht@umich.edu
Obesity and PTDM are frequent and significant morbidities that are associated with organ transplant
Lin, Jiandie (LSI - Cell & Developmental Biology) jdlin@umich.edu
Hepatic lipid metabolism, circadian metabolic regulation, and brown fat function
Lombard, David (Pathology) davidlom@umich.edu
Low, Malcolm (Molecular & Integrative Physiology) mjlow@umich.edu
Hypothalamic regulation of appetite, body weight, adiposity, and metabolism; regulation of propiomelanocortin gene expression in the CNS; behavioral analysis of meal patterns and food reward; somatostatin and beta cell function
Lubman, David M. (Surgery) dmlubman@umich.edu
Proteomic screening of cells, serum, and urine
Lumeng, Carey (Pediatrics) dclumeng@umich.edu
Obesity, inflammation, diabetes, asthma
Lumeng, Julie (Pediatrics) jlumeng@umich.edu
Mother-child interaction around eating, child eating behavior, children's cognitions about food
MacDougald, Ormond (Molecular and Integrative Physiology) macdouga@umich.edu
Determining the molecular mechanisms by which extracellular signals regulate adipocyte differentiation and metabolism
Mancuso, Peter (Environmental Health Sciences) pmancuso@umich.edu
The role of adipocytokines in innate and adaptive immune responses. The influence of adipocytokines in cardiovascular disease risk factors in women across the menopause transition
Mortensen, Richard (Internal Medicine -Molecular and Integrative Physiology) rmort@umich.edu
Lipodystrophy, PPAR-family, diabetes, related cardiovascular disease.
Moseley, Richard H. (Internal Medicine - Hepatology) rmoseley@umich.edu
Pathogenesis of non-alcoholic fatty liver disease
Mulholland, Michael (General Surgery) micham@umich.edu
Myers, Martin (Internal Medicine - MEND) mgmyers@umich.edu
Neural mechanisms of leptin action in feeding and metabolism
Nafiu, Olubukola (Anesthesiology) onafiu@umich.edu
Childhood obesity and perioperative complications. Obesity as a risk factor for perioperative adverse events in adults.
Neubig, Richard (Pharmacology) rneubig@umich.edu
The role of RGS proteins in the control of metabolic function - insulin secretion, insulin sensitivity, body weight, and pituitary neurohomone secretion.
Nriagu, Jerome (School of Public Health - Environmental Health Sciences) jnriagu@umich.edu
Environmental drivers of obesity risk factors
Omenn, Gilbert * (Molecular Medicine and Genetics) gomenn@umich.edu
Earlier diagnosis of cancers using protein biomarkers, based on proteomics and computational biology
Oral, Elif (Internal Medicine - MEND) eliforal@umich.edu
Fatty liver disease, bariatric surgery, type 2 diabetes
Padmanabhan, Vasantha (Pediatrics) vasantha@umich.edu
Prenatal programming of IUGR/catch up growth and Polycystic Ovarin Disease with emphasis on infertility and insulin resistance and how obesity exacerbates the phenotype
Patel, Jignesh M. (School of Engineering - EECS) jignesh@umich.edu
I am interested in developing new pattern matching and pattern mining algorithms on large datasets, and have a particular interest in mining large pathway databases, which are increasinglly becoming important in metabolomics
Pek, Sumer (Internal Medicine) spek@umich.edu
Pancreatic islet dysfunction inflammatory process
Pennathur, Subramaniam (Nephrology) spennath@umich.edu
Mechanisms of diet induced insulin resistance, the role of ROS in mediating insulin resistance and metabolic complications of obesity/diabetes including CVD risk
Peterson, Karen (Environmental Health Sciences) karenep@umich.edu
Her research focuses on determinants of intergenerational patterns of growth in mothers and children and the design and evaluation of domestic and international surveillance systems and community-based interventions in low-income, multiethnic populations.
Pop-Busui, Rodica (Internal Medicine - MEND) rpbusui@umich.edu
The cause of diabetic complications (specifically diabetic neuropathy) and deveoping novel therapeutic treatments
Qi, Nathan (Internal Medicine - MMOC) nathanqi@umich.edu
Mitochondrial dysfunction in diabetic nephropathy and the metabolic syndrome
Qin, Zhaohui (Steve) (Biostatistics-School of Public Health) qin@umich.edu
Pathway analysis utilizing bioinformatics tools
Reddy, Raju (Internal Medicine) rajuc@umich.edu
PPARs and the role of endogenous PPAR ligands in regulating adipogenesis. These nuclear receptors play key roles in obesity/diabetes.
Resnicow, Ken (School of Public Health) kresnic@umich.edu
Richardson, Caroline (Family Medicine) caroli@umich.edu
Physical activity measurement and Internet mediated physical activity intervention development. Objective assessment of physical activity. Pedometer based walking interventions
Richardson, Rudy (EHS/Toxicology Program) rjrich@umich.edu
New research interests include investigating the mechanisms of insulin, insulin-like growth factors, and nutritional status in the regulation of patatin-like lipases and their potential roles in development, lipid metabolism, obesity, vasculogenesis, and neurodegenerative disorders. Research involves collaborations using clinical, computational, epidemiological, experimental, and informatics approaches.
Robins, Diane (Human Genetics) drobins@umich.edu
Ross, Theodora (Internal Medicine) tsross@umich.edu
HIP1 is a protein that we focus on in the lab and we are working to understand its significance and function in the intact organism. Because knockout mice of the HIP1 gene display weight loss, we are interested in understanding how that phenotype develops as a clue to the in vivo function of the HIP1 family of proteins.
Rothberg, Amy (Internal Medicine - MEND) arothber@umich.edu
Effective strategies for weight loss and maintenance of weight loss
Rubenstein, Joel (Internal Medicine - Gastroenterology) jhr@umich.edu
The association of obesity with esophageal adenocarcinoma; in particular, examining the effect of circulating levels of adipokines among human subjects on the risk of Barrett's esophagus, the accepted precursor condition for esophageal adenocarcinoma
Ruddon, Raymond *
Rui, Liangyou (Molecular and Integrative Physiology) ruily@umich.edu
Neuronal regulation of energy balance and body weight, and mechanisms of insulin resistance and type 2 diabetes
Saltiel, Alan * (Life Sciences Institute) saltiel@umich.edu
Sanders, Georgiana (Internal Medicine / Allergy) gsanders@umich.edu
Obesity as it relates to asthma
Schwartz, Jessica (Molecular and Integrative Physiology) jeschwar@umich.edu
Molecular mechanisms of growth homrone-induced insulin resistance, including adipogenesis and overall metabolic regulation
Scott, Laura (School of Public Health - Biostatistics) ljst@umich.edu
Genetic variants that increase the risk for type 2 diabetes and cause variation in diabetes-related phenotypes including obesity; obesity as a modifying factor for genes that influence the risk of type 2 diabetes
Sha, Su-Hua (Kresge Hearing Institute) shasha@umich.edu
Mechanisms of age-related hearing loss, which may have some connection with the metabolomic and obesity-related changes
Smith, Gary (Physiology, Urology) smithgd@umich.edu
Our lab studies insulin resistance (insulin), polycystic ovarian syndrome, obesity (leptin, adiponectin) and reproductive compromise, at the ovarian, oocyte, and embryo level with emphasis on understanding intracellular signaling pathways.
Smith, William (Biological Chemistry) smithww@umich.edu
Smith, Yolanda R. (Neuroendocrinology) ysmith@med.umich.edu
Metabolic effects of obesity on cognition during the menopausal transition; metabolic effects of insulin-resistant Polycystic Ovary Syndrome on cognition
Sowers, MaryFran (Epidemiology) mfsowers@umich.edu
Body composition, adipocytokines, metabolism, osteoarthritis, diabetes
Spino, Cathie (Biostatistics) spino@umich.edu
Design, conduct and analyze clinical studies
Subauste, Angela (Internal Medicine - MEND) asubaust@umich.edu
Investigating the role of the enzyme AGPAT2 on adipogenesis
Teitelbaum, Daniel H. (Surgery/Medicine) dttlbm@umich.edu
Bariatric surgery
Thompson, Robert (Psychiatry) mutant@umich.edu
The mechanism by which leptin rescues the female reproductive acis during food deprivation and the neuroanatomical pathways and molecules that mediate these leptin effects; the means by which stress, appetite, and feeding disorders interact as they might exist in various psychiatric disease states
Uhley, Virginia (Int Med - MEND) vuhley@umich.edu
Mechanisms of body weight regulation, biomarkers of dietary intake, and nutrition assessment/dietary intake methodology
Vahratian, Anjel (Obstetrics/Gynecology) amv@med.umich.edu
Maternal obesity and pregnancy
Weinberg, Joel (Nephrology) wnberg@umich.edu
Mitochondrial and fatty acid metabolism in the kidney
Williams, John * (Molecular and Integrative Physiology) jawillms@umich.edu
The role of the pancreas in digestion and how nutrients affect digestive enzyme synthesis and secretion
Woolford, Susan (Pediatrics) swoolfor@umich.edu
Physician-patient communication and its impact on adherence in the treatment of childhood obesity
Woolf, Peter (Chemical Engineering) pwoolf@umich.edu
Systems biology, computational biology, bioinformatics, pharmacogenomics, high-throughput screening, developmental biology, complex systems
Wu, Audrey H. (Internal Medicine) ahwu@med.umich.edu
Examining relationships between heart failure and obesity in the context of epidemiological analysis, clinical outcomes, and translational study
Yung, Raymond (Internal Medicine - Geriatrics) ryung@umich.edu
Zhang, Weizhen (Medical School - Surgery) weizhenz@umich.edu
Ghrelin and its short term effect on appetite and long term effect on development of adipose tissue
Zubieta, Jon-Kar (Molecular and Behavioral Neuroscience Institute) zubieta@umich.edu
(*) Executive Advisory Committee members |
