Core Laboratories
Current:
Animal Phenotyping Core (Nathan Qi). The Animal Metabolic Phenotyping laboratory provides the University of Michigan research community with the capability for sophisticated, standardized, physiologic phenotyping of rodent models with genetic manipulation or other interventions that may result in altered metabolism and metabolic diseases. This core is currently accepting applications for use by U-M researchers.
Human Phenotyping Core (Jeffrey Horowitz). The Human Metabolic Phenotyping Laboratory provides a comprehensive assessment of the metabolic state of humans during metabolic alterations that arise from dietary, drug or other interventions. The laboratory's primary home is in the U-M Clinical Research Unit(formerly the General Clinical research center0and in the laboratory being developed by the School of Kinesiology.
Metabolomics Core. This new laboratory provides interested researchers an opportunity to quantify and identify lipids and other biological material in cells, organs or other biological fluids of test animals or in human subjects. The laboratory works with individual investigators to develop directed methods for metabolite analysis. The analytic platforms include mass spectrometry instrumentation in several configurations (GC/MS, LC/MS, MS/MS) and NMR-based mass isotopomer analysis for measurement of flux in specific metabolic pathways.
To be developed:
Systems Biology Core. Metabolomic Systems Biology Laboratory will provide computational and statistical support for investigators who wish to integrate metabolomic, genomic, proteomic, lipomic or other data to meaningfully explore complex biological systems. A strong computational infrastructure is a requisite component of the laboratory. The laboratory director will be charged with developing a research program and providing assistance in the analysis of complex biological data. This will involve developing computational tools to integrate and model information provided by investigators. The focus of the core laboratory will be to help investigators ‘mine’ data sets and develop methods to use the output data to enhance predictive models that could be used to design additional experiments.
For more information, please contact:
Charles Burant, MMOC Director,
University of Michigan, 5560D MSRB II, SPC 5678
1150 W. Medical Center Dr., Ann Arbor, MI 48109-5678
Tel: (734)615-3481; Fax: (734)936-6684
or e-mail burantc@umich.edu
