Faculty
 |
Mary O'Riordan |
Host & Bacterial Adaptation to Intracellular Infection
Our laboratory explores the interaction of intracellular bacterial pathogens with their host cells. We primarily study the Gram-positive bacterium Listeria monocytogenes, a facultative intracytosolic pathogen, investigating mechanisms of adaptation to the host cell environment. In addition, we use L. monocytogenes as a model pathogen with which to explore host mechanisms that regulate infection and innate immune signaling.
Projects in the lab include:
Characterizing host transporters that modulate bacterial entry into the host cytosol
Defining bacterial factors that facilitate rapid intracellular replication of L. monocytogenes
Elucidating molecular mechanisms that govern host cell responses to cytosolic bacteria
Selected Publications:
M. O'Riordan, C. H. Yi, R. Gonzales, K. D. Lee and D. A. Portnoy. 2002. Innate Recognition of Bacteria by a Macrophage Cytosolic Surveillance Pathway. Proc. Natl. Acad. Sci. 99(21): 13861-13866. [PMID: 12359878]
M. O'Riordan, M. A. Moors and D. A. Portnoy. 2003. Listeria intracellular growth and virulence require host-derived lipoic acid. Science. 302(5644): 462-4. [PMID: 14564012]
R. McAffrey, P. Fawcett, M. O'Riordan, K.D. Lee, E. A. Havell, P. Brown and D. A. Portnoy. 2004. A Cytosol-specific Program of Gene Expression Induced by Gram-positive Intracytosolic Bacteria. Proc. Natl. Acad. Sci.101(31):11386-91. [PMID: 15269347]
V. Auerbuch, D. Brockstedt, N. Meyer-Morse, M. O'Riordan and D.A. Portnoy. 2004. Mice lacking the Type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med. 200(4):527-33. [PMID: 15302899]
L. Delbridge and M. O'Riordan. Innate Recognition of Intracellular Bacteria.. 2007. Current Opinion in Immunology. Feb;19(1):10-6. Epub 2006 Nov 28. [PMID: 17126540]
A. Radtke, L. Delbridge S. Balachandran, G. Barber and M. O'Riordan. 2007. TBK1 protects vacuolar integrity during intracellular bacterial infection. PLoS Pathogens. Mar 2;3(3):e29. [PMID: 17335348]
K. Keeney, J. Stuckey, and M. O'Riordan. 2007. Utilization of host lipoyl-peptides by Listeria LplA1 is required for cytosolic growth and virulence. Mol Microbiol. Nov;66(3):758-70. [PMID: 17908209]
A. Radtke and M. O'Riordan. 2008. Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cellular Microbiology. Nov;10(11):2197-207. [PMID: 18665841]
L. Bauler, C. Duckett and M. O'Riordan. 2008. XIAP regulates cytosolic-specific innate immunity to Listeria infection. PLoS Pathogens. Aug 29;4(8):e1000142. [PMID: 18769721]
M. O'Riordan, L. Bauler, F. Scott and C.Duckett. 2008. Inhibitor of Apoptosis (IAP) Proteins in eukaryotic evolution and development: a model of thematic conservation. Developmental Cell. Oct;15(4):497-508. [PMID: 18854135]
K. Keeney, L. Colosi, W. Weber and M.O'Riordan. Generation of branched chain fatty acids through lipoate dependent metabolism facilitates intracellular growth of Listeria monocytogenes. J Bacteriol. 2009 Apr;191(7):2187-96. [PMID: 19181817]
Y. Sun and M. O'Riordan. Branched chain fatty acids promote Listeria monocytogenes intracellular infection and virulence. Infect Immun. 2010 Sep 7. [Epub ahead of print] PMID: 20823206.
A. Radtke, K. Anderson, M. Davis, M. DiMagno, J. Swanson and M. O'Riordan. Listeria monocytogenes exploits CFTR-mediated chloride transport to escape the phagosome. In revision
