Michigan Gastrointestinal Peptide Research Center

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Pilot Feasibility

The Michigan Gastrointestinal Peptide Research Center Invites Applications for Pilot Feasibility Projects in the Area of Peptide Biology and Gastrointestinal Function - 2014

April 4, 2014 Deadline for Pilot Feasibility Applications.

SUBJECT MATTER:

The University of Michigan's Digestive Disease Center is focused in the area of peptide biology and its role in GI function and pathology. The Center is especially interested to receive applications in the following areas:

1. Regulatory peptide biology, including the biogenesis of the GI-related peptides (transcriptional control, tissue specific expression, mRNA regulation, post-translational processing) the regulation of secretion, receptor interactions (structure function aspects, multiplicity of receptors, binding or post-binding events), and cell biology (electrophysiology, ion fluxes). Projects dealing with peptides outside the GI tract or brain/gut axis must include relevance to the brain/gut axis.

2. Gastrointestinal Peptidergic Function, at the integrative level of physiology and pathophysiology. Such projects would include whole animal as well as human studies, studies of interaction between peptidergic and non-peptidergic transmitters in the GI tract, and studies of peptidergic dysfunction in specific disease states.

3. Other areas of gastrointestinal function or pathology. As evidenced by the above description, both basic and clinical animal models focusing on GI function are encouraged. Studies on the human application of peptides, peptides used in biomarker discovery.

4. Microarray Gene Chip Technology and Proteomics applications designed to elucidate peptide involvement in GI function and pathology.

5. Projects relating to the GI Microbiome and inflammation of Gut microflora, Molecular Imaging using peptides for identifying dysplastic cells, Metabolism and Obesity.

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Who Can Apply:

First priority will be given to young investigators at the University of Michigan embarking on a research career, with the hope that the Pilot Feasibility Project will lead to the successful funding of an RO1 type application.

At least three years of postdoctoral training is required prior to the start of the award. Postdocs meeting this requirement, instructors/lecturers and young faculty through Assistant Professors are encouraged to apply.

More senior investigators, will be considered only if the project represents a new direction in their research, and will be given lower priority.

Under normal circumstances, investigators will be eligible for a maximum of 2 years support in total from the Center.

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 Format:

Applications must be submitted using the NIH PHS 398 application packet forms which are available through DRDA. A link is also provided for you below. Please use the face page, abstract page, key personnel page, table of contents, detailed budget page and budget for entire proposed project period (not the modular budget pages), budget justification page, NIH biosketch, resource page, then science . You may also attach any relevant papers or supporting letters, etc. The science portion of the application is not to exceed a total of 5 pages (Aims, Significance, Work-to-Date and Research Plan). Font size in the application is to be no smaller than 12 pt. No applications will be accepted without the Submittal Form for Pilot Feasibility Projects for the Peptide Research Center which can be downloaded on this page. It should include a paragraph on relevance to the mission of the Peptide Gut Center. Please submit 7 paper copies plus the original, as well as an electronic copy with all pages and associated forms converted into a single .PDF file on CD or by email to jcole@umich.edu. Business address: Room 6520E MSRB I, Box 5682.

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Budget:

Grants will be awarded for $10,000 to $25,000; the maximum request is for $25,000/year. A maximum of two years of funding will be provided. Applicants seeking a second year will be expected to submit another competitive application in the year of requested funding.

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Deadline/Review:

Deadline for application is April 4, 2014. The proposals will be reviewed, including evaluation by the Center's External Advisory Committee in a fashion similar to the NIH review process.  Finalists will be expected to give a 10-15 minute presentation on their projects to this committee before award selections are made. Funding period is September 1 to August 31 for up to 2 years. For questions or information, you may contact the Center's Director, Dr. Chung Owyang (734-936-4785), Associate Director, Dr. John Williams (734-764-4376), or Center Administrator, Jeffery Cole (734-647-2939).

Form Sample:
Name  
 
Department  
 
SUBMITTAL FORM FOR PILOT FEASIBILITY PROJECTS FOR
THE PEPTIDE RESEARCH CENTER
  Category
  Priority 1
_____
  Young investigator seeking to establish independence
  Priority 2
_____

  Established investigator with reputation in other scientific areas
considering initiatives in gastrointestinal research

  Priority 3
_____
  Established investigator seeking a new direction
  1. RELEVANCE OF RESEARCH TO THE PEPTIDE RESEARCH CENTER
 
 
  2. STATEMENT FROM MENTOR INDICATING JUNIOR FACULTY’S TERM   PLANS. PLEASE INDICATE WHAT UNIQUE QUALIFICATIONS THIS APPLICANT POSSESSES, AS WELL AS HOW THIS PROJECT WILL MOVE THE APPLICANT TOWARDS INDEPENDENT FUNDING
 
 
 
   
  3. PEPTIDE CENTER CORES THAT YOU EXPECT TO INTERACT WITH AND POTENTIALLY UTILIZE DURING THE COURSE OF YOUR PROJECT (http://www.med.umich.edu/mgpc/cores/index.htm)
 
 
 
  4. DESCRIBE SCIENTIFIC AND BUDGETARY OVERLAP
 
  5. IS THIS APPLICATION A CONTINUATION OF A MAJOR PROJECT
   OR A NEW PROJECT
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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