University of Michigan Center for Gastrointestinal Research


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    2017 - 2018

    UMCGR Weekly Noon Conference

    01/11/16-Jeffery Perry, Ph.D. "Functional mapping of the Dengue virus genome by insertional mutagenesis and next generation sequencing"

    01/18/16-Andrew Shreiner, M.D. "Description of a clinical study on the impact of dietary FODMAPs on functional GI symptoms in Crohn's patients"

    01/25/16-John Kao, M.D. "Presenting National Meetings"

    02/01/16-Mo El-Zaatari, Ph.D. "Novel mechanisms mediating GI pre-neoplasia"

    02/08/16-Bishr Omary, M.D., Ph.D. "When is it time to tell your story & to which journal"

    02/15/16-Kate Walton, Ph.D. "Building Intestinal Villi"

    03/07/16-Melody Zeng, Ph.D. "Research Update"

    03/14/16-Rebecca Hughes, Ph.D. and Joe Austin, Ph.D. "IRB 101 Discussion"

    03/21/16-Chung Owyang, M.D. "Academic Skills Workshop Seminar titled "How to write a successful R01 Grant"

    03/28/16-Jason Spence, Ph.D. "Research Advice"

    04/11/16-Alana Chin, Ph.D. "β-catenin destruction complex-independent regulation of hippo-YAP signaling by APC in Intestinal Tumorigenesis"

    04/18/16-Andrea Wright, Ph.D. "Body Composition in Non-Alcoholic Fatty Liver Disease: An Analysis of the Framingham Heart Study"

    04/25/16-Daniel Triner, Ph.D. "Pro-Inflammatory HIF-2a/MAZ Signaling in Colitis and Colon Cancer"

    05/02/16-Graham Brady, M.D. "Role of nuclear lamins in liver disease"

    05/09/16-Heather Schofield, Ph.D. "Elucidating the Role of Bmi1 in Pancreatitis and the Initiation of Pancreatic Cancer"

    05/16/16-Kate Walton, Ph.D. "Defining the role of vasculature in villus morphogenesis"

    No weekly noon seminars for summer months June, July and August

    09/19/16-Heather Schofield, Ph.D. and Daniel Triner, Ph.D., (Research Updates) "New mouse model demonstrates the necessity of mutant p53 expression for pancreatic cancer progression" and "MAZ as a novel regulator of the proinflammatory response in colitis and colon cancer"

    09/26/16-Graham Brady, M.D., and Joseph Pickard Ph.D., (Research Updates) "Role of nuclear lamina in liver disease" and "Mechanisms of colonization resistance to enteric pathogens"

    10/03/16-Tina Morhardt, M.D., and Holly Turala, Ph.D., "IL-10 producing small intestinal macrophages has protective role in intestinal inflammation" and "Host and bacterial modulation of norovirus pathogenesis"

    10/10/16-Matthew Sturm, M.D. "Multiplexed molecular imaging of biliary intraepithelial neoplasia; imaging strategies for the early detection of cancer in indeterminate biliary strictures"

    10/17/16-Marina Pasca di Magliano, Ph.D., "Myeloid cells regulate Acinar cell plasticity and pancreatic remodeling in mice".

    10/24/16-Heather Schofield, Ph.D. "Journal Club"

    10/31/16-Jeffery Perry, Ph.D., "Investigation of Dengue Virus through Functional Mapping of Its Genome"

    11/07/16-Christiane Wobus, Ph.D., "Mechanisms of Norovirus - host Interactions"

    11/14/16-Daniel Triner, Ph.D., "IRAK-M expression in tumor cells supports colorectal cancer progression through reduction of antimicrobial defense and stabilization of STAT3"

    11/21/16-Eric Martens, Ph.D., "Degradation of Complex Carbohydrates By Human Gut Bacteria During Health & Disease"

    11/28/16-Graham Brady, M.D., "p62/SQSTM1 by binding to vitamin d receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer"

    12/05/16-Juanita L. Merchant, M.D., Ph.D., “Men1 Gastrinomas”

    12/12/16-Yatrik Shah, Ph.D., "Intestinal Control of Systemic Iron Homeostasis"

    12/19/16-Linda Samuelson, Ph.D., "Dynamic regulation of intestinal stem cell self-renewal by notch signaling"

    12/26/16- No Conference

    01/30/17- Nobuhiko Kamada, Ph.D., "The Gut Microbiota and IBD"

    02/06/17- Joseph Pickard, Research, “Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome”

    02/13/17-Bishr Omary, M.D., Ph.D., Professor & Chair, Molecular & Integrative Physiology, and Professor of Internal Medicine, "Physiologic Exosomal Release of a Mitochondrial Enzyme Into Bile and Its Function As Circulatory Cytokine During Liver Injury"

    02/20/17- Matthew Sturm, M.D., GI Fellow, "A Tissue Systems Pathology Test Detects Abnormalities Associated with Prevalent High-Grade Dysplasia and Esophageal Cancer in Barrett's Esophagus"

    02/27/17- No Conference

    03/06/17- Elise Demitrack, Ph.D., "Wnt and Notch Regulation of Human Gastric Stem Cells"

    03/13/17- Thomas Wang, M.D., Ph.D., "Opportunities for Molecular Imaging in the Digestive Tract"

    03/20/17- Heather Schofield, Graduate Student,  "A New Mouse Model Demonstrates the Necessity of Mutant p53 Expression for Pancreatic Cancer Progression"

    03/27/17- Daniel Triner, student in the M.D./Ph.D., "Opposing Roles of Intratumoral Neutrophils in Colon Cancer"

    04/03/17-No Conference

    04/10/17- Canceled: Graham Brady, M.D., GI Fellow, "Role of the Nuclear Lamina in Nonalcoholic Fatty Liver Disease"

    04/10/17- Dhiman Maitra, Ph.D., Post-Doctoral Fellow from the Bishr Omary Lab, "A Novel Mechanism of Porphyria-Associated Cellular Toxicity"

    04/17/17 Gabriel Núñez, M.D., Paul de Kruif Professor of Pathology, "Control of Pathogen Colonization by Host Immunity and the Microbiota"

    04/24/17- Holly Turula, Graduate Student, "Secretory Immunoglobulins Enhance Norovirus Infection by Promoting Immune Tolerance"

    05/01/17- Tina Morhardt, M.D., "The Role of IL-10-producing Resident Macrophages in Small Intestinal Homeostasis”

    05/08/17-  DDW – No Conference

    05/15/17-  Joseph Pickard, Research, "Canceled"                                                                                       
    05/22/17- Matthew Sturm, M.D., GI Fellow, "Molecular Imaging Strategies for Dysplasia and Early Cancer Detection in Barrett's Esophagus"                                                                                              
    05/29/17- Memorial Day

    06/05/17- Joseph Pickard, Research Fellow, "Identifying Molecular Mechanisms of Colonization Resistance to Enteric Pathogens”

    06/12/17- Graham Brady, M.D., GI Fellow, "Nuclear Lamina-Related Variants in a Cohort of Twins with NAFLD”

    09/16/17 - David Lin, Graduate Student, "The Role of the Endoplasmic Reticulum Membrane Protein Complex in Dengue Virus Infection”

    09/25/17 - Jeanine Ruggeri,"The Role of Discoidin Domain Receptor 1 in Pancreatic Disease”

    10/02/17 - Canceled

    10/09/17 - Andrew Tai, M.D., "Reorganizing Cellular Membrane Trafficking to Build a Viral Replication Organelle”

    10/16/17 - Matthew Sturm, M.D., GI Fellow, "Molecular Imaging of ErbB2 and FGFR2 in Early Esophageal Cancer Using Bivalent Fluorescent Peptides”

    10/23/17 - David Lin, Graduate Student, "A Single Mutation in the prM Protein of Zika Virus Contributes to Fetal Microcephaly”

    10/30/17 - Canceled

    11/06/17 - Tina Morhardt, M.D., "IL-10 Producing Macrophages and Their Role in Small Intestine Homeostasis”

    11/13/17 - David R. Hill, Ph.D., Postdoctoral Fellow, “Bacterial Colonization Stimulates a Complex Physiological Response in the Immature Human Intestinal Epithelium”

    11/20/17 - Jeanine Ruggeri, Graduate Student, "Epithelial NEMO/IKKɣ Limits Fibrosis and Promotes Regeneration During Pancreatitis”

    11/27/17 - Andrew Schwartz, from the Yatrik Shah Lab, will present “Integration of Hepatic Hepcidin and Intestinal HIF-2 alpha in Systemic Iron Metabolism”

    12/04/17 - Howard Crawford, Ph.D., “Cellular Crosstalk in Pancreatitis and Tumorigenesis”

    12/11/17 - Holly Turula, “Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk”

    12/18/17 - Yatrik Shah, Ph.D., “Rigor and Reproducibility Training”

    01/08/18 - Canceled

    01/15/18 - Matthew Sturm, M.D., GI Fellow, "Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity"

    01/22/17 - John Kao, M.D., "Academic Skills Workshop"

    01/29/18 - Juanita Merchant, M.D., Ph.D., “How to Write a Grant”

    02/05/18 - Samuel Handelman, Ph.D., "Journal Bluc with Recent Statistics Review"

    02/12/18 - Yatrick Shah, Ph.D., "Hypoxia in Inflammation and Cancer"

    02/19/18 - Nobuhiko Kamada, Ph.D. "Microbial and Immunological Connections Between the Mouth and the Gut"

    02/26/18 - Canceled

    03/05/18 - Monique O’Leary, Ph.D.,“Regulation of Intestinal Epithelial Homeostasis by JAM-A Interacting Proteins”

    03/12/18 - Christiane Wobus, Ph.D., Associate Professor, Department of Microbiology and Immunology, will present “The Fascinating Biology of Enteric Viruses”

    03/19/18 - Canceled

    03/26/18 - Canceled

    04/02/18 - Elise Hibdon, Ph.D., “Wnt Regulation of Human and Mouse Gastric Stem Cells”

    04/09/18 - Scott Leiser, Ph.D., “The Conserved Role of Stress Response in Aging”

    04/16/18 - Tom Wang, M.D., “Novel Technologies for Imaging of the Gastrointestinal Tract”

    04/23/18 - David Lin, “Characterization of Dengue Virus Host Factors Identified by a Genome-Wide CRISPR-Cas9 Screen”

    04/30/18 - Matthew Sturm, M.D., "Molecular Imaging of Esophageal and Biliary Neoplasia Using Disease Targeted Fluorescent Peptides"

    05/07/18 - Canceled

    05/14/18 - Holly Turula, "Natural Secretory Immunoglobulins Promote Enteric Virus Infection by Facilitating Intestinal Homeostasis"

    05/21/18 - Tina Morhardt, “IL-10 Producing Macrophages and Their Role in Small Intestine Homeostasis”

    2017 Visiting Professor Seminars

    The UMCGR Visiting Professor Seminar Series has been temporarily suspended as the Center grant is on no-cost time extension currently.

    03/17/17- Jyoti Malhotra, Ph.D., Mitobridge Therapeutics, Sr. Principal Scientist/Associate Director, Translational Biology and In Vitro Pharmacology, Cambridge, MA and Adjunct Research Investigator, University of Michigan.   Presentation: “Protein Homeostasis: Functional Roles in Disease and Drug Discovery” 

    10/10/17 - Gabriel Corfas, Ph.D., Professor and Associate Chair for Research Department of Otolaryngology—Head and Neck Surgery, Director, Kresge Hearing Research Institute, The Lynn and Ruth Townsend Professor of Communication Disorders, The University of Michigan. Presentation: “Novel insights into enteric glia diversity and function”   

    10/31/17 - Laurence J. Miller, M.D., Karl F. and Marjory Hasselmann
    Professor of Research and Medicine, Biochemistry & Molecular Biology and Pharmacology, Mayo Clinic College of Medicine, Mayo Clinic Arizona.“Type 1 cholecystokinin receptor in metabolic disease. Target of endogenous and therapeutic allosteric modulation”

    2018 Visiting Professor Seminars

    Wednesday, November 7, 2018

    *Peter J. Dempsey, Ph.D., Associate Professor of Medicine at the University of Colorado Anschutz Medical Campus. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics. Presentation title: TBA. 7745 Medical Science Building, 4:00-5:00 PM (co-hosted with Molecular and Integrative Physiology).

    Tuesday, March 12, 2019

    Michelle A. Battle, Ph.D., Associate Professor, Department of Cell Biology, Neurobiology and Anatomy, Medical School of Wisconsin. Presentation title: TBA. 5330 Medical Science Building I, 12:00-1:00 PM

    Tuesday, April 16, 2019

    Nancy Allbritton, M.D., Ph.D., Kenan Professor and Chair, Jiont Department of Biomedical Engineering, University of Notch Carolina and North Carolina State University. Presentation title: TBA. 5330 Medical Science Building I, 12:00-1:00 PM

    2018 Annual Academic Workshop and Retreat

    Friday February 09, 2018

    Presentations by T32 Trainees and Pilot Awardees will be held in the Biomedical Science Research Building Seminar
    Rooms 1170, 1150, 1150 (A, B, C) from 12:30pm – 6:00pm.
    Presenters: Tina Morhardt, M.D., Elise Hibdon, Ph.D., Matthew Sturm, M.D., Ph.D., Deqiang Zhang, Ph.D., Scott Leiser, Ph.D., Monique O'Leary, Ph.D., Holly Turula Ph.D. Candidate, David Hill, Ph.D., and P. Kay Lund, Ph.D.

    12:30 – 12:40 PM- Welcome by Chung Owyang, M.D/John Kao, M.D.
    12:40 – 1:10 PM-Tina Morhardt, M.D., House Officer, Pediatrics Gastroenterology, University of Michigan Hospitals. "IL-10 producing macrophages play a protective role in small intestinal inflammation"                                            
    1:10 – 1:40 PM-Elise Hibdon, Ph.D., Research Investigator, Dept. of Molecular and Integrative Physiology, Medical School.“Wnt pathway regulation of human gastric stem cells in the normal and FAP stomach.”

    1:40 – 2:10 PM-Matthew Sturm, M.D., Ph.D., House Officer, Internal Medicine Gastroenterology, University of Michigan Hospitals.“Prevalence and multi-spectral imaging of biomarker claudin-1, EGFR, c-Met, and ErbB2 in biliary intraepithelial neoplasia, a precursor of cholangiocarcinoma”

     2:10 – 2:40 PM- Deqiang Zhang, Ph.D., Postdoctoral Fellow of Molecular and Integrative Physiology, Medical School,“The protective role of lipogenic factor ChREBP against high-fructose diet-induced hepatotoxicity”

    2:40 – 2:50 PM Break

    2:50 – 3:20 PM- Scott Leiser, Ph.D., Assistant Professor of Molecular and Integrative Physiology and Assistant Professor of Internal Medicine, Medical School,“Conserved regulation of metabolism and health” 

     3:20 – 3:50 PM- Monique O'Leary, Ph.D., Research Investigator, Pathology, Medical School, Pathology Department.“Regulation of intestinal epithelial homeostasis by JAM-A interacting proteins”

     3:50 – 4:20 PM- Holly Turula, Ph.D. Candidate, Graduate Student Instructor and Graduate Student Research Assistant, Microbiology and Immunology, Medical School.“Natural secretory immunoglobulins enhance norovirus infection”

     4:20 – 4:50 PM- David Hill, Ph.D., Research Fellow, Internal Medicine, Gastroenterology. “Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface”

     4:50 – 5:00 PM- Break  

     5:00 – 6:00 PM- Presentation by Judy H. Cho, M.D., Director of the Charles Bronfman Institute for Personalized Medicine (CBIPM), the Ward-Coleman Chair for Translational Genetics, and the Vice-Chair for Research in Gastroenterology at the Icahn School of Medicine at Mount Sinai), as our key note speaker and sixth year Yamada Lectureship honoree.“The GI Research Community: competition and collaboration”

    Saturday, February 10, 2018 (Retreat Keynote Speaker)

    Judy H. Cho, M.D., Director of the Charles Bronfman Institute for Personalized Medicine (CBIPM), the Ward-Coleman Chair for Translational Genetics, and the Vice-Chair for Research in Gastroenterology at the Icahn School of Medicine at Mount Sinai), as our key note speaker and sixth year Yamada Lectureship honoree. Topic: “Leveraging population differences in innate immunity: Towards Precision IBD.” 10:15-11:15 AM, BSRB Kahn Auditorium, Hosted by The Michigan Center for Gastrointestinal Research.


    2018 Midwest DDRCC Academic Workshop- Case Western Reserve University School of Medicine March 5-6th, Cleveland, Ohio.

    Monday March 5th

    Welcome and Networking 12:00 - 12:30 PM
    Lunch Service 12:30 - 12:45 PM
    Lunch Speaker (State of the Art Lecture) 12:45 - 1:45 PM
    Pilot and Feasibility Presentations (3) 1:45 - 2:45 PM
    Break 2:45 - 3:00 PM
    Pilot and Feasibility Presentations (3) 3:00 - 4:00 PM
    Break 4:00 - 4:10 PM
    Pilot and Feasibility Presentations (3) 4:10 - 5:10 PM
    Dinner 6:30 - 8:30 PM

    Tuesday March 6th

    Breakfast 7:30 - 8:00 AM
    Pilot and Feasibility Presentations (3) 8:00 - 9:30 AM
    Speaker 2 9:30 - 10:45 AM
    Mock Study Section 10:45 - 11:45 AM
    Lunch and Networking 11:45 - 12:45 PM
    Closing Remarks 12:45 - 1:00 PM


* Co-sponsored seminars


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