M1 Sequence Overview
Patients and Populations
Sequence Directors:
Thomas D. Gelehrter, Professor of Human Genetics & Internal Medicine
Department of Human Genetics
E-mail: tdgum@umich.edu
Phone: 734-764-5491
Sequence Mission Statement & Intended Learning Outcomes
MISSION STATEMENT

This is the first module of the new curriculum. The emphasis of this module is on genetics, principles of disease, epidemiology, information gathering and assessment

KNOWLEDGE

1. Each student should understand the basic principles of medical genetics and their application to clinical medicine so that he/she can understand ongoing developments in medical genetics and their application to clinical problems.

2. All students should acquire an understanding of the basis mechanisms of disease, the pathogeneses and morphology of prototypical tissue changes which occur in the major classes of disease, and how these relate to clinical signs and symptoms of disease.

3. Through the study of General Pathology students will learn the basic elements of a medical vocabulary.

4. Each student should have an understanding of how clinical observations, advances in scientific knowledge, and serendipity all contribute to our understanding of disease mechanisms and the development of effective treatments.

5. The student should have a sufficient understanding of biostatistics and epidemiology in order to understand and critically evaluate the presentation, analysis and interpretation of data in the biomedical literature.

6. All students will acquire a basic understanding of the fundamental principles of hypothesis generation and testing, study design, measurement and statistical inference as it pertains to the creation and application of new medical knowledge.

7. An introductory understanding of how new medical knowledge is created and applied.

SKILLS
1. All students will be able to assess the quality of study design and implementation in research reported in major medical journals, focusing on both internal and external validity principles:

INTERNAL VALIDITY
• The appropriateness of the study design with respect to the research hypothesis
• The appropriateness of the study design with respect to its outcomes
• The appropriateness of the selection of outcomes with respect to the RQ
• Adherence of the study’s methods to its fundamental validity criteria

EXTERNAL VALIDITY
• The appropriateness of the study’s conclusions with respect to the strength of its findings
• The appropriateness of the study’s methods and outcomes with respect to the importance of the problem
• A basic understanding of how to establish rapport with a patient and to gather and organize medical information from the patient.

PROFESSIONALISM: ATTITUDES, BEHAVIORS AND CHARACTERISTICS
1. An appreciation of the role and importance of clinical research and investigation in the care of patients.

2. Each student should have a sufficient understanding of basic principles to understand new developments in medical genetics and their application to clinical practice. The student should be developing the abilities to access, acquire, and interpret new findings in basic biomedicine and clinical research.

3. Students need to understand that medicine is not a static field, that treatment paradigms are constantly shifting, and that what we do not know far exceeds what we do know.
Resources
Medical School Portal