November 12, 2012
12:00 - 1:00 PM
Ford Auditorium, University Hospital

Don't miss the next Research Town Hall! Sponsored by the UMMS Office of Research and the Michigan Institute for Clinical & Health Research (MICHR), the focus of this event will be research funding and education & mentoring opportunities, with a variety of speakers presenting. A Q&A session will follow the presentations.

A light lunch will be provided outside the auditorium before the event starts.

RSVP for this event.

On April 7, 2008 the National Institutes of Health made it mandatory for all researchers who hold an NIH grant to comply with its Public Access Policy. Merle Rosenzweig from the U-M Taubman Health Sciences Library has just released a new five-part video lecture that covers all aspects of complying with this policy:

Part 1 – About the Policy
Part 2 – Complying
Part 3 – Submitting to NIHMS
Part 4 – NIHPAP & the Grant Process
Part 5 – The Policy & eRA Commons

Slides for the lectures are also available (information at URL above).  It takes about an hour to watch all five parts of the video.

Several other helpful resources as well as the video lecture are listed on the Office of Research & Sponsored Projects website.

More about the NIH Public Access Policy

The NIH public access policy requires that a PubMed Central identification number (PMCID) be added to the end of a journal citation in grant proposals, progress reports, and the NIH biosketch that may accompany these to show compliance for research that is supported by NIH grant funding.

Principal Investigators (PIs) and Program Directors (PDs) now must use My NCBI's online portal "My Bibliography" to manage their bibliographies. Citations must be added to My Bibliography to ensure that they appear in eRA Commons and thereby become associated with future annual progress reports. My Bibliography helps users address NIH Public Access compliance by assigning the appropriate NIH grant(s) with publications and expedites and facilitates their deposit into the National Institutes of Health Manuscript Submission System (NIHMS).

U-M Medical School faculty, staff, and students interested in the entrepreneurial side of life sciences research have a smorgasbord of upcoming events from which to choose.  Celebrate Invention, the U-M Office of Technology Transfer’s annual showcase honoring campus inventors—many from the Medical School—is today (Thursday, October 18).  U-M Medical School start-ups have been consistently recognized at the annual Accelerate Michigan business plan competition, this year taking place November 13-15 at the Westin Book Cadillac in Detroit.  And from now until November 16, UMMS students have the opportunity to craft a “pitch” with the potential to solve problems in the health or technology sectors by participating in 1000 Pitches, hosted by the on-campus organization MPowered Entrepreneurship and sponsored by UMMS Business Development.

Celebrate Invention
Thursday, October 18, 2012
3:00 - 6:00 PM
Michigan League Ballroom
Website

Accelerate Michigan
Tuesday, November 13 - Thursday, November 15, 2012
Westin Book Cadillac Hotel, Detroit
http://www.acceleratemichigan.org/

1000 Pitches
Accepting Pitches until November 16, 2012
Sunday, December 9, 2012 – Awards Ceremony
Michigan Union Ballroom
https://1000pitches.com/

Tuesday, October 23, 2012
12:00 – 1:00 PM
Forum Hall, Palmer Commons

Christopher P. Austin, M.D., newly appointed director of the NIH's newest center, the National Center for Advancing Translational Sciences (NCATS), will be presenting at the Center for the Discovery of New Medicine (CDNM) lecture series on October 23. Come listen as he shares his perspective on accelerating translational research.

The lecture is sponsored by the Michigan Institute for Clinical & Health Research (MICHR).

The Michigan Institute for Clinical & Health Research (MICHR) has introduced a new version of OpenClinica clinical trial management software. Mi-OC (University of Michigan OpenClinica) has the same features and functionality as the previously released edition, but allows researchers a "do-it-yourself" option.

MICHR began offering V-OC (Validated OpenClinica) in the fall of 2011 for clinical trial databases. This version is fully compliant with FDA regulations for studies that are intended to be used for FDA submissions and requires research teams to partner with MICHR experts to build and manage study databases. With the introduction of Mi-OC, researchers can now build and manage their clinical study databases themselves, after receiving free training from MICHR.

“OpenClinica’s electronic data capture and clinical data management system is now within easier reach of investigators with Mi-OC,” said Mary Phelps, Associate Managing Director, MICHR. ”It is free, secure, and has robust features including discrepancy management, source data verification, and reusability of study report forms.”

MICHR also continues to offer REDCap – the easy-to-use, no-cost, secure, HIPAA-compliant, web-based application – for simple, do-it-yourself data capture and data management, and recommends Mi-OC for studies requiring more complex databases that require data management functionality. MICHR recommends V-OC for more complex studies requiring compliance with federal regulations.

For more information on OpenClinica and other clinical research enabling solutions, contact MICHR at 734-998-7474 or um-michr@umich.edu to schedule a consultation.

The Medical School Office of Research has created a new collaborative group for those individuals who help the faculty write or edit biomedical grant proposals.  The purpose of the group is to share insights, discussion, news, and resources about grant proposal development. The focus is on (1) pre-award activities related to preparing/writing the project description portion of grant proposals or (2) T32 (training) grant proposals.

A CTools site has been created for the group, and we’ve populated it with many resources.  If you contribute to proposal content (e.g., aims, strategy, resources), please consider joining this network – simply complete this online form.

Contact Chris Black with any questions.

By Chris Black, M.L.S., Assistant Director for Research Services, Office of Research

(This is one in a series of tips published in UMMS Research News about writing proposals.)

Good preliminary data can be used to improve reviewer confidence in both the credibility of the investigator and the feasibility of research. Data that support the PI’s hypothesis are especially important, and demonstrate that the team has already begun to “fill the gap in knowledge” that is so significant. (Remember: don’t irritate the reviewers with irrelevant data just to show you have experience conducting studies.)

While the data need to be substantial, they cannot be so substantial that the reviewer asks why the research needs to be funded, i.e., you already have your answer! Here is a simple formula that looks at preliminary results and statistical power:

• Positive results with high power = why are you applying?
• Negative results with high power = does not sound promising!
• Positive results with low power = let’s learn more!

In other words, have good enough results and enough power to show that this is a good scientific bet, but needs to be better substantiated.

Wednesday, October 24, 2012
9:30 - 11:00 AM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by Taubman Health Sciences Libraries.

This workshop offers instruction on the efficient and proper placement of images, charts, and graphics into grant proposal applications. The session will cover basic features in Microsoft Word such as image placement, captioning, and text wrapping. Following a brief presentation and hands-on instruction, instructors will assist you with specific issues you’re encountering in formatting your grant application. The session will cover all versions of Microsoft Word and applies to placement of graphics into any Word document. Please feel free to bring sample documents!

Contact Merle Rosenzweig with any questions. You can also view a video of this workshop and related documentation online.

Register to attend this workshop.

This series, sponsored through the U-M Medical School Dean's office in coordination with local venture funding groups, will be an introduction to commercialization of healthcare innovations. The four-part series will take place:

October 25, November 8, November 29, and December 13, 2012
(all Thursdays)
5:30 - 8:00 PM
Ford Auditorium

Topics will include: Commercializing Life Sciences/Medical Technology Innovations; Market Potential; Financing, Fundraising, and Liquidity Planning.  There will also be an entrepreneur panel.
 
Participation is free of charge and dinner will be included. RSVP requested to Erin McKean, M.D., M.B.A.

Wednesday, November 14, 2012
9:00 - 11:00 AM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by Taubman Health Sciences Libraries.

This hands-on workshop will provide instruction on using EndNote to support academic research and publications. This software is compatible with many online databases available through the University of Michigan libraries. When using the Microsoft Word add-in, EndNote becomes invaluable for writing manuscripts, grants, and papers for course assignments.

Register for this workshop.

The A. Alfred Taubman Medical Research Institute’s Consortium for Stem Cell Therapies (CSCT) seek proposals for innovative research at the University of Michigan that utilize either human embryonic stem cell (hESC) lines or human induced pluripotent stem cell (hiPSC) lines derived by the CSCT. These grants are made possible from the generous contribution of Robert and Marge Alpern to a capital Fund for Stem Cell Research.

Two grants of $15,000 each will be available to support the transfer, directed differentiation, and phenotypic analysis of existing CSCT-produced disease-specific hESC lines. These lines are unique in that several represent the only existing line(s) for specific single-gene defects available worldwide. These funds can also support basic training, if needed, in pluripotent stem cell maintenance, growth, and characterization. A list of CSCT-derived hESC lines can be found online.

Two grants of $50,000 each will be available for the derivation of new lines (either hESC or hiPSC). Successful projects might include, but are not limited to:

• Derivation of a disease-specific hESC line. Funds will support acquisition of disease tested and affected human embryos under an IRB-approved study. Funds will support the production, expansion, and characterization of the disease-specific hESC line with submission and acceptance on the NIH hESC registry.
• Derivation of novel disease-specific hiPSC lines. Funds will support the derivation of fibroblast cell lines from a tissue biopsy (or cell bank), derivation, and characterization of at least four iPSC lines.

Applications should include a two-page research proposal (not including references), along with a brief budget summary (no PI salary support) and an NIH-format biosketch. They must be submitted electronically by November 1, 2012 through this website.

Proposals will be judged for scientific merit by the CSCT Scientific Advisory Board. Successful applicants will be notified by December 1, 2012 with funds available January 1, 2013.

For additional information, contact:
Gary D. Smith, Ph.D. (734-764-4134 or smithgd@umich.edu)
Sue O’Shea, Ph.D. (734-763-2550 or oshea@umich.edu)

The Robert and Marge Alpern Stem Cell Research Fund was established at the University of Michigan in 2008 to support stem cell research with the greatest potential for increasing an understanding of fundamental stem cell biology as well as the potential for treating human disease.

Contributors to the A. Alfred Taubman Medical Research Institute's Consortium for Stem Cell Therapies include the Taubman Institute; the Office of the Executive Vice President for Medical Affairs; the Office of the Medical School Dean; the Comprehensive Cancer Center; the Department of Pediatrics and Communicable Diseases; the Office of the Vice President for Research; the School of Dentistry; the Department of Pathology; the Department of Cell and Developmental Biology; the College of Engineering; the Life Sciences Institute; the Department of Neurology; and U-M's Michigan Institute for Clinical and Health Research.

The Bill & Melinda Gates Foundation is now accepting grant proposals for Round 10 of Grand Challenges Explorations, an initiative to encourage innovative and unconventional global health and development solutions. Applicants can be at any experience level; in any discipline; and from any organization, including colleges and universities, government laboratories, research institutions, non-profit organizations and for-profit companies.

Two-page grant proposals are being accepted on the following topics:

• Labor Saving Innovations for Women Smallholder Farmers
• New Approaches in Model Systems, Diagnostics, and Drugs for Specific Neglected Tropical Diseases
• New Approaches for the Interrogation of Anti-malarial Compounds
• Aid is Working. Tell the World

Initial grants will be US $100,000 each, and projects showing promise will have the opportunity to receive additional funding of up to US $1 million. Full descriptions of the topics and application instructions are available online.

You can view a PowerPoint document that offers insight from Michigan's performance in past rounds.  It describes the review process and shares sample proposal language that has proven successful.  Michigan has received eight of these awards, more than most of our peers across the country.

To learn more about the Grand Challenges Explorations program and the Grand Challenges in Global Health program:

• View the Foundation's Interactive Map that gives information on 813 grants that have been awarded for projects in 49 countries.
• Meet the Grand Challenges community through videos and project slideshows.

The Foundation looks forward to receiving innovative ideas from around the world and from all disciplines. If you have a great idea, apply through the foundation’s website.

Anesthesiology

PI: *Poe,Gina
Title: REM Sleep and Memory
Sponsor: NIH  2 R01 MH 060670 11 A1
Project Dates and Amount of Award: 09/01/12-08/31/17; $1,699,967

PI: *Smith,William
Title: Personalized NSAID Therapeutics Consortium (PENTACON)
Sponsor: NIH - Subcontracts TO University of Pennsylvania  U54 HL 117798
Project Dates and Amount of Award: 08/01/12-05/31/13; $31,100

PI: *Burant,Charles
Co-I: Athey, Brian (Psychiatry Department) / Byun, Jaeman (Int Med-Nephrology) / Jagadish, H. V. (COE EECS - CSE Division) / Karnovsky, Alla (CCMB-Initiatives) / Kennedy, Robert (LSA Chemistry) / Mirel, Barbara (School of Education) / Pennathur, Subramaniam (Int Med-Nephrology) / Rajendiran, Thekkelnaycke (Ctr fr Translational Pathology) / Schnell, Santiago (Molec & Integrative Physiology) / Wang, Naisyin (LSA Statistics)
Title: Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
Sponsor: NIH  1 U24 DK 097153 01
Project Dates and Amount of Award: 09/04/12-08/31/17; $9,170,679

PI: *Elder,James
Co-I: Nair, Rajan (Dermatology Department) / Tejasvi, Trilokraj (Dermatology Department)
Title: Genetic and Genomic Dissection of Psoriatic Arthritis
Sponsor: NIH  1 R01 AR 063611 01
Project Dates and Amount of Award: 09/12/12-08/31/17; $3,147,133

PI: *Younger,John
Awardee / Fellow: Conrad, Erin
Title: Spatial Biochemical Dynamics of Central Venous Catheter Infections
Sponsor: Emergency Medicine Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $2,400

PI: *Younger,John
Title: Collaborative Research: Microbial Flocculation Dynamics
Sponsor: NSF
Project Dates and Amount of Award: 09/15/12-08/31/15; $162,451

PI: *Aikens,James
Co-I: Eisenberg, Daniel (Health Management and Policy) / Fetters, Michael (Family Medicine) / Piette, John (Int Med-General Medicine) / Saunders, Daniel (School of Social Work) / Sen, Ananda (Family Medicine) / Valenstein, Marcia (Psychiatry Department) / Watkins, Daphne C (School of Social Work)
Title: Telemonitoring Enhanced Support for Depression Self Management
Sponsor: NIH  1 R01 MH 096699 01 A1
Project Dates and Amount of Award: 09/18/12-06/30/17; $2,972,481

PI: *Meisler,Miriam
Title: Gene Interaction in Development and Disease
Sponsor: NIH  2 R01 GM 024872 35
Project Dates and Amount of Award: 09/01/12-08/31/16; $1,635,522

PI: *Carethers,John
Co-I: Mukherjee, Bhramar (Biostatistics Department)
Title: Inflammatory Differentiation of Colorectal Cancer Among African Americans
Sponsor: NIH  1 U01 CA 0162147 01 A1
Project Dates and Amount of Award: 09/01/12-08/31/17; $1,443,060

PI: *Chugh,Aman
Title: QuickFlex u Model 1258T Left Heart Pacing Lead Post Approval Study
Sponsor: Pacesetter, Inc.
Project Dates and Amount of Award: 10/01/12-10/31/12; $2,500

PI: *Gitlin,Scott
Awardee / Fellow: Reichert, Zachery
Title: Investigating the Human Endogenous Retrovirus type K (HERV-K) Primary Sequence and Copy Number within Centromeres in Mammalian Tumors to Elucidate its Possible Role in Karyotypic Complexity
Sponsor: American Society of Hematology
Project Dates and Amount of Award: 07/01/12-06/30/13; $4,000

PI: *Higgins,Peter
Title: A PHASE II OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY OF rhuMAb BETA7 IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS
Sponsor: Genentech, Inc. TO Pharmaceutical Product Development, Inc.
Project Dates and Amount of Award: 08/29/12-08/28/16; $334,617

PI: *Humes,H
Title: Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome
Sponsor: NIH - Subcontracts TO Innovative Biotherapies
Project Dates and Amount of Award: 09/08/12-05/31/14; $123,134

PI: *Katz,Steven
Co-I: An, Lawrence (Int Med-General Medicine) / Elliott, Michael (Biostatistics Department) / Fagerlin, Angela (Int Med-General Medicine) / Friese, Christopher (School of Nursing) / Griggs, Jennifer (Int Med-Hematology/Oncology) / Hawley, Sarah (Int Med-General Medicine) / Hofer, Timothy (Int Med-General Medicine) / Jagsi, Reshma (Radiation Oncology - Ann Arbor) / Janz, Nancy (Hlth Behavior & Hlth Ed Dept) / Li, Yun (Biostatistics Department) / Resnicow, Kenneth (Hlth Behavior & Hlth Ed Dept) / Taylor, Jeremy (Biostatistics Department)
Title: The Challenge of Individualizing Treatments for Patients with Breast Cancer
Sponsor: NIH  1 P01 CA 163233 01 A1
Project Dates and Amount of Award: 09/01/12-08/31/17; $13,639,427

PI: *Khanna,Puja
Co-I: Trivedi, Mona (Int Med-Rheumatology)
Title: Observational Study of the Use of KRYSTEXXA (Pegloticase) in Adult Hyperuricemic Patients with Gout Refractory to Conventional Therapy
Sponsor: Savient Pharmaceuticals, Inc TO PPD, Inc.
Project Dates and Amount of Award: 09/20/12-09/19/16; $136,493

PI: *Koelling,Todd
Title: Medtronic 2012 Heart Failure Fellowship Program
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $20,000

PI: *Pelosi Jr,Frank
Title: Medtronic 2012 EP Fellowship Program
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $30,000

PI: *Pelosi Jr,Frank
Title: Biotronik 2012 CCEP Fellowship Training Program
Sponsor: Biotronik, Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $40,000

PI: *Reddy,Pavan
Co-I: Braun, Thomas (Biostatistics Department) / Goldstein, Steven (Int Med-Hematology/Oncology)
Title: Alpha 1-Antitrypsin as a Novel Strategy to Modulate GVHD
Sponsor: Leukemia and Lymphoma Society
Project Dates and Amount of Award: 10/01/12-09/30/15; $600,000

PI: *Saran,Rajiv
Co-I: Gillespie, Brenda (Ctr Statistical Consul & Res) / Heung, Michael (Int Med-Nephrology) / Hirth, Richard (Health Management and Policy) / Kalbfleisch, John (Biostatistics Department) / Leichtman, Alan (Int Med-Nephrology) / Shahinian, Vahakn (Int Med-Nephrology) / Webb, Randall (Biostatistics Department) / Zheng, Kai (Health Management and Policy)
Title: Developing a Comprehensive National Kidney Disease Registry for the Department of Veterans Affairs
Sponsor: Veterans Affairs, Dept. of
Project Dates and Amount of Award: 09/24/12-09/24/14; $3,716,016

PI: *Somers,Emily
Co-I: Hassett, Afton (Anesthesiology Department) / Marder, Wendy (Int Med-Rheumatology) / Mccune, William (Int Med-Rheumatology) / Phillips, Kristine (Int Med-Rheumatology) / Wang, Lu (Biostatistics Department)
Title: Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort
Sponsor: CDC 1 U01 DP 003250 01
Project Dates and Amount of Award: 09/30/12-09/29/16; $3,000,000

PI: *Talpaz,Moshe
Title: An Open-Label, Multiple Simon 2-Stage Study of INCB039110 Administered Orally to Subjects with Primary Myelofibrosis (PMF), Post Polycythemia Vera-Myelofibrosis (PPVMF) or Post Essential Thrombocythemia-Myelofibrosis (PET-MF):  UMCC 2012.039
Sponsor: Incyte Pharmaceuticals, Inc.
Project Dates and Amount of Award: 09/28/12-09/28/16; $523,556

PI: *Wiley,John
Co-I: Hong, Shuangsong (Int Med-Gastroenterology)
Title: Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
Sponsor: NIH  1 R56 DK 093631 01
Project Dates and Amount of Award: 09/20/12-08/31/13; $334,325

PI: *Chang,Cheong-Hee
Title: Mechanisms Generating Suppressor CD4 T Cells by Thymocyte-Mediated Development
Sponsor: NIH  1 r56 AI 093586 01 A1
Project Dates and Amount of Award: 09/01/12-08/31/13; $388,750

PI: *Mobley,Harry
Title: UPEC 06-EPA Vaccine Protection in Mice Model for Urinary Tract Infection
Sponsor: GlycoVaxyn
Project Dates and Amount of Award: 08/14/12-02/13/13; $27,023

PI: *Mobley,Harry
Awardee / Fellow: Subashchandrabose, Sargurunathan
Title: Identification of Genes Expressed in Uropathogenic Escherichia Coli During Human Infection
Sponsor: American Urological Association Foundation
Project Dates and Amount of Award: 07/01/12-06/30/14; $80,000

PI: *Sutton,Michael
Awardee / Fellow: Renoux, Abigail
Title: Neuronal dysfunction in fragile X spectrum disorders
Sponsor: NIH  1 F31 MH 097451 01 A1
Project Dates and Amount of Award: 09/01/12-08/31/15; $97,455

PI: *Braley,Tiffany
Title: Radiographic Markers of Sleep Disordered Breathing in Multiple Sclerosis
Sponsor: American Sleep Medicine Foundation
Project Dates and Amount of Award: 08/01/12-07/31/13; $75,000

PI: *Chervin,Ronald
Awardee / Fellow: Wilson, Katherine
Title: Sleep Habits and Environments for Elementary School Children in Urban, Low Socioeconomic Settings
Sponsor: American Sleep Medicine Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $75,000

PI: *Fan,Xing
Title: Investigating Cancer Stem Cells - Niche Interactions in Brain Tumor
Sponsor: NIH  1 R01 CA 163737 01
Project Dates and Amount of Award: 09/18/12-07/31/17; $1,127,375

PI: *Xi,Guohua
Co-I: Hua, Ya (Neurosurgery) / Keep, Richard (Neurosurgery)
Title: Mechanisms of Early Brain Injury after Subarachnoid Hemmorrhage
Sponsor: NIH  1 R01 NS 079157 01 A1
Project Dates and Amount of Award: 09/01/12-07/31/17; $1,700,780

PI: *Harris,Lisa
Awardee / Fellow: Lance, Audrey
Co-I: Vahratian, Anjel (Obstetrics and Gynecology Dept)
Title: Can 16 and Pregnant Affect Attitudes and Knowledge on Contraception and Pregnancy among Teen Women? A Randomized Controlled Trial
Sponsor: Society of Family Planning
Project Dates and Amount of Award: 04/01/12-06/30/13; $70,000

PI: *Gardner,Thomas
Awardee / Fellow: Besirli, Cagri
Title: Feasibility Study of ONL-101 for Photoreceptor Neuroprotection
Sponsor: NIH - Subcontracts TO ONL
Project Dates and Amount of Award: 08/01/12-12/31/12; $67,500

PI: *Jayasundera,Kanishka
Awardee / Fellow: Zahid, Sarwar
Title: Quantification of Changes in Macular Autofluorescence in Dry Age-Related Macular Degeneration and Retinal Dystrophies
Sponsor: Fight for Sight, Inc.
Project Dates and Amount of Award: 09/01/12-12/31/12; $2,100

PI: *Mian,Shahzad
Title: Eye Bank Preparation of Donor Tissue for Descemet's Membrane Endothelial Keratoplasty
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/12-06/30/13; $5,000

PI: *Kozloff,Kenneth
Co-I: Caird, Michelle (Orthopaedic Surgery)
Title: Sclerostin Antibody Therapy for Treatment of Osteogenesis Imperfecta
Sponsor: NIH  1 R01 AR 062522 01 A1
Project Dates and Amount of Award: 09/24/12-06/30/17; $1,691,244

PI: *Chinnaiyan,Arul
Title: BC112721P1: Advancing our Understanding of the Etiologies and Mutational Landscapes of Basal-like, Luminal A, and Luminal B Breast Cancers
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/15/12-09/14/17; $3,727,880

PI: *Hess,Jay
Awardee / Fellow: Collins, Cailin
Title: Role of Collaborator Proteins in Hoxa9-Mediated Leukemogenesis
Sponsor: NIH  1 F30 CA 171917 01 A1
Project Dates and Amount of Award: 09/01/12-08/31/14; $68,454

PI: *Hogaboam,Cory
Title: Targeting Arginase in Idiopathic Pulmonary Fibrosis: An in Vitro Study.
Sponsor: Corridor Pharmaceuticals
Project Dates and Amount of Award: 10/01/12-09/30/13; $59,612

PI: *Hogaboam,Cory
Title: Acid-reflex Mediated Initiation and Exacerbation of Pulmonary Fibrosis and COPD
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 09/01/12-08/31/13; $162,029

PI: *Davis,Matthew
Awardee / Fellow: Auger, Katherine
Title: Improving Hospital Discharge Processes and Practices to Reduce Re-Hospitalization Risk
Sponsor: Blue Cross Blue Shield of Michigan Foundation
Project Dates and Amount of Award: 09/01/12-08/31/13; $10,000

PI: *Goldberg,Caren
Awardee / Fellow: Uzark, Karen
Title: The Relationship of Family Factors to Developmental and Psychosocial Outcomes in Children with Hypoplastic Left Heart Syndrome at 6 Years of Age
Sponsor: NIH - Subcontracts TO Children's Hospital of Wisconsin, Inc.
Project Dates and Amount of Award: 09/07/12-06/30/14; $12,000

PI: *Lumeng,Carey
Title: Hematopoietic Origins of Obesity-Induced Inflammation
Sponsor: American Diabetes Assoc, Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $187,625

PI: *Lumeng,Julie
Awardee / Fellow: Hastings, Elizabeth
Title: Primary Care Physicians' Interactions with Schools
Sponsor: Blue Cross Blue Shield of Michigan Foundation
Project Dates and Amount of Award: 07/15/12-07/14/13; $10,000

PI: *Mody,Rajen
Title: Scientific Leadership NIH COG Chair Grant U10CA098543
Sponsor: NIH - Subcontracts TO Children's Hospital of Philadelphia, The  U10 CA 098543
Project Dates and Amount of Award: 04/13/12-02/28/13; $16,936

PI: *Mody,Rajen
Co-I: Levine, John (Pediatrics-Hematology/Oncology)
Title: Master Subaward with The Children's Oncology Group and Children's Hospital of Philadelphia for Phase II/Phase III studies 2012-2013
Sponsor: NIH - Subcontracts TO Children's Hospital of Philadelphia, The  U10 CA 097452
Project Dates and Amount of Award: 03/01/12-02/28/13; $185,500

PI: *Moler,Frank
Title: Impact of Hypothermia on Midazolam/Morphine Pharmacokinetics
Sponsor: NIH - Subcontracts TO Children's Hospital of Philadelphia, The  R01 HL 112745
Project Dates and Amount of Award: 04/01/12-03/31/13; $3,600

PI: *Pipe,Steven
Title: 2012 ASPIRE US Hemo-Bioengineering Advancements in Recombinant Factor VIII Expression
Sponsor: Pfizer
Project Dates and Amount of Award: 09/01/12-12/31/14; $250,000

PI: *Prosser,Lisa
Title: Equipping PRISM for Pandemic Influenza (Medical Countermeasures Initiative)
Sponsor: Health and Human Services, Department of-Food and Drug Administration-Subcontracts TO Harvard Pilgrim Health Care
Project Dates and Amount of Award: 11/01/11-09/30/13; $20,735

PI: *Shavit,Jordan
Awardee / Fellow: Rabik, Cara
Title: Role of Modifier Genes in Coagulation of Zebrafish
Sponsor: American Society of Hematology
Project Dates and Amount of Award: 07/01/12-06/30/13; $4,000

PI: *Iniguez-Lluhi,Jorge
Title: Development of SUMO Protease Inhibitors as a Novel Strategy for Dual-Action Prostate Cancer Therapy - PC111395
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/30/12-09/29/15; $564,821

PI: *Tate,Denise
Co-I: Kalpakjian, Claire (Physical Medicine & Rehab Dept) / Rodriguez, Gianna (Physical Medicine & Rehab Dept)
Title: Psychosocial and Behavioral Factors Associated with Bowel and Bladder Management after SCI - SC110228
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/30/12-09/29/15; $614,110

PI: *Rosenblum,Katherine
Co-I: Mcdonough, Susan (School of Social Work) / Muzik, Maria (Psychiatry Department)
Title: Strong Famlies: Enhancing Resilence of Military Families with Young Children
Sponsor: Flinn, Ethel and James, Foundation
Project Dates and Amount of Award: 01/01/13-12/31/14; $190,000

PI: *Sripada,Sekhar
Title: Prospective Psychology Stage 1: Imagination and Being Drawn into the Future
Sponsor: Templeton, John, Foundation TO University of Pennsylvania
Project Dates and Amount of Award: 09/01/12-08/31/15; $380,110

PI: *Hamstra,Daniel
Co-I: Daignault-Newton, Stephanie () / Kunju, Lakshmi ()
Title: A PHASE I STUDY WITH BIOMARKER ANALYSIS OF MTOR INHIBITION IN COMBINATION WITH HORMONAL THERAPY AND RADIATION THERAPY FOR HIGH RISK PROSTATE CANCER
Sponsor: ASCO
Project Dates and Amount of Award: 07/01/10-06/30/13; $200,000

PI: *Morgan,Meredith
Co-I: Lawrence, Theodore (Radiation Oncology - Ann Arbor) / Maybaum, Jonathan (Pharmacology Department) / Simeone, Diane (GSA - Administration (GSA/ADM))
Title: Selective Sensitization of Pancreatic Cancer to Therapy by Chk1 and PARP1 Inhibition
Sponsor: NIH  1 R01 CA 163895 01 A1
Project Dates and Amount of Award: 09/01/12-06/30/17; $1,649,039

PI: *Chenevert,Thomas
Title: UM Core Lab/ACRIN #6698
Sponsor: NIH - Subcontracts TO American College of Radiology  U01 CA 080098
Project Dates and Amount of Award: 06/01/12-05/31/14; $155,336

PI: *Mukherji,Suresh
Awardee / Fellow: Wang, Page
Title: Perfusion CT, IL-8, and GRO- a: Biomarkers for Head and Neck Squamous Cell Carcinoma
Sponsor: American Society of Head and Neck Radiology (ASHNR)
Project Dates and Amount of Award: 07/01/12-06/30/13; $15,000

PI: *Cui,Xiao
Title: CYR61/CCN1 Increases Tumor Growth and Metastasis in Human Ovarian Cancer
Sponsor: Pardee, Elsa U., Foundation
Project Dates and Amount of Award: 09/01/12-08/31/13; $123,949

PI: *Hendren,Samantha
Co-I: Birkmeyer, Nancy (Surgery Department)
Title: Improving Rectal Cancer Surgery through Regional Collaboration
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/12-06/30/17; $728,000

PI: *Wong,Sandra
Co-I: Banerjee, Mousumi (Biostatistics Department) / Birkmeyer, John (GSA - Administration (GSA/ADM)) / Griggs, Jennifer (Int Med-Hematology/Oncology)
Title: Understanding Variation in Treatment Intensity of Poor Prognosis Cancers
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/12-06/30/15; $579,000

PI: *Macoska,Jill
Title: Society for Basic Urologic Research Fall Symposium 2012
Sponsor: NIH  1 R13 DK 097916 01
Project Dates and Amount of Award: 09/15/12-08/31/13; $10,000

PI: *Sarma,Aruna
Title: Community Based Assessment of PCA3
Sponsor: NIH - Subcontracts TO University of Texas Health Science Center at San Antonio  U01 CA 086402
Project Dates and Amount of Award: 07/01/12-06/30/13; $77,750

PI: *Weizer,Alon
Title: Robot Assisted versus Open Radical Cystectomy: A Randomized Clinical Trial
Sponsor: NIH - Subcontracts TO University of Miami, Florida  R01 CA 155388
Project Dates and Amount of Award: 08/01/12-04/30/13; $25,658

Journal Articles

Anesthesiology

Bauer Melissa E B, Bauer Samuel T, Rabbani Amir B, Mhyre Jill M. Case-report: Peripartum Management of Dual Antiplatelet Therapy and Neuraxial Labor Analgesia After Bare Metal Stent Insertion for Acute Myocardial Infarction. Anesthesia and analgesia. 2012 Sep. 115(3): 613-5. PMID# 22584549

Cardiac Surgery

Aaronson Keith D, Slaughter Mark S, Miller Leslie W, McGee Edwin C, Cotts William G, Acker Michael A, Jessup Mariell L, Gregoric Igor D, Loyalka Pranav, Frazier O H, Jeevanandam Valluvan, Anderson Allen S, Kormos Robert L, Teuteberg Jeffrey J, Levy Wayne Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation. 2012 Jun 26. 125(25): 3191-200. PMID# 22619284

Cell & Developmental Biology

Emmett Lisa S D, O'Shea K Sue. Geminin is required for epithelial to mesenchymal transition at gastrulation. Stem cells and development. 2012 Sep 1. 21(13): 2395-409. PMID# 22335560

Zhang Weibin, Miley Natasha, Zastrow Michael S, Macqueen Amy J, Sato Aya, Nabeshima Kentaro, Martinez-Perez Enrique, Mlynarczyk-Evans Susanna, Carlton Peter M, Villeneuve Anne M. HAL-2 Promotes Homologous Pairing during Caenorhabditis elegans Meiosis by Antagonizing Inhibitory Effects of Synaptonemal Complex Precursors. PLoS genetics. 2012 Aug. 8(8): e1002880. PMID# 22912597

Center for Computational Medicine and Bioinformatics

Huang Steven K, Scruggs Anne M, Donaghy Jake, McEachin Richard C, Fisher Aaron S, Richardson Bruce C, Peters-Golden Marc. Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Sep. 26(9): 3703-14. PMID# 22645246

Emergency Medicine

Thornton Margaret M, Chung-Esaki Hangyul M, Irvin Charlene B, Bortz David M, Solomon Michael J, Younger John G. Multicellularity and antibiotic resistance in Klebsiella pneumoniae grown under bloodstream-mimicking fluid dynamic conditions. The Journal of infectious diseases. 2012 Aug 15. 206(4): 588-95. PMID# 22711903

Family Medicine

Reed Barbara D, Harlow Siobán D, Sen Ananda, Edwards Rayna M, Chen Di, Haefner Hope K. Relationship between vulvodynia and chronic comorbid pain conditions. Obstetrics and gynecology. 2012 Jul. 120(1): 145-51. PMID# 22914403

Human Genetics

Krebs Christopher J, Schultz David C, Robins Diane M. The KRAB Zinc Finger Protein RSL1 Regulates Sex- and Tissue-Specific Promoter Methylation and Dynamic Hormone-Responsive Chromatin Configuration. Molecular and cellular biology. 2012 Sep. 32(18): 3732-42. PMID# 22801370

Internal Medicine – Cardiovascular Medicine

Bates Eric R, Menees Daniel S. Acute ST-elevation myocardial infarction. Current opinion in critical care. 2012 Oct. 18(5): 417-23. PMID# 22889871

Vodnala Deepthi, Rubenfire Melvyn, Brook Robert D. Secondary causes of dyslipidemia. The American journal of cardiology. 2012 Sep 15. 110(6): 823-5. PMID# 22658245

Berenfeld Omer, Oral Hakan. The quest for rotors in atrial fibrillation: Different nets catch different fishes. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Sep. 9(9): 1440-1. PMID# 22521928

Yokokawa Miki, Kim Hyungjin Myra, Good Eric, Crawford Thomas, Chugh Aman, Pelosi Frank, Jongnarangsin Krit, Latchamsetty Rakesh, Armstrong William, Alguire Craig, Oral Hakan, Morady Fred, Bogun Frank. Impact of QRS duration of frequent premature ventricular complexes on the development of cardiomyopathy. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Sep. 9(9): 1460-4. PMID# 22542704

Yokokawa Miki, Sundaram Baskaran, Oral Hakan, Morady Fred, Chugh Aman. The course of the sinus node artery and its impact on achieving linear block at the left atrial roof in patients with persistent atrial fibrillation. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Sep. 9(9): 1395-402. PMID# 22516185

Lehmann Michael H, Ilg Karl J. The reply. The American journal of medicine. 2012 Sep. 125(9): e13. PMID# 22938931

Avula Uma Mahesh R, Kim Gwangseong, Lee Yong-Eun Koo, Morady Fred, Kopelman Raoul, Kalifa Jérôme. Cell-specific nanoplatform-enabled photodynamic therapy for cardiac cells. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Sep. 9(9): 1504-9. PMID# 22579922

Thacker Seth G, Zhao Wenpu, Smith Carolyne K, Luo Wei, Wang Hui, Vivekanandan-Giri Anuradha, Rabquer Bradley J, Koch Alisa E, Pennathur Subramaniam, Davidson Anne, Eitzman Daniel T, Kaplan Mariana J. Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis and rheumatism. 2012 Sep. 64(9): 2975-85. PMID# 22549550

Alaali Yathreb, Barnes Geoffrey D, Froehlich James B, Kaatz Scott. Management of oral anticoagulation in patients undergoing minor dental procedures. The Journal of the Michigan Dental Association. 2012 Aug. 94(8): 36-41. PMID# 22924225

Aaronson Keith D, Slaughter Mark S, Miller Leslie W, McGee Edwin C, Cotts William G, Acker Michael A, Jessup Mariell L, Gregoric Igor D, Loyalka Pranav, Frazier O H, Jeevanandam Valluvan, Anderson Allen S, Kormos Robert L, Teuteberg Jeffrey J, Levy Wayne Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation. 2012 Jun 26. 125(25): 3191-200. PMID# 22619284

Chan Paul S, Spertus John A, Krumholz Harlan M, Berg Robert A, Li Yan, Sasson Comilla, Nallamothu Brahmajee K. A validated prediction tool for initial survivors of in-hospital cardiac arrest. Archives of internal medicine. 2012 Jun 25. 172(12): 947-53. PMID# 22641228

Internal Medicine – Gastroenterology

El-Zaatari Mohamad, Daignault Stephanie, Tessier Art, Kelsey Gail, Travnikar Lisa A, Cantu Esperanza F, Lee Jamie, Plonka Caitlyn M, Simeone Diane M, Anderson Michelle A, Merchant Juanita L. Plasma shh levels reduced in pancreatic cancer patients. Pancreas. 2012 Oct. 41(7): 1019-28. PMID# 22513293

Fontana Robert J, Hughes Eric A, Appelman Henry, Hindes Robert, Dimitrova Dessislava, Bifano Marc. Case report of successful peginterferon, ribavirin, and daclatasvir therapy for recurrent cholestatic hepatitis C after liver retransplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2012 Sep. 18(9): 1053-9. PMID# 22706796

Internal Medicine – General Medicine

Griggs Jennifer J, Hawley Sarah T, Graff John J, Hamilton Ann S, Jagsi Reshma, Janz Nancy K, Mujahid Mahasin S, Friese Christopher R, Salem Barbara, Abrahamse Paul H, Katz Steven J. Factors associated with receipt of breast cancer adjuvant chemotherapy in a diverse population-based sample. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Sep 1. 30(25): 3058-64. PMID# 22869890

Kerr Eve A, Lucatorto Michelle A, Holleman Rob, Hogan Mary M, Klamerus Mandi L, Hofer Timothy P. Monitoring performance for blood pressure management among patients with diabetes mellitus: too much of a good thing? Archives of internal medicine. 2012 Jun 25. 172(12): 938-45. PMID# 22641246

Internal Medicine – Hematology and Oncology

Ateeq Bushra, Vellaichamy Adaikkalam, Tomlins Scott A, Wang Rui, Cao Qi, Lonigro Robert J, Pienta Kenneth J, Varambally Sooryanarayana. Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models. The Prostate. 2012 Oct 1. 72(14): 1542-9. PMID# 22415461

Griggs Jennifer J, Hawley Sarah T, Graff John J, Hamilton Ann S, Jagsi Reshma, Janz Nancy K, Mujahid Mahasin S, Friese Christopher R, Salem Barbara, Abrahamse Paul H, Katz Steven J. Factors associated with receipt of breast cancer adjuvant chemotherapy in a diverse population-based sample. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Sep 1. 30(25): 3058-64. PMID# 22869890

Friese Christopher R, Himes-Ferris Laurel, Frasier Megan N, McCullagh Marjorie C, Griggs Jennifer J. Structures and processes of care in ambulatory oncology settings and nurse-reported exposure to chemotherapy. BMJ quality&safety. 2012 Sep. 21(9): 753-9. PMID# 21846769

Korkaya Hasan, Kim Gwang-Il, Davis April, Malik Fayaz, Henry N Lynn, Ithimakin Suthinee, Quraishi Ahmed A, Tawakkol Nader, D'Angelo Rosemarie, Paulson Amanda K, Chung Susan, Luther Tahra, Paholak Hayley J, Liu Suling, Hassan Khaled A, Zen Qin, Clouthier S Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Molecular cell. 2012 Aug 24. 47(4): 570-84. PMID# 22819326

Internal Medicine – Molecular Medicine & Genetics

Cohen Stephanie A, Gustafson Shanna L, Marvin Monica L, Riley Bronson D, Uhlmann Wendy R, Liebers S Bonnie, Rousseau Julie A. Report from the national society of genetic counselors service delivery model task force: a proposal to define models, components, and modes of referral. Journal of genetic counseling. 2012 Oct. 21(5): 645-51. PMID# 22566244

Internal Medicine – Nephrology

Thacker Seth G, Zhao Wenpu, Smith Carolyne K, Luo Wei, Wang Hui, Vivekanandan-Giri Anuradha, Rabquer Bradley J, Koch Alisa E, Pennathur Subramaniam, Davidson Anne, Eitzman Daniel T, Kaplan Mariana J. Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis and rheumatism. 2012 Sep. 64(9): 2975-85. PMID# 22549550

Robinson Bruce M, Tong Lin, Zhang Jinyao, Wolfe Robert A, Goodkin David A, Greenwood Roger N, Kerr Peter G, Morgenstern Hal, Li Yun, Pisoni Ronald L, Saran Rajiv, Tentori Francesca, Akizawa Tadao, Fukuhara Shunichi, Port Friedrich K. Blood pressure levels and mortality risk among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney international. 2012 Sep. 82(5): 570-80. PMID# 22718187

Internal Medicine – Pulmonary and Critical Care

Badri Linda, Lama Vibha N. Lysophosphatidic Acid Induces Migration of Human Lung-Resident Mesenchymal Stem Cells Through the ß-Catenin Pathway. Stem cells (Dayton, Ohio). 2012 Sep. 30(9): 2010-9. PMID# 22782863

Huang Steven K, Scruggs Anne M, Donaghy Jake, McEachin Richard C, Fisher Aaron S, Richardson Bruce C, Peters-Golden Marc. Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Sep. 26(9): 3703-14. PMID# 22645246

Internal Medicine – Rheumatology

Chung Kevin C, Burns Patricia B, Kim H Myra, Burke Frank D, Wilgis E F Shaw, Fox David A. Long-term followup for rheumatoid arthritis patients in a multicenter outcomes study of silicone metacarpophalangeal joint arthroplasty. Arthritis care&research. 2012 Sep. 64(9): 1292-300. PMID# 22511483

Thacker Seth G, Zhao Wenpu, Smith Carolyne K, Luo Wei, Wang Hui, Vivekanandan-Giri Anuradha, Rabquer Bradley J, Koch Alisa E, Pennathur Subramaniam, Davidson Anne, Eitzman Daniel T, Kaplan Mariana J. Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis and rheumatism. 2012 Sep. 64(9): 2975-85. PMID# 22549550

Gorelik Gabriela J, Yarlagadda Sushma, Richardson Bruce C. Protein kinase C¿ oxidation contributes to ERK inactivation in lupus T cells. Arthritis and rheumatism. 2012 Sep. 64(9): 2964-74. PMID# 22549474

Microbiology and Immunology

Spehalski Elizabeth, Kovalchuk Alexander L, Collins John T, Liang Genqing, Dubois Wendy, Morse Herbert C, Ferguson David O, Casellas Rafael, Dunnick Wesley A. Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus. Proceedings of the National Academy of Sciences of the United States of America. 2012 Aug 21. 109(34): 13728-32. PMID# 22869734

Marcoe Jeffrey P, Lim James R, Schaubert Keri L, Fodil-Cornu Nassima, Matka Marsel, McCubbrey Alexandra L, Farr Alexander R, Vidal Silvia M, Laouar Yasmina. TGF-ß is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nature immunology. 2012 Aug 12. 13(9): 843-50. PMID# 22863752

Molecular & Integrative Physiology

Billecke Scott S, D'Alecy Louis G, Marcovitz Pamela A. Potential treatment influences and mechanisms related to asymmetric dimethylarginine control in heart failure. Journal of the American College of Cardiology. 2012 Sep 4. 60(10): 948-9. PMID# 22935469

Yu Yue, Sun Ying, He Shengqi, Yan Cheng, Rui Liangyou, Li Wenjun, Liu Yong. Neuronal Cbl Controls Biosynthesis of Insulin-Like Peptides in Drosophila melanogaster. Molecular and cellular biology. 2012 Sep. 32(18): 3610-23. PMID# 22778134

Neurosurgery

Wang Lin, Park Paul, Zhang Huina, La Marca Frank, Claeson Amy, Than Khoi, Rahman Shayan, Lin Chia-Ying. BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. International journal of cancer. Journal international du cancer. 2012 Oct 15. 131(8): 1941-50. PMID# 22275155

Wang Jinhu, Jin Hang, Hua Ya, Keep Richard F, Xi Guohua. Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia. Stroke; a journal of cerebral circulation. 2012 Sep. 43(9): 2476-82. PMID# 22811450

Sagher Oren. Editorial: Decompressive craniectomy. Journal of neurosurgery. 2012 Sep. 117(3): 587-8. PMID# 22794323

Khan Adam, Chaudhary Neeraj, Pandey Aditya S, Gemmete Joseph J. Direct puncture of the highest cervical segment of the internal carotid artery for treatment of an iatrogenic carotid cavernous fistula in a patient with Ehlers-Danlos syndrome. Journal of neurointerventional surgery. 2012 Sep 1. 4(5): e29. PMID# 22131435

Weaver Frances M, Follett Kenneth A, Stern Matthew, Luo Ping, Harris Crystal L, Hur Kwan, Marks William J, Rothlind Johannes, Sagher Oren, Moy Claudia, Pahwa Rajesh, Burchiel Kim, Hogarth Penelope, Lai Eugene C, Duda John E, Holloway Kathryn, Samii Ali, H Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology. 2012 Jul 3. 79(1): 55-65. PMID# 22722632

Obstetrics & Gynecology

Smorgick Noam, Delancey John, Patzkowsky Kristin, Advincula Arnold, Song Arleen, As-Sanie Sawsan. Risk factors for postoperative urinary retention after laparoscopic and robotic hysterectomy for benign indications. Obstetrics and gynecology. 2012 Sep. 120(3): 581-6. PMID# 22914467

Reed Barbara D, Harlow Siobán D, Sen Ananda, Edwards Rayna M, Chen Di, Haefner Hope K. Relationship between vulvodynia and chronic comorbid pain conditions. Obstetrics and gynecology. 2012 Jul. 120(1): 145-51. PMID# 22914403

Ophthalmology & Visual Sciences

Titchenell Paul M, Lin Cheng-Mao, Keil Jason M, Sundstrom Jeffrey M, Smith Charles D, Antonetti David A. Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction. The Biochemical journal. 2012 Sep 15. 446(3): 455-67. PMID# 22721706

Lott Mary E J, Slocomb Julia E, Shivkumar Vikram, Smith Bruce, Gabbay Robert A, Quillen David, Gardner Thomas W, Bettermann Kerstin. Comparison of retinal vasodilator and constrictor responses in type 2 diabetes. Acta ophthalmologica. 2012 Sep. 90(6): e434-41. PMID# 22682034

Orthopaedic Surgery

Magerkurth Olaf, Jacobson Jon A, Girish Gandikota, Brigido Monica Kalume, Bedi Asheesh, Fessell David. Paralabral cysts in the hip joint: findings at MR arthrography. Skeletal radiology. 2012 Oct. 41(10): 1279-85. PMID# 22434590

Calve Sarah, Isaac Jahdonna, Gumucio Jonathan P, Mendias Christopher L. Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy. American journal of physiology. Cell physiology. 2012 Sep. 303(5): C577-88. PMID# 22785117

Murphy Joshua M, Vanderhave Kelly L, Urquhart Andrew G. Total hip arthroplasty in adolescents with severe hip arthropathy and dysplasia associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome. The Journal of arthroplasty. 2012 Sep. 27(8): 1581.e5-8. PMID# 22386609

Jacobson Jon A, Bedi Asheesh, Sekiya Jon K, Blankenbaker Donna G. Evaluation of the painful athletic hip: imaging options and imaging-guided injections. AJR. American journal of roentgenology. 2012 Sep. 199(3): 516-24. PMID# 22915391

Otolaryngology

Lin Giant C, Basura Gregory J, Wong Hiu Tung, Heidenreich Katherine D. Canal switch after canalith repositioning procedure for benign paroxysmal positional vertigo. The Laryngoscope. 2012 Sep. 122(9): 2076-8. PMID# 22549695

Colacino Justin A, Arthur Anna E, Dolinoy Dana C, Sartor Maureen A, Duffy Sonia A, Chepeha Douglas B, Bradford Carol R, Walline Heather M, McHugh Jonathan B, D'Silva Nisha, Carey Thomas E, Wolf Gregory T, Taylor Jeremy M G, Peterson Karen E, Rozek Laura S Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas. Epigenetics : official journal of the DNA Methylation Society. 2012 Aug 1. 7(8): 883-91. PMID# 22722388

Pathology

Ateeq Bushra, Vellaichamy Adaikkalam, Tomlins Scott A, Wang Rui, Cao Qi, Lonigro Robert J, Pienta Kenneth J, Varambally Sooryanarayana. Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models. The Prostate. 2012 Oct 1. 72(14): 1542-9. PMID# 22415461

Kiel Mark J, Velusamy Thirunavukkarasu, Betz Bryan L, Zhao Lili, Weigelin Helmut G, Chiang Mark Y, Huebner-Chan David R, Bailey Nathanael G, Yang David T, Bhagat Govind, Miranda Roberto N, Bahler David W, Medeiros L Jeffrey, Lim Megan S, Elenitoba-Johnson Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. The Journal of experimental medicine. 2012 Aug 27. 209(9): 1553-65. PMID# 22891276

Spehalski Elizabeth, Kovalchuk Alexander L, Collins John T, Liang Genqing, Dubois Wendy, Morse Herbert C, Ferguson David O, Casellas Rafael, Dunnick Wesley A. Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus. Proceedings of the National Academy of Sciences of the United States of America. 2012 Aug 21. 109(34): 13728-32. PMID# 22869734

Colacino Justin A, Arthur Anna E, Dolinoy Dana C, Sartor Maureen A, Duffy Sonia A, Chepeha Douglas B, Bradford Carol R, Walline Heather M, McHugh Jonathan B, D'Silva Nisha, Carey Thomas E, Wolf Gregory T, Taylor Jeremy M G, Peterson Karen E, Rozek Laura S Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas. Epigenetics : official journal of the DNA Methylation Society. 2012 Aug 1. 7(8): 883-91. PMID# 22722388

Pediatrics & Communicable Diseases

Peirano Patricio, Algarin Cecilia, Chamorro Rodrigo, Manconi Mauro, Lozoff Betsy, Ferri Raffaele. Iron deficiency anemia in infancy exerts long-term effects on the tibialis anterior motor activity during sleep in childhood. Sleep medicine. 2012 Sep. 13(8): 1006-12. PMID# 22770698

Desai Ankita Patel, Stanley Theresa, Atuan Maria, McKey Jonelle, Lipuma John J, Rogers Beverly, Jerris Robert. Use of matrix assisted laser desorption ionisation-time of flight mass spectrometry in a paediatric clinical laboratory for identification of bacteria commonly isolated from cystic fibrosis patients. Journal of clinical pathology. 2012 Sep. 65(9): 835-8. PMID# 22639406

Sarkar Subrata, Donn Steven M, Bapuraj Jayapalli R, Bhagat Indira, Barks John D. Distribution and severity of hypoxic-ischaemic lesions on brain MRI following therapeutic cooling: selective head versus whole body cooling. Archives of disease in childhood. Fetal and neonatal edition. 2012 Sep. 97(5): F335-9. PMID# 22933091

Popova Antonia P, Bentley J Kelley, Anyanwu Anuli C, Richardson Michelle N, Linn Marisa J, Lei Jing, Wong Elizabeth J, Goldsmith Adam M, Pryhuber Gloria S, Hershenson Marc B. Glycogen synthase kinase-3ß/ß-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation. American journal of physiology. Lung cellular and molecular physiology. 2012 Sep. 303(5): L439-48. PMID# 22773696

Gilbert Gary E, Novakovic Valerie A, Kaufman Randal J, Miao Hongzhi, Pipe Steven W. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood. 2012 Aug 30. 120(9): 1923-32. PMID# 22613792

Psychiatry

Hanna Gregory L, Carrasco Melisa, Harbin Shannon M, Nienhuis Jenna K, Larosa Christina E, Chen Poyu, Fitzgerald Kate D, Gehring William J. Error-related negativity and tic history in pediatric obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2012 Sep. 51(9): 902-10. PMID# 22917203

Zivin Kara, Campbell Duncan G, Lanto Andrew B, Chaney Edmund F, Bolkan Cory, Bonner Laura M, Miller Erin M, Valenstein Marcia, Waltz Thomas J, Rubenstein Lisa V. Relationships between mood and employment over time among depressed VA primary care patients. General hospital psychiatry. 2012 Sep. 34(5): 468-77. PMID# 22771108

Radiation Oncology

Stenmark Matthew H, Cai Xu-Wei, Shedden Kerby, Hayman James A, Yuan Shuanghu, Ritter Timothy, Ten Haken Randall K, Lawrence Theodore S, Kong Feng-Ming Spring. Combining physical and biologic parameters to predict radiation-induced lung toxicity in patients with non-small-cell lung cancer treated with definitive radiation therapy. International journal of radiation oncology, biology, physics. 2012 Oct 1. 84(2): e217-22. PMID# 22935395

Kong Feng Ming Spring, Ritter Timothy, Quint Douglas, Marsh Lon, Senan Suresh, Gaspar Laurie, Komaki Ritsuko, Hurkmans Coen, Timmerman Robert, Choy Hak, Bezjak Andrea, Bradley Jeffrey, Mosvas Benjamin, Okunieff Paul, Curran Walter. In reply to zagar and marks. International journal of radiation oncology, biology, physics. 2012 Oct 1. 84(2): 305-6. PMID# 22935391

Feng Mary, Demiroz Candan, Vineberg Karen A, Eisbruch Avraham, Balter James M. Normal tissue anatomy for oropharyngeal cancer: contouring variability and its impact on optimization. International journal of radiation oncology, biology, physics. 2012 Oct 1. 84(2): e245-9. PMID# 22583602

Jagsi Reshma, Bekelman Justin E, Brawley Otis W, Deasy Joseph O, Le Quynh-Thu, Michalski Jeff M, Movsas Benjamin, Thomas Charles R, Lawton Colleen A, Lawrence Theodore S, Hahn Stephen M. A Research Agenda for Radiation Oncology: Results of the Radiation Oncology Institute's Comprehensive Research Needs Assessment. International journal of radiation oncology, biology, physics. 2012 Oct 1. 84(2): 318-22. PMID# 22436790

Griggs Jennifer J, Hawley Sarah T, Graff John J, Hamilton Ann S, Jagsi Reshma, Janz Nancy K, Mujahid Mahasin S, Friese Christopher R, Salem Barbara, Abrahamse Paul H, Katz Steven J. Factors associated with receipt of breast cancer adjuvant chemotherapy in a diverse population-based sample. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 Sep 1. 30(25): 3058-64. PMID# 22869890

Kapadia Nirav S, Mamet Rizvan, Zornosa Carrie, Niland Joyce C, D'Amico Thomas A, Hayman James A. Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer. Cancer. 2012 Sep 1. 118(17): 4339-45. PMID# 22252390

Sun Gordon H, Steinberg Jeffrey D, Jagsi Reshma. The calculus of national medical research policy--the United States versus Asia. The New England journal of medicine. 2012 Aug 23. 367(8): 687-90. PMID# 22913678

Huang Jie, Cao Yue. Functional MRI as a biomarker for evaluation and prediction of effectiveness of migraine prophylaxis. Biomarkers in medicine. 2012 Aug. 6(4): 517-27. PMID# 22917153

Radiology

Magerkurth Olaf, Jacobson Jon A, Girish Gandikota, Brigido Monica Kalume, Bedi Asheesh, Fessell David. Paralabral cysts in the hip joint: findings at MR arthrography. Skeletal radiology. 2012 Oct. 41(10): 1279-85. PMID# 22434590

Trout Andrew T, Dillman Jonathan R, Neef Haley C, Rabah Raja, Gadepalli Samir, Geiger James D. Case 189. Radiology. 2012 Sep. 264(3): 910-1. PMID# 22919042

Khan Adam, Chaudhary Neeraj, Pandey Aditya S, Gemmete Joseph J. Direct puncture of the highest cervical segment of the internal carotid artery for treatment of an iatrogenic carotid cavernous fistula in a patient with Ehlers-Danlos syndrome. Journal of neurointerventional surgery. 2012 Sep 1. 4(5): e29. PMID# 22131435

Jacobson Jon A, Bedi Asheesh, Sekiya Jon K, Blankenbaker Donna G. Evaluation of the painful athletic hip: imaging options and imaging-guided injections. AJR. American journal of roentgenology. 2012 Sep. 199(3): 516-24. PMID# 22915391

Styn Nicholas R, Hall Timothy L, Fowlkes J Brian, Cain Charles A, Roberts William W. Histotripsy of Renal Implanted VX-2 Tumor in a Rabbit Model: Investigation of Metastases. Urology. 2012 Sep. 80(3): 724-9. PMID# 22925247

Yokokawa Miki, Sundaram Baskaran, Oral Hakan, Morady Fred, Chugh Aman. The course of the sinus node artery and its impact on achieving linear block at the left atrial roof in patients with persistent atrial fibrillation. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Sep. 9(9): 1395-402. PMID# 22516185

Surgery – General Surgery

El-Zaatari Mohamad, Daignault Stephanie, Tessier Art, Kelsey Gail, Travnikar Lisa A, Cantu Esperanza F, Lee Jamie, Plonka Caitlyn M, Simeone Diane M, Anderson Michelle A, Merchant Juanita L. Plasma shh levels reduced in pancreatic cancer patients. Pancreas. 2012 Oct. 41(7): 1019-28. PMID# 22513293

Xia Ze-Feng, Fritze Danielle M, Li Ji-Yao, Chai Biaoxin, Zhang Chao, Zhang Weizhen, Mulholland Michael W. Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats. American journal of physiology. Gastrointestinal and liver physiology. 2012 Sep. 303(5): G570-7. PMID# 22723266

Varni James W, Thissen David, Stucky Brian D, Liu Yang, Gorder Hally, Irwin Debra E, Dewitt Esi Morgan, Lai Jin-Shei, Amtmann Dagmar, Dewalt Darren A. PROMIS(®) Parent Proxy Report Scales: an item response theory analysis of the parent proxy report item banks. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2012 Sep. 21(7): 1223-40. PMID# 21971875

Frankel Heidi L, Butler Karyn L, Cuschieri Joseph, Friese Randall S, Huynh Toan, Mohr Alicia M, Schinco Miren A, Napolitano Lena M, Britt L D, Coimbra Raul, Croce Martin A, Davis James W, Jurkovich Gregory J, Moore Ernest E, Morris John A, Peitzman Andrew The role and value of surgical critical care, an essential component of Acute Care Surgery, in the Affordable Care Act: a report from the Critical Care Committee and Board of Managers of the American Association for the Surgery of Trauma. The journal of trauma and acute care surgery. 2012 Jul. 73(1): 20-6. PMID# 22743368

Surgery – Plastic Surgery

Sebastin Sandeep J, Larson Bradley P, Chung Kevin C. History and evolution of the sauvé-kapandji procedure. The Journal of hand surgery. 2012 Sep. 37(9): 1895-902. PMID# 22763060

Chung Kevin C, Burns Patricia B, Kim H Myra, Burke Frank D, Wilgis E F Shaw, Fox David A. Long-term followup for rheumatoid arthritis patients in a multicenter outcomes study of silicone metacarpophalangeal joint arthroplasty. Arthritis care&research. 2012 Sep. 64(9): 1292-300. PMID# 22511483

Cederna Paul S. Discussion: A Comparison of Collateral Sprouting of Sensory and Motor Axons after End-to-Side Neurorrhaphy with and without the Perineurial Window. Plastic and reconstructive surgery. 2012 Sep. 130(3): 615-7. PMID# 22929247

Surgery – Thoracic Surgery

Sood Vikram, Reddy Rishindra M. An analysis of preclinical students' perceptions of cardiothoracic surgical procedures. The Annals of thoracic surgery. 2012 Sep. 94(3): 800-6. PMID# 22742844

Perez-Cruet Mick J, Welsh Robert J, Hussain Namath S, Begun Evan M, Lin Jules, Park Paul. Use of the da vinci minimally invasive robotic system for resection of a complicated paraspinal schwannoma with thoracic extension: case report. Neurosurgery. 2012 Sep. 71(1 Suppl Operative): onsE209-eE214. PMID# 22653397

Surgery – Vascular Surgery

Spratt Deborah, Cowles Charles E, Berguer Ramon, Dennis Vangie, Waters Thomas R, Rodriguez Margaret, Spry Cynthia, Groah Linda. Workplace safety equals patient safety. AORN journal. 2012 Sep. 96(3): 235-44. PMID# 22935253

Urology

Tan Hung-Jui, Hollingsworth John M. Reply by the authors. Urology. 2012 Sep. 80(3): 743. PMID# 22925255

Schroeck Florian R, Hollingsworth John M, Kaufman Samuel R, Hollenbeck Brent K, Wei John T. Introduction of laser technology and procedure use for benign prostatic hyperplasia: data from Florida. Urology. 2012 Sep. 80(3): 678-83. PMID# 22840735

Schade George R, Hall Timothy L, Roberts William W. Urethral-sparing Histotripsy of the Prostate in a Canine Model. Urology. 2012 Sep. 80(3): 730-5. PMID# 22840869

Styn Nicholas R, Hall Timothy L, Fowlkes J Brian, Cain Charles A, Roberts William W. Histotripsy of Renal Implanted VX-2 Tumor in a Rabbit Model: Investigation of Metastases. Urology. 2012 Sep. 80(3): 724-9. PMID# 22925247

Strope Seth A, Wei John T, Smith Alexandria, Wilt Timothy J, Saigal Christopher S, Elliott Sean P. Evaluative care guideline compliance is associated with provision of benign prostatic hyperplasia surgery. Urology. 2012 Jul. 80(1): 84-9. PMID# 22608799