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JULY 2012, Vol. 30

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HEADLINES

New and Expanded Bridging Opportunities

Dear Colleagues,

Earlier this year, the Dean commissioned a faculty panel to review internal investments in research to ensure that creative and productive faculty members can maintain and expand their research programs. I chaired the effort and want to thank the committee members for their thoughtful suggestions, one of which is the FAST TRACK Bridging program for UMMS faculty. As part of the Medical School’s Strategic Research Initiative, “FASTFORWARD to Tomorrow’s Cures,” this bridging expansion will allow us to continue to support our faculty in this difficult funding environment.

FAST TRACK funding provides support to prepare A1 submissions of biomedical research projects that demonstrate a likelihood of successfully competing for NIH R series funding. To be eligible for funding, the A0 impact score must be within 10 percentile points of the NIH Institute payline, and a resubmission must be planned. Upon receiving a complete application (verifying financial need), the Office of Research will award up to $4,166/month (annual $50,000) to be matched 1:1 by the PI’s department. This award decision will be expedited since it does not require an internal scientific review.

View details of the FAST TRACK Bridging Program


Concurrent BMRC Bridging changes:

The Biomedical Research Council (BMRC) has increased the award amount to up to $50,000 (matched 1:1 by PI’s department). In addition, the categories of grants eligible for bridge funding have expanded to include: (a) new grants after first review, and (b) R01s that were spawned from a failed Center or Program Project grant, e.g., P30. In all cases, NIH summary sheets and plans to respond are required, and the work must reflect a continuation of the PI’s federally-funded research trajectory.

View details of the BMRC Bridging Program


Sincerely,
Steven L. Kunkel, Ph.D.
Senior Associate Dean for Research
Endowed Professor in Pathology Research

Medical School’s Participation in MCubed

The Medical School is excited to announce its participation in the MCubed program, the University of Michigan’s first-of-its-kind, real-time research funding initiative. MCubed puts $15 million into the hands of investigators to jumpstart new projects they believe in by immediately receiving $60,000 to hire a postdoc, graduate student, or undergraduate student.

Additional information regarding the MCubed program is described below:

  • Who in the Medical School is eligible to receive a token and participate?
    • Tenure and tenure-track faculty members
    • Research professors and associate/assistant research professors
    • Clinical professors and associate/assistant professors with a 50% or greater appointment
  • Once three investigators establish a “cube” to form a new research project, their three tokens ($20,000 each) are redeemed for $60,000 to immediately hire a postdoc, graduate student, or undergraduate student.
  • Up to 15% of the cube’s funding ($9,000) can be used to cover expenses such as laboratory supplies, core services, equipment, and travel necessary for research (i.e., to research sites). Funding cannot be used to cover faculty salaries or travel to conferences.
  • The three researchers who make up a cube must be from at least two different units (schools/colleges or LSA divisions).  Multiple cubes can be created in order to hire more than one person.
  • The three investigators who form a cube must have a new idea for a project, i.e., cannot be working on a project together that already has external funding.
  • To make up the value of the $20,000 token, investigators must contribute a cost-share from their discretionary funds to the funding contributed by the Medical School and the Provost’s office.
    • To hire a postdoc or undergraduate with your token as part of your cube, Medical School investigators will have to cost-share $7,800 from their discretionary funds as part of their contribution to the $20,000 token.
    • To hire a graduate student with your token as part of your cube, Medical School investigators will have to cost-share $7,800 or less (minus a contribution from Rackham, exact amount is forthcoming).
    • Different schools require different levels of cost-share from the investigators.

Hundreds of faculty members are eligible to participate in MCubed, with the Medical School currently planning to fund 200 tokens. To be included in the list of eligible Medical School participants potentially available to form a cube, CLICK HERE to complete and submit a brief profile by 4:00 PM on Friday, July 27.

Further questions about this exciting new program should be directed to ummsresearch@umich.edu.

William L. Smith to Receive the 2012 Distinguished Faculty Lectureship Award in Biomedical Research
William L. Smith, Ph.D.William L. Smith, Ph.D.

The Biomedical Research Council (BMRC) has the honor of selecting a Medical School faculty member for the annual Distinguished Faculty Lectureship Award in Biomedical Research. They are pleased to announce this year’s winner is William L. Smith, Ph.D., Minor J. Coon Collegiate Professor of Biological Chemistry, and Professor and Chair of the Department of Biological Chemistry. This award, initiated in 1979, continues to be the highest honor bestowed by the Medical School upon a faculty member for research in the biomedical sciences. Dr. Smith is being recognized for his numerous research accomplishments, his valuable leadership to science and the university, and his extensive contributions in mentoring and training along with the hiring and development of junior faculty in the Department of Biological Chemistry.

Dr. Smith is highly respected in the national and international biochemical and pharmacological communities for his consistently leading research contributions. His laboratory covers research on nutritionally essential fatty acids, prostaglandins, cyclooxygenases in thrombosis and colon cancer, and cyclooxygenase biochemistry including modulation by aspirin, ibuprofen, coxibs and fish oil. Dr. Smith is known for our understanding of the chemical processes underlying the biosynthesis and functions of prostaglandins. He purified, sequenced and cloned a cyclooxygenase enzyme (COX-1). This enzyme converts specific dietary long-chain fatty acids to prostaglandins, multifunctional hormone-like regional chemical messengers that mediate a number of bodily functions, including inflammation, blood clotting, and smooth muscle actions. Dr. Smith demonstrated that aspirin blocks the enzyme and identified the precise molecular site that aspirin acetylates, and thereby blocks the action of the enzyme. This prompted much effort and success in pharmaceutical development for new non-steroidal anti-inflammatory drugs with longer action than aspirin and fewer side affects. Other work continues on prostaglandin functions related to increased consumption of fish oil that may be useful in preventing colon cancer. The laboratory is collaborating with clinical investigators in the UM Cancer Center in addressing this topic. Additional studies cover defining how COX-1 and COX-2 function including how catalysis is modulated by interactions with NSAIDs, COX-2 inhibitors such as Celebrex and fish oil fatty acids. More recent discoveries about COXs are also important clinically because they suggest that aspirin will not provide cardiovascular protection to patients taking COX-2 inhibitors like Celebrex.

Dr. Smith will receive this award and present a lecture later this year. The details for Dr. Smith’s lecture, award presentation, and reception will be announced in a future issue of this newsletter.

Save the Date for Researchpalooza! August 22
Researchpalooza

Wednesday, August 22, 2012
11:00 AM - 2:00 PM
Location TBD

Join the UMMS Office of Research for the third annual Researchpalooza during the annual Ice Cream Social, with 50+ exhibitors from labs and offices of the Medical School and across campus. Researchpalooza is the perfect opportunity for colleagues and friends to have a great time and meet, mingle, and learn more about many of the organizations that offer their stellar services to faculty, students, and staff, all at one convenient time and location.

Visit the website for more details.

If your office is interested in exhibiting, view more information here.

Report Your Outside Interests, Activities, or Relationships Before July 31, 2012

---------------  Changes Going into Effect! ---------------

UMHS Policy requires faculty members, house officers/fellows, executives, and management staff to disclose outside interests, activities, or relationships related to their work or position at UMHS. Your outside interest disclosures must be updated within 30 days of any change, and at least annually if there have been no changes.


You can access the outside interest disclosure system, M-Inform, at
http://www.umms.med.umich.edu/minform/



Note that new Federal rules regarding disclosure and management of conflicts of interest related to PHS-funded research go into effect in August 2012.  With only a few changes, M-Inform, which has been used by UMHS for years, is well positioned to accommodate these new rules.  Watch for more information in the coming weeks, but in the meantime, key changes that you will notice include:

  • You will be required to report information regarding the past year (in addition to the upcoming year).
  • Throughout the year, any addition or other change must be entered within 30 days.
  • Disclosure must include information about any travel paid for or reimbursed by the outside organization.
  • Failure to complete disclosure or manage conflicts by deadlines could result in delay of Federal grant submission/award.

Definitions that may be helpful to keep in mind as you prepare to make your disclosure include:

  • Outside organization means an organization other than the University of Michigan or a Federal agency.  An outside organization can be domestic or foreign, public or private, for-profit or non-profit.
  • Outside interest, activity, or relationship means any paid or unpaid interest, activity, or relationship with an outside organization.
  • Related to your institutional responsibilities means any interest, activity, or relationship that relies upon the same expertise as does your ability to carry out your University responsibilities; as well as any interest, activity, or relationship that has the potential to influence the duties that the University considers to be part of your work.  In this regard, “institutional responsibilities” means a person’s professional responsibilities on behalf of the University, such as research, teaching, professional practice, and institutional committee membership.

Examples of interests, activities, or relationships that should not be reported include salary and/or other support administered by ORSP (such as a grant from NIH or a research contract from Pfizer), and service as an NIH reviewer.

For more information on the outside interest disclosure process or the M-Inform system, visit http://www.med.umich.edu/u/coi/.

For general questions, send an email to coi-oid-questions@med.umich.edu.

View information about:

Other UM policies regarding conflict of interest are available at:

MICHR Awards 15 Pilot Grants for Health Research Studies

The Michigan Institute for Clinical & Health Research (MICHR) recently awarded more than $671,573 in pilot grants for health research studies at the University of Michigan. Matching funds from the Medical School along with partnering U-M departments, schools, centers, and institutes have made it possible to fund the best 15 proposals in this round.

A majority of the funded projects are related to significant public health needs in Michigan, such as cancer, asthma, and liver disease. Projects also address major health concerns identified by Michigan community members and advocates, such as mental health, substance abuse, obesity, and access to care. Together, they represent MICHR’s commitment to accelerate the process of transforming scientific discoveries into real health gains.

The 15 recipients of the first round of 2012 MICHR pilot grants are listed below. Applications for the second round of 2012 pilot grants are due September 14, 2012. Details are available here.

  • Periostin and Allergic Airways Disease
    PI – John Kelley Bentley, PhD, Department of Pediatrics, Medical School
  • Characterization of Naturally Occurring Papillomaviral Infection Status and the Vaginal Microbiome in a Baboon Model of Female Reproductive Disease
    PI – Ingrid Bergin, VMD, Unit for Laboratory Animal Medicine, Medical School
  • Mineralocorticoids in Obesity-Related Hypertension
    PI – James Brian Byrd, MD, MS, Department of Internal Medicine, Medical School
  • A Placebo-controlled Crossover Trial Using Cyproheptadine To Treat Children with Functional Abdominal Pain
    PI – Daniel Clauw, MD, Department of Anesthesiology, Medical School
  • Pharmacometabolomics of Bipolar Disorder Treatments
    PI – Vicki Ellingrod, PharmD, Department of Clinical Social & Administrative Sciences, College of Pharmacy
  • Neural Predictors of Response to Cognitive Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder
    PI – Kate Fitzgerald, MD, Department of Psychiatry, Medical School
  • Evaluation of a Bioresorbable Splint for Treating Tracheobronchomalacia
    PI – Glenn Green, MD, Department of Otolaryngology , Medical School
  • 3D Sonographic Measurement of Volumetric flow in Transjugular Intrahepatic Porto-systemic Shunts (TIPS)
    PI – Oliver Kripfgans, PhD, Department of Radiology, Medical School
  • Buenos Vecinos Survey: Building Capacity to Promote Washtenaw County Latino/a Health
    PI – Daniel Kruger, PhD, Department of Health Behavior & Health Education, School of Public Health
  • Longitudinal Patterns of Speech in Bipolar Disorder
    PI – Melvin McInnis, MD, Department of Psychiatry, Medical School
  • Oxytocin, Parenting, Stress-Related Eating Behavior, and Obesity in Low-Income Preschoolers
    PI – Alison Miller, PhD, Department of Health Behavior & Health Education, School of Public Health
  • Cytokine-mediated Glycan Structural Alterations in Esophageal Epithelium
    PI – David Misek, PhD, Department of Surgery, Medical School
  • Moms 4 Moms:  Community-Participatory Parenting Project for African American Teen Moms in Metro Detroit
    PI – Maria Musik, MD, Department of Psychiatry, Medical School
  • Serum Glycoproteome Characterization for Prediction of Intestinal Fibrosis in Crohn's Disease
    PI – Ryan Stidham, MD, Department of Internal Medicine, Medical School
  • High-Density Deafness Gene-Centric (DGC) Array
    PI – Marwan Tayeh, PhD, Department of Pediatrics, Medical School

Since 2007, U-M researchers have received more than $13M in funding through this program, resulting in $82M in extramural funding.

Funding for these grants is provided through MICHR along with matching funds from participating departments at U-M. MICHR holds University of Michigan’s Clinical & Translational Research Award (CTSA). Working together as a national consortium, 60 CTSA institutions have committed to improve human health by streamlining science, transforming training environments and improving the conduct, quality and dissemination of clinical and translational research. The CTSA program is led by the National Center for Advancing Translational Sciences, part of the National Institutes of Health.

Undergraduate Research Opportunity Program Seeks Research Partners
Deadline: August 15, 2012

UROP Logo

The Undergraduate Research Opportunity Program (UROP) is currently recruiting research partners for the coming academic year. UROP students can provide biomedical researchers with invaluable assistance as well as the opportunity to work with bright and enthusiastic students. Many medical school faculty, research investigators and postdoctoral fellows have formed valuable research partnerships with students who began their research experiences during their freshman and sophomore years.  In many cases, students have worked in the same laboratory until they graduate, going on to pursue careers in biomedical and life sciences research.

UROP targets first and second year students, engaging them as research assistants on ongoing research projects.   Last year, approximately 55% of our research partnerships took place on the Medical School campus.   Since its inception in 1988, UROP has been committed to engaging a diverse group of students in research.  While UROP is open to all first and second year students on campus, we maintain a strong interest in engaging women in science and historically underrepresented minority students in research.  UROP students participate in the program for either academic credit or work-study funds.  All work-study costs are covered by UROP.  Limited supplementary research funds are also available from UROP to the sponsoring laboratory.

Our online application can be found by following the Sponsor Quick Links on the UROP website.

We would like to receive as many applications as possible by August 15, 2012 but will welcome project submissions through mid-September. (Applications received through mid-September will have a smaller applicant pool.)

If you have questions, please feel free to email:
Sandra Gregerman, Director
Katy Downs, Assistant Director


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendars at Health System Headlines to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Animal Research

eRAM Expansion Coming in September!

UCUCA, ULAM, and ITS are very excited about the implementation of the next phase of the eResearch Animal Management (eRAM) system coming in September 2012.  The overall goal of eRAM is to streamline the animal management process by creating a completely integrated system that will link protocol development and maintenance with animal ordering, animal transfers and non-vendor acquisitions.  Listed below are the current paper animal management forms that will be phased out with the new component of the eRAM system:

  • Animal Ordering Form
  • Animal Procurement & Disposition Forms, 8225-A, 8225-C, and 8225-D Forms
  • Authorized to Charge/Change Form
  • Rodent Import Form

This additional eRAM component will allow investigators, authorized staff, departments and units to better manage their protocol and animal data as well as improve communication between all these different groups.  In the future ITS, ULAM, and UCUCA will be adding per diem census and invoicing to further enhance the integration of animal research data.  This implementation will allow customers to have access to invoices as well as cage counts/census data.  Ordering of breeding sheets and barcode stickers will also be included in future implementations.

Since this is an implemented enhancement with the current eRAM system, there will be no need for any additional login or passwords.  We will be simply adding functionality to your existing eRAM access.  Further information regarding the eResearch Animal Management System including changes in the current process of administering standing orders will be provided in the next few weeks.   Please keep an eye out for additional communications that will include implementation dates, presentation dates, training and other pertinent information.  These additional communications will come in the form of emails, flyers and posters.

If you have any questions or concerns, please contact the ULAM Business Office at 734-764-0277.


SHARPENING THE FOCUS:

Tips on Grant Proposal Preparation

NIH Scoring: What Are the Two Top Cards in Hand for an Impact Win?

By Chris Black, M.L.S., Assistant Director for Research Services, Office of Research

(This is one in a series of tips published in UMMS Research News about writing proposals.)

The Impact score is the synthesis/integration of the five core review criteria that are scored individually and the additional review criteria, which are not scored individually. To evaluate, the reviewer(s) make an assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the scored review criteria, and additional review criteria (as applicable for the project proposed). Likelihood (i.e., probability) is primarily derived from the investigator(s), approach, and environment criteria. Sustained powerful influence is primarily derived from the significance and innovation criteria. However, the overall Impact score is not the arithmetic mean of the scored review criteria.

While we all strive for a royal flush in the five criteria, getting two very high cards may be all you need for a great Impact score, depending on what those two cards are. The NIH Office of Extramural Research analyzed the correlations between the overall impact scores of 32,608 applications (FY2010) across Institutes and the five Individual criterion scores. The highest correlations were between 1) Approach and 2) Significance, and then 3) Innovation, 4) Investigator and 5) Environment, in that order. So play your cards right, and hope for a little luck, and you could be in the big game.

Related articles:


EDUCATIONAL OPPORTUNITIES


EndNote for Academic Research and Publishing for the Health Sciences

Thursday, July 26, 2012
1:00 - 3:00 PM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by Taubman Health Sciences Libraries.

This hands-on workshop will provide instruction on using EndNote to support academic research and publications. This software is compatible with many online databases available through the University of Michigan libraries. When using the Microsoft Word add-in, EndNote becomes invaluable for writing manuscripts, grants, and papers for course assignments.

Register for this workshop.

Inserting Graphics into Grant Applications & Other Word Documents

Wednesday, August 1, 2012
10:00 AM - 12:00 PM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by Taubman Health Sciences Libraries.

This workshop offers instruction on the efficient and proper placement of images, charts, and graphics into grant proposal applications. The session will cover basic features in Microsoft Word such as image placement, captioning, and text wrapping. Following a brief presentation and hands-on instruction, instructors will assist you with specific issues you’re encountering in formatting your grant application. The session will cover all versions of Microsoft Word and applies to placement of graphics into any Word document. Please feel free to bring sample documents!  Contact Merle Rosenzweig with any questions. You can also view a video of this workshop and related documentation online.

Register to attend this workshop.


GRADUATE AND POSTDOC STUDIES


UMMS Graduate Student Award for Excellence in Research
Deadline: August 10, 2012

Any graduate student who is actively pursuing a degree in one of the 14 degree-granting programs within the PIBS umbrella can be nominated for the Graduate Student Award for Excellence in Research. The criteria for nomination include:

  • Scientific excellence, as judged by publications, academic record, or other forms of recognition for scientific accomplishment. (Copies of any publications should be included with the nomination.)

When determining nominees, please consider the following:

  • Quality of the science, not just number of papers (including quality of the Mentor's science).
  • Quality of the journals in which the work was published.
  • Level of scientific independence in the laboratory.

Nominations may originate from directors, department chairs, program directors, faculty, postdocs, or students. However, no more than two nominations from any given department or interdisciplinary program will be accepted or considered. Up to two awards of up to $500 each will be made at a fall awards ceremony.

Download complete details, nomination forms and required CV format.

Contact the Program in Biomedical Sciences (734-647-7005) with any questions.

UMMS Graduate Student Award for Excellence in Teaching and Service
Deadline: August 10, 2012

Graduate students who are actively pursuing a degree in one of the 14 degree-granting programs within the PIBS umbrella and who have (1) participated in teaching as a teaching assistant, lecturer, and/or tutor and (2) demonstrated service to the University and/or community, are eligible to compete for the Graduate Student Award for Excellence in Teaching and Service.  Nominees must demonstrate:

  • Effectiveness and creativity as a teacher.
  • Effective interactions with students—both inside and outside the classroom.
  • Potential for continued growth as a scholar and teacher.
  • Service to the University and/or its community— various committees, event management, and outreach activities.

When determining nominees, please consider the following:

  • The level of involvement of the TA in the given course.
  • Was the TA the only one for a given course?
  • Duration of the assistantship.
  • What was the student's service contribution?  Was it substantial?

Nominations may originate from directors, department chairs, program directors, faculty, postdocs, or students. However, no more than two nominations from any given department or program will be accepted or considered. Up to two awards of up to $500 each will be made at a fall awards ceremony.

Download complete details, nomination forms and required CV format.

Contact the Program in Biomedical Sciences (734-647-7005) with any questions.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Searle and Pew Scholars Program Awards
Internal Deadline: Wednesday, August 1, 2012

Nominations of faculty from all units of the University are welcome for both the Searle Scholars Program and the Pew Scholars Program in the Biomedical Sciences. Only one nomination package is required for the internal selection of the University’s nominees for both programs. Faculty members who were nominated but not selected for the 2012 programs may apply for the 2013 programs if they continue to meet program eligibility requirements. Specific program information is noted below.

The internal nomination package must include:

  • Cover sheet (downloaded from the web link below)
  • A letter of nomination from the appropriate department chair or section head. This letter should indicate if the candidate is to be considered for the Searle and/or Pew Scholars Programs. Please also include the nominee's UM start date as an assistant professor (month/date/year).
  • A one to five page research statement including (1) current areas of research and (2) an overview of the specific areas of research the nominee would like to pursue with this funding award. Please also indicate the significance of this work and explain why it is particularly novel and important.
  • A current copy of the nominee's NIH formatted biosketch including a list of any current awards held by the nominee or awards they will have that overlap with the funding period of the Searle or Pew awards. Please also list if you will be applying for any of the following awards and notify us when you apply for these awards:  Rita Allen Scholars, Burroughs-Wellcome Career Awards, Beckman Young Investigators Program, Ellison New Scholar Award, Keck Foundation, Damon-Runyon Early Career Award, and the Kimmel Scholars Award.
  • Any recent letters of support attesting to the potential of the nominee and the quality and scope of his/her research. These letters are for internal review; if they were obtained for another recent award review, please use those.

Please submit all application materials electronically by August 1, 2012 following the instructions listed on the cover sheet. Download the cover sheet.

We acknowledge receipt of all electronic submissions by the end of the next business day. If you do not receive a response from us, please call us at 734-615-8802.



Searle Scholars Program


http://www.searlescholars.net
Applicants for year 2013 awards will be expected to be pursuing independent research careers in biochemistry, cell biology, genetics, immunology, neuroscience, pharmacology, and related areas in chemistry, medicine, and the biological sciences. Candidates should have begun their first appointment at the assistant professor level on or after July 1, 2011 and therefore be in their first or second year in a tenure-track position. The awards are grants of $100,000 per year for three years, with funding for the second and third year contingent upon acceptable progress reports. The sponsor deadline is September 28, 2012. The University of Michigan is allowed to submit two nominations.



Pew Scholars Program in the Biomedical Sciences


http://www.pewtrusts.org/our_work_category.aspx?id=194
The Pew Scholars Program in the Biomedical Sciences is designed to support young investigators of outstanding promise in science relevant to the advancement of human health. The award is intended to provide support for junior faculty as they establish their laboratories. Candidates must hold a doctorate in medicine or biomedical sciences. As of November 1, 2012, candidates must hold full time appointments at the rank of assistant professor. On July 1, 2013, they must not have been in this appointment for more than three years. Applicants with committed awards from the Searle Scholars Program, Rita Allen Scholars, Burroughs-Wellcome Career Awards, Beckman Young Investigators Program, Ellison New Scholar Award, Keck Foundation, Damon-Runyon Early Career Award, and the Kimmel Scholars Award that overlap for the first two years of the Pew Scholarship would not be eligible. Funding from the NIH, other government sources, and project grants from non-profit associations do not pose a conflict with the Pew Scholars Program. The award is $60,000 per year for four years subject to annual review of the Scholar’s progress. The sponsor’s deadline is November 1, 2012 (12:00 PM EDT). The University of Michigan is allowed to submit one nomination.

Contact Camille Mrozowski at 734-615-8802 or (cmrozow@umich.edu) with any questions about these programs.

Gabrielle's Angel Foundation for Cancer Research Medical Research Award
Internal Deadline: August 1, 2012

Gabrielle’s Angel Foundation funds the nation’s best science in the fields of leukemia, lymphoma, and related cancers of the blood.  The Foundation not only funds conventional scientific research, but also projects that combine integrative (complementary) therapies or botanical agents. It focuses on projects for cancer prevention, detection and treatment that are most likely to be translated into clinical trials within a 3–5 year period. In recent years, the Foundation has expanded its reach to include the funding of select pediatric oncology initiatives, music therapy programs, and international projects.  The Foundation is committed to funding innovative, translational proposals and to supporting promising junior investigators, rather than well-established, senior scientists.  The Medical Research Awards are three-year grants totaling $225,000 ($75,000.00/per year contingent on the submission of acceptable annual progress reports).

UM may nominate two junior faculty members:

  • One who proposes a project involving mainstream or conventional research.
  • One who proposes a project involving complementary or integrative research (i.e. using methods which employ complementary therapies, botanical agents, or supportive care).

To be eligible, applicants must:

  • Currently hold a junior faculty position (i.e. has not been promoted to Associate Professor).
  • Have a Ph.D. or M.D.
  • Clearly state that they have their independent research, and resources, especially if their title is anything other than “Assistant Professor.”

Deadline for submission of a proposal to the Foundation is September 14, 2012. Applicants will be notified of the Foundation’s decision by December 28, 2012.

For consideration as an institutional nominee, submit ONLY the items below electronically by August 1, 2012 following the instructions listed on the cover sheetDownload the cover sheet, see FAQs, and view the Foundation’s 2012 Grants brochure.

  • Cover sheet
  • Nominating letter from the department chair
  • 3-page research plan
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. The website for the Gabrielle's Angel Foundation for Cancer Research is (http://www.gabriellesangels.org).

Burroughs Wellcome Fund Career Awards for Medical Scientists
Internal Deadline: August 9, 2012

The Career Awards for Medical Scientists (CAMS) is the result of the reformulation of the Career Awards in the Biomedical Sciences (CABS) program.  In response to the NIH’s K99/R00 Pathway to Independence program, the Burroughs Wellcome Fund (BWF) has shifted focus to address the ongoing problem of increasing the number of physician scientists and keeping them in research.  This award provides $700,000 over five years for physician-scientists to bridge advanced postdoctoral/fellowship training and the early years of faculty service.  Proposals must be in the area of basic biomedical, disease-oriented, or translational research.  Proposals in health services research or involving large-scale clinical trials are ineligible. BWF encourages nominations from candidates who work in reproductive science.

To be eligible, candidates must:

  • Be citizens or permanent residents of the U.S. or Canada at the time of application.
  • Have an M.D., D.D.S., or D.V.M. degree.  Candidates must not be more than 10 years past their most recent doctorate degree. No exceptions will be made.  Candidates with a clinical degree not awarded in the U.S. or Canada must be fully licensed to practice in the U.S. or Canada or have completed a residency in the U.S. or Canada.
  • Be a fellow, resident, or a postdoctoral researcher and have at least two years of postdoctoral research experience at the time of application. Candidates who hold a junior faculty appointment - Lecturer, Instructor, Assistant Professor (non-tenure track), etc. - may be eligible if they have been in a faculty position for two years or less at the time of application. To meet this requirement, the appointment must have begun no earlier than July 1, 2010.
  • Be committed to a full-time career in research as an independent investigator at a North American degree-granting institution. Award recipients are required to devote at least 75 percent of their time to research-related activities.

The following candidates are NOT eligible:

  • Candidates with tenure-track appointments as an Instructor or Assistant Professor at the time of application.
  • Candidates that have faculty appointments with institutional start-up funds or hold an R01 grant from the NIH.

UM may nominate up to five candidates. If a woman or underrepresented minority is nominated within the initial five candidates, a sixth candidate may be nominated provided that candidate is a woman or underrepresented minority (i.e. African American, Hispanic, or Native American). The Foundation deadline is October 1, 2012.

NOTE: Not all eligibility criteria may be listed in this abstract. Before submitting an application for this internal competition, it is the applicant’s responsibility to visit the foundation website and verify that both the applicant and their project meet ALL eligibility criteria.

For consideration as an institutional nominee, submit ONLY the items below electronically by August 9, 2012 following the instructions listed on the cover sheetDownload the cover sheet and see FAQs.

  • Cover sheet
  • Nominating letter from the current mentor
  • 3-page research plan
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions.


UMMS AWARDED GRANTS

External Awarded Grants

An asterisk next to a name means that they are the Contact PI for the program, since some projects are awarded with multiple PIs.

Click here to view.

Anesthesiology

PI: *Blum,James / *Syed,Zeeshan
Co-I: Latchamsetty, Rakesh (Int Med-Cardiology)
Title: Exploring the Feasibility of Computational Markers to predict Atrial Fibrillation Following Cardiac Surgery
Sponsor: NIH  1 R21 LM 011026 01 A1
Project Dates and Amount of Award: 06/06/12-06/05/14; $352,363

PI: *Tait,Alan
Title: Interactive Informed Consent for Pediatric Clinical Trials
Sponsor: NIH - Subcontracts TO ArchieMD, Inc.
Project Dates and Amount of Award: 03/30/12-03/29/14; $391,568

Biomedical Research Core Facilities

PI: *Moore,Thomas
Title: Flow Cytometry - Sample Analysis/Fee for Service - Non-Fed Various
Sponsor: Various Sponsors
Project Dates and Amount of Award: 09/10/11-08/31/12; $5,160

Cell & Developmental Biology

PI: *Barald,Kate
Co-I: Shen, Yu-Chi (Cell and Developmental Biology)
Title: Role of Cytokin Macrophage Migration Inhibitory Factor (MIF) as a Neurotrophin in Zebrafish Neurogenesis
Sponsor: NSF
Project Dates and Amount of Award: 06/15/12-05/31/15; $525,000

PI: *Engel,James
Awardee / Fellow: Shi, Lihong
Title: LSD1 Inhibitor as a Novel Therapeutic Agent for Sickle Cell Disease
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/13; $48,428

PI: *Fingar,Diane
Awardee / Fellow: Huang, Kezhen
Title: Regulation and Function of mTORC1 by GSK3-Mediated Raptor Phosphorylation
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $90,772

Dermatology

PI: *Wong,Sunny
Title: Characterizing the Cells of Origin for Basal Cell Carcinoma
Sponsor: NIH  4 R00 AR 059796 03
Project Dates and Amount of Award: 07/01/12-06/30/15; $735,814

Internal Medicine

PI: *Anumonwo,Justus
Awardee / Fellow: O'Connell, Ryan
Title: Elevated Fatty Acids Remodel Atrial Electrophysiology and Calcium Homeostasis
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $52,000

PI: *Bach,David
Co-I: Kolias, Theodore (Int Med-Cardiology)
Title: Trifecta Comparative Stress Hemodynamic Study
Sponsor: St. Jude Medical, Inc.
Project Dates and Amount of Award: 06/28/12-06/27/14; $239,275

PI: *Barkan,Ariel
Title: A Phase III, Multicenter, Randomized, Parallel-Group Study to Assess the Efficacy and Safety of Double-Blind Pasireotide LAR 40 mg and Pasireotide LAR 60 mg Versus Open-Label Octreotide LAR or Lanreotide ATG in Patients with Inadequately Controlled Acromegaly
Sponsor: Novartis
Project Dates and Amount of Award: 06/11/12-06/01/14; $74,787

PI: *Brosius III,Frank
Title: Consulting on the Preclinical and Clinical Research of Diabetic Nephropathy
Sponsor: Merck Sharp & Dohme
Project Dates and Amount of Award: 07/03/12-07/02/13; $2,925

PI: *Cooney,Kathleen
Awardee / Fellow: Wilcox, Ryan
Title: GATA-3 as a Master Non-autonomous Regulator of the Tumor Microenvironment in Peripheral T-cell Lymphomas
Sponsor: Leukemia Res. Fdn. Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $100,000

PI: *Fontana,Robert
Title: A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients with Acute Liver Failure due to Acetaminophen Overdose (STOP-ALF)
Sponsor: NIH - Subcontracts TO University Of Texas Southwest  U01 DK 058369
Project Dates and Amount of Award: 09/01/11-08/31/12; $56,496

PI: *Hammer,Gary
Title: Efficacy of Adjuvant Mitotane Treatment in Prolonging Recurrence-Free Survival in Patients With Adrenocortical Carcinoma at Low-Intermediate Risk of Recurrence
Sponsor: HRA Pharma
Project Dates and Amount of Award: 03/01/12-02/28/13; $25,000

PI: *Higgins,Peter
Title: A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Oral CP-690,550 as an Induction Therapy in Subjects with Moderate to Severe Ulcerative Colitis
Sponsor: Pfizer TO ICON Clinical Research, Inc.
Project Dates and Amount of Award: 05/01/12-04/30/14; $111,410

PI: *Higgins,Peter
Title: A Multi-center, Open-Label, Study of CP-690,550 in Subjects With Moderate to Severe Ulcerative Colitis
Sponsor: Pfizer Incorporated TO ICON Clinical Research, Inc.
Project Dates and Amount of Award: 06/07/12-06/06/17; $258,301

PI: *Jalife,Jose
Awardee / Fellow: Willis, Cicero
Title: Molecular Interplay Between Nav1.5 and Kir2.1 in Cardiac Loss-of-Function SCN5A Mutations.
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $85,972

PI: *Koch,Alisa
Awardee / Fellow: Tsou, Pei-Suen
Title: Contribution of Oxidative Stress to Aberrant Angiogenesis in Scleroderma
Sponsor: Arthritis Foundation, The
Project Dates and Amount of Award: 07/01/12-06/30/14; $100,000

PI: *Koch,Alisa
Co-I: Fox, David (Int Med-Rheumatology) / Kaplan, Mariana (Int Med-Rheumatology)
Title: Training of Arthritis Research Scientists
Sponsor: NIH  2 T32 AR 007080 34 A1
Project Dates and Amount of Award: 07/01/12-06/30/17; $1,323,570

PI: *Kretzler,Matthias
Title: Chronic Kidney Disease Consultation
Sponsor: Lilly, Eli, and Company
Project Dates and Amount of Award: 06/25/12-04/01/13; $20,000

PI: *Kretzler,Matthias
Co-I: Guan, Yuanfang (Comp Med and Bioinformatics)
Title: European Consortium for High-Throughput Research in Rare Kidney Diseases
Sponsor: University of Heidelberg TO European Commission
Project Dates and Amount of Award: 10/01/12-09/30/17; $543,517

PI: *Lawrence,Daniel
Co-I: Su, Enming (Int Med-Cardiology)
Title: Mechanism of Thrombolytic tPA Induced Intracerebral Hemorrhage after Stroke
Sponsor: NIH  1 R01 NS 079639 01
Project Dates and Amount of Award: 07/01/12-04/30/17; $1,700,780

PI: *Liu,Suling / Korkaya,Hasan
Title: Targeting EMT and MET States of Breast Cancer Stem Cells and its Therapeutic Utility in Overcoming Trastuzumab Resistance
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 01/06/12-05/13/13; $349,999

PI: *Malek,Sami
Title: Genomic Correlative Analysis For PI3K Delta Inhibitor From Incyte (INCB40093) Tested In Lymphoid Malignancies
Sponsor: Incyte Pharmaceuticals, Inc.
Project Dates and Amount of Award: 06/18/12-06/17/15; $676,835

PI: *Marrero,Jorge
Title: EARLY DETECTION AND PROGNOSIS OF HEPATOCELLULAR CARCINOMA
Sponsor: NIH - Subcontracts TO Johns Hopkins University  U01 CA 086402
Project Dates and Amount of Award: 04/01/12-03/31/13; $558,666

PI: *McMahon Jr,Laurence
Awardee / Fellow: Chen, Lena
Title: Understanding Hospital Efficiency for Inpatient Medical Care
Sponsor: AHRQ 1 K08 HS 020671 01 A1
Project Dates and Amount of Award: 07/01/12-06/30/16; $599,886

PI: *Owyang,Chung
Co-I: Grabauskas, Gintautas (Int Med-Gastroenterology) / Thompson, Robert (Psychiatry Department) / Zhou, Shi-Yi (Int Med-Gastroenterology)
Title: Characterization of Portal Vein Glucose Sensor Responsible for Satiety Control
Sponsor: NIH  2 R01 DK 048419 15
Project Dates and Amount of Award: 05/01/12-04/30/16; $1,352,852

PI: *Owyang,Chung / Omary,Bishr
Co-I: Samuelson, Linda (Molec & Integrative Physiology)
Title: Training in Basic and Translational Digestive Sciences
Sponsor: NIH  1 T32 DK 094775 01
Project Dates and Amount of Award: 07/01/12-06/30/17; $1,465,079

PI: *Peters-Golden,Marc
Title: Evaluating the Efficacy of 2 NYC Compounds Using a Bleomycin-induced Pulmonary Fibrosis Model in Female C57Bl/6 Mice
Sponsor: NYCOMED GmbH
Project Dates and Amount of Award: 04/01/12-03/31/13; $85,394

PI: *Sawalha,Amr
Title: Genetic-epigenetic Interaction in Lupus
Sponsor: Lupus Research Institute
Project Dates and Amount of Award: 04/01/12-01/31/14; $42,389

PI: *Shayman,James
Co-I: Larsen, Scott (PHARMACY Medicinal Chemistry) / Sun, Duxin (PHARMACY Pharmaceutical Sci)
Title: In Vivo Proof of Efficacy Studies for a Novel Glucosylceramide Synthase Inhibitor with Central Nervous System Activity
Sponsor: NIH  1 R21 NS 079633 01
Project Dates and Amount of Award: 08/01/12-07/31/14; $427,625

PI: *Speliotes,Elizabeth
Title: GENETIC EPIDEMIOLOGY STUDIES OF NONALCOHOLIC FATTY LIVER DISEASE IN DIVERSE ANCESTRIES
Sponsor: Duke, Doris, Charitable Fdn
Project Dates and Amount of Award: 07/01/12-06/30/15; $486,000

PI: *Talpaz,Moshe
Title: (2012.044) Expanded Access Program of Ponatinib (AP24534) for Patients with Refractory Chronic Myeloid Leukemia or Ph+ Acute Lymphoblastic Leukemia
Sponsor: Ariad Pharmaceuticals, Inc.
Project Dates and Amount of Award: 06/18/12-06/17/17; $28,620

PI: *Wellik,Deneen
Co-I: Arruda, Ellen (Mechanical Engineering) / Larkin, Lisa (Molec & Integrative Physiology)
Title: Using BMSC-derived Bone-Ligament-Bone Tissue as a Live Template for ACL Regeneration In Vivo
Sponsor: NIH  1 R21 AR 063444 01
Project Dates and Amount of Award: 07/01/12-06/30/14; $384,863

PI: *Yung,Raymond
Co-I: Manu, Erika (IntMed-Geri & Palliative Med.) / Min, Lillian (IntMed-Geri & Palliative Med.)
Title: Hartford Center of Excellence in Geriatrics 2012 - 2013
Sponsor: Hartford, John A. Foundation TO American Federation for Aging Research
Project Dates and Amount of Award: 07/01/12-06/30/13; $60,000

Michigan Institute for Clinical and Health Research

PI: *Shanley,Thomas
Title: Michigan Institute for Clinical & Health Research (MICHR- K-Award)
Sponsor: NIH  2 KL2 TR 000434 06
Project Dates and Amount of Award: 06/27/12-05/31/17; $2,006,875

PI: *Shanley,Thomas
Title: Michigan Institute for Clinical & Health Research (MICHR- T-Award)
Sponsor: NIH  2 TL1 TR 000435 06
Project Dates and Amount of Award: 06/27/12-05/31/17; $2,335,320

PI: *Shanley,Thomas
Co-I: Adar, Sara (Epidemiology Department) / Albin, Roger (Neurology Department) / Alexander, Neil (Int Med-Geriatric Medicine) / An, Lawrence (Int Med-General Medicine) / Anderson, Robert (Med Ed/Ofc of Ed Resources&Res) / Armitage, Roseanne (Psychiatry Department) / Athey, Brian (Psychiatry Department) / Blumenthal, Jane (Library Pub Svcs - Health Sci) / Burant, Charles (Metabolism, Endo & Diabetes) / Burgio, Louis (School of Social Work) / Cavalcoli, James (CCMB-Initiatives) / Chinnaiyan, Arul (Pathology Department) / Clauw, Daniel (Anesthesiology Department) / Davis, Matthew (Pediatrics-Ambulatory Care Pgm) / Dolinoy, Dana (Environmental Health Sciences) / Flanders, Scott (Int Med-General Medicine) / Geisser, Michael (Physical Medicine & Rehab Dept) / Giannobile, William (DENT Periodontics and Oral Med) / Gipson, Debbie (Pediatrics-Nephrology) / Gordon, David (Pathology Department) / Grazier, Kyle (Health Management and Policy) / Green, Lee (Family Medicine) / Hanauer, David (Pediatrics-Ambulatory Care Pgm) / Hawley, Sarah (Int Med-General Medicine) / Hutchinson, Raymond (Medical School Administration) / Isom, Lori (Pharmacology Department) / Kalpakjian, Claire (Physical Medicine & Rehab Dept) / Larson, Janet (School of Nursing) / Macoska, Jill (Urology Surgery) / Martinez, Fernando (Int Med-Pulm./Critical Care) / Meadows, Phyllis (Sch of Public Hlth-Dean's Ofc) / Mirel, Barbara (School of Education) / Morgenstern, Hal (Epidemiology Department) / Murphy, Susan (Physical Medicine & Rehab Dept) / Noll, Douglas (Biomedical Engineering) / Omenn, Gilbert (Int Med-Molecular Med&Genetics) / Raghunathan, Trivellore (Biostatistics Department) / Riba, Michelle (Psychiatry Department) / Ringold, Vicki (PHARMACY Clin, Soc & Admin Sci) / Roessler, Blake (Int Med-Rheumatology) / Russell, Mark (Pediatrics-Cardiology) / Sampselle, Carolyn (School of Nursing) / Schteingart, David (Metabolism, Endo & Diabetes) / Smith, Dean (Health Management and Policy) / Smith, Yolanda (Obstetrics and Gynecology Dept) / Spino, Catherine (Biostatistics Department) / Titler, Marita (School of Nursing) / Tsodikov, Alexander (Biostatistics Department) / Unnikrishnan, K (Comp Med and Bioinformatics) / Van Oyen, Mark (Industrial Operations) / Vazquez, Delia (Pediatrics-Endocrinology) / Vereen, Donald (Sch of Public Hlth-Dean's Ofc) / Wang, Stewart (GSA - Administration (GSA/ADM)) / Weder, Alan (Int Med-Cardiology) / Welage, Lynda (PHARMACY Clin, Soc & Admin Sci) / Wiley, John (Int Med-Gastroenterology) / Williams, David (Anesthesiology Department) / Wong, Sandra (GSA - Administration (GSA/ADM)) / Zheng, Kai (Health Management and Policy) / Zimmerman, Marc (Hlth Behavior & Hlth Ed Dept)
Title: Michigan Institute for Clinical and Health Research (MICHR)
Sponsor: NIH  2 UL1 TR 000433 06
Project Dates and Amount of Award: 06/27/12-05/31/17; $48,788,667

Microbiology and Immunology

PI: *O'Riordan,Mary / Wobus,Christiane
Co-I: Donato, Nicholas (Int Med-Hematology/Oncology) / Showalter, Hollis (PHARMACY Medicinal Chemistry) / Sun, Duxin (PHARMACY Pharmaceutical Sci)
Title: Targeting Host Deubiquitinases for Broad Spectrum Anti-Infective Therapy
Sponsor: NIH  1 R21 AI 102106 01
Project Dates and Amount of Award: 07/01/12-06/30/14; $422,571

PI: *Swanson,Joel
Co-I: O'Riordan, Mary (Microbiology and Immunology)
Title: Cellular Biotechnology Training Program
Sponsor: NIH  2 T32 GM 008353 21 A1
Project Dates and Amount of Award: 07/01/12-06/30/17; $2,046,080

Molecular & Integrative Physiology

PI: *MacDougald,Ormond
Awardee / Fellow: Cawthorn, William
Title: Bone Marrow Adipose Tissue as a Regulator of Metabolism and Skeletal Remodeling
Sponsor: Lilly, Eli, and Company
Project Dates and Amount of Award: 07/01/12-06/30/16; $180,000

PI: *MacDougald,Ormond
Title: Role of Sweet Taste Receptors in Adipocyte Differentiation and Metabolism
Sponsor: NIH  1 R01 DK 095705 01
Project Dates and Amount of Award: 06/01/12-03/31/16; $1,300,040

PI: *Michele,Daniel
Awardee / Fellow: Mcdade, Joel
Title: Mechanism of Damage-Induced Dysferlin Repair-Vesicle Patch Formation in Adult Cardiomyocytes
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $52,000

PI: *Mortensen,Richard
Title: Leukocyte Phenotype, Mineralocorticoid Receptor and Stroke
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $143,000

Neurology

PI: *Albin,Roger
Awardee / Fellow: Kotagal, Vikas
Title: Postural Instability and Gait Difficulty is Associated with Cholinergic Denervation and Increased Non-Motor Features of Parkinson disease
Sponsor: American Academy of Neurology
Project Dates and Amount of Award: 07/01/12-06/30/14; $130,000

PI: *Kutcher,Jeffrey / Broglio,Steven / Eckner,James
Title: National Sport Concussion Outcomes Study - Phase I: The Role of Equipment and Head Impact Exposure on Neurological Outcomes
Sponsor: National Collegiate Athletic Association
Project Dates and Amount of Award: 07/01/12-06/30/16; $289,630

PI: *Paulson,Henry
Awardee / Fellow: Scaglione, Kenneth
Title: Protein Fate in Neurodegeneration: Investigations of Novel Regulatory Mechanisms
Sponsor: NIH  1 K99 NS 073936 01 A1
Project Dates and Amount of Award: 07/01/12-06/30/14; $197,358

PI: *Segal,Benjamin
Awardee / Fellow: Lalor, Stephen
Title: Investigating the Trafficking Behavior of Encephalitogenic Th17 Cells Prior to Entering the CNS in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Sponsor: National Multiple Sclerosis Society
Project Dates and Amount of Award: 07/01/12-06/30/15; $169,946

Ophthalmology & Visual Sciences

PI: *Gardner,Thomas
Title: Genes in Diabetic Retinopathy
Sponsor: NIH - Subcontracts TO Jaeb Center for Health Res  U10 EY 01423
Project Dates and Amount of Award: 01/01/12-12/31/13; $3,738

PI: *Stein,Joshua
Title: Understanding the Relationship Between Components of Metabolic Syndromes and  Open-Angle Glaucoma.
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 06/01/12-05/31/13; $100,000

PI: *Thompson,Debra
Co-I: Khan, Naheed (Ophthalmology & Visual Science)
Title: Gene-replacement Therapy for RDH12 Mutations
Sponsor: The RDH12 Fund for Sight
Project Dates and Amount of Award: 05/01/12-04/30/14; $171,008

Otolaryngology

PI: *Lesperance,Marci
Title: Quality of Life and Hearing Loss in Adolescents Research Study
Sponsor: American Hearing Research Fdn TO Washington University
Project Dates and Amount of Award: 07/01/11-06/30/12; $1,100

PI: *Pynnonen,Melissa
Title: Rhinosinusitis: Variations in Care and Opportunities for Improvement
Sponsor: American Academy of Otolaryngology - Head & Neck Surgery Foundation, Inc.
Project Dates and Amount of Award: 08/01/12-07/31/14; $40,000

PI: *Raphael,Yehoash
Title: Histology of the Cochlea, Histological Services to the University of Illinois
Sponsor: University of Illinois-Urbana-Champaign
Project Dates and Amount of Award: 06/01/12-09/30/12; $6,500

Pathology

PI: *Figueroa,Maria
Title: The Contribution of Epigenetic Gene Silencing to Leukemogenesis
Sponsor: Leukemia Res. Fdn. Inc.
Project Dates and Amount of Award: 07/01/12-06/30/13; $100,000

PI: *Rual,Jean-Francois
Title: Characterization of the MLL and HOXA9-regulated Enhanceosome Molecular Networks in Acute Leukemia
Sponsor: When Everyone Survives Foundation (WES)
Project Dates and Amount of Award: 07/01/12-06/30/13; $50,000

PI: *Varani,James
Title: Biological Endpoints in Cell Culture: Evaluation of Three Additional Compounds
Sponsor: JV Biolabs
Project Dates and Amount of Award: 06/01/12-11/30/12; $26,000

Pediatrics & Communicable Diseases

PI: *Dowling,James
Title: Zebrafish Models of Congenital Muscular Dystrophies
Sponsor: The Samantha J. Brazzo Foundation
Project Dates and Amount of Award: 02/01/12-01/31/13; $41,829

PI: *Dowling,James
Title: CCDC78 and the Pathogenesis of Centronuclear Myopathy
Sponsor: NIH  1 R03 AR 062810 01
Project Dates and Amount of Award: 07/01/12-06/30/15; $233,250

PI: *Hildebrandt,Friedhelm
Awardee / Fellow: Gee, Heon Yung
Title: Functional Characterization of the Novel FSGS-causing Genes ARHGDIA and MED28.
Sponsor: American Society Of Nephrology
Project Dates and Amount of Award: 07/01/12-06/30/14; $100,000

PI: *Lee,Joyce
Co-I: Eagle, Kim (Int Med-Cardiology)
Title: Cumulative Effects of BMI on Cardiovascular Risk
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $110,000

PI: *Sallinen,Bethany
Co-I: Kaciroti, Niko (Center for Human Growth & Dev)
Title: A Parent-Targeted Obesity Intervention for Children Attending Head Start
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/12-06/30/14; $143,000

PI: *Sandberg,David
Co-I: Fisseha, Senait (Obstetrics and Gynecology Dept) / Goldman, Edward (Obstetrics and Gynecology Dept) / Park, John (Urology Surgery) / Prosser, Lisa (Pediatrics-Ambulatory Care Pgm)
Title: Disorders of Sex Development: Platform for Basic and Translational Research
Sponsor: NIH - Subcontracts TO Univ Of California Los Angeles  R01 HD 068138
Project Dates and Amount of Award: 09/26/11-06/30/12; $217,073

Psychiatry

PI: *Abelson,James
Co-I: Diez Roux, Ana (Epidemiology Department) / King, Anthony (Psychiatry Department) / Liberzon, Israel (Psychiatry Department) / Sanchez Loya, Brisa (Biostatistics Department)
Title: Stress Biomarkers:  Attaching Biological Meaning to Field Friendly Salivary Measures
Sponsor: NIH  1 R01 MH 093486 01 A1
Project Dates and Amount of Award: 07/01/12-06/30/17; $2,595,786

Radiation Oncology

PI: *Jagsi,Reshma
Title: Influence of Female Role Models on Women's Choices of Medical Specialties
Sponsor: Burroughs Wellcome Fund TO Alliance for Academic Internal Medicine (AAIM)
Project Dates and Amount of Award: 04/01/12-03/31/13; $34,000

Radiology

PI: *Gemmete,Joseph
Awardee / Fellow: Elias, Augusto
Title: SNIS Fellowship Grant
Sponsor: Society of NeuroInterventional
Project Dates and Amount of Award: 06/01/12-05/30/13; $22,750

PI: *Kilbourn,Michael
Title: Carbon-11 PET Ligand Tracer Development
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 06/07/12-06/06/13; $44,500

Surgery

PI: *Kryczek,Ilona
Title: Human Myeloid Suppressor Cells Maintain Ovarian Cancer Stemness
Sponsor: Marsha Rivkin Center for Ovarian Cancer Research
Project Dates and Amount of Award: 04/01/12-03/31/13; $75,000

PI: *Wang,Stewart
Awardee / Fellow: Delarosa, Sara
Title: Craniofacial Morphomics Enhance Facial Trauma Risk Stratification
Sponsor: Hughes, Howard Medical Inst.
Project Dates and Amount of Award: 07/09/12-07/07/13; $39,000

PI: *Wong,Sandra
Title: Understanding Variation in Treatment Intensity of Poor Prognosis Cancers
Sponsor: NIH  1 K08 HS 020937 01
Project Dates and Amount of Award: 07/01/12-06/30/17; $681,860

Unit for Laboratory Animal Medicine

PI: *Nemzek,Jean
Title: Efficacy of Tramadol Analgesia in Murine Models of Inflammation and Sepsis
Sponsor: American Association for Laboratory Animal Science
Project Dates and Amount of Award: 06/01/12-05/31/13; $40,000

Urology

PI: *Day,Mark
Title: Bladder Cancer Research and Training Collaboration between European Egyptian Pharmaceutical Industries
Sponsor: Pharco Group
Project Dates and Amount of Award: 07/01/12-06/30/13; $97,118

PI: *Keller,Evan
Awardee / Fellow: Sottnik, Joseph
Title: Effect of Physical Forces on the Metastatic Bone Microenvironment
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/01/12-08/31/12; $116,052

PI: *Wei,John
Title: Canary Prostate Active Surveillance Study Protocol
Sponsor: Canary Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $16,400


UMMS RESEARCH PUBLICATIONS

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Journal Articles

Anesthesiology

Pannucci Christopher J, Shanks Amy, Moote Marc J, Bahl Vinita, Cederna Paul S, Naughton Norah N, Wakefield Thomas W, Henke Peter K, Campbell Darrell A, Kheterpal Sachin. Identifying patients at high risk for venous thromboembolism requiring treatment after outpatient surgery. Annals of surgery. 2012 Jun. 255(6): 1093-9. PMID# 22584630

Arnold Lesley M, Clauw Daniel J, Dunegan L Jean, Turk Dennis C. A framework for fibromyalgia management for primary care providers. Mayo Clinic proceedings. Mayo Clinic. 2012 May. 87(5): 488-96. PMID# 22560527

Biological Chemistry

Vitvitsky Victor, Kabil Omer, Banerjee Ruma. High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations. Antioxidants&redox signaling. 2012 Jul 1. 17(1): 22-31. PMID# 22229551

Umekawa Midori, Klionsky Daniel J. Ksp1 Kinase Regulates Autophagy via the Target of Rapamycin Complex 1 (TORC1) Pathway. The Journal of biological chemistry. 2012 May 11. 287(20): 16300-10. PMID# 22447937

Cell & Developmental Biology

Novak Heidi M, Baccetti Tiziano, Sigler Lauren M, McNamara James A. A controlled study on diagnostic and prognostic measurements of palatally displaced canines on lateral cephalograms. Progress in orthodontics. 2012 May. 13(1): 42-8. PMID# 22583586

Center for Bioethics and Social Sciences in Medicine

Witteman Holly O, Zikmund-Fisher Brian J. The defining characteristics of Web 2.0 and their potential influence in the online vaccination debate. Vaccine. 2012 May 28. 30(25): 3734-40. PMID# 22178516

Center for Computational Medicine and Bioinformatics

Sartor Maureen A, Ade Alex, Wright Zach, States David, Omenn Gilbert S, Athey Brian, Karnovsky Alla. Metab2MeSH: annotating compounds with medical subject headings. Bioinformatics (Oxford, England). 2012 May 15. 28(10): 1408-10. PMID# 22492643

Dermatology

Rittié Laure, Elder James T. Capturing the Finer Points of Gene Expression in Psoriasis: Beaming in on the CCL19/CCR7 Axis. The Journal of investigative dermatology. 2012 Jun. 132(6): 1535-8. PMID# 22584500

Harting Mandy S, Ludgate Mathew W, Fullen Douglas R, Johnson Timothy M, Bichakjian Christopher K. Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma. Journal of the American Academy of Dermatology. 2012 Jun. 66(6): 923-7. PMID# 21978573

Jordan Catherine T, Cao Li, Roberson Elisha D O, Duan Shenghui, Helms Cynthia A, Nair Rajan P, Duffin Kristina Callis, Stuart Philip E, Goldgar David, Hayashi Genki, Olfson Emily H, Feng Bing-Jian, Pullinger Clive R, Kane John P, Wise Carol A, Goldbach-Ma Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. American journal of human genetics. 2012 May 4. 90(5): 796-808. PMID# 22521419

Emergency Medicine

Skolarus L E, Meurer W J, Burke J F, Prvu Bettger J, Lisabeth L D. Effect of insurance status on postacute care among working age stroke survivors. Neurology. 2012 May 15. 78(20): 1590-5. PMID# 22551730

Kocher Keith E, Meurer William J, Desmond Jeffrey S, Nallamothu Brahmajee K. Effect of testing and treatment on emergency department length of stay using a national database. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2012 May. 19(5): 525-34. PMID# 22594356

Nigrovic Lise E, Lee Lois K, Hoyle John, Stanley Rachel M, Gorelick Marc H, Miskin Michelle, Atabaki Shireen M, Dayan Peter S, Holmes James F, Kuppermann Nathan. Prevalence of clinically important traumatic brain injuries in children with minor blunt head trauma and isolated severe injury mechanisms. Archives of pediatrics&adolescent medicine. 2012 Apr. 166(4): 356-61. PMID# 22147762

Family Medicine

Zazove Philip, Meador Helen E, Reed Barbara D, Sen Ananda, Gorenflo Daniel W. Effectiveness of videos improving cancer prevention knowledge in people with profound hearing loss. Journal of cancer education : the official journal of the American Association for Cancer Education. 2012 Jun. 27(2): 327-37. PMID# 22528628

Gill James M, Chen Ying Xia, Grimes Angela, Klinkman Michael S. Using electronic health record-based tools to screen for bipolar disorder in primary care patients with depression. Journal of the American Board of Family Medicine : JABFM. 2012 May. 25(3): 283-90. PMID# 22570391

Dorman Janice S, Valdez Rodolfo, Liu Tiebin, Wang Catharine, Rubinstein Wendy S, O'Neill Suzanne M, Acheson Louise S, Ruffin Mack T, Khoury Muin J. Health beliefs among individuals at increased familial risk for type 2 diabetes: implications for prevention. Diabetes research and clinical practice. 2012 May. 96(2): 156-62. PMID# 22257420

Human Genetics

Bedoyan Jirair Krikor, Schaibley Valerie M, Peng Weiping, Bai Yongsheng, Mondal Kajari, Shetty Amol C, Durham Mark, Micucci Joseph A, Dhiraaj Arti, Skidmore Jennifer M, Kaplan Julie B, Skinner Cindy, Schwartz Charles E, Antonellis Anthony, Zwick Michael E Disruption of RAB40AL function leads to Martin-Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder. Journal of medical genetics. 2012 May. 49(5): 332-40. PMID# 22581972

Institute of Gerontology

Finlayson Emily, Zhao Shoujun, Boscardin W John, Fries Brant E, Landefeld C Seth, Dudley R Adams. Functional status after colon cancer surgery in elderly nursing home residents. Journal of the American Geriatrics Society. 2012 May. 60(5): 967-73. PMID# 22428583

Internal Medicine – Cardiovascular Medicine

Chan Paul S, Nallamothu Brahmajee K. Improving outcomes following in-hospital cardiac arrest: life after death. JAMA : the journal of the American Medical Association. 2012 May 9. 307(18): 1917-8. PMID# 22570458

Latchamsetty Rakesh, Oral Hakan. Ablation of atrial fibrillation using an irrigated-tip catheter: open or closed? Pacing and clinical electrophysiology : PACE. 2012 May. 35(5): 503-5. PMID# 22360611

Nallamothu Brahmajee K, Cohen David J. No "i" in heart team: incentivizing multidisciplinary care in cardiovascular medicine. Circulation. Cardiovascular quality and outcomes. 2012 May 1. 5(3): 410-3. PMID# 22592755

Kocher Keith E, Meurer William J, Desmond Jeffrey S, Nallamothu Brahmajee K. Effect of testing and treatment on emergency department length of stay using a national database. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2012 May. 19(5): 525-34. PMID# 22594356

Bradley Steven M, Chan Paul S, Spertus John A, Kennedy Kevin F, Douglas Pamela S, Patel Manesh R, Anderson H Vernon, Ting Henry H, Rumsfeld John S, Nallamothu Brahmajee K. Hospital Percutaneous Coronary Intervention Appropriateness and In-Hospital Procedural Outcomes: Insights From the NCDR. Circulation. Cardiovascular quality and outcomes. 2012 May 1. 5(3): 290-7. PMID# 22576845

Bun Sok-Sithikun, Kober Frank, Jacquier Alexis, Espinosa Leon, Kalifa Jérôme, Bonzi Marie-France, Kopp Francis, Lalevee Nathalie, Zaffran Stephane, Deharo Jean-Claude, Cozzone Patrick J, Bernard Monique. Value of in vivo T2 measurement for myocardial fibrosis assessment in diabetic mice at 11.75 T. Investigative radiology. 2012 May. 47(5): 319-23. PMID# 22488510

Internal Medicine – Gastroenterology

Luther Jay, Faje Alexander J, Al-Hawary Mahmoud, Kao John Y. Anaplastic lymphoma masquerading as sclerosing mesenteritis: a case report. Journal of gastrointestinal cancer. 2012 Jun. 43(2): 364-6. PMID# 21360272

Lok Anna S F, Ward John W, Perrillo Robert P, McMahon Brian J, Liang T Jake. Reactivation of hepatitis B during immunosuppressive therapy: potentially fatal yet preventable. Annals of internal medicine. 2012 May 15. 156(10): 743-5. PMID# 22586011

Zhang Wen-Jie, Sui Yan-Xia, Budha Arun, Zheng Jian-Bao, Sun Xue-Jun, Hou Ying-Chun, Wang Thomas D, Lu Shao-Ying. Affinity peptide developed by phage display selection for targeting gastric cancer. World journal of gastroenterology : WJG. 2012 May 7. 18(17): 2053-60. PMID# 22563192

Singal Amit G, Conjeevaram Hari S, Volk Michael L, Fu Sherry, Fontana Robert J, Askari Fred, Su Grace L, Lok Anna S, Marrero Jorge A. Effectiveness of hepatocellular carcinoma surveillance in patients with cirrhosis. Cancer epidemiology, biomarkers&prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2012 May. 21(5): 793-9. PMID# 22374994

Aldrich Melissa B, Marshall Milton V, Sevick-Muraca Eva M, Lanza Greg, Kotyk John, Culver Joseph, Wang Lihong V, Uddin Jashim, Crews Brenda C, Marnett Lawrence J, Liao Joseph C, Contag Chris, Crawford James M, Wang Ken, Reisdorph Bill, Appelman Henry, Tur Seeing it through: translational validation of new medical imaging modalities. Biomedical optics express. 2012 Apr 1. 3(4): 764-76. PMID# 22574264

Internal Medicine – General Medicine

Maslowsky Julie, Valsangkar Bina, Chung Jennifer, Rasanathan Jennifer, Cruz Freddy Trujillo, Ochoa Marco, Chiriboga Monica, Astudillo Fernando, Heisler Michele, Merajver Sofia. Engaging patients via mobile phone technology to assist follow-up after hospitalization in Quito, Ecuador. Telemedicine journal and e-health : the official journal of the American Telemedicine Association. 2012 May. 18(4): 277-83. PMID# 22428551

Internal Medicine – Geriatric Medicine

Gure Tanya R, McCammon Ryan J, Cigolle Christine T, Koelling Todd M, Blaum Caroline S, Langa Kenneth M. Predictors of self-report of heart failure in a population-based survey of older adults. Circulation. Cardiovascular quality and outcomes. 2012 May 1. 5(3): 396-402. PMID# 22592753

Internal Medicine – Hematology and Oncology

Uddin Nazneen, Fateem Elham, Hablas Ahmed, Seifeldin Ibrahim A, Brown Elissa, Merajver Sofia D, Soliman Amr S. Erratum to: Public and Professional Educational Needs for Downstaging Breast Cancer in Egypt. Journal of cancer education : the official journal of the American Association for Cancer Education. 2012 Jun. 27(2): 393. PMID# 22241023

Park Serk In, Liao Jinhui, Berry Janice E, Li Xin, Koh Amy J, Michalski Megan E, Eber Matthew R, Soki Fabiana N, Sadler David, Sud Sudha, Tisdelle Sandra, Daignault Stephanie D, Nemeth Jeffrey A, Snyder Linda A, Wronski Thomas J, Pienta Kenneth J, McCaule Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis. Cancer research. 2012 May 15. 72(10): 2522-32. PMID# 22589273

Camacho Daniel F, Pienta Kenneth J. Disrupting the networks of cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 May 15. 18(10): 2801-8. PMID# 22442061

Mungamuri Sathish Kumar, Benson Erica Kay, Wang Shaomeng, Gu Wei, Lee Sam W, Aaronson Stuart A. p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nature structural&molecular biology. 2012 May. 19(5): 478-84, S1. PMID# 22466965

Pedersen Elisabeth A, Shiozawa Yusuke, Pienta Kenneth J, Taichman Russell S. The prostate cancer bone marrow niche: more than just 'fertile soil'. Asian journal of andrology. 2012 May. 14(3): 423-7. PMID# 22367179

Shedden K, Li Y, Ouillette P, Malek S N. Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in NOTCH1 exon 34. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2012 May. 26(5): 1108-10. PMID# 22182918

Lutz Expert Panel On Radiation Oncology-Bone Metastases Stephen T, Lo Simon Shek-Man, Chang Eric L, Galanopoulos Nicholas, Howell David D, Kim Edward Y, Konski Andre A, Pandit-Taskar Neeta D, Ryu Samuel, Silverman Larry N, Van Poznak Catherine, Weber Kris ACR Appropriateness Criteria® Non-Spine Bone Metastases. Journal of palliative medicine. 2012 May. 15(5): 521-6. PMID# 22536988

Internal Medicine – Infectious Diseases

Aronoff David M, Bergin Ingrid L, Lewis Casey, Goel Deepti, O'Brien Edmund, Peters-Golden Marc, Mancuso Peter. E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins&other lipid mediators. 2012 May. 98(1-2): 23-30. PMID# 22575745

Ning Ning, Pan Qin, Zheng Fang, Teitz-Tennenbaum Seagal, Egenti Martin, Yet Ji, Li Mu, Ginestier Christophe, Wicha Max S, Moyer Jeffrey S, Prince Mark E P, Xu Yingxin, Zhang Xiao-Lian, Huang Shiang, Chang Alfred E, Li Qiao. Cancer stem cell vaccination confers significant antitumor immunity. Cancer research. 2012 Apr 1. 72(7): 1853-64. PMID# 22473314

Internal Medicine – Metabolism, Endocrinology & Diabetes

Hinder Lucy M, Vincent Andrea M, Burant Charles F, Pennathur Subramaniam, Feldman Eva L. Bioenergetics in diabetic neuropathy: what we need to know. Journal of the peripheral nervous system : JPNS. 2012 May. 17 Suppl 2(): 10-4. PMID# 22548617

Internal Medicine – Molecular Medicine & Genetics

Uhlmann Wendy R, Sharp Richard R. Genetic testing integration panels (GTIPs): a novel approach for considering integration of direct-to-consumer and other new genetic tests into patient care. Journal of genetic counseling. 2012 Jun. 21(3): 374-81. PMID# 22246561

Sartor Maureen A, Ade Alex, Wright Zach, States David, Omenn Gilbert S, Athey Brian, Karnovsky Alla. Metab2MeSH: annotating compounds with medical subject headings. Bioinformatics (Oxford, England). 2012 May 15. 28(10): 1408-10. PMID# 22492643

Nesse Randolph M, Ganten Detlev, Gregory T Ryan, Omenn Gilbert S. Evolutionary molecular medicine. Journal of molecular medicine (Berlin, Germany). 2012 May. 90(5): 509-22. PMID# 22544168

Qin Shizhen, Zhou Yong, Lok Anna S, Tsodikov Alex, Yan Xiaowei, Gray Li, Yuan Min, Moritz Robert L, Galas David, Omenn Gilbert S, Hood Leroy. SRM targeted proteomics in search for biomarkers of HCV-induced progression of fibrosis to cirrhosis in HALT-C patients. Proteomics. 2012 Apr. 12(8): 1244-52. PMID# 22577025

Internal Medicine – Nephrology

Zhang Hui, Schaubel Douglas E, Kalbfleisch John D, Bragg-Gresham Jennifer L, Robinson Bruce M, Pisoni Ronald L, Canaud Bernard, Jadoul Michel, Akiba Takashi, Saito Akira, Port Friedrich K, Saran Rajiv. Dialysis outcomes and analysis of practice patterns suggests the dialysis schedule affects day-of-week mortality. Kidney international. 2012 Jun. 81(11): 1108-15. PMID# 22297673

Shahinian Vahakn B. High-risk prostate cancer: is androgen deprivation monotherapy still appropriate? Asian journal of andrology. 2012 May. 14(3): 419-20. PMID# 22306913

Hinder Lucy M, Vincent Andrea M, Burant Charles F, Pennathur Subramaniam, Feldman Eva L. Bioenergetics in diabetic neuropathy: what we need to know. Journal of the peripheral nervous system : JPNS. 2012 May. 17 Suppl 2(): 10-4. PMID# 22548617

Internal Medicine – Pulmonary and Critical Care

Erb-Downward John R, Huffnagle Gary B, Martinez Fernando J. The microbiota in respiratory disease. American journal of respiratory and critical care medicine. 2012 May 15. 185(10): 1037-8. PMID# 22589308

Raghu Ganesh, Collard Harold R, Anstrom Kevin J, Flaherty Kevin R, Fleming Thomas R, King Talmadge E, Martinez Fernando J, Brown Kevin K. Idiopathic pulmonary fibrosis: clinically meaningful primary endpoints in phase 3 clinical trials. American journal of respiratory and critical care medicine. 2012 May 15. 185(10): 1044-8. PMID# 22505745

Aronoff David M, Bergin Ingrid L, Lewis Casey, Goel Deepti, O'Brien Edmund, Peters-Golden Marc, Mancuso Peter. E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins&other lipid mediators. 2012 May. 98(1-2): 23-30. PMID# 22575745

Medical Education

Mullan Patricia B. Promoting international cancer education: report from the 2012 European association for cancer education. Journal of cancer education : the official journal of the American Association for Cancer Education. 2012 Jun. 27(2): 197-8. PMID# 22539054

Microbiology and Immunology

Finefield Jennifer M, Sherman David H, Kreitman Martin, Williams Robert M. Enantiomeric natural products: occurrence and biogenesis. Angewandte Chemie (International ed. in English). 2012 May 14. 51(20): 4802-36. PMID# 22555867

Tsang Tiffany M, Annis Douglas S, Kronshage Malte, Fenno Jesse T, Usselman Lisa D, Mosher Deane F, Krukonis Eric S. Ail Protein Binds Ninth Type III Fibronectin Repeat (9FNIII) within Central 120-kDa Region of Fibronectin to Facilitate Cell Binding by Yersinia pestis. The Journal of biological chemistry. 2012 May 11. 287(20): 16759-67. PMID# 22447929

Molecular & Integrative Physiology

Linford Nancy J, Chan Tammy P, Pletcher Scott D. Re-Patterning Sleep Architecture in Drosophila through Gustatory Perception and Nutritional Quality. PLoS genetics. 2012 May. 8(5): e1002668. PMID# 22570630

Kuo Tsung-Han, Fedina Tatyana Y, Hansen Ingrid, Dreisewerd Klaus, Dierick Herman A, Yew Joanne Y, Pletcher Scott D. Insulin signaling mediates sexual attractiveness in Drosophila. PLoS genetics. 2012 Apr. 8(4): e1002684. PMID# 22570625

Neurology

Glass Jonathan D, Boulis Nicholas M, Johe Karl, Rutkove Seward B, Federici Thais, Polak Meraida, Kelly Crystal, Feldman Eva L. Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem cells (Dayton, Ohio). 2012 Jun. 30(6): 1144-51. PMID# 22415942

Villa-Diaz L G, Brown S E, Liu Y, Ross A M, Lahann J, Parent J M, Krebsbach P H. Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates. Stem cells (Dayton, Ohio). 2012 Jun. 30(6): 1174-81. PMID# 22415987

Dong Hairong, Blaivas Mila, Wang Michael M. Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain research. 2012 May 25. 1456(): 64-71. PMID# 22503071

Skolarus L E, Meurer W J, Burke J F, Prvu Bettger J, Lisabeth L D. Effect of insurance status on postacute care among working age stroke survivors. Neurology. 2012 May 15. 78(20): 1590-5. PMID# 22551730

Hinder Lucy M, Vincent Andrea M, Burant Charles F, Pennathur Subramaniam, Feldman Eva L. Bioenergetics in diabetic neuropathy: what we need to know. Journal of the peripheral nervous system : JPNS. 2012 May. 17 Suppl 2(): 10-4. PMID# 22548617

Costa Maria do Carmo, Paulson Henry L. Toward understanding Machado-Joseph disease. Progress in neurobiology. 2012 May. 97(2): 239-57. PMID# 22133674

Rudakova E V, Makhaeva G F, Galenko T G, Aksinenko A Yu, Sokolov V B, Richardson R J, Martynov I V. Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects. Doklady. Biochemistry and biophysics. 2012 Mar-Apr. 443(): 81-5. PMID# 22562631

Neurosurgery

Wang Lin, Rahman Shayan, Lin Chia-Ying, Valdivia Juan, Than Khoi, Marca Frank La, Park Paul. A novel murine model of human renal cell carcinoma spinal metastasis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2012 Jun. 19(6): 881-3. PMID# 22516545

Ophthalmology & Visual Sciences

Heitor de Paula Fernando, Kamyar Roheena, Shtein Roni M, Sugar Alan, Mian Shahzad I. Endothelial keratoplasty without descemet stripping after failed penetrating keratoplasty. Cornea. 2012 Jun. 31(6): 645-8. PMID# 22391580

Fernando Roshini, Atkins Stephen, Raychaudhuri Nupur, Lu Ying, Li Bin, Douglas Raymond S, Smith Terry J. Human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Proceedings of the National Academy of Sciences of the United States of America. 2012 May 8. 109(19): 7427-32. PMID# 22517745

Shtein Roni M, Kelley Kurt H, Musch David C, Sugar Alan, Mian Shahzad I. In vivo confocal microscopic evaluation of corneal wound healing after femtosecond laser-assisted keratoplasty. Ophthalmic surgery, lasers&imaging : the official journal of the International Society for Imaging in the Eye. 2012 May 1. 43(3): 205-13. PMID# 22329795

Gillespie Erin F, Papageorgiou Konstantinos I, Fernando Roshini, Raychaudhuri Nupur, Cockerham Kimberly P, Charara Laya K, Goncalves Allan C P, Zhao Shuang-Xia, Ginter Anna, Lu Ying, Smith Terry J, Douglas Raymond S. Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production. The Journal of clinical endocrinology and metabolism. 2012 May. 97(5): E740-6. PMID# 22399514

Otolaryngology

Garadat Soha N, Zwolan Teresa A, Pfingst Bryan E. Across-site patterns of modulation detection: relation to speech recognition. The Journal of the Acoustical Society of America. 2012 May. 131(5): 4030-41. PMID# 22559376

Ning Ning, Pan Qin, Zheng Fang, Teitz-Tennenbaum Seagal, Egenti Martin, Yet Ji, Li Mu, Ginestier Christophe, Wicha Max S, Moyer Jeffrey S, Prince Mark E P, Xu Yingxin, Zhang Xiao-Lian, Huang Shiang, Chang Alfred E, Li Qiao. Cancer stem cell vaccination confers significant antitumor immunity. Cancer research. 2012 Apr 1. 72(7): 1853-64. PMID# 22473314

Pathology

Harting Mandy S, Ludgate Mathew W, Fullen Douglas R, Johnson Timothy M, Bichakjian Christopher K. Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma. Journal of the American Academy of Dermatology. 2012 Jun. 66(6): 923-7. PMID# 21978573

Valiathan Rajeshwari R, Marco Marta, Leitinger Birgit, Kleer Celina G, Fridman Rafael. Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer metastasis reviews. 2012 Jun. 31(1-2): 295-321. PMID# 22366781

McCauley Laurie K, Martin T John. Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012 Jun. 27(6): 1231-9. PMID# 22549910

Dong Hairong, Blaivas Mila, Wang Michael M. Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain research. 2012 May 25. 1456(): 64-71. PMID# 22503071

Thompson Andrea D, Makley Leah N, McMenimen Kathryn, Gestwicki Jason E. The three cornerstones of chemical biology: innovative probes, new discoveries, and enabling tools. ACS chemical biology. 2012 May 18. 7(5): 791-6. PMID# 22594530

Petersen Bryan C, Lukacs Nicholas W. IL-17A and IL-25: therapeutic targets for allergic and exacerbated asthmatic disease. Future medicinal chemistry. 2012 May. 4(7): 833-6. PMID# 22571608

Poisson Laila M, Sreekumar Arun, Chinnaiyan Arul M, Ghosh Debashis. Pathway-directed weighted testing procedures for the integrative analysis of gene expression and metabolomic data. Genomics. 2012 May. 99(5): 265-74. PMID# 22497771

Pediatrics & Communicable Diseases

Felt Barbara T, Peirano Patricio, Algarín Cecilia, Chamorro Rodrigo, Sir Teresa, Kaciroti Niko, Lozoff Betsy. Long-term neuroendocrine effects of iron-deficiency anemia in infancy. Pediatric research. 2012 Jun. 71(6): 707-12. PMID# 22337224

Gowda Charitha, Carlos Ruth C, Butchart Amy T, Singer Dianne C, Davis Matthew M, Clark Sarah J, Dempsey Amanda F. CHIAS: A Standardized Measure of Parental HPV Immunization Attitudes and Beliefs and Its Associations With Vaccine Uptake. Sexually transmitted diseases. 2012 Jun. 39(6): 475-81. PMID# 22592835

Skurnik David, Davis Michael R, Benedetti Dennis, Moravec Katie L, Cywes-Bentley Colette, Roux Damien, Traficante David C, Walsh Rebecca L, Maira-Litràn Tomas, Cassidy Sara K, Hermos Christina R, Martin Thomas R, Thakkallapalli Erin L, Vargas Sara O, McAd Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. The Journal of infectious diseases. 2012 Jun. 205(11): 1709-18. PMID# 22448004

Patrick Stephen W, Schumacher Robert E, Benneyworth Brian D, Krans Elizabeth E, McAllister Jennifer M, Davis Matthew M. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. JAMA : the journal of the American Medical Association. 2012 May 9. 307(18): 1934-40. PMID# 22546608

Patrick Stephen W, Schumacher Robert E, Benneyworth Brian D, Krans Elizabeth E, McAllister Jennifer M, Davis Matthew M. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. JAMA : the journal of the American Medical Association. 2012 May 9. 307(18): 1934-40. PMID# 22546608

Lu Jimmy C, Dorfman Adam L, Attili Anil K, Ghadimi Mahani Maryam, Dillman Jonathan R, Agarwal Prachi P. Evaluation with Cardiovascular MR Imaging of Baffles and Conduits Used in Palliation or Repair of Congenital Heart Disease. Radiographics : a review publication of the Radiological Society of North America, Inc. 2012 May. 32(3): E107-27. PMID# 22582368

Bedoyan Jirair Krikor, Schaibley Valerie M, Peng Weiping, Bai Yongsheng, Mondal Kajari, Shetty Amol C, Durham Mark, Micucci Joseph A, Dhiraaj Arti, Skidmore Jennifer M, Kaplan Julie B, Skinner Cindy, Schwartz Charles E, Antonellis Anthony, Zwick Michael E Disruption of RAB40AL function leads to Martin-Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder. Journal of medical genetics. 2012 May. 49(5): 332-40. PMID# 22581972

Telfer William R, Nelson Darcee D, Waugh Trent, Brooks Susan V, Dowling James J. neb: a zebrafish model of nemaline myopathy due to nebulin mutation. Disease models&mechanisms. 2012 May. 5(3): 389-96. PMID# 22159874

Sadigh Gelareh, Dempsey Amanda F, Ruffin Mack, Resnicow Ken, Carlos Ruth C. National patterns in human papillomavirus vaccination: An analysis of the National Survey of Family Growth. Human vaccines&immunotherapeutics. 2012 Feb 1. 8(2): 234-42. PMID# 22414967

Pharmacology

Sharma Shilpy, Shah Nicholas A, Joiner Ariell M, Roberts Katelyn H, Canman Christine E. DNA Polymerase ¿ Is a Major Determinant of Resistance to Platinum-Based Chemotherapeutic Agents. Molecular pharmacology. 2012 Jun. 81(6): 778-87. PMID# 22387291

Manglik Aashish, Kruse Andrew C, Kobilka Tong Sun, Thian Foon Sun, Mathiesen Jesper M, Sunahara Roger K, Pardo Leonardo, Weis William I, Kobilka Brian K, Granier Sébastien. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 May 17. 485(7398): 321-6. PMID# 22437502

Lee Tien-Yi, Park Yoon Shin, Garcia George A, Sunahara Roger K, Woods James H, Yang Victor C. Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination. Molecular pharmaceutics. 2012 May 7. 9(5): 1361-73. PMID# 22404344

Physical Medicine & Rehabilitation

Drag Lauren L, Spencer Robert J, Walker Sara J, Pangilinan Percival H, Bieliauskas Linas A. The contributions of self-reported injury characteristics and psychiatric symptoms to cognitive functioning in OEF/OIF veterans with mild traumatic brain injury. Journal of the International Neuropsychological Society : JINS. 2012 May. 18(3): 576-84. PMID# 22390876

Psychiatry

Valenstein Marcia, Kim Hyungjin Myra, Ganoczy Dara, Eisenberg Daniel, Pfeiffer Paul N, Downing Karen, Hoggatt Katherine, Ilgen Mark, Austin Karen L, Zivin Kara, Blow Frederic C, McCarthy John F. Antidepressant agents and suicide death among US Department of Veterans Affairs patients in depression treatment. Journal of clinical psychopharmacology. 2012 Jun. 32(3): 346-53. PMID# 22544011

Yamawaki Shigeto, Okada Go, Okamoto Yasumasa, Liberzon Israel. Mood dysregulation and stabilization: perspectives from emotional cognitive neuroscience. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2012 Jun. 15(5): 681-94. PMID# 21733243

Sen Srijan, Prabhu Maya. Reporting bias in industry-supported medication trials presented at the American Psychiatric Association meeting. Journal of clinical psychopharmacology. 2012 Jun. 32(3): 435. PMID# 22561482

Sartor Maureen A, Ade Alex, Wright Zach, States David, Omenn Gilbert S, Athey Brian, Karnovsky Alla. Metab2MeSH: annotating compounds with medical subject headings. Bioinformatics (Oxford, England). 2012 May 15. 28(10): 1408-10. PMID# 22492643

Drag Lauren L, Spencer Robert J, Walker Sara J, Pangilinan Percival H, Bieliauskas Linas A. The contributions of self-reported injury characteristics and psychiatric symptoms to cognitive functioning in OEF/OIF veterans with mild traumatic brain injury. Journal of the International Neuropsychological Society : JINS. 2012 May. 18(3): 576-84. PMID# 22390876

Capoccia Victor A, Grazier Kyle L, Toal Christopher, Ford James H, Gustafson David H. Massachusetts's experience suggests coverage alone is insufficient to increase addiction disorders treatment. Health affairs (Project Hope). 2012 May. 31(5): 1000-8. PMID# 22566439

Nesse Randolph M, Ganten Detlev, Gregory T Ryan, Omenn Gilbert S. Evolutionary molecular medicine. Journal of molecular medicine (Berlin, Germany). 2012 May. 90(5): 509-22. PMID# 22544168

Radiation Oncology

Williams Terence M, Flecha Athena R, Keller Paul, Ram Ashwin, Karnak David, Galbán Stefanie, Galbán Craig J, Ross Brian D, Lawrence Theodore S, Rehemtulla Alnawaz, Sebolt-Leopold Judith. Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer. Molecular cancer therapeutics. 2012 May. 11(5): 1193-202. PMID# 22411900

Radiology

Hansen Neil, Sanchez Ramon, Ivancic Vesna. Unusual combination of bilateral testicular microlithiasis and tubular ectasia of the rete testis with left intra- and extratesticular varicocele in a 17-year-old boy. Journal of clinical ultrasound : JCU. 2012 Jun. 40(5): 314-8. PMID# 21953309

Gowda Charitha, Carlos Ruth C, Butchart Amy T, Singer Dianne C, Davis Matthew M, Clark Sarah J, Dempsey Amanda F. CHIAS: A Standardized Measure of Parental HPV Immunization Attitudes and Beliefs and Its Associations With Vaccine Uptake. Sexually transmitted diseases. 2012 Jun. 39(6): 475-81. PMID# 22592835

Foerster B R, Callaghan B C, Petrou M, Edden R A E, Chenevert T L, Feldman E L. Decreased motor cortex ¿-aminobutyric acid in amyotrophic lateral sclerosis. Neurology. 2012 May 15. 78(20): 1596-600. PMID# 22517106

Williams Terence M, Flecha Athena R, Keller Paul, Ram Ashwin, Karnak David, Galbán Stefanie, Galbán Craig J, Ross Brian D, Lawrence Theodore S, Rehemtulla Alnawaz, Sebolt-Leopold Judith. Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer. Molecular cancer therapeutics. 2012 May. 11(5): 1193-202. PMID# 22411900

Lu Jimmy C, Dorfman Adam L, Attili Anil K, Ghadimi Mahani Maryam, Dillman Jonathan R, Agarwal Prachi P. Evaluation with Cardiovascular MR Imaging of Baffles and Conduits Used in Palliation or Repair of Congenital Heart Disease. Radiographics : a review publication of the Radiological Society of North America, Inc. 2012 May. 32(3): E107-27. PMID# 22582368

Sadigh Gelareh, Dempsey Amanda F, Ruffin Mack, Resnicow Ken, Carlos Ruth C. National patterns in human papillomavirus vaccination: An analysis of the National Survey of Family Growth. Human vaccines&immunotherapeutics. 2012 Feb 1. 8(2): 234-42. PMID# 22414967

Surgery

Wilcox Ryan A, Ansell Stephen M, Lim Megan S, Zou Weiping, Chen Lieping. The B7 Homologues and their Receptors in Hematologic Malignancies. European journal of haematology. 2012 Jun. 88(6): 465-75. PMID# 22372959

Surgery – General Surgery

Ghaferi Amir A, Dimick Justin B. Variation in mortality after high-risk cancer surgery: failure to rescue. Surgical oncology clinics of North America. 2012 Jul. 21(3): 389-95. PMID# 22583988

Laird Amanda M, Gauger Paul G, Miller Barbra S, Doherty Gerard M. Evaluation of Postoperative Radioactive Iodine Scans in Patients who Underwent Prophylactic Central Lymph Node Dissection. World journal of surgery. 2012 Jun. 36(6): 1268-73. PMID# 22270997

Yan Zhe, Liu Yang, Huang Hui. Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. Asian Pacific journal of tropical medicine. 2012 Jun. 5(6): 469-71. PMID# 22575980

Xu G, Wang Z, Li Y, Li Z, Tang H, Zhao J, Xiang X, Ding L, Ma L, Yuan F, Fei J, Wang W, Wang N, Guan Y, Tang C, Mulholland M, Zhang W. Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice. Diabetologia. 2012 Jun. 55(6): 1813-23. PMID# 22391948

Ning Ning, Pan Qin, Zheng Fang, Teitz-Tennenbaum Seagal, Egenti Martin, Yet Ji, Li Mu, Ginestier Christophe, Wicha Max S, Moyer Jeffrey S, Prince Mark E P, Xu Yingxin, Zhang Xiao-Lian, Huang Shiang, Chang Alfred E, Li Qiao. Cancer stem cell vaccination confers significant antitumor immunity. Cancer research. 2012 Apr 1. 72(7): 1853-64. PMID# 22473314

Surgery – Plastic Surgery

Pannucci Christopher J, Shanks Amy, Moote Marc J, Bahl Vinita, Cederna Paul S, Naughton Norah N, Wakefield Thomas W, Henke Peter K, Campbell Darrell A, Kheterpal Sachin. Identifying patients at high risk for venous thromboembolism requiring treatment after outpatient surgery. Annals of surgery. 2012 Jun. 255(6): 1093-9. PMID# 22584630

Unit for Laboratory Animal Medicine

Aronoff David M, Bergin Ingrid L, Lewis Casey, Goel Deepti, O'Brien Edmund, Peters-Golden Marc, Mancuso Peter. E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins&other lipid mediators. 2012 May. 98(1-2): 23-30. PMID# 22575745

Urology

Clemens J Quentin. Con. The Journal of urology. 2012 Jun. 187(6): 1963-5. PMID# 22503026

Hampson Lindsay A, Montie James E. Conflict of interest in urology. The Journal of urology. 2012 Jun. 187(6): 1971-7. PMID# 22498209

Bellinger Adam S, Elliott Sean P, Yang Liu, Wei John T, Saigal Christopher S, Smith Alexandria, Wilt Timothy J, Strope Seth A. Changes in initial expenditures for benign prostatic hyperplasia evaluation in the Medicare population: a comparison to overall Medicare inflation. The Journal of urology. 2012 May. 187(5): 1739-46. PMID# 22425128

Skolarus Ted A, Weizer Alon Z, Hedgepeth Ryan C, He Chang, Wood David P, Hollenbeck Brent K. Understanding early functional recovery after robotic prostatectomy. Surgical innovation. 2012 Mar. 19(1): 5-10. PMID# 21521701

 


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