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JUNE 2012, Vol. 30

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HEADLINES

Be a Part of the Strategic Research Initiative

Strategic Research Initiative

Strategic Research InitiativeSteven L. Kunkel, Ph.D., Senior Associate Dean for Research, Endowed Professor in Pathology Research

On June 11th, the Medical School Office of Research held a retreat with more than 100 of our leading researchers to focus on the scientific component of our research strategic plan.  The objective of the retreat was to identify how to best leverage our existing deep research expertise into a more integrated research approach. The research strategic plan, which is part of the overall UMHS strategic plan, was purposefully organized around existing areas of research excellence and creating new synergies by aligning interests, expertise, and infrastructure to address significant health issues.  By converging and focusing our strengths in a selected manner, the Medical School aims to FASTFORWARD solutions that exceed the scope of individual investigators and individual disciplines.

The research strategic plan was developed with input from leadership, faculty and staff across the Health System. The plan was assembled mindful of the broad spectrum of our research faculty and their investigative efforts, including basic, translational, clinical, and health outcomes research. Earlier this year, the Research Board of Directors was launched as a part of the strategic research initiative and includes all department chairs, representatives from the Medical School’s major centers and institutes, and leadership from the Office of Research and Health System. The Board’s role is to provide the intellectual, academic, and financial support required to drive the research enterprise forward.

The strategic research initiative maps our strengths, identifies our weaknesses, and outlines a path for the future. Taking action to make our scientific concepts a reality, the retreat participants identified opportunities that exist at the intersections of our strengths. Ultimately, the opportunities were distilled into ten research concepts. Each concept will receive $10,000 in planning funds to engage the broader research community in transforming the concepts into mature, robust proposals for funding consideration. The Dean of the Medical School has committed $100 million in new funds to resource the strategic research initiative, nearly half of which will be invested in the proposals stemming from the research concepts. You can learn more about the ten research concepts here.

You can also indicate your interest in participating in the next steps of our strategic research initiative.

Continue to watch for FASTFORWARD communications to stay up to date on the research strategic initiative.

FastForward to Tomorrow's Cures
Save the Date for Researchpalooza! August 22
Researchpalooza

Wednesday, August 22, 2012
11:00 AM - 2:00 PM
Location TBD

Join the UMMS Office of Research for the third annual Researchpalooza during the annual Ice Cream Social, with 50+ exhibitors from labs and offices of the Medical School and across campus. Researchpalooza is the perfect opportunity for colleagues and friends to have a great time and meet, mingle, and learn more about many of the organizations that offer their stellar services to faculty, students, and staff, all at one convenient time and location.

Visit the website for more details.

If your office is interested in exhibiting, view more information here.

Report Your Outside Interests, Activities, or Relationships Starting July 1, 2012

---------------  Changes Going into Effect! ---------------

As in previous years, UMHS Policy requires faculty members, house officers/fellows, executives, and management staff to disclose outside interests, activities, or relationships related to their work or position at UMHS.  To comply with this policy, enter your outside interest disclosures during the month of July, update your disclosures within 30 days of any change, and also at least annually if there have been no changes.


Beginning July 1, 2012, access the outside interest disclosure system, M-Inform, at
http://www.umms.med.umich.edu/minform/



Note that new Federal rules regarding disclosure and management of conflicts of interest related to PHS-funded research go into effect in August 2012.  With only a few changes, M-Inform, which has been used by UMHS for years, is well positioned to accommodate these new rules.  Watch for more information in the coming weeks, but in the meantime, key changes that you will notice include:

  • You will be required to report information regarding the past year (in addition to the upcoming year).
  • Throughout the year, any addition or other change must be entered within 30 days.
  • Disclosure must include information about any travel paid for or reimbursed by the outside organization.
  • Failure to complete disclosure or manage conflicts by deadlines could result in delay of Federal grant submission/award.

Definitions that may be helpful to keep in mind as you prepare to make your disclosure include:

  • Outside organization means an organization other than the University of Michigan or a Federal agency.  An outside organization can be domestic or foreign, public or private, for-profit or non-profit.
  • Outside interest, activity, or relationship means any paid or unpaid interest, activity, or relationship with an outside organization.
  • Related to your institutional responsibilities means any interest, activity, or relationship that relies upon the same expertise as does your ability to carry out your University responsibilities; as well as any interest, activity, or relationship that has the potential to influence the duties that the University considers to be part of your work.  In this regard, “institutional responsibilities” means a person’s professional responsibilities on behalf of the University, such as research, teaching, professional practice, and institutional committee membership.

Examples of interests, activities, or relationships that should not be reported include salary and/or other support administered by ORSP (such as a grant from NIH or a research contract from Pfizer), and service as an NIH reviewer.

For more information on the outside interest disclosure process or the M-Inform system, visit http://www.med.umich.edu/u/coi/.

For general questions, send an email to coi-oid-questions@med.umich.edu.

View information about:

Other UM policies regarding conflict of interest are available at:

Lab Safety This Summer and All Year Long

Research faculty must provide a safe research and educational environment for staff and students.  While it is impossible to create a zero-risk environment in a research laboratory, the Department of Occupational Safety and Environmental Health (OSEH) provides faculty the guidance listed below to assist them in providing a research environment free of recognized safety deficiencies:

  • Provide lab coats, safety glasses, and gloves to all lab users and aggressively ensure that they are used.  Ensure proper clothing is worn in the lab.  Shorts, sandals, and other attire that leave the legs exposed are not allowed.  During summer months, encourage staff to bring or leave a pair of long pants and closed-toe shoes to change into at the beginning of the workday.   Do not permit unsafe behaviors in the lab to go unchallenged.  Support lab members who wear proper safety equipment and challenge those who do not. 
  • Keep lab safety training current.  All laboratory staff must complete the Comprehensive Laboratory Safety training course and receive laboratory-specific training.  Students must complete similar training and be closely supervised when working in the lab.
  • Identify high-risk activities in the laboratory and provide task-specific training.  Document the training in your laboratory Chemical Hygiene Plan.  OSEH can assist you with training and risk assessments.
  • Participate in lab safety audits.  Assign your lab manager or senior lab member to participate in the audit if you cannot attend, and review audit results as soon as practicable.  Correct the deficiencies identified by the audit as quickly as possible and reply to OSEH with confirmation of completion.

For more information about lab safety, visit http://www.oseh.umich.edu/.

Best wishes for a safe and productive summer in the laboratory!

UMMS Regulatory Affairs
UMMS-RegAffairs@med.umich.edu
http://msa.med.umich.edu/RegulatoryAffairs
734-764-6730

International Adrenal Cancer Consortium, Started at the University of Michigan, Publishes Its First Collaborative Research Results
David Edward Schteingart, M.D.David Edward Schteingart, M.D.

Initial results from a first-of-its-kind international consortium of adrenal cancer researchers were recently published in the New England Journal of Medicine (May 2, 2012, online at NEJM.org). The consortium grew out of an international adrenal cancer symposium organized by David Edward Schteingart, M.D., Professor Emeritus of Internal Medicine in the Division of Metabolism, Endocrinology & Diabetes, and hosted by the Endocrinology Oncology program at the University of Michigan Health System in 2003.

This large-scale international collaboration consisted of trials with 304 patients conducted at 40 adrenal cancer specialty centers across 12 countries. The consortium’s collaborative research agreement also allowed the group to better negotiate for resources to study the disease in the lab and in the clinic.

A large-scale study of this magnitude is “so critical for a rare disease,” stated Gary Hammer, M.D., Ph.D., Millie Schembechler Professor of Adrenal Cancer and director of the Endocrine Oncology Program. About 600 Americans a year are diagnosed with adrenal cancer and almost all will die within five years of diagnosis.

Because of the small number of people diagnosed, conducting clinical research to improve treatments is challenging for individual cancer programs and physicians, who do not see enough patients with this disease. “In order to study enough patients, we needed to pull together available resources in many different places,” said Dr. Schteingart. “And that’s what happened. For rare diseases, it’s essential to have this type of collaborative effort in order to glean useful information for treating patients.”

The researchers compared the two most successful combination chemotherapy treatments for adrenal cancer. It was shown that one treatment staved off progression of the disease longer than the other option. However, neither regimen improved how long patients lived.

The researchers will continue to meet at international Adrenal Cancer Consortium meetings every two years. For more about the paper, see the press release.  (Information from this press release by Justin Harris is included in this article.)


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Human Research

The University of Michigan IRB Collaborative (U-MIC)

The University of Michigan’s institutional review boards work together to make multimedia educational material available online. The University of Michigan IRB Collaborative (U-MIC)—launched this past spring—offers nearly a dozen short videos and voiceover slideshows, treating various topics in human subjects research ethics. New presentations are constantly in development, and U-MIC invites members of the research community to recommend topics for future presentations.

Please contact the IRBMED office for more information about U-MIC.

 

Animal Research

Why Are Pharmaceutical Grade Compounds Important in Animal Research?

The Guide for the Care and Use of Laboratory Animals, the USDA Animal Welfare Regulations, and the Public Health Service Policy all require that pharmaceutical-grade substances be used when conducting animal research.  The use of pharmaceutical-grade substances in laboratory animals ensures that the substances administered meet established standards of purity and composition and helps ensure animal health and welfare, as well as the validity of experimental results. The use of lower grade (or reagent-grade) substances can introduce unwanted experimental variables or even toxic effects, and so should be avoided if at all possible. Pharmaceutical grade substances should be used in experimental animals whenever possible; however, the use of non-pharmaceutical-grade substances in experimental animals is an acceptable practice under certain circumstances. The use of non-pharmaceutical-grade substances requires approval by the University Committee on Use and Care of Animals (UCUCA), within your animal use protocol, and must be justified using reasons such as scientific necessity or non-availability of an acceptable veterinary or human pharmaceutical-grade product.  Cost savings alone is not an acceptable justification for use of reagent-grade substances.

So, how do you determine if the substances you are using or plan to use are pharmaceutical grade?  A pharmaceutical grade compound is a drug, biologic, or reagent that is approved by the Food and Drug Administration (FDA) or for which a chemical purity standard has been established by the United States Pharmacopeia-National Formulary (USP-NF), or British Pharmacopeia (BP).  Pharmaceutical grade substances will have an NDC (National Drug Code) number on the box, bottle, or vial and will also contain a lot number and expiration date.  In addition, the source from which you purchase your substances is important.  Only USDA-licensed vendors or FDA licensed pharmacies supply pharmaceutical grade compounds.  Drugs or chemicals obtained from biochemical companies, such as Fisher Scientific or Sigma-Aldrich, are not considered pharmaceutical-grade and require UCUCA justification.  The UCUCA Office or ULAM Office can assist you in identifying sources for pharmaceutical-grade substances. Get more information regarding these requirements by visiting the Office of Laboratory Animal Welfare (OLAW) website.

If you have any questions, please do not hesitate to contact the UCUCA Office (UCUCA-Office@med.umich.edu).  We are always here to help!


SHARPENING THE FOCUS:

Tips on Grant Proposal Preparation

Federal Contracts vs. Grants – Be Sure You Can Deliver

By Chris Black, M.L.S., Assistant Director for Research Services, Office of Research

(This is one in a series of tips published in UMMS Research News about writing proposals.)

If you see a solicitation for a federal contract (as opposed to a grant) that is suited to your scientific strengths, just know that there are differences between the two mechanisms. A contract addresses specific programmatic needs, such as a clinical trial, product development, product testing, or development of an animal model. At NIH, contracts are handled by the Office of Acquisition Management and Policy.

The Office of Research & Sponsored Projects (ORSP) states that a grant from a federal sponsor generally is construed to allow greater discretion than a contract in the conduct of the research, and to provide less specificity in the definition of the intended outcome of the research. A few other ways contracts are different from grants are:

  • contracts are legally binding with specific deadlines and deliverables
  • government oversight of work
  • relatively inflexible as to scope of work
  • payment often based on deliverables and milestones
  • budget, and other changes
  • the contractor usually has the first right to the data produced
  • do not contact anyone in NIH outside of the Office of Acquisition ahead of time to discuss the opportunity
  • typically not renewable.

For more information, visit this page on the ORSP website or the related article in the NIAID Funding Newsletter.


EDUCATIONAL OPPORTUNITIES


Helium Ion Microscopy: Extending the Frontiers in Materials and Bioscience Research

Wednesday, June 20, 2012
9:30 AM
Room 2710 Furstenberg, Medical Sciences Bldg. I

Hosted by the Microscopy and Image Analysis Laboratory (MIL).

Join us to learn how the ability of a helium ion microscope to produce surface-sensitive and high-resolution images of non-conductive samples is enabling cutting-edge research in material science and biosciences.  Professor David Joy, University of Tennessee, will discuss applications for the materials sciences and Professor Dennis Brown, Massachusetts General Hospital, will discuss applications for kidney research.

For questions, contact Jim Smith from Carl Zeiss.  View more information online.

Finding Funding for Medical Research

Thursday, June 21, 2012
9:00 - 11:00 AM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by the University Library.

This workshop will introduce faculty and research administrators in the health sciences seeking sponsored project funding to available resources. The session will cover how to formulate a search strategy and discuss several key internet tools, including the University Library, Office for Research and Sponsored Projects (ORSP) and Foundation Center websites, the Community of Science, SPIN, and Foundation Directory Online funding databases, as well as other ORSP and Library resources.

Register for this workshop.

EndNote for Academic Research and Publishing for the Health Sciences

Wednesday, June 27, 2012
1:00 - 3:00 PM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by the Taubman Health Sciences Library.

This hands-on workshop will provide instruction on using EndNote to support academic research and publications. This software is compatible with many online databases available through the University of Michigan libraries. When using the Microsoft Word add-in, EndNote becomes invaluable for writing manuscripts, grants, and papers for course assignments.

Register for this workshop.

Inserting Graphics into Grant Applications & Other Word Documents

Wednesday, August 1, 2012
10:00 AM - 12:00 PM
Taubman Learning Center, 2802 Medical Sciences Building II

Sponsored by Taubman Health Sciences Libraries.

This workshop offers instruction on the efficient and proper placement of images, charts, and graphics into grant proposal applications. The session will cover basic features in Microsoft Word such as image placement, captioning, and text wrapping. Following a brief presentation and hands-on instruction, instructors will assist you with specific issues you’re encountering in formatting your grant application. The session will cover all versions of Microsoft Word and applies to placement of graphics into any Word document. Please feel free to bring sample documents!  Contact Merle Rosenzweig with any questions. You can also view a video of this workshop and related documentation online.

Register to attend this workshop.


KUDOS


Wrobel Gives 14th Annual Earl Kaplan Memorial Lecture for State Podiatric Association
James Wrobel, DPM, MSJames Wrobel, DPM, MS

Podiatrist James Wrobel, DPM, MS, Associate Professor of Internal Medicine in the Division of Metabolism, Endocrinology & Diabetes, was honored with an award from the Michigan Podiatric Medical Association in March. Dr. Wrobel gave the 14th Annual Earl Kaplan Memorial Lecture at the organization’s State Conference and Great Lakes Conference in Troy, Michigan, entitled “Gait Changes in Diabetes-Related Peripheral Neuropathy.”

Dr. Wrobel also gave a second talk at the four-day conference, on the APMA-Thomson Reuters Study.

The Earl G. Kaplan, DPM, FACS, Memorial Lecturer is chosen “in recognition of extraordinary accomplishments, dedication, and outstanding contributions to podiatric medical education and to podiatric medicine and surgery.”

Kaplan was the founder of Civic Hospital in Ottawa, Ontario, the first podiatric hospital in the world, and established the first podiatric surgical residency. His other accomplishments include founding the Midwest Podiatric Conference and serving as president of the Michigan Podiatric Medical Association, the American Podiatric Medical Association, and the American College of Foot and Ankle Surgeons.

Dr. Schteingart Receives Lifetime Achievement Award from MICHR

The Michigan Institute for Clinical & Health Research (MICHR) honored David Edward Schteingart, M.D., with a special Lifetime Achievement Award for Mentoring in Clinical and Translational Research. Dr. Schteingart is the first recipient of this award, which coincides with the Mentoring Awards program that MICHR instituted this year.

Dr. Schteingart, Professor Emeritus of Internal Medicine in the Division of Metabolism, Endocrinology & Diabetes (MEND), received the award during the Awards Ceremony at MICHR’s Research Education Symposium 2012 held in March.

“The launching of the first-ever MICHR Mentoring Awards presented the perfect opportunity to honor Dr. Schteingart’s career-long dedication to clinical research mentoring,” said Lise (Elizabeth) Anderson, Instructional Designer at MICHR. “The award for Dr. Schteingart was distinct from the nomination process for all the mentoring awards this year. He has been a consistent, steady presence in improving the institutional support for clinical research mentoring.”

Dr. Schteingart was cited for “mentoring more than 100 people during his long and distinguished career at U-M.” The award was presented to Dr. Schteingart by his MEND colleague, Chuck Burant, M.D., Ph.D.

MICHR Awards Ceremony
Chuck Burant, M.D., Ph.D. (left) and Ed Schteingart, M.D. at the MICHR Awards Ceremony.

Stefan Fajans Adds the Steiner Award for Outstanding Mentorship in Diabetes Research to His Honors

Stefan Fajans, M.D., Active Professor Emeritus of Internal Medicine, Division of Metabolism, Endocrinology & Diabetes, was having dinner with three distinguished guests after the 3rd Annual Fajans Lecture in Diabetes on May 4 when he received an unexpected honor: he was awarded the Donald Steiner Award for Outstanding Mentorship in Diabetes Research right at the dinner table!

As far as Dr. Fajans knew, his old friends and colleagues Graeme Bell, Ph.D., and Donald Steiner, M.D., both of the University of Chicago, had come to Ann Arbor to visit him and to attend the Fajans Lecture given by another close friend, Susumu Seino, M.D., D.M. Sci., of Kobe University in Japan. But they also brought a lovely Tiffany glass sculpture inscribed with his name, the award, and the date.

“We believe Steve deserves the Steiner Award more than anybody else,” said Dr. Seino, Professor and Head of the Divisions of Diabetes & Endocrinology and Cellular & Molecular Medicine at Kobe University, who was a 2010 recipient of the award.

The Donald F. Steiner Award for Outstanding Achievement in Diabetes Research was established in 2006 to honor an investigator carrying out research in the field of diabetes. The international, committee-selected award is named for Donald F. Steiner, M.D., the A.N. Pritzker Distinguished Service Professor at the University of Chicago, the diabetes investigator who discovered proinsulin.

In 1958, Fajans began studying a Michigan family with more than 360 members now spanning six generations. The family that would become known as the “R-W pedigree” had an astonishing 74 members with a form of non-insulin-dependent diabetes, now called type 2 diabetes. The disease appeared unusually early in this family – diagnosed in children and adolescents by the age of 25, unlike the usual onset after age 40.

This form of diabetes is inherited in an autosominal dominant fashion, meaning that it appears in approximately 50 percent of each successive generation and is due to a mutation of a single gene. The study of this family, as well as others, led Dr. Fajans to name this form of diabetes as Maturity Onset Diabetes of the Young in 1964, abbreviated as MODY.

During the late 1980s, Dr. Fajans began collaborating with Graeme Bell, Ph.D., Louis Block Professor of Biochemistry & Molecular Biology and Medicine at the University of Chicago. Dr. Fajans co-published the first paper describing a genetic marker of MODY in 1991.

In 1996, Dr. Bell and his colleagues found the MODY gene for the R-W pedigree, designated as MODY 1, and a related gene for MODY 3. Today, Dr. Fajans is still studying the R-W pedigree, as well as families with MODY 2, MODY 3, and MODY 4.

In August 2011, at the age of 93, Dr. Fajans published a review in Diabetes Care with Graeme Bell as co-author. The paper explores MODY and its history, genetics, pathophysiology, and clinical decision-making.

Steiner Award for Outstanding Mentorship in Diabetes Research
(From L to R) Peter Arvan, Donald Steiner, Susumu Seino, Stefan Fajans, and Alan Saltiel (Director, U-M Life Sciences Institute) after the 3rd Annual Fajans Lecture.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

V Foundation for Cancer Research V Scholar Grant
Internal Deadline: June 25, 2012

The V Foundation, founded in 1993 by award-winning coach and commentator Jim Valvano, seeks to find a cure for cancer.  Funding is available for basic science research projects through the V Scholar Grant.  Each grant will total $200,000, and is given in two yearly installments.  This grant has a zero indirect cost policy.

The UM Comprehensive Cancer Center may nominate one individual. To be eligible, the candidate must meet the following criteria:

  • Demonstrated expertise and promise in the designated areas of research
  • Completed at least two years of fellowship training
  • Must currently hold a tenure track faculty position
  • No more than five years since joining the faculty as Instructor or Assistant Professor
  • No more than 10 years since terminal degree (M.D. or Ph.D.) – Exceptions must be approved prior to submission.
  • Not been promoted to Associate Professor

Researchers who have secured their own R01 funding are not eligible for this award.  Applicants with institutional or K08 awards are eligible.

Deadline for submission of a proposal to the Foundation is July 27, 2012.  Grants will be awarded in September 2012 and first payment will be made in October 2012.

For consideration as the institutional nominee, submit ONLY the items below electronically by June 25, 2012 following the instructions listed on the cover sheet.  Download the cover sheet.

  • Cover sheet
  • Two-page outline of the proposed research
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. The V Foundation’s website is (http://www.jimmyv.org).

Searle and Pew Scholars Program Awards
Internal Deadline: Wednesday, August 1, 2012

Nominations of faculty from all units of the University are welcome for both the Searle Scholars Program and the Pew Scholars Program in the Biomedical Sciences. Only one nomination package is required for the internal selection of the University’s nominees for both programs. Faculty members who were nominated but not selected for the 2012 programs may apply for the 2013 programs if they continue to meet program eligibility requirements. Specific program information is noted below.

The internal nomination package must include:

  • Cover sheet (downloaded from the web link below)
  • A letter of nomination from the appropriate department chair or section head. This letter should indicate if the candidate is to be considered for the Searle and/or Pew Scholars Programs. Please also include the nominee's UM start date as an assistant professor (month/date/year).
  • A one to five page research statement including (1) current areas of research and (2) an overview of the specific areas of research the nominee would like to pursue with this funding award. Please also indicate the significance of this work and explain why it is particularly novel and important.
  • A current copy of the nominee's NIH formatted biosketch including a list of any current awards held by the nominee or awards they will have that overlap with the funding period of the Searle or Pew awards. Please also list if you will be applying for any of the following awards and notify us when you apply for these awards:  Rita Allen Scholars, Burroughs-Wellcome Career Awards, Beckman Young Investigators Program, Ellison New Scholar Award, Keck Foundation, Damon-Runyon Early Career Award, and the Kimmel Scholars Award.
  • Any recent letters of support attesting to the potential of the nominee and the quality and scope of his/her research. These letters are for internal review; if they were obtained for another recent award review, please use those.

Please submit all application materials electronically by August 1, 2012 following the instructions listed on the cover sheet. Download the cover sheet.

We acknowledge receipt of all electronic submissions by the end of the next business day. If you do not receive a response from us, please call us at 734-615-8802.



Searle Scholars Program


http://www.searlescholars.net
Applicants for year 2013 awards will be expected to be pursuing independent research careers in biochemistry, cell biology, genetics, immunology, neuroscience, pharmacology, and related areas in chemistry, medicine, and the biological sciences. Candidates should have begun their first appointment at the assistant professor level on or after July 1, 2011 and therefore be in their first or second year in a tenure-track position. The awards are grants of $100,000 per year for three years, with funding for the second and third year contingent upon acceptable progress reports. The sponsor deadline is September 28, 2012. The University of Michigan is allowed to submit two nominations.



Pew Scholars Program in the Biomedical Sciences


http://www.pewtrusts.org/our_work_category.aspx?id=194
The Pew Scholars Program in the Biomedical Sciences is designed to support young investigators of outstanding promise in science relevant to the advancement of human health. The award is intended to provide support for junior faculty as they establish their laboratories. Candidates must hold a doctorate in medicine or biomedical sciences. As of November 1, 2012, candidates must hold full time appointments at the rank of assistant professor. On July 1, 2013, they must not have been in this appointment for more than three years. Applicants with committed awards from the Searle Scholars Program, Rita Allen Scholars, Burroughs-Wellcome Career Awards, Beckman Young Investigators Program, Ellison New Scholar Award, Keck Foundation, Damon-Runyon Early Career Award, and the Kimmel Scholars Award that overlap for the first two years of the Pew Scholarship would not be eligible. Funding from the NIH, other government sources, and project grants from non-profit associations do not pose a conflict with the Pew Scholars Program. The award is $60,000 per year for four years subject to annual review of the Scholar’s progress. The sponsor’s deadline is November 1, 2012 (12:00 PM EDT). The University of Michigan is allowed to submit one nomination.

Contact Camille Mrozowski at 734-615-8802 or (cmrozow@umich.edu) with any questions about these programs.


UMMS AWARDED GRANTS

External Awarded Grants

An asterisk next to a name means that they are the Contact PI for the program, since some projects are awarded with multiple PIs.

Click here to view.

Anesthesiology

PI: *Brummett,Chad
Title: The Impact of Centralized Pain on the Analgesic Response to Cervical and Lumbar Facet Interventions
Sponsor: ASRA
Project Dates and Amount of Award: 01/01/12-12/31/13; $50,000

Cardiac Surgery

PI: *Bolling,Steven
Co-I: Romano, Matthew (Cardiac Surgery)
Title: Medtronic Contour 3D Tricuspid Annuloplasty Ring Post-Market Clinical Trial
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 05/11/12-02/28/14; $199,350

Cell & Developmental Biology

PI: *Barolo,Scott
Title: Interpreting Hedgehog Signaling Gradients With Cis-Regulatory DNA: A Quantitative In Vivo/Computational Approach
Sponsor: NSF
Project Dates and Amount of Award: 06/01/12-05/31/15; $860,235

PI: *Engel,James
Title: 18th Hemoglobin Switching Conference
Sponsor: Amgen, Inc.
Project Dates and Amount of Award: 05/01/12-12/31/12; $3,000

Comprehensive Cancer Center

PI: *Talpaz,Moshe
Co-I: Lebovic, Daniel (Int Med-Hematology/Oncology)
Title: A Phase 1 Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB040093 in Subjects with Previously Treated B-cell Malignancies
Sponsor: Incyte Pharmaceuticals, Inc.
Project Dates and Amount of Award: 04/19/12-04/18/14; $353,950

Dermatology

PI: *Fisher,Gary
Awardee / Fellow: Wang, Frank
Title: Reversal of Aged Skin Appearance by Enhancing Structural Support with Cross-Linked Hyaluronic Acid
Sponsor: Dermatology Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $55,000

PI: *Gudjonsson,Johann
Title: Dissection of the Inflammatory Network in Psoriasis and its Role as a Predictor of Treatment Response
Sponsor: National Psoriasis Foundation
Project Dates and Amount of Award: 05/15/12-05/15/13; $100,000

Internal Medicine

PI: *An,Lawrence
Co-I: Resnicow, Kenneth (Hlth Behavior & Hlth Ed Dept)
Title: Encouraging Young Adults to Make Effective Nutrition Choices: MENU Gen Y Study
Sponsor: NIH - Subcontracts TO Henry Ford Health System  R01 HD 067314
Project Dates and Amount of Award: 03/01/12-02/28/13; $348,144

PI: *Aronoff,David
Awardee / Fellow: Soares, Elyara
Title: Leukotriene Signaling and Immunoregulation in Postpartum Streptococcus Infection
Sponsor: International Society for Infectious Diseases (ISID)
Project Dates and Amount of Award: 07/01/12-09/30/12; $7,500

PI: *Auchus,Richard
Title: APS/NIDDK Short Term Education Program for Underrepresented Persons (STEP-UP)
Sponsor: American Physiological Society
Project Dates and Amount of Award: 05/01/12-08/31/12; $500

PI: *Buckanovich,Ronald
Title: 2011.124:  A Randomized Phase 2 Non-Comparative Study of the Efficacy of PF-04691502 and PF-05212384 in Patients With Recurrent Endometrial Cancer
Sponsor: Pfizer Incorporated
Project Dates and Amount of Award: 04/16/12-04/15/17; $243,429

PI: *Chiang,Mark
Awardee / Fellow: Decker, Margaret
Title: Regulation of Gene Expression by NOTCH1 and ZMIZ1 in T-cell Leukemia
Sponsor: American Society of Hematology
Project Dates and Amount of Award: 07/01/12-06/30/13; $5,000

PI: *Cooney,Kathleen
Awardee / Fellow: Roychowdhury, Sameek
Title: Rationally Selected Therapies for Genomic Targets: A Personalized Oncology Pilot Study
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/12-06/30/17; $729,000

PI: *Fearon,Eric
Title: Collaborative Research Agreement on Mammalian Eye Development
Sponsor: University of California - Davis
Project Dates and Amount of Award: 01/02/12-08/31/12; $58,860

PI: *Guan,Jun-Lin
Title: Genetic Analysis of FAK Kinase and Scaffold Functions in Breast Cancer
Sponsor: NIH  1 R01 CA 163493 01
Project Dates and Amount of Award: 06/01/12-03/31/17; $1,613,315

PI: *Gurm,Hitinder
Co-I: Corbett, James (Department of Radiology) / Magenau, John (Int Med-Hematology/Oncology) / Mueller, Gisela (Department of Radiology)
Title: A Prospective Randomized Double Blinded Placebo Controlled Phase II Trial of Intra-coronary Infusion of AMR-001, a Bone Marrow Derived Autologous CD34+ Selected Cell Product, in Patients with Acute Myocardial Infarction
Sponsor: Cardiovascular Clinical Studies, LLC
Project Dates and Amount of Award: 05/30/12-03/30/15; $232,663

PI: *Higgins,Peter
Title: Observational Multicenter Study in Patients with Crohn's Disease for Characterization of Magnetic Resonance Enterography Assays for Assessment of Disease Activity
Sponsor: Genentech, Inc.
Project Dates and Amount of Award: 04/26/12-03/31/13; $80,119

PI: *Kaplan,Mariana
Co-I: Gizinski, Alison (Int Med-Rheumatology)
Title: Neutrophil Extracellular Traps in the Pathogenesis of Rheumatoid Arthritis
Sponsor: Amer College of Rheumatology
Project Dates and Amount of Award: 07/01/12-06/30/13; $75,000

PI: *Khanna,Dinesh
Co-I: Schiopu, Elena (Int Med-Rheumatology)
Title: A Phase II/III, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the EFFICACY and Safety of Tocilizumab versus Placebo in Patients with Systemic Sclerosis
Sponsor: Hoffmann-Laroche, Inc TO PPD, Inc.
Project Dates and Amount of Award: 04/26/12-03/01/16; $292,399

PI: *Kim,Kevin
Title: Function of Epithelial-Mesenchymal Transition during Pulmonary Fibrosis
Sponsor: NIH  1 R01 HL 108904 01 A1
Project Dates and Amount of Award: 05/15/12-03/31/17; $1,943,750

PI: *Lama,Vibha
Title: Cellular and Biochemical Modulation of Inflammation and Fibrosis in Systemic Sclerosis
Sponsor: Scleroderma Foundation
Project Dates and Amount of Award: 05/01/12-04/30/13; $60,000

PI: *Marrero,Jorge
Title: A Randomized, Placebo-controlled, Double-blind, Multicenter Phase II Trial of Intravenous GC33 at 1600 mg Q2W in Previously Treated Patients with Unresectable Advanced or Metastatic Hepatocellular Carcinoma (HCC) Protocol NP27884
Sponsor: Hoffmann-Laroche, Inc TO PPD, Inc.
Project Dates and Amount of Award: 04/24/12-06/30/15; $272,472

PI: *Martinez,Fernando
Co-I: Han, Meilan (Int Med-Pulm./Critical Care)
Title: Design and Testing of Practical Tools to Identify Individuals at High Risk for COPD
Sponsor: NIH  1 R01 HL 114055 01
Project Dates and Amount of Award: 06/01/12-03/31/15; $2,398,722

PI: *Saad,Richard
Title: A 12-Week, Randomized, Double-Blind,  Placebo-Controlled Study of Asimadoline in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome
Sponsor: RTI Health Solutions (RTI-HS) TO Tioga Pharmaceuticals, Inc
Project Dates and Amount of Award: 03/27/12-05/31/13; $38,975

PI: *Shayman,James
Co-I: Abe, Akira (Int Med-Nephrology)
Title: New Approach to Phospholipidosis Prediction
Sponsor: NIH - Subcontracts TO Echelon Biosciences, Inc (EBI)  R43 FD 004052
Project Dates and Amount of Award: 09/01/11-02/29/12; $33,000

PI: *Simon,Richard
Title: Cystic Fibrosis Foundation Data Safety Monitoring Board
Sponsor: Cystic Fibrosis Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $28,864

PI: *Stein,Adam
Co-I: Hurd, Elizabeth (Pediatrics-Genetics)
Title: Investigating the Role of Chd7 in Neural Crest Lineage Cells
Sponsor: The Charge Syndrome Foundation
Project Dates and Amount of Award: 05/01/12-04/30/13; $25,000

PI: *Talpaz,Moshe
Title: UMCC 2012.016 - Carfilzomib Multiple Myeloma Expanded Access Protocol for Patients with Relapsed and Refractory Disease
Sponsor: Onyx Pharmaceuticals, Inc. TO Onyx Pharmaceuticals, Inc.
Project Dates and Amount of Award: 06/07/12-06/30/17; $418,523

PI: *Talpaz,Moshe
Title: A Randomized Phase 2, Open-Label Study of the Efficacy and Safety of Orally Administered SAR302503 in Patients with Polycythemia Vera (PV) or Essential Thrombocythemia (ET) Who are Resistant or Intolerant to Hydroxyurea (2011.116)
Sponsor: Sanofi-Aventis Pharmaceuticals
Project Dates and Amount of Award: 04/20/12-04/19/17; $445,633

PI: *Yu,Xiaochun
Awardee / Fellow: Zhang, Feng
Title: Functional analysis of WT1 in DNA damage response
Sponsor: Association for Research Childhood Cancer (AROCC)
Project Dates and Amount of Award: 06/01/12-05/13/13; $25,000

PI: *Zalupski,Mark
Title: 2011.127:  A Phase III Study of Chemotherapy and Chemoradiotherapy With or Without HyperAcute®-Pancreas (algenpantucel-L) Immunotherapy in Subjects with Surgically Resected Pancreatic Cancer
Sponsor: Pharmatech Oncology, Inc. TO Pharmatech Oncology, Inc.
Project Dates and Amount of Award: 06/11/12-06/30/18; $289,675

Medical Education

PI: *Gruppen,Larry
Co-I: Mullan, Patricia (Med Ed/Ofc of Ed Resources&Res) / Stalburg, Caren (Obstetrics and Gynecology Dept)
Title: The Joint Development of a Master's Degree in Education for Health Professions Faculty in the United States and India
Sponsor: United States-India Educational Foundation
Project Dates and Amount of Award: 05/01/12-04/30/15; $249,989

Michigan Nanotechnology Institute for Medicine and Biological Sciences

PI: *Makidon,Paul
Title: Evaluation of New Virus Strain
Sponsor: Merck Sharp & Dohme TO NanoBio Corporation
Project Dates and Amount of Award: 06/01/12-09/30/12; $135,335

Microbiology and Immunology

PI: *Mobley,Harry
Awardee / Fellow: Armbruster, Chelsie
Title: Proteus Mirabilis Swarming: Initiation and Role During Urinary Tract Infection
Sponsor: NIH  1 F32 AI 102552 01
Project Dates and Amount of Award: 06/01/12-05/31/15; $155,346

Neurology

PI: *Heidebrink,Judith
Title: Phase II Study to Evaluate the Impact on Biomarkers of Resveratrol Treatment in Patients with Mild to Moderate Alzheimer's Disease
Sponsor: NIH - Subcontracts TO Univ Of California - San Diego  U01 AG 024904
Project Dates and Amount of Award: 11/01/11-12/31/14; $176,650

PI: *Wang,Michael
Awardee / Fellow: Young, Kelly
Title: Mature Smooth Muscle Protein Expression in Intimal Hyperplasia of CADASIL
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 06/01/12-08/31/12; $4,000

Obstetrics & Gynecology

PI: *DeLancey,John
Title: P & G Consulting
Sponsor: Procter and Gamble Company
Project Dates and Amount of Award: 01/01/12-03/31/12; $10,000

Ophthalmology & Visual Sciences

PI: *Heckenlively,John
Co-I: Khan, Naheed (Ophthalmology & Visual Science)
Title: A Phase II Multiple Site, Randomized, Placebo-Controlled Trial of Oral Valproic Acid for Retinitis Pigmentosa
Sponsor: Defense, Department of-Army, Department of the-Subcontracts TO National Neurovision Research Institute (NNRI)
Project Dates and Amount of Award: 05/01/12-08/31/14; $439,260

PI: *Sugar,Alan
Co-I: Mian, Shahzad (Ophthalmology & Visual Science)
Title: Effect of Corneal Preservation Time on Long-Term Graft Success
Sponsor: NIH - Subcontracts TO Jaeb Center for Health Res  U10 EY 020797
Project Dates and Amount of Award: 04/09/12-03/14/17; $138,349

PI: *Zacks,David
Title: Autophagy and Age-Related Macular Degeneration
Sponsor: Beckman Foundation
Project Dates and Amount of Award: 07/01/12-06/30/13; $100,000

Otolaryngology

PI: *Lesperance,Marci
Co-I: Prince, Mark (Otorhinolaryngology Department)
Title: Advanced Research Training in Otolaryngology
Sponsor: NIH  2 T32 DC 005356 11
Project Dates and Amount of Award: 07/01/12-06/30/17; $1,327,950

Pathology

PI: *Chinnaiyan,Arul
Title: Dissecting the Role of PARP1 and DNA-PKcs in the Repair of ETS-Induced DNA Damage
Sponsor: Prostate Cancer Foundation
Project Dates and Amount of Award: 10/01/11-09/30/12; $75,000

PI: *Davenport,Robertson
Title: Invitro Study of Diagnostic Grifols WADiana(r) Compact for ABO/Rh Grouping, Antigen Typing, Direct Antiglobulin Tests, Red Cell Antibody Detection, Identification and Compatibility Testing
Sponsor: Grifols Biologicals, Inc TO Hoppe Regulatory Consultants, Inc.
Project Dates and Amount of Award: 05/16/12-07/30/12; $41,118

PI: *Lieberman,Andrew
Co-I: Gestwicki, Jason (Life Sciences Institute-Admin) / Sun, Duxin (PHARMACY Pharmaceutical Sci)
Title: Mechanisms of Motor Neuron Toxicity in Kennedy Disease
Sponsor: NIH  2 R01 NS 055746 06 A1
Project Dates and Amount of Award: 05/15/12-04/30/17; $1,700,780

PI: *Palanisamy,Nallasivam
Title: ETV ISH & Antibody Assay Development
Sponsor: Ventana Medical Systems
Project Dates and Amount of Award: 06/01/12-05/31/13; $42,210

Pediatrics & Communicable Diseases

PI: *Dempsey,Peter
Title: ADAM10 in Intestinal Homeostasis and Regeneration
Sponsor: NIH  1 R01 DK 093697 01 A1
Project Dates and Amount of Award: 07/01/12-06/30/17; $1,521,955

PI: *Dorfman,Adam
Title: Do Biochemical, Hematopoietic, and Stool Biomarkers Predict Low Cardiac Index in Patients with Fontan Physiology?
Sponsor: Children's Heart Foundation, The TO Cincinnati Children's Hospital Medical Center
Project Dates and Amount of Award: 02/15/12-12/31/12; $10,656

PI: *Ferrara,James
Title: Training Grant in Molecular and Translational Hematology
Sponsor: NIH  2 T32 HL 007622 26 A1
Project Dates and Amount of Award: 07/01/12-06/30/17; $1,908,569

PI: *Gipson,Debbie
Title: Safety and Pharmacokinetics of Multiple Dose Lisinopril in Pediatric Kidney Transplant Recipients
Sponsor: NIH - Subcontracts TO Duke University
Project Dates and Amount of Award: 05/11/12-08/21/13; $35,000

PI: *Hutchinson,Raymond
Title: Childhood Cancer Survivor Study
Sponsor: NIH - Subcontracts TO St. Jude Children's Research Hospital  U24
Project Dates and Amount of Award: 12/01/11-11/30/12; $13,331

PI: *Kitko,Carrie
Title: Retrospective, Secondary Analysis of Six Subjects Treated with Defibrotide Under an Earlier Trial, umcc #2006.123 (HUM00010277)
Sponsor: Gentium
Project Dates and Amount of Award: 05/11/12-07/31/12; $4,000

PI: *LiPuma,John
Title: Burkholderia Cepacia Research Laboratory & Repository (2012-2013)
Sponsor: Cystic Fibrosis Foundation
Project Dates and Amount of Award: 03/01/12-02/28/13; $379,949

PI: *Moler,Frank
Title: Hypothermias Impact on Pharmacology
Sponsor: NIH - Subcontracts TO Children's Hospital of Philadelphia, The  R01 HL
Project Dates and Amount of Award: 04/01/12-03/31/13; $18,442

PI: *Pipe,Steven
Title: Region V East 2012-2013 Cascade Hemophilia Consortium Grant Proposal for Patient Assistance Project
Sponsor: Hemophilia Foundation Of Mi.
Project Dates and Amount of Award: 06/01/12-05/31/13; $88,644

PI: *Zhou,Weibin
Title: Zebrafish Model of Steroid-Sensitive Nephrotic Syndrome
Sponsor: American Society Of Nephrology
Project Dates and Amount of Award: 07/01/12-06/30/14; $200,000

Psychiatry

PI: *Cranford,James
Awardee / Fellow: Day, Kyla
Title: African American Romantic Relationships: Intimacy, Substance Use, and HIV Testing
Sponsor: NIH - Subcontracts TO Yale University  R25 MH 087217
Project Dates and Amount of Award: 11/01/11-07/15/12; $20,000

PI: *Kees,Michelle / Greden,John
Title: National Research Summit on Reserve Component Military Families
Sponsor: NIH  1 R13 HD 072720 01
Project Dates and Amount of Award: 06/01/12-05/31/13; $25,000

PI: *Zubieta,Jon
Awardee / Fellow: Prossin, Alan
Title: Etanercept: a Mechanistic Probe of Central Mu-Opioid Dysregulation in Pain States
Sponsor: NIH  1 K99 AR 033454 01
Project Dates and Amount of Award: 05/15/12-04/30/14; $351,000

Radiation Oncology

PI: *Feng,Felix
Awardee / Fellow: Song, Yeohan
Title: Investigating the Associations and Prognostic Values of Clinical Factors and TMPRSS2:ERG Fusion and PTEN Deletion on Post-Prostatectomy Salvage Radiation Therapy Outcomes: An Institutional Cohort Study
Sponsor: Radiological Society of North America
Project Dates and Amount of Award: 05/01/12-06/30/13; $3,000

PI: *Ljungman,Mats
Co-I: Wilson, Thomas (Pathology Department)
Title: Development and Validation of BruChase-Seq and BrUV-Seq
Sponsor: NIH  1 R01 HG 006786 01
Project Dates and Amount of Award: 05/01/12-02/28/15; $1,170,291

Surgery

PI: *Lubman,David
Co-I: Marrero, Jorge (Int Med-Gastroenterology) / Shedden, Kerby (LSA Statistics)
Title: Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach
Sponsor: NIH  1 R01 CA 160254 01 A1
Project Dates and Amount of Award: 05/01/12-03/30/16; $1,471,875

PI: *Mychaliska,George
Awardee / Fellow: Bryner, Benjamin
Title: Development of an Artificial Placenta for Premature Infants
Sponsor: American College of Surgeons
Project Dates and Amount of Award: 07/01/12-06/30/13; $30,000

Urology

PI: *Clemens,James
Awardee / Fellow: Suskind, Anne
Title: Understanding the Dissemination of Sacral Neuromodulation
Sponsor: Society of Women in Urology
Project Dates and Amount of Award: 01/01/12-01/31/13; $2,500

PI: *Hollenbeck,Brent
Awardee / Fellow: Schroeck, Florian
Title: Impact of Technology on the Quantity and Quality of Prostate Cancer Care
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/12-06/30/13; $48,000


UMMS RESEARCH PUBLICATIONS

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Books – Chapters or Volumes of Books – Contributions to Books

Otolaryngology

Kroeker A, Shuman A, McKean E.  Melanoma of the head and neck.  In: Dimick J, Upchurch G, Sonnenday C, editors.  Clinical scenarios in surgery:  decision making and operative technique.  Philadelphia: Lippincott Williams & Wilkins; 2012. Chapter 123.

Spector M, McKean E.  Head and neck cancer.  In: Dimick J, Upchurch G, Sonnenday C, editors.  Clinical scenarios in surgery:  decision making and operative technique.  Philadelphia: Lippincott Williams & Wilkins; 2012. Chapter 124.

Journal Articles

Anesthesiology

Mhyre Jill M. Maternal mortality. Current opinion in anaesthesiology. 2012 Jun. 25(3): 277-85. PMID# 22459982

Platts-Mills Timothy F, Burke Gary F, Lee Young M, Swor Robert A, Zaleski Erin Z, Clauw Daniel J, McLean Samuel A. Pain and interference of pain with function and mood in elderly adults involved in a motor vehicle collision: a pilot study. Experimental aging research. 2012 May. 38(3): 330-43. PMID# 22540386

Gerstner G E, Gracely R H, Deebajah A, Ichesco E, Quintero A, Clauw D J, Sundgren P C. Posterior insular molecular changes in myofascial pain. Journal of dental research. 2012 May. 91(5): 485-90. PMID# 22451533

As-Sanie Sawsan, Harris Richard E, Napadow Vitaly, Kim Jieun, Neshewat Gina, Kairys Anson, Williams David, Clauw Daniel J, Schmidt-Wilcke Tobias. Changes in regional gray matter volume in women with chronic pelvic pain: A voxel-based morphometry study. Pain. 2012 May. 153(5): 1006-14. PMID# 22387096

Cagnoli Patricia C, Sundgren Pia C, Kairys Anson, Graft Courtney C, Clauw Daniel J, Gebarski Stephen, McCune W Joseph, Schmidt-Wilcke Tobias. Changes in regional brain morphology in neuropsychiatric systemic lupus erythematosus. The Journal of rheumatology. 2012 May. 39(5): 959-67. PMID# 22467931

Biological Chemistry

Chemler Joseph A, Buchholz Tonia J, Geders Todd W, Akey David L, Rath Christopher M, Chlipala George E, Smith Janet L, Sherman David H. Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor. Journal of the American Chemical Society. 2012 May 2. 134(17): 7359-66. PMID# 22480290

Klionsky Daniel J, Hurley James H. Self-eating with your fingers. Cell research. 2012 May. 22(5): 783-5. PMID# 22410794

Cardiac Surgery

Cornell Timothy T, Sun Lei, Hall Mark W, Gurney James G, Ashbrook Matthew J, Ohye Richard G, Shanley Thomas P. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery. 2012 May. 143(5): 1160-1166.e1. PMID# 21996297

Center for Bioethics and Social Sciences in Medicine

Zikmund-Fisher Brian J, Couper Mick P, Fagerlin Angela. Disparities in patient reports of communications to inform decision making in the DECISIONS survey. Patient education and counseling. 2012 May. 87(2): 198-205. PMID# 21890299

Dermatology

Thorleifsdottir Ragna Hlin, Sigurdardottir Sigrun Laufey, Sigurgeirsson Bardur, Olafsson Jon Hjaltalin, Sigurdsson Martin Ingi, Petersen Hannes, Arnadottir Sigurlaug, Gudjonsson Johann Eli, Johnston Andrew, Valdimarsson Helgi. Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants. Journal of immunology (Baltimore, Md. : 1950). 2012 May 15. 188(10): 5160-5. PMID# 22491250

Grekin Sarah J, Fox Matthew C, Gudjonsson Johann E, Fullen Douglas R. Psoriasiform pemphigus foliaceus: a report of two cases. Journal of cutaneous pathology. 2012 May. 39(5): 549-53. PMID# 22449394

Emergency Medicine

Resko Stella M, Walton Maureen A, Chermack Stephen T, Blow Frederic C, Cunningham Rebecca M. Therapist competence and treatment adherence for a brief intervention addressing alcohol and violence among adolescents. Journal of substance abuse treatment. 2012 Jun. 42(4): 429-37. PMID# 22119182

Cerdá Magdalena, Digangi Julia, Galea Sandro, Koenen Karestan. Abstracts. Depression and anxiety. 2012 May. 29(5): 359-85. PMID# 22553006

Family Medicine

Alrawi Sara, Fetters Michael D, Killawi Amal, Hammad Adnan, Padela Aasim. Traditional healing practices among american muslims: perceptions of community leaders in southeast michigan. Journal of immigrant and minority health / Center for Minority Public Health. 2012 Jun. 14(3): 489-96. PMID# 21739160

Aikens James E, Klinkman Michael S. Changes in patients' beliefs about their antidepressant during the acute phase of depression treatment. General hospital psychiatry. 2012 May. 34(3): 221-6. PMID# 22325627

Human Genetics

Jiao Baowei, Ma Hong, Shokhirev Maxim N, Drung Alexander, Yang Qin, Shin Jongdae, Lu Shaolei, Byron Meg, Kalantry Sundeep, Mercurio Arthur M, Lawrence Jeanne B, Hoffmann Alexander, Bach Ingolf. Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells. Cell. 2012 Apr 27. 149(3): 630-41. PMID# 22541433

Institute of Gerontology

Shyu Yea-Ing L, Tsai Wen-Che, Chen Min-Chi, Liang Jersey, Cheng Huey-Shinn, Wu Chi-Chuan, Su Juin-Yih, Chou Shih-Wei. Two-year effects of an interdisciplinary intervention on recovery following hip fracture in older Taiwanese with cognitive impairment. International journal of geriatric psychiatry. 2012 May. 27(5): 529-38. PMID# 21732418

Internal Medicine – Allergy and Clinical Immunology

Huang Baohua, Kukowska-Latallo Jolanta F, Tang Shengzhuang, Zong Hong, Johnson Kali B, Desai Ankur, Gordon Chris L, Leroueil Pascale R, Baker James R. The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry. Bioorganic&medicinal chemistry letters. 2012 May 1. 22(9): 3152-6. PMID# 22480432

Internal Medicine – Cardiovascular Medicine

Pitt Bertram, Loscalzo Joseph, Monyak John, Miller Elinor, Raichlen Joel. Comparison of Lipid-Modifying Efficacy of Rosuvastatin Versus Atorvastatin in Patients With Acute Coronary Syndrome (from the LUNAR Study). The American journal of cardiology. 2012 May 1. 109(9): 1239-46. PMID# 22360820

Chen Y. State of the Science in SCI Rehabilitation. Spinal cord. 2012 May. 50(5): 341. PMID# 22555408

Koenig Gerald C, Rowe R Grant, Day Sharlene M, Sabeh Farideh, Atkinson Jeffrey J, Cooke Kenneth R, Weiss Stephen J. MT1-MMP-Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction. The American journal of pathology. 2012 May. 180(5): 1863-78. PMID# 22464947

Kocher Keith E, Nallamothu Brahmajee K. In reply. Annals of emergency medicine. 2012 May. 59(5): 446-8. PMID# 22525540

Pandit Sandeep V, Noujaim Sami F, Jalife José. Postrepolarization refractoriness in acute ischemia and after antiarrhythmic drug administration. Heart rhythm : the official journal of the Heart Rhythm Society. 2012 May. 9(5): e13-4. PMID# 22426151

Zannad Faiez, Stough Wendy Gattis, Pocock Stuart J, Sleight Peter, Cushman William C, Cleland John G F, McMurray John J V, Lonn Eva, Geller Nancy L, Wedel Hans, Abadie Eric, Alonso-Garcia Angeles, Pitt Bertram. Diabetes clinical trials: helped or hindered by the current shift in regulatory requirements? European heart journal. 2012 May. 33(9): 1049-57. PMID# 22422830

Chia Chih-Chun, Rubinfeld Ilan, Scirica Benjamin M, McMillan Sean, Gurm Hitinder S, Syed Zeeshan. Looking beyond historical patient outcomes to improve clinical models. Science translational medicine. 2012 Apr 25. 4(131): 131ra49. PMID# 22539773

Guiot Aurelie, Baman Timir, Morady Fred, Chugh Aman. Elimination Of Right Superior Pulmonary Vein Firing During Radiofrequency Ablation Around the Left Pulmonary Veins: What is the Mechanism? Journal of cardiovascular electrophysiology. 2012 Apr. 23(4): 442-4. PMID# 21668565

Yokokawa Miki, Good Eric, Chugh Aman, Pelosi Frank, Crawford Thomas, Jongnarangsin Krit, Latchamsetty Rakesh, Oral Hakan, Morady Fred, Bogun Frank. Intramural idiopathic ventricular arrhythmias originating in the intraventricular septum: mapping and ablation. Circulation. Arrhythmia and electrophysiology. 2012 Apr 1. 5(2): 258-63. PMID# 22407415

Internal Medicine – Gastroenterology

Cole Tyler S, Zhang Min, Standiford Theodore J, Newstead Michael, Luther Jay, Zhang Jiajie, Chen Chun-Chia, Kao John Y. IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells. Immunology letters. 2012 May 30. 144(1-2): 49-59. PMID# 22472665

Scaglione Steven J, Lok Anna S F. Effectiveness of hepatitis B treatment in clinical practice. Gastroenterology. 2012 May. 142(6): 1360-1368.e1. PMID# 22537444

Casado Arroyo Rubén, Polo-Tomas Mónica, Roncalés Maria P, Scheiman James, Lanas Angel. Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: long-term follow-up of a cohort of patients commonly using PPI co-therapy. Heart (British Cardiac Society). 2012 May. 98(9): 718-23. PMID# 22523056

Lok Anna S F, Pawlotsky Jean-Michel. Viral hepatitis at a crossroad. Gastroenterology. 2012 May. 142(6): 1261-3. PMID# 22537431

Elmunzer B Joseph, Scheiman James M, Lehman Glen A, Chak Amitabh, Mosler Patrick, Higgins Peter D R, Hayward Rodney A, Romagnuolo Joseph, Elta Grace H, Sherman Stuart, Waljee Akbar K, Repaka Aparna, Atkinson Matthew R, Cote Gregory A, Kwon Richard S, McHe A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. The New England journal of medicine. 2012 Apr 12. 366(15): 1414-22. PMID# 22494121

Fontana Robert J, Litman Heather J, Dienstag Jules L, Bonkovsky Herbert L, Su Grace, Sterling Richard K, Lok Anna S. YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C. Liver international : official journal of the International Association for the Study of the Liver. 2012 Apr. 32(4): 665-74. PMID# 22103814

Scheiman James M. Prevention of damage induced by aspirin in the GI tract. Best practice&research. Clinical gastroenterology. 2012 Apr. 26(2): 153-62. PMID# 22542153

Internal Medicine – General Medicine

Padela Aasim I, Killawi Amal, Forman Jane, Demonner Sonya, Heisler Michele. American muslim perceptions of healing: key agents in healing, and their roles. Qualitative health research. 2012 Jun. 22(6): 846-58. PMID# 22393065

Hawley Sarah T, McQueen Amy, Bartholomew L Kay, Greisinger Anthony J, Coan Sharon P, Myers Ronald, Vernon Sally W. Preferences for colorectal cancer screening tests and screening test use in a large multispecialty primary care practice. Cancer. 2012 May 15. 118(10): 2726-34. PMID# 21948225

Fakih Mohamad G, Greene M Todd, Kennedy Edward H, Meddings Jennifer A, Krein Sarah L, Olmsted Russell N, Saint Sanjay. Introducing a population-based outcome measure to evaluate the effect of interventions to reduce catheter-associated urinary tract infection. American journal of infection control. 2012 May. 40(4): 359-64. PMID# 21868133

Rogers Mary A M, Levine Deborah A, Blumberg Neil, Flanders Scott A, Chopra Vineet, Langa Kenneth M. Triggers of hospitalization for venous thromboembolism. Circulation. 2012 May 1. 125(17): 2092-9. PMID# 22474264

Zikmund-Fisher Brian J, Couper Mick P, Fagerlin Angela. Disparities in patient reports of communications to inform decision making in the DECISIONS survey. Patient education and counseling. 2012 May. 87(2): 198-205. PMID# 21890299

Fortenberry Gamola Z, Hu Howard, Turyk Mary, Barr Dana Boyd, Meeker John D. Association between urinary 3, 5, 6-trichloro-2-pyridinol, a metabolite of chlorpyrifos and chlorpyrifos-methyl, and serum T4 and TSH in NHANES 1999-2002. The Science of the total environment. 2012 May 1. 424(): 351-5. PMID# 22425279

Iwashyna Theodore J, Netzer Giora, Langa Kenneth M, Cigolle Christine. Spurious Inferences about Long-Term Outcomes: The Case of Severe Sepsis and Geriatric Conditions. American journal of respiratory and critical care medicine. 2012 Apr 15. 185(8): 835-41. PMID# 22323301

Elmunzer B Joseph, Scheiman James M, Lehman Glen A, Chak Amitabh, Mosler Patrick, Higgins Peter D R, Hayward Rodney A, Romagnuolo Joseph, Elta Grace H, Sherman Stuart, Waljee Akbar K, Repaka Aparna, Atkinson Matthew R, Cote Gregory A, Kwon Richard S, McHe A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. The New England journal of medicine. 2012 Apr 12. 366(15): 1414-22. PMID# 22494121

Internal Medicine – Geriatric Medicine

Fisch Jay, Lansing Bonnie, Wang Linda, Symons Kathleen, Cherian Kay, McNamara Sara, Mody Lona. New acquisition of antibiotic-resistant organisms in skilled nursing facilities. Journal of clinical microbiology. 2012 May. 50(5): 1698-703. PMID# 22378900

Internal Medicine – Hematology and Oncology

Reddy Pavan. Editorial: HDAC inhibition begets more MDSCs. Journal of leukocyte biology. 2012 May. 91(5): 679-81. PMID# 22547132

Yang Dong, Zhao Yongchao, Li Amy Y, Wang Shaomeng, Wang Gongxian, Sun Yi. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast cancer research and treatment. 2012 May. 133(1): 189-99. PMID# 21901386

Bashir Qaiser, Munsell Mark F, Giralt Sergio, de Padua Silva Leandro, Sharma Manish, Couriel Daniel, Chiattone Alexandre, Popat Uday, Qazilbash Muzaffar H, Fernandez-Vina Marcelo, Champlin Richard E, de Lima Marcos J. Randomized phase II trial comparing two dose levels of thymoglobulin in patients undergoing unrelated donor hematopoietic cell transplant. Leukemia&lymphoma. 2012 May. 53(5): 915-9. PMID# 22023525

Roca Hernan, Craig Matthew J, Ying Chi, Varsos Zachary S, Czarnieski Paul, Alva Ajjai S, Hernandez James, Fuller David, Daignault Stephanie, Healy Patrick N, Pienta Kenneth J. IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation. Journal of cellular biochemistry. 2012 May. 113(5): 1569-80. PMID# 22174091

Ciurea Stefan O, Saliba Rima M, Hamerschlak Nelson, Karduss Aurueta Amado J, Bassett Roland, Fernandez-Vina Marcelo, Petropoulos Demetrios, Worth Laura L, Chan Ka Wah, Couriel Daniel R, Rondon Gabriela, Sharma Manish, Qazilbash Muzaffar, Jones Roy B, Kebr Fludarabine, melphalan, thiotepa and anti-thymocyte globulin conditioning for unrelated cord blood transplant. Leukemia&lymphoma. 2012 May. 53(5): 901-6. PMID# 21988645

Cha Hyuk C, Harting Mandy, Cha Kelly B, Ludgate Mathew W, Olsen Stephen H, Zhao Lili, Lao Christopher D. Effects of contiguous scars in dermatoscopic evaluation of clinically atypical melanocytic nevi. Journal of the American Academy of Dermatology. 2012 May. 66(5): e179-80. PMID# 22507589

Ng Yee Seng, Roca Hernan, Fuller David, Sud Sudha, Pienta Kenneth J. Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. Journal of cellular biochemistry. 2012 May. 113(5): 1714-23. PMID# 22213010

Toubai Tomomi, Tawara Isao, Sun Yaping, Liu Chen, Nieves Evelyn, Evers Rebecca, Friedman Thea, Korngold Robert, Reddy Pavan. Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cells. Blood. 2012 Apr 19. 119(16): 3844-53. PMID# 22101894

Pienta Kenneth J, Gelato Marie C, Lichtenstein Michael J. Forging the Association for Clinical and Translational Science (ACTS). Clinical and translational science. 2012 Apr. 5(2): 117-8. PMID# 22507114

Henry N Lynn, Hayes Daniel F. Cancer biomarkers. Molecular oncology. 2012 Apr. 6(2): 140-6. PMID# 22356776

Rosenthal Devin T, Merajver Sofia D. Rethinking the war on cancer: multidisciplinary collaborations between biologists and physical scientists. Future oncology (London, England). 2012 Apr. 8(4): 339-41. PMID# 22515435

Rae James M, Drury Suzy, Hayes Daniel F, Stearns Vered, Thibert Jacklyn N, Haynes Ben P, Salter Janine, Sestak Ivana, Cuzick Jack, Dowsett Mitch. CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients. Journal of the National Cancer Institute. 2012 Mar 21. 104(6): 452-60. PMID# 22395643

Internal Medicine – Infectious Diseases

Beck Angela J, Boulton Matthew L. Building an effective workforce: a systematic review of public health workforce literature. American journal of preventive medicine. 2012 May. 42(5 Suppl 1): S6-S16. PMID# 22502927

Internal Medicine – Metabolism, Endocrinology & Diabetes

Blandino-Rosano M, Alejandro E U, Sathyamurthy A, Scheys J O, Gregg B, Chen A Y, Rachdi L, Weiss A, Barker D J, Gould A P, Elghazi L, Bernal-Mizrachi E. Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 ( Cip ). Diabetologia. 2012 May. 55(5): 1380-9. PMID# 22327314

Burant Charles F, Viswanathan Prabhakar, Marcinak John, Cao Charlie, Vakilynejad Majid, Xie Benhuai, Leifke Eckhard. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. 2012 Apr 14. 379(9824): 1403-11. PMID# 22374408

Internal Medicine – Molecular Medicine & Genetics

Koenig Gerald C, Rowe R Grant, Day Sharlene M, Sabeh Farideh, Atkinson Jeffrey J, Cooke Kenneth R, Weiss Stephen J. MT1-MMP-Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction. The American journal of pathology. 2012 May. 180(5): 1863-78. PMID# 22464947

Internal Medicine – Nephrology

Garg Puneet, Holzman Lawrence B. Podocytes: Gaining a foothold. Experimental cell research. 2012 May 15. 318(9): 955-63. PMID# 22421512

Szeifert Lilla, Bragg-Gresham Jennifer L, Thumma Jyothi, Gillespie Brenda W, Mucsi Istvan, Robinson Bruce M, Pisoni Ronald L, Disney Alex, Combe Christian, Port Friedrich K. Psychosocial variables are associated with being wait-listed, but not with receiving a kidney transplant in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 May. 27(5): 2107-13. PMID# 22058174

Internal Medicine – Pulmonary and Critical Care

Kovach Melissa A, Standiford Theodore J. The function of neutrophils in sepsis. Current opinion in infectious diseases. 2012 Jun. 25(3): 321-7. PMID# 22421753

Wozniak Karen L, Hardison Sarah, Olszewski Michal, Wormley Floyd L. Induction of protective immunity against cryptococcosis. Mycopathologia. 2012 Jun. 173(5-6): 387-94. PMID# 22143898

Kahn Jeremy M, Werner Rachel M, Carson Shannon S, Iwashyna Theodore J. Variation in long-term acute care hospital use after intensive care. Medical care research and review : MCRR. 2012 Jun. 69(3): 339-50. PMID# 22311957

Cole Tyler S, Zhang Min, Standiford Theodore J, Newstead Michael, Luther Jay, Zhang Jiajie, Chen Chun-Chia, Kao John Y. IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells. Immunology letters. 2012 May 30. 144(1-2): 49-59. PMID# 22472665

Martinez Carlos H, Chen Ya-Hong, Westgate Phillip M, Liu Lyrica X, Murray Susan, Curtis Jeffrey L, Make Barry J, Kazerooni Ella A, Lynch David A, Marchetti Nathaniel, Washko George R, Martinez Fernando J, Han Meilan K. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax. 2012 May. 67(5): 399-406. PMID# 22514236

Han Meilan K, Huang Yvonne J, Lipuma John J, Boushey Homer A, Boucher Richard C, Cookson William O, Curtis Jeffrey L, Erb-Downward John, Lynch Susan V, Sethi Sanjay, Toews Galen B, Young Vincent B, Wolfgang Matthew C, Huffnagle Gary B, Martinez Fernando J Significance of the microbiome in obstructive lung disease. Thorax. 2012 May. 67(5): 456-63. PMID# 22318161

Iwashyna Theodore J, Netzer Giora, Langa Kenneth M, Cigolle Christine. Spurious Inferences about Long-Term Outcomes: The Case of Severe Sepsis and Geriatric Conditions. American journal of respiratory and critical care medicine. 2012 Apr 15. 185(8): 835-41. PMID# 22323301

Lane-Fall Meghan B, Iwashyna Theodore J, Cooke Colin R, Benson Nicole M, Kahn Jeremy M. Insurance and racial differences in long-term acute care utilization after critical illness. Critical care medicine. 2012 Apr. 40(4): 1143-9. PMID# 22020247

Internal Medicine – Rheumatology

Cagnoli Patricia C, Sundgren Pia C, Kairys Anson, Graft Courtney C, Clauw Daniel J, Gebarski Stephen, McCune W Joseph, Schmidt-Wilcke Tobias. Changes in regional brain morphology in neuropsychiatric systemic lupus erythematosus. The Journal of rheumatology. 2012 May. 39(5): 959-67. PMID# 22467931

Michigan Diabetes Research and Training Center

Fukumoto Masanori, Nakaizumi Atsuko, Zhang Ting, Lentz Stephen I, Shibata Maho, Puro Donald G. Vulnerability of the retinal microvasculature to oxidative stress: ion channel-dependent mechanisms. American journal of physiology. Cell physiology. 2012 May. 302(9): C1413-20. PMID# 22345512

Michigan Nanotechnology Institute for Medicine and Biological Sciences

Huang Baohua, Kukowska-Latallo Jolanta F, Tang Shengzhuang, Zong Hong, Johnson Kali B, Desai Ankur, Gordon Chris L, Leroueil Pascale R, Baker James R. The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry. Bioorganic&medicinal chemistry letters. 2012 May 1. 22(9): 3152-6. PMID# 22480432

Microbiology and Immunology

Chemler Joseph A, Buchholz Tonia J, Geders Todd W, Akey David L, Rath Christopher M, Chlipala George E, Smith Janet L, Sherman David H. Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor. Journal of the American Chemical Society. 2012 May 2. 134(17): 7359-66. PMID# 22480290

Taube Stefan, Perry Jeffrey W, McGreevy Eoghan, Yetming Kristen, Perkins Cheryl, Henderson Kenneth, Wobus Christiane E. Murine noroviruses bind glycolipid and glycoprotein attachment receptors in a strain-dependent manner. Journal of virology. 2012 May. 86(10): 5584-93. PMID# 22438544

Korotkov Konstantin V, Sandkvist Maria, Hol Wim G J. The type II secretion system: biogenesis, molecular architecture and mechanism. Nature reviews. Microbiology. 2012 May. 10(5): 336-51. PMID# 22466878

Finefield Jennifer M, Frisvad Jens C, Sherman David H, Williams Robert M. Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids. Journal of natural products. 2012 Apr 27. 75(4): 812-33. PMID# 22502590

Molecular & Behavioral Neuroscience Institute

Liu Jing, Khaing Oo Maung Kyaw, Reddy Karthik, Gianchandani Yogesh B, Schultz Jack C, Appel Heidi M, Fan Xudong. Adaptive two-dimensional microgas chromatography. Analytical chemistry. 2012 May 1. 84(9): 4214-20. PMID# 22468727

Villafuerte S, Heitzeg M M, Foley S, Wendy Yau W-Y, Majczenko K, Zubieta J-K, Zucker R A, Burmeister M. Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Molecular psychiatry. 2012 May. 17(5): 511-9. PMID# 21483437

Molecular & Integrative Physiology

Xue Xiang, Taylor Matthew, Anderson Erik, Hao Cathy, Qu Aijuan, Greenson Joel K, Zimmermann Ellen M, Gonzalez Frank J, Shah Yatrik M. Hypoxia-inducible factor-2ż activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer research. 2012 May 1. 72(9): 2285-93. PMID# 22419665

Schumacher Michael A, Donnelly Jessica M, Engevik Amy C, Xiao Chang, Yang Li, Kenny Susan, Varro Andrea, Hollande Frédéric, Samuelson Linda C, Zavros Yana. Gastric Sonic Hedgehog Acts as a Macrophage Chemoattractant During the Immune Response to Helicobacter pylori. Gastroenterology. 2012 May. 142(5): 1150-1159.e6. PMID# 22285806

Neurology

Blain-Moraes Stefanie, Schaff Riley, Gruis Kirsten L, Huggins Jane E, Wren Patricia A. Barriers to and mediators of brain-computer interface user acceptance: focus group findings. Ergonomics. 2012 May. 55(5): 516-25. PMID# 22455595

Segal Benjamin M. The unwavering commitment of regulatory T cells in the suppression of autoimmune encephalomyelitis: Another aspect of immune privilege in the CNS. European journal of immunology. 2012 May. 42(5): 1102-5. PMID# 22539285

Kotagal Vikas, Albin Roger L, Müller Martijn L T M, Koeppe Robert A, Chervin Ronald D, Frey Kirk A, Bohnen Nicolaas I. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Annals of neurology. 2012 Apr. 71(4): 560-8. PMID# 22522445

Neurosurgery

Rajajee Venkatakrishna, Fletcher Jeffrey J, Pandey Aditya S, Gemmete Joseph J, Chaudhary Neeraj, Jacobs Teresa L, Gregory Thompson B. Low pulsatility index on transcranial Doppler predicts symptomatic large-vessel vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2012 May. 70(5): 1195-206. PMID# 22089755

Obstetrics & Gynecology

Menon K M J, Menon Bindu. Structure, function and regulation of gonadotropin receptors - A perspective. Molecular and cellular endocrinology. 2012 Jun 5. 356(1-2): 88-97. PMID# 22342845

Johnson Timothy R B. Announcing the winner of the John J. Sciarra IJGO Prize Paper Award for 2011. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2012 Jun. 117(3): 209-10. PMID# 22465557

As-Sanie Sawsan, Harris Richard E, Napadow Vitaly, Kim Jieun, Neshewat Gina, Kairys Anson, Williams David, Clauw Daniel J, Schmidt-Wilcke Tobias. Changes in regional gray matter volume in women with chronic pelvic pain: A voxel-based morphometry study. Pain. 2012 May. 153(5): 1006-14. PMID# 22387096

Legro Richard S, Kunselman Allen R, Brzyski Robert G, Casson Peter R, Diamond Michael P, Schlaff William D, Christman Gregory M, Coutifaris Christos, Taylor Hugh S, Eisenberg Esther, Santoro Nanette, Zhang Heping. The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemporary clinical trials. 2012 May. 33(3): 470-81. PMID# 22265923

Denver Robert J. The inaugural meeting of the North American Society for Comparative Endocrinology (NASCE; La Societé Nord-Americaine d'Endocrinologie Comparée; La Sociedad Norteamericana de Endocrinologia Comparada). General and comparative endocrinology. 2012 May 1. 176(3): 276-8. PMID# 22465689

Xu Xiao, Menees Stacy B, Zochowski Melissa K, Fenner Dee E. Economic cost of fecal incontinence. Diseases of the colon and rectum. 2012 May. 55(5): 586-98. PMID# 22513438

Swain J E. Is there an optimal pH for culture media used in clinical IVF? Human reproduction update. 2012 May. 18(3): 333-9. PMID# 22311857

Morris Vikky C, Murray Meghan P, Delancey John O L, Ashton-Miller James A. A comparison of the effect of age on levator ani and obturator internus muscle cross-sectional areas and volumes in nulliparous women. Neurourology and urodynamics. 2012 Apr. 31(4): 481-6. PMID# 22378544

Ophthalmology & Visual Sciences

Gillespie Erin F, Smith Terry J, Douglas Raymond S. Thyroid eye disease: towards an evidence base for treatment in the 21st century. Current neurology and neuroscience reports. 2012 Jun. 12(3): 318-24. PMID# 22354545

Fukumoto Masanori, Nakaizumi Atsuko, Zhang Ting, Lentz Stephen I, Shibata Maho, Puro Donald G. Vulnerability of the retinal microvasculature to oxidative stress: ion channel-dependent mechanisms. American journal of physiology. Cell physiology. 2012 May. 302(9): C1413-20. PMID# 22345512

Jackson Gregory R, Scott Ingrid U, Quillen David A, Walter Laura E, Gardner Thomas W. Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. The British journal of ophthalmology. 2012 May. 96(5): 699-703. PMID# 22174096

Puro Donald G. Retinovascular physiology and pathophysiology: New experimental approach/new insights. Progress in retinal and eye research. 2012 May. 31(3): 258-70. PMID# 22333041

Archer Steven M. Arguing with success: Pulley surgery versus conventional surgery for convergence excess esotropia. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. 2012 Apr. 16(2): 110-1. PMID# 22525163

Orthopaedic Surgery

Kelly Bryan T, Bedi Asheesh, Robertson Catherine M, Dela Torre Katrina, Giveans M Russell, Larson Christopher M. Alterations in internal rotation and alpha angles are associated with arthroscopic cam decompression in the hip. The American journal of sports medicine. 2012 May. 40(5): 1107-12. PMID# 22392560

Mohtadi Nicholas G H, Griffin Damian R, Pedersen M Elizabeth, Chan Denise, Safran Marc R, Parsons Nicholas, Sekiya Jon K, Kelly Bryan T, Werle Jason R, Leunig Michael, McCarthy Joseph C, Martin Hal D, Byrd J W Thomas, Philippon Marc J, Martin Robroy L, Gu The Development and Validation of a Self-Administered Quality-of-Life Outcome Measure for Young, Active Patients With Symptomatic Hip Disease: The International Hip Outcome Tool (iHOT-33). Arthroscopy : the journal of arthroscopic&related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2012 May. 28(5): 595-610.e1. PMID# 22542433

Alford Andrea I, Reddy Anita B, Goldstein Steven A, Murthy Prithvi, Tayim Riyad, Sharma Gorav. Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing. Calcified tissue international. 2012 May. 90(5): 420-8. PMID# 22362307

Araujo Paulo H, Rabuck Stephen J, Fu Freddie H, Miller Bruce S, Downie Brian K, Kohen Robert B, Kijek Theresa G, Lesniak Bryson, Jacobson Jon A, Hughes Richard E, Carpenter James E. Are we allowing patients to return to participation too soon? Letter to the editor. The American journal of sports medicine. 2012 May. 40(5): NP5-6. PMID# 22547157

Berkes Marschall B, Cross Michael B, Shindle Michael K, Bedi Asheesh, Kelly Bryan T. Traumatic posterior hip instability and femoroacetabular impingement in athletes. American journal of orthopedics (Belle Mead, N.J.). 2012 Apr. 41(4): 166-71. PMID# 22530218

Otolaryngology

Liu Jun, Wang Xiaodong, Jin Qiming, Jin Taocong, Chang Syweren, Zhang Zhaocheng, Czajka-Jakubowska Agata, Giannobile William V, Nör Jacques E, Clarkson Brian H. The stimulation of adipose-derived stem cell differentiation and mineralization by ordered rod-like fluorapatite coatings. Biomaterials. 2012 Jul. 33(20): 5036-46. PMID# 22483243

Duffy Sonia A, Cohen Kathleen A, Choi Seung Hee, McCullagh Marjorie C, Noonan Devon. Predictors of obesity in michigan operating engineers. Journal of community health. 2012 Jun. 37(3): 619-25. PMID# 22005801

Sherman Eric J, Fisher Susan G, Kraus Dennis H, Zelefsky Michael J, Seshan Venkatraman E, Singh Bhuvanesh, Shaha Ashok R, Shah Jatin P, Wolf Gregory T, Pfister David G. TALK score: Development and validation of a prognostic model for predicting larynx preservation outcome. The Laryngoscope. 2012 May. 122(5): 1043-50. PMID# 22374653

Shuman Andrew G, Hu Hsou Mei, Pannucci Christopher J, Jackson Christopher R, Bradford Carol R, Bahl Vinita. Stratifying the risk of venous thromboembolism in otolaryngology. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012 May. 146(5): 719-24. PMID# 22261490

Pathology

Bosmann Markus, Haggadone Mikel D, Hemmila Mark R, Zetoune Firas S, Sarma J Vidya, Ward Peter A. Complement Activation Product C5a Is a Selective Suppressor of TLR4-Induced, but Not TLR3-Induced, Production of IL-27(p28) from Macrophages. Journal of immunology (Baltimore, Md. : 1950). 2012 May 15. 188(10): 5086-93. PMID# 22491257

Lee Kangwon, Lee Jiseok, Jeong Eun Jeong, Kronk Adam, Elenitoba-Johnson Kojo S J, Lim Megan S, Kim Jinsang. Conjugated polyelectrolyte-antibody hybrid materials for highly fluorescent live cell-imaging. Advanced materials (Deerfield Beach, Fla.). 2012 May 8. 24(18): 2479-84. PMID# 22488758

Cha Hyuk C, Harting Mandy, Cha Kelly B, Ludgate Mathew W, Olsen Stephen H, Zhao Lili, Lao Christopher D. Effects of contiguous scars in dermatoscopic evaluation of clinically atypical melanocytic nevi. Journal of the American Academy of Dermatology. 2012 May. 66(5): e179-80. PMID# 22507589

Bosmann Markus, Grailer Jamison J, Zhu Ketong, Matthay Michael A, Sarma J Vidya, Zetoune Firas S, Ward Peter A. Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 May. 26(5): 2137-44. PMID# 22318967

Simon Derek P, Giordano Thomas J, Hammer Gary D. Upregulated JAG1 Enhances Cell Proliferation in Adrenocortical Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 May 1. 18(9): 2452-64. PMID# 22427350

Miller Richard A. Genes against aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2012 May. 67(5): 495-502. PMID# 22459617

Xue Xiang, Taylor Matthew, Anderson Erik, Hao Cathy, Qu Aijuan, Greenson Joel K, Zimmermann Ellen M, Gonzalez Frank J, Shah Yatrik M. Hypoxia-inducible factor-2ż activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer research. 2012 May 1. 72(9): 2285-93. PMID# 22419665

Sahu Anirban, Iyer Matthew K, Chinnaiyan Arul M. Insights into Chinese prostate cancer with RNA-seq. Cell research. 2012 May. 22(5): 786-8. PMID# 22453238

Purdy Julianne K, Appelman Henry D, McKenna Barbara J. Sloughing esophagitis is associated with chronic debilitation and medications that injure the esophageal mucosa. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2012 May. 25(5): 767-75. PMID# 22282305

Grekin Sarah J, Fox Matthew C, Gudjonsson Johann E, Fullen Douglas R. Psoriasiform pemphigus foliaceus: a report of two cases. Journal of cutaneous pathology. 2012 May. 39(5): 549-53. PMID# 22449394

Demichelis Francesca, Setlur Sunita R, Banerjee Samprit, Chakravarty Dimple, Chen Jin Yun Helen, Chen Chen X, Huang Julie, Beltran Himisha, Oldridge Derek A, Kitabayashi Naoki, Stenzel Birgit, Schaefer Georg, Horninger Wolfgang, Bektic Jasmin, Chinnaiyan Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk. Proceedings of the National Academy of Sciences of the United States of America. 2012 Apr 24. 109(17): 6686-91. PMID# 22496589

Pediatrics & Communicable Diseases

Zakhem Elie, Raghavan Shreya, Gilmont Robert R, Bitar Khalil N. Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials. 2012 Jun. 33(19): 4810-7. PMID# 22483012

Gidengil Courtney, Lieu Tracy A, Payne Katherine, Rusinak Donna, Messonnier Mark, Prosser Lisa A. Parental and societal values for the risks and benefits of childhood combination vaccines. Vaccine. 2012 May 14. 30(23): 3445-52. PMID# 22449423

Woolford Susan J, Clark Sarah J, Sallinen Bethany J, Geiger James D, Freed Gary L. Bariatric surgery decision making challenges: the stability of teens' decisions and the treatment failure paradox. Pediatric surgery international. 2012 May. 28(5): 455-60. PMID# 22453927

Woolford Susan J, Clark Sarah J, Sallinen Bethany J, Geiger James D, Freed Gary L. Bariatric surgery decision making challenges: the stability of teens' decisions and the treatment failure paradox. Pediatric surgery international. 2012 May. 28(5): 455-60. PMID# 22453927

Sun Gordon H, Davis Matthew M. The patient protection and affordable care act of 2010: impact on otolaryngology practice and research. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012 May. 146(5): 690-3. PMID# 22282865

Woolford Susan J, Clark Sarah J, Sallinen Bethany J, Geiger James D, Freed Gary L. Bariatric surgery decision making challenges: the stability of teens' decisions and the treatment failure paradox. Pediatric surgery international. 2012 May. 28(5): 455-60. PMID# 22453927

Krans Elizabeth E, Davis Matthew M. Preventing Low Birthweight: 25 years, prenatal risk, and the failure to reinvent prenatal care. American journal of obstetrics and gynecology. 2012 May. 206(5): 398-403. PMID# 21889122

Cornell Timothy T, Sun Lei, Hall Mark W, Gurney James G, Ashbrook Matthew J, Ohye Richard G, Shanley Thomas P. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery. 2012 May. 143(5): 1160-1166.e1. PMID# 21996297

Pipe Steven W. The hope and reality of long-acting hemophilia products. American journal of hematology. 2012 May. 87 Suppl 1(): S33-9. PMID# 22389200

Han Meilan K, Huang Yvonne J, Lipuma John J, Boushey Homer A, Boucher Richard C, Cookson William O, Curtis Jeffrey L, Erb-Downward John, Lynch Susan V, Sethi Sanjay, Toews Galen B, Young Vincent B, Wolfgang Matthew C, Huffnagle Gary B, Martinez Fernando J Significance of the microbiome in obstructive lung disease. Thorax. 2012 May. 67(5): 456-63. PMID# 22318161

Amoako Kagya A, Archangeli Christopher, Handa Hitesh, Major Terry, Meyerhoff Mark E, Annich Gail M, Bartlett Robert H. Thromboresistance characterization of extruded nitric oxide-releasing silicone catheters. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2012 May. 58(3): 238-46. PMID# 22395119

Cornell Timothy T, Sun Lei, Hall Mark W, Gurney James G, Ashbrook Matthew J, Ohye Richard G, Shanley Thomas P. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery. 2012 May. 143(5): 1160-1166.e1. PMID# 21996297

Liu Yiqing, Shangguan Yu, Barks John D E, Silverstein Faye S. Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model. Pediatric research. 2012 May. 71(5): 559-65. PMID# 22398701

Liu Yiqing, Shangguan Yu, Barks John D E, Silverstein Faye S. Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model. Pediatric research. 2012 May. 71(5): 559-65. PMID# 22398701

Ramirez Ixsy, Lumeng Carey N. Daily and intermittent corticosteroids have similar impact on recurrent wheezing in young children. The Journal of pediatrics. 2012 May. 160(5): 881. PMID# 22516330

Levine John E, Logan Brent R, Wu Juan, Alousi Amin M, Bolańos-Meade Javier, Ferrara James L M, Ho Vincent T, Weisdorf Daniel J, Paczesny Sophie. Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. Blood. 2012 Apr 19. 119(16): 3854-60. PMID# 22383800

Ramsey Bonnie W, Banks-Schlegel Susan, Accurso Frank J, Boucher Richard C, Cutting Garry R, Engelhardt John F, Guggino William B, Karp Christopher L, Knowles Michael R, Kolls Jay K, Lipuma John J, Lynch Susan, McCray Paul B, Rubenstein Ronald C, Singh Pra Future Directions in Early Cystic Fibrosis Lung Disease Research: An NHLBI Workshop Report. American journal of respiratory and critical care medicine. 2012 Apr 15. 185(8): 887-92. PMID# 22312017

Zickafoose Joseph S, Gebremariam Achamyeleh, Davis Matthew M. Medical home disparities for children by insurance type and state of residence. Maternal and child health journal. 2012 Apr. 16 Suppl 1(): 178-87. PMID# 22453328

Abir Mahshid, Choi Hwajung, Cooke Colin R, Wang Stewart C, Davis Matthew M. Effect of a mass casualty incident: clinical outcomes and hospital charges for casualty patients versus concurrent inpatients. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2012 Mar. 19(3): 280-6. PMID# 22435860

Pharmacology

Satin L S. Synapsins I and II Are Not Required for ß-Cell Insulin Secretion: Granules Must Pool Their Own Weight. Endocrinology. 2012 May. 153(5): 2059-61. PMID# 22523332

Edwards Bruce S, Zhu Jingshu, Chen Jun, Carter Mark B, Thal David M, Tesmer John J G, Graves Steven W, Sklar Larry A. Cluster cytometry for high-capacity bioanalysis. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012 May. 81(5): 419-29. PMID# 22438314

Lin Hsia-Lien, Kenaan Cesar, Hollenberg Paul F. Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect. Drug metabolism and disposition: the biological fate of chemicals. 2012 May. 40(5): 998-1006. PMID# 22344702

Physical Medicine & Rehabilitation

Jensen M P, Molton I R, Groah S L, Campbell M L, Charlifue S, Chiodo A, Forchheimer M, Krause J S, Tate D. Secondary health conditions in individuals aging with SCI: Terminology, concepts and analytic approaches. Spinal cord. 2012 May. 50(5): 373-8. PMID# 22143678

Blain-Moraes Stefanie, Schaff Riley, Gruis Kirsten L, Huggins Jane E, Wren Patricia A. Barriers to and mediators of brain-computer interface user acceptance: focus group findings. Ergonomics. 2012 May. 55(5): 516-25. PMID# 22455595

Bombardier Charles H, Fann Jesse R, Tate Denise G, Richards J Scott, Wilson Catherine S, Warren Ann Marie, Temkin Nancy R, Heinemann Allen W. An exploration of modifiable risk factors for depression after spinal cord injury: which factors should we target? Archives of physical medicine and rehabilitation. 2012 May. 93(5): 775-81. PMID# 22440484

Boninger M L, Brienza D, Charlifue S, Chen Y-Y, Curley K C, Graves D E, Groah S, Heinemann A W, Hudson L M, Jackson A B, Johnson K L, Kalpakjian C Z, Kusiak A, Larson K E, Agustin T S, Sherwood A M, Shinowara N, Stripling T, Tate D. State of the Science Conference in Spinal Cord Injury Rehabilitation 2011: introduction. Spinal cord. 2012 May. 50(5): 342-3. PMID# 22450887

Peterson Mark D, Haapala Heidi J, Hurvitz Edward A. Predictors of cardiometabolic risk among adults with cerebral palsy. Archives of physical medicine and rehabilitation. 2012 May. 93(5): 816-21. PMID# 22541309

Schepens Stacey L, Braun Marcia E, Murphy Susan L. Effect of tailored activity pacing on self-perceived joint stiffness in adults with knee or hip osteoarthritis. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association. 2012 May-Jun. 66(3): 363-7. PMID# 22549602

Psychiatry

Polak Katarzyna Anna, Puttler Leon I, Ilgen Mark Andrew. The Relationship between Structural Aspects of Self-Concept and Psychosocial Adjustment in Adolescents from Alcoholic Families. Substance use&misuse. 2012 Jun. 47(7): 827-36. PMID# 22489772

Resko Stella M, Walton Maureen A, Chermack Stephen T, Blow Frederic C, Cunningham Rebecca M. Therapist competence and treatment adherence for a brief intervention addressing alcohol and violence among adolescents. Journal of substance abuse treatment. 2012 Jun. 42(4): 429-37. PMID# 22119182

Villafuerte S, Heitzeg M M, Foley S, Wendy Yau W-Y, Majczenko K, Zubieta J-K, Zucker R A, Burmeister M. Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Molecular psychiatry. 2012 May. 17(5): 511-9. PMID# 21483437

Reppell Mark, Boehnke Michael, Zöllner Sebastian. FTEC: a coalescent simulator for modeling faster than exponential growth. Bioinformatics (Oxford, England). 2012 May 1. 28(9): 1282-3. PMID# 22441586

Shapiro Danielle N, Kaplow Julie B, Amaya-Jackson Lisa, Dodge Kenneth A. Behavioral markers of coping and psychiatric symptoms among sexually abused children. Journal of traumatic stress. 2012 Apr. 25(2): 157-63. PMID# 22522729

Dalack Gregory W, Jibson Michael D. Clinical skills verification, formative feedback, and psychiatry residency trainees. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry. 2012 Mar 1. 36(2): 122-5. PMID# 22532202

Radiation Oncology

Chung Eugene, Stenmark Matthew H, Evans Cheryl, Narayana Vrinda, McLaughlin Patrick W. Expansion/De-expansion Tool to Quantify the Accuracy of Prostate Contours. International journal of radiation oncology, biology, physics. 2012 May 1. 83(1): 33-7. PMID# 22079729

Ben-Josef Edgar, Taylor Jeremy M G, Lawrence Theodore S. Radiotherapy Improves Survival in Unresectable Pancreatic Cancer: Small Trial but Big (and Credible) Results. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012 May 1. 30(13): 1565-6. PMID# 22412130

Yang Dong, Zhao Yongchao, Li Amy Y, Wang Shaomeng, Wang Gongxian, Sun Yi. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast cancer research and treatment. 2012 May. 133(1): 189-99. PMID# 21901386

Radiology

Araujo Paulo H, Rabuck Stephen J, Fu Freddie H, Miller Bruce S, Downie Brian K, Kohen Robert B, Kijek Theresa G, Lesniak Bryson, Jacobson Jon A, Hughes Richard E, Carpenter James E. Are we allowing patients to return to participation too soon? Letter to the editor. The American journal of sports medicine. 2012 May. 40(5): NP5-6. PMID# 22547157

Avram Anca M. Radioiodine Scintigraphy with SPECT/CT: An Important Diagnostic Tool for Thyroid Cancer Staging and Risk Stratification. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012 May. 53(5): 754-64. PMID# 22550280

Rajajee Venkatakrishna, Fletcher Jeffrey J, Pandey Aditya S, Gemmete Joseph J, Chaudhary Neeraj, Jacobs Teresa L, Gregory Thompson B. Low pulsatility index on transcranial Doppler predicts symptomatic large-vessel vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2012 May. 70(5): 1195-206. PMID# 22089755

Bou-Assaly Wessam, Srinivasan Ashok, Mukherji Suresh K. Head and neck high-field imaging: oncology applications. Neuroimaging clinics of North America. 2012 May. 22(2): 285-96. PMID# 22548933

Sadigh Gelareh, Carlos Ruth C, Neal Colleen H, Dwamena Ben A. Ultrasonographic differentiation of malignant from benign breast lesions: a meta-analytic comparison of elasticity and BIRADS scoring. Breast cancer research and treatment. 2012 May. 133(1): 23-35. PMID# 22057974

Kaza Ravi K, Platt Joel F, Al-Hawary Mahmoud M, Wasnik Ashish, Liu Peter S, Pandya Amit. CT Enterography at 80 kVp With Adaptive Statistical Iterative Reconstruction Versus at 120 kVp With Standard Reconstruction: Image Quality, Diagnostic Adequacy, and Dose Reduction. AJR. American journal of roentgenology. 2012 May. 198(5): 1084-92. PMID# 22528897

Kotagal Vikas, Albin Roger L, Müller Martijn L T M, Koeppe Robert A, Chervin Ronald D, Frey Kirk A, Bohnen Nicolaas I. Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Annals of neurology. 2012 Apr. 71(4): 560-8. PMID# 22522445

Surgery

Zhang Xuejun, Liu Jin-Qing, Shi Yun, Reid Hugh H, Boyd Richard L, Khattabi Mazin, El-Omrani Hani Y, Zheng Pan, Liu Yang, Bai Xue-Feng. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. European journal of immunology. 2012 Apr. 42(4): 924-35. PMID# 22213356

Surgery – General Surgery

Pohlmann Joshua R, Akay Begum, Camboni Daniele, Koch Kelly L, Mervak Benjamin M, Cook Keith E. A low mortality model of chronic pulmonary hypertension in sheep. The Journal of surgical research. 2012 Jun 1. 175(1): 44-8. PMID# 21529838

Bosmann Markus, Haggadone Mikel D, Hemmila Mark R, Zetoune Firas S, Sarma J Vidya, Ward Peter A. Complement Activation Product C5a Is a Selective Suppressor of TLR4-Induced, but Not TLR3-Induced, Production of IL-27(p28) from Macrophages. Journal of immunology (Baltimore, Md. : 1950). 2012 May 15. 188(10): 5086-93. PMID# 22491257

Merkow Ryan P, Hall Bruce L, Cohen Mark E, Dimick Justin B, Wang Edward, Chow Warren B, Ko Clifford Y, Bilimoria Karl Y. Relevance of the C-statistic when evaluating risk-adjustment models in surgery. Journal of the American College of Surgeons. 2012 May. 214(5): 822-30. PMID# 22440055

Wang Ying, Zhao Beilei, Zhang Yi, Tang Zhihui, Shen Qiang, Zhang Youyi, Zhang Weizhen, Du Jie, Chien Shu, Wang Nanping. Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury. British journal of pharmacology. 2012 Apr. 165(7): 2378-88. PMID# 22017667

Yue Hao, Fan Zhenxin, Liu Shaoying, Liu Yang, Song Zhaobin, Zhang Xiuyue. A Mitogenome of the Chevrier's Field Mouse (Apodemus Chevrieri) and Genetic Variations Inferred from the Cytochrome b Gene. DNA and cell biology. 2012 Apr. 31(4): 460-9. PMID# 21870961

Zhang Xuejun, Liu Jin-Qing, Shi Yun, Reid Hugh H, Boyd Richard L, Khattabi Mazin, El-Omrani Hani Y, Zheng Pan, Liu Yang, Bai Xue-Feng. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. European journal of immunology. 2012 Apr. 42(4): 924-35. PMID# 22213356

Liu Runhua, Kain Mandy, Wang Lizhong. Inactivation of X-linked tumor suppressor genes in human cancer. Future oncology (London, England). 2012 Apr. 8(4): 463-81. PMID# 22515449

Liu Y, Weinert M, Li L. Spiral Growth without Dislocations: Molecular Beam Epitaxy of the Topological Insulator Bi_{2}Se_{3} on Epitaxial Graphene/SiC(0001). Physical review letters. 2012 Mar 16. 108(11): 115501. PMID# 22540484

Abir Mahshid, Choi Hwajung, Cooke Colin R, Wang Stewart C, Davis Matthew M. Effect of a mass casualty incident: clinical outcomes and hospital charges for casualty patients versus concurrent inpatients. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2012 Mar. 19(3): 280-6. PMID# 22435860

Ahrns-Klas Karla S, Wahl Wendy L, Hemmila Mark R, Wang Stewart C. Do burn centers provide juvenile firesetter intervention? Journal of burn care&research : official publication of the American Burn Association. 2012 Mar-Apr. 33(2): 272-8. PMID# 22540137

Surgery – Plastic Surgery

Diaz-Garcia Rafael J, Chung Kevin C. The evolution of distal radius fracture management: a historical treatise. Hand clinics. 2012 May. 28(2): 105-11. PMID# 22554653

Chung Kevin C. Preface. Hand clinics. 2012 May. 28(2): xi-xii. PMID# 22554669

Naguib Mohamed, Xu Jijun J, Diaz Philippe, Brown David L, Cogdell David, Bie Bihua, Hu Jianhua, Craig Suzanne, Hittelman Walter N. Prevention of Paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system. Anesthesia and analgesia. 2012 May. 114(5): 1104-20. PMID# 22392969

Nellans Kate W, Kowalski Evan, Chung Kevin C. The epidemiology of distal radius fractures. Hand clinics. 2012 May. 28(2): 113-25. PMID# 22554654

Sebastin Sandeep J, Chung Kevin C. An asian perspective on the management of distal radius fractures. Hand clinics. 2012 May. 28(2): 151-6. PMID# 22554658

Diaz-Garcia Rafael J, Chung Kevin C. Common myths and evidence in the management of distal radius fractures. Hand clinics. 2012 May. 28(2): 127-33. PMID# 22554655

Ozer Kagan, Chung Kevin C. The use of bone grafts and substitutes in the treatment of distal radius fractures. Hand clinics. 2012 May. 28(2): 217-23. PMID# 22554665

Haase Steven C, Chung Kevin C. Management of malunions of the distal radius. Hand clinics. 2012 May. 28(2): 207-16. PMID# 22554664

Davis Sears Erika, Chung Kevin C. A guide to interpreting a study of patient-reported outcomes. Plastic and reconstructive surgery. 2012 May. 129(5): 1200-7. PMID# 22544102

Ono Shimpei, Shauver Melissa J, Chang Kate W C, Chung Kevin C. Outcomes of pyrolytic carbon arthroplasty for the proximal interphalangeal joint at 44 months' mean follow-up. Plastic and reconstructive surgery. 2012 May. 129(5): 1139-50. PMID# 22261566

Surgery – Vascular Surgery

Berguer Ramon. Near infrared fluorescent imaging as a surgical navigation tool: the time has come. AORN journal. 2012 May. 95(5): 653-7. PMID# 22541776

Meissner Mark H, Gloviczki Peter, Comerota Anthony J, Dalsing Michael C, Eklof Bo G, Gillespie David L, Lohr Joann M, McLafferty Robert B, Murad M Hassan, Padberg Frank, Pappas Peter, Raffetto Joseph D, Wakefield Thomas W. Early thrombus removal strategies for acute deep venous thrombosis: Clinical Practice Guidelines of the Society for Vascular Surgery and the American Venous Forum. Journal of vascular surgery : official publication, the Society for Vascular Surgery [and]International Society for Cardiovascular Surgery, North American Chapter. 2012 May. 55(5): 1449-62. PMID# 22469503

Rodriguez April L, Wojcik Brandon M, Wrobleski Shirley K, Myers Daniel D, Wakefield Thomas W, Diaz Jose A. Statins, inflammation and deep vein thrombosis: a systematic review. Journal of thrombosis and thrombolysis. 2012 May. 33(4): 371-82. PMID# 22278047

Urology

Williams Stephen B, Salami Simpa, Regan Meredith M, Ankerst Donna P, Wei John T, Rubin Mark A, Thompson Ian M, Sanda Martin G. Selective detection of histologically aggressive prostate cancer: An Early Detection Research Network Prediction model to reduce unnecessary prostate biopsies with validation in the Prostate Cancer Prevention Trial. Cancer. 2012 May 15. 118(10): 2651-8. PMID# 22006057

Hollenbeck Brent K. Editorial comment. Urology. 2012 May. 79(5): 1178-9. PMID# 22546397

Wheat Jeffery C, Weizer Alon Z, Wolf J Stuart, Lotan Yair, Remzi Mesut, Margulis Vitaly, Wood Christopher G, Montorsi Francesco, Roscigno Marco, Kikuchi Eiji, Zigeuner Richard, Langner Cord, Bolenz Christian, Koppie Theresa M, Raman Jay D, Fernández Mario Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy. Urologic oncology. 2012 May. 30(3): 252-8. PMID# 20451416

Jacobs Bruce L, Tan Hung-Jui, Montgomery Jeffrey S, Weizer Alon Z, Wood David P, Miller David C, Wolf J Stuart, Hafez Khaled S. Understanding criteria for surveillance of patients with a small renal mass. Urology. 2012 May. 79(5): 1027-33. PMID# 22546379

Ng Yee Seng, Roca Hernan, Fuller David, Sud Sudha, Pienta Kenneth J. Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. Journal of cellular biochemistry. 2012 May. 113(5): 1714-23. PMID# 22213010

Roca Hernan, Craig Matthew J, Ying Chi, Varsos Zachary S, Czarnieski Paul, Alva Ajjai S, Hernandez James, Fuller David, Daignault Stephanie, Healy Patrick N, Pienta Kenneth J. IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation. Journal of cellular biochemistry. 2012 May. 113(5): 1569-80. PMID# 22174091

Gadzinski Adam J, Roberts William W, Faerber Gary J, Wolf J Stuart. Long-term Outcomes of Immediate Versus Delayed Nephroureterectomy for Upper Tract Urothelial Carcinoma. Journal of endourology / Endourological Society. 2012 May. 26(5): 566-73. PMID# 21879886

Demichelis Francesca, Setlur Sunita R, Banerjee Samprit, Chakravarty Dimple, Chen Jin Yun Helen, Chen Chen X, Huang Julie, Beltran Himisha, Oldridge Derek A, Kitabayashi Naoki, Stenzel Birgit, Schaefer Georg, Horninger Wolfgang, Bektic Jasmin, Chinnaiyan Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk. Proceedings of the National Academy of Sciences of the United States of America. 2012 Apr 24. 109(17): 6686-91. PMID# 22496589

Tan Hung-Jui, Norton Edward C, Ye Zaojun, Hafez Khaled S, Gore John L, Miller David C. Long-term survival following partial vs radical nephrectomy among older patients with early-stage kidney cancer. JAMA : the journal of the American Medical Association. 2012 Apr 18. 307(15): 1629-35. PMID# 22511691

 


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