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FEBRUARY 2012, Vol. 30

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Enter $50 Prize Drawing by Taking the Office of Research Website Survey!

Every day, hundreds of people navigate and use the Web resources of the Health System and Medical School. To better understand the needs and usage habits of actual users among faculty and staff, the Office of Research has crafted a brief online survey that we would ask you to take 10 minutes to complete:

Click here to answer the survey.

Your feedback will help us plan and maintain better web resources. PLUS everyone who submits a completed survey will be entered automatically in a prize drawing to win a $50 Barnes & Noble gift card!

First BRCF Technology & Services Showcase Draws More than 250 Attendees

The BRCF Technology & Services Showcase brought together dozens of vendors and the Biomedical Research Core Facilities to exhibit the latest technology and service innovations available to U-M biomedical researchers. More than 250 people attended the showcase, and more than 75 people attended the DNA Next-Gen Sequencing speaking sessions, hosted by DNA Sequencing Core Director Robert Lyons, Ph.D.

The Biomedical Research Core Facilities strive to meet your needs, and would like to hear attendee’s feedback and comments from the event in order to improve the Showcase in the future. Please share your thoughts by filling out the event survey.

Passport to Prizes Winners Announced!
Congratulations to the prize-drawing winners from the showcase:

  • Trenton Lawrence Baker, who won the iPad 2
  • Sarah Geisler, who won the Kindle Fire
  • Dr. Mohammad Amin, who won the $50 Whole Foods Gift Card

Thank you again to everyone who attended and made the event a success. Visit the BRCF website to see a slideshow of the event.

Judy Birk Named Interim-Director of IRBMED Office

Judy Birk, J.D., has been named Interim-Director of the Institutional Review Boards of the University of Michigan Medical School (IRBMED).

Birk has served as the director of the Health Sciences and Behavioral Sciences IRBs since 2003, reporting to the Office of the Vice President for Research, and was formerly the director of Patient Relations for the U-M Health System.

Birk, who will be responsible for daily oversight of the operations of the IRBs and their regulatory compliance, will be serving in a dual director role of the IRBs during a national search for a permanent director. As a long-standing staff member at U-M, Judy has served on multiple compliance, ethics and research regulatory committees.

Birk’s colleagues have noted her willingness to share her leadership, deep regulatory knowledge and insights during this time of transition.


Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


Human Research

IRBMED Offers Consultations

IRBMED (Institutional Review Boards of the U-M Medical School) offers consultations on various human subjects’ research protection topics.  These educational consults are designed for small groups (typically less than 10 people).  For information about what topics are offered or to request a consult visit the IRBMED website.


Animal Research

Expansion of eResearch Animal Management (eRAM)

The ULAM Business Office along with the UCUCA Office is very excited about the expansion of the eResearch Animal Management (eRAM) system to include paperless animal ordering and transfers coming in the spring of 2012.  This will be part of the same eRAM system you are familiar with and currently using for protocol application and management.   The overall goal of eRAM is to streamline the animal management process by creating a completely integrated system that will link protocol development and maintenance with animal ordering, animal transfers and non-vendor acquisitions.

This additional Animal Management component will allow investigators, authorized staff, departments and units to better management their protocol and animal data as well as improve communication between all these different groups.  In the future we will be adding per diem census and invoicing to further enhance the integration of animal research data.  This implementation will allow customers to have access to invoices as well as cage counts/census data.  Ordering of breeding sheets and barcode stickers will also be included in future implementations.

Since this is an implemented enhancement with the current eRAM system, there will be no need for any additional login or passwords.  We will be simply adding functionality to your existing eRAM access.

If you have any questions or concerns, please contact the ULAM Business Office at 734-764-0277.


Tips on Grant Proposal Preparation

Project Scope: Set Boundaries… Especially for New Investigators

By Christine Black, Assistant Director for Research Services, Office of Research

(This is one in a series of tips published in UMMS Research News about writing proposals.)

Over ambition is a common diagnosis for new investigators’ grant proposals. After the reviewers assess whether the approach matches the aims, they will ask – is this work realistic?

As you are developing your experimental plan/approach, think about:

  1. How much time will it take for all steps, e.g., subject recruitment; project preparation; controls; experimentation; replications; data collection, analysis, interpretation?
  2. How much will your experiments cost (especially for personnel effort or expensive materials or equipment)?
  3. How feasible will it be to gather your data?  Determine your alternative strategies – consider time/expense.
  4. What resources do you need to obtain with grant funding (e.g., consultants, subcontracts)?

Assess early in the proposal development process and be realistic about what you can accomplish. Reviewers recognize both research naiveté and smugness – and do not fancy either.

Unsure? You may want to get advice from your colleagues, program officer, or comprehensive reviews through the BMRC Pilot Program for Grant Pre-Reviews.

Related article


New Laboratory Management Support Document Available

U-M Occupational Safety and Environmental Health (OSEH) wants to make the university research community aware of a valuable new informational tool for research safety that has recently been published by Federal OSHA.  The publication contains educational materials for laboratory managers on protecting their workers from exposure to chemical, biological, and physical hazards:

Laboratory Safety Guidance

This document describes how electrical hazards, fire, explosions, and falls, among other hazards, can be minimized or eliminated if employers use safety plans, worker training, engineering controls, and personal protective equipment.  The materials also include fact sheets that each focus on a specific hazard related to laboratory environments.  For future reference, the link to this document can be found on the UM-OSEH “Research Safety” webpage.

New Risk Communication Tips for Laboratory Managers

The recent laboratory accidents at UCLA, Texas Tech University, and others point to communication challenges for laboratory directors and managers.  It is often a challenge to ensure that graduate students and other research laboratory personnel have completely understood important instructions about the safety aspects of their assigned materials and methods.  A recent article in the C&EN News is focused on the faculty perspective, and gives some good tips on how a faculty member can ensure that their reports have understood their instructions.  One telling quote from this article reads as follows:

“After the accident what became clear to me was that oral communication with students was never enough to ensure they understood,” Hope-Weeks says.  [Louisa Hope-Weeks is a chemistry professor at Texas Tech University.]  Now, “when it comes to lab work, we discuss it, and then I say go away and write it down and send it to me.”  Hope-Weeks reviews the document, flags any issues, and the student will rewrite as necessary until Hope-Weeks is confident that the student knows what to do and how to do it safely.

OSEH recommends that you discuss this communication tool with your staff.


Need Help Inserting Images into Grant Proposal Applications?

You can now access a document on the Medical School Office of Research website that will help you do just that.  The document offers instruction on the efficient and proper placement of images, charts, and graphics that are critical in grant proposal applications. Basic features in Microsoft Word such as image placement, captioning, and word wrapping are explained.

“Inserting Images into Grant Proposal Applications”

If you would like additional assistance, workshops on this topic are offered through the Taubman Health Sciences Library. Contact Merle Rosenzweig for information on upcoming workshops.

Free Consultation Services and Workshops Offered by the Center for Statistical Consultation and Research (CSCAR)

The Center for Statistical Consultation and Research (CSCAR) provides free statistical consulting to all U-M faculty, staff, and graduate students to help with the design, planning, analysis, and presentation of results of research studies.

CSCAR also presents workshops on statistical methods, statistical software, qualitative data analysis and geographic information systems. Fall, Winter and Spring workshop offerings include SAS, SPSS, Stata, SEM and Statistics Review.

Visit the CSCAR website for current offerings and additional information.

For registration, call 734-764-7828.

University of Michigan - Medical Innovation Center Summit
“Achieving Global Biomedical Innovation for Children”
Register now at a discounted rate of $250!! (Regular rate is $395.)

Tuesday, March 20 - Thursday, March 22, 2012
Sheraton Ann Arbor Hotel, Ann Arbor, MI

Global participants from industry, academia, and government will converge to witness pediatric device, diagnostic, and therapeutic success stories, develop strategies for overcoming commercial barriers, and collaboratively design solutions to emerging pediatric clinical markets.

Confirmed speakers include:

  • Dan Strauch, Director of Marketing, Maternal Infant Care, GE Healthcare
  • Richard G. Ohye, M.D., U-M Associate Professor of Surgery, Director of Pediatric Cardiac Surgery and Pediatric Cardiovascular Transplant Programs
  • Martin Bocks, M.D., U-M Assistant Professor of Pediatrics and Internal Medicine
  • Susan Alpert, Ph.D., M.D., formerly Medtronic's Senior Vice President & Chief Regulatory Officer
  • P. Brian Smith, M.D., M.P.H., M.H.S., Associate Professor of Pediatrics, Duke Clinical Research Institute Member, Drug Pediatrics Trial Network Steering Committee
  • Robert H. Bartlett, M.D., U-M Professor Emeritus, General Surgery
  • James J. Huttner, M.D., Ph.D., co-Founder and VP New Product Development, Bionix
  • Andre A. Muelenaer, Jr., M.S., M.D., President and CMO, PMDI, and Carilion Clinic Pediatric Pulmonology/Allergy Section Chief, Device Pediatrics Trial Network Steering Committee
  • Daniel Teitelbaum, M.D., U-M Professor of Surgery
  • James Geiger, M.D., U-M Professor of Surgery
  • Anil Mankodi, Program Director, Transcatheter Pulmonary Valve Development Programs Structural Heart, Medtronic Cardiac and Vascular

Click here to register and view complete information.

Masters in Entrepreneurship Program Now at the University of Michigan

The University of Michigan is proud to announce the launch of a new Master of Entrepreneurship Program. The Master of Entrepreneurship Program is a collaborative effort between Michigan's College of Engineering and the Ross School of Business. This new program offers students a specialized focus on technology-based startups combined with an education in entrepreneurial business fundamentals. This intense, one-year program develops entrepreneurial leaders who are prepared to start their own enterprise or assist companies in developing and launching new technologies. Students can enroll with their own technology or will team with researchers developing technologies at the University. Applications are now being accepted. Apply today!


Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.

Internal Submissions

UM Cancer Center Grants
Deadline: First Thursday of each month as funds are available. Grants may not be reviewed in a given month if too few are received. Grants are not reviewed in July and August.

The Cancer Center’s Cancer Research Committee (CRC) invites applications from faculty requesting support for investigator-initiated research proposals that focus on the cancer problem or have clear cancer relevance. For further information, visit the website.

  • Research Grants are available for an investigator for his/her cancer-related research, or for any interesting and innovative collaboration between scientists. Funds are available for faculty in any unit of the University, but cannot be used for salary support for persons holding a Ph.D. or M.D. Total amount may not exceed $40,000.
  • Idea Grants are available for any investigator who has a novel and innovative idea for cancer research. Preliminary data to support the feasibility of the proposed studies are not required; however preliminary data may be helpful in assessing the merits of the application, and applicants are encouraged to include preliminary data if they are available. Funds may not be used for salary support for any person holding a Ph.D. or M.D. Funding may not exceed $30,000.
Michigan Nutrition Obesity Research Center (MNORC) Pilot / Feasibility Grant Program
Deadline: March 15, 2012 (5:00 PM)

The purpose of the MNORC Pilot /Feasibility (P/F) Grant Program is to promote research on the biological and behavioral determinants of obesity, and to develop interventions to reduce obesity and its disease sequelae using basic, clinical, or population approaches. The program’s aim is to enable both new and established University of Michigan investigators to generate sufficient preliminary information for a successful application for major research funding from NIH or other national granting agencies.

Grant proposals may be in areas of basic biomedical research or in clinical, epidemiological, or translational research, e.g., interventions in clinical or population-based settings. Animal or human models may be considered. Grant proposals involving cross-disciplinary expertise, faculty from different UM schools, and that utilize the core laboratories of the MNORC are especially encouraged.

Individuals who have full-time instructional or research faculty positions at the University of Michigan are eligible to apply as Principal Investigators of P/F proposals. Eligible applicants are: (a) new investigators beginning careers in research on nutrition and obesity; (b) established investigators in areas of biomedical research who wish to focus their expertise on nutrition, obesity and related areas; or (c) established nutritional sciences or obesity investigators who wish to take an entirely new direction from their usual work. This new direction cannot be an extension or outgrowth of research currently being undertaken by the applicant.

Proposals should request one year of support in direct costs, with requested funding up to $50,000. For the application and further instructions, visit the website.
Administrative Contact: Grace Wu

UM Postdoctoral Translational Scholars Program
Deadline: April 16, 2012

The Postdoctoral Translational Scholars Program is a multidisciplinary career development award supported by the Michigan Institute for Clinical & Health Research (MICHR) that is designed to prepare individuals with a Ph.D. in a biomedical science or social science discipline for independent careers in translational research.

Individuals with Ph.D. degrees who are interested in obtaining additional training in translational sciences are encouraged to apply for this unique funding opportunity that will provide trainees with a $100,000 career development award that can be utilized over two to three years. Award funding can be used to support the individual's salary, course work, and/or research activities. Postdoctoral Translational Scholars will be expected to commit 50-75 percent of full time effort to the program. You must be a U.S. citizen or U.S. permanent resident to apply.

More details are available on the website.


External Awarded Grants

An asterisk next to a name means that they are the Contact PI for the program, since some projects are awarded with multiple PIs.

Click here to view.


PI: *Harte,Steven
Title: The Role of Central Neurotransmitters in the Pathophysiology of Interstitial Cystitis/Painful Bladder Syndrome
Sponsor: NIH - Subcontracts TO University of Pennsylvania  U01 DK 082345
Project Dates and Amount of Award: 07/01/11-06/30/12; $50,300

PI: *Malviya,Shobha
Title: Development and Management of Pain Assessment Training Materials - Cadence IV Acetaminophen Project
Sponsor: Cadence Pharmaceuticals
Project Dates and Amount of Award: 02/13/12-02/12/15; $35,367

Biological Chemistry

PI: *Saper,Mark
Title: Protein-protein Interaction Essential for Bacterial Growth and Virulence
Sponsor: NIH  1 R21 AI 099984 01
Project Dates and Amount of Award: 02/01/12-01/31/14; $430,995

Cell & Developmental Biology

PI: *Engel,James
Co-I: Hosoya, Tomonori (Cell and Developmental Biology) / Maillard, Ivan (Life Sciences Institute-Admin)
Title: GATA3 Regulation in Transcriptional Networks During Hematopoietic Cell Development
Sponsor: NIH  1 R01 AI 094642 01 A1
Project Dates and Amount of Award: 02/01/12-01/31/17; $1,937,060

PI: *Fingar,Diane
Title: mTOR Complex (mTORC) Regulation by Site-Specific mTOR Phosphorylation
Sponsor: American Diabetes Assoc, Inc.
Project Dates and Amount of Award: 01/01/12-12/31/12; $109,150

Comprehensive Cancer Center

PI: *Talpaz,Moshe
Awardee / Fellow: Lebovic, Daniel
Title: A Multi-Center, Open-Label, Dose Escalation, Phase 1 Study of Oral LGH447 in Patients with Relapsed and/or Refractory Multiple Myeloma
Sponsor: Novartis
Project Dates and Amount of Award: 01/18/12-10/31/14; $90,161

Family Medicine

PI: *Fetters,Michael
Title: Japanese Family Health Program, University of Michigan Health System
Sponsor: Japanese Business Society of Detroit Foundation
Project Dates and Amount of Award: 01/01/12-12/31/12; $3,000

Human Genetics

PI: *Glover,Thomas
Co-I: Wilson, Thomas (Pathology Department)
Title: De Novo CNV Formation In Vivo with Sickle Cell Anemia Therapy
Sponsor: NIH  1 R01 ES 020875 01
Project Dates and Amount of Award: 01/30/12-11/30/16; $1,852,490

PI: *Kidd,Jeffrey
Title: Characterizing the Global Architecture of Genomic Diversity
Sponsor: NIH  7 DP5 OD 009154 01
Project Dates and Amount of Award: 01/01/12-08/31/16; $1,908,390

Internal Medicine

PI: *Anderson,Michelle
Title: NAPS2 Continuation Genome Wide Association Study of Pancreatitis
Sponsor: NIH - Subcontracts TO University of Pittsburgh  R56 DK 061541
Project Dates and Amount of Award: 08/23/11-08/31/12; $8,397

PI: *Auchus,Richard
Title: An Open-Label, Multiple-Dose, Dose-Finding Study of Abiraterone Acetate in Adults With 21-Hydroxylase Deficiency (ID number 212082HPL1002)
Sponsor: Johnson & Johnson
Project Dates and Amount of Award: 12/27/11-11/30/12; $166,396

PI: *Brenner,Dean
Awardee / Fellow: Kakarala, Madhuri
Title: Targeting Stem and Myoepithelial Cells with Nutritional Compounds to Prevent Breast Cancer in Women with High Risk Ductal Carcinoma In Situ
Sponsor: Susan G. Komen for the Cure
Project Dates and Amount of Award: 01/18/12-01/17/15; $450,000

PI: *Cibrik,Diane
Sponsor: Pfizer
Project Dates and Amount of Award: 01/18/12-12/31/12; $8,674

PI: *Hasler,William
Co-I: Rothberg, Amy (Metabolism, Endo & Diabetes)
Title: Gastroparesis Clinical Research Consortium - University of Michigan Clinical Center
Sponsor: NIH  2 U01 DK 073985 06
Project Dates and Amount of Award: 09/01/11-08/31/16; $706,740

PI: *Herman,William
Co-I: Pop-Busui, Rodica (Metabolism, Endo & Diabetes)
Title: Epidemiology of Diabetes Intervention and Complications (EDIC).
Sponsor: NIH - Subcontracts TO Case Western Reserve Univ  U01 DK 094157
Project Dates and Amount of Award: 09/30/11-06/30/12; $172,502

PI: *Higgins,Peter
Title: A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn's Disease (study 3002)
Sponsor: Centocor, Inc. TO Parexel International Corp
Project Dates and Amount of Award: 01/22/22-02/22/22; $111,207

PI: *Humes,H
Title: Diabetes in the Military
Sponsor: Defense, Department of-Army, Department of the-Subcontracts TO Innovative Biotherapies
Project Dates and Amount of Award: 09/01/11-08/31/12; $86,223

PI: *Iwashyna,Theodore
Title: Physician Practice Communities
Sponsor: Johnson, Robert Wood, Fdn. TO Weill Cornell Medical College-Qatar
Project Dates and Amount of Award: 08/15/11-08/14/12; $7,512

PI: *Kaminski,Mark
Title: A Phase II, Open-Label, Multicenter Study Of Efficacy, Safety, And Biomarkers In Patients With Previously Untreated Advanced Diffuse Large B Cell Lymphoma Treated With Ga101 (Ro5072759) In Combination With Chop Chemotherapy
Sponsor: Genentech, Inc.
Project Dates and Amount of Award: 01/27/12-01/11/16; $218,134

PI: *Kaplan,Mariana
Awardee / Fellow: Knight, Jason
Title: Role of NET Formation in Models of Lupus Vascular Damage
Sponsor: Amer College of Rheumatology
Project Dates and Amount of Award: 07/01/12-06/30/14; $125,000

PI: *Kaplan,Mariana
Co-I: Berthier, Celine (Int Med-Nephrology) / Pennathur, Subramaniam (Int Med-Nephrology)
Title: Linking Innate Immunity, Oxidative Stress and Dysfunctional Lipids in Lupus
Sponsor: Lupus Research Institute
Project Dates and Amount of Award: 12/01/11-11/30/14; $300,000

PI: *Koelling,Todd
Title: Medtronic 2011 Heart Failure Fellowship Program
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 07/01/11-06/30/12; $30,000

PI: *Koelling,Todd
Title: Patient and Physician Survey Determinants of Appropriate ICD Utilization
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 01/20/12-01/20/14; $156,835

PI: *Lok,Anna
Title: An Open-Label Pilot Study to Evaluate the Antiviral Activity, Safety and Pharmacokinetics of ABT-450 with Ritonavir (ABT-450/r) Dosed in Combination with ABT-333 and Ribavirin (RBV) in Treatment-Naive Subjects with Genotype 1 Chronic Hepatitis C Virus (HCV) Infection
Sponsor: Abbott Pharmaceutical Products Division
Project Dates and Amount of Award: 07/01/11-06/30/12; $7,050

PI: *Marks,Rory
Title: ACR-REF Amgen/Pfizer Rheumatology Fellowship Training Award 2011
Sponsor: Amer College of Rheumatology
Project Dates and Amount of Award: 07/01/12-06/30/13; $25,000

PI: *Marrero,Jorge
Title: A Multicenter, Randomized, Double-Blind, Phase 3 Study of Ramucirumab (IMC-1121B) Drug Product and Best Supportive Care (BSC) Versus Placebo and BSC as Second-Line Treatment in Patients With Hepatocellular Carcinoma Following First-Line Therapy With Sorafenib
Sponsor: ImClone Systems Inc. TO Parexel International Corp
Project Dates and Amount of Award: 11/08/11-12/31/13; $94,559

PI: *Martinez,Fernando
Title: Lung Genomics Research Consortium
Sponsor: NIH - Subcontracts TO University of Colorado  RC2 HL 101715
Project Dates and Amount of Award: 07/01/11-08/31/12; $3,762

PI: *McLaughlin,Vallerie
Co-I: Rubenfire, Melvyn (Int Med-Cardiology)
Title: Registry to PROSPECTively Describe Use of Epoprostenol for Injection ("RTS Epoprostenol") in Patients with Pulmonary Arterial Hypertension
Sponsor: Actelion
Project Dates and Amount of Award: 11/01/11-12/31/12; $36,425

PI: *Pelosi Jr,Frank
Title: Biosense Webster 2011 EP Fellowship Program
Sponsor: Biosense Webster, Inc.
Project Dates and Amount of Award: 07/01/11-06/30/12; $50,000

PI: *Ramnath,Nithya
Title: Simple Serum Predictors for Erlotinib Sensitivity in Advanced Lung Cancer
Sponsor: Univ Of California - San Diego
Project Dates and Amount of Award: 06/15/11-06/14/12; $10,385

PI: *Schiopu,Elena
Co-I: Khanna, Dinesh (Int Med-Rheumatology) / Trivedi, Mona (Int Med-Rheumatology)
Title: DUAL-1:  Prospective, Randomized, Placebo-Controlled, Double-Blind, Multicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Patients with Ischemic Digital Ulcers Associated with Systemic Sclerosis.
Sponsor: Actelion
Project Dates and Amount of Award: 01/27/12-01/26/15; $458,360

PI: *Schott,Anne
Co-I: Thomas, Dafydd (Pathology Department)
Title: 2011.079:  Phase Ib Pilot Study to Evaluate Reparixin in Combination with Chemotherapy with Weekly Paclitaxel in Patients with HER-2 Negative Metastatic Breast Cancer (MBC))
Sponsor: Dompe  S.p.A.
Project Dates and Amount of Award: 09/30/11-09/30/12; $399,605

PI: *Segal,Jonathan
Title: Magnetic Drive Mechanism for VF Doppler Smart Sensor
Sponsor: NIH - Subcontracts TO Arbor Technologies, Inc.
Project Dates and Amount of Award: 01/01/12-06/30/12; $44,902

PI: *Stoffel,Elena
Title: Genetic Testing and Cancer Screening in Hereditary Cancer Syndromes
Sponsor: NIH  7 K07 CA 120448 05
Project Dates and Amount of Award: 12/22/11-05/31/12; $101,586

PI: *Wang,Shaomeng
Co-I: Chen, Jianyong (Int Med-Hematology/Oncology) / Sun, Duxin (PHARMACY Pharmaceutical Sci) / Woods, James (Pharmacology Department) / Yang, Chao-Yie (Int Med-Hematology/Oncology)
Title: Potent and Highly Selective D3 Ligands for the Treatment of Cocaine Abuse
Sponsor: NIH  1 R01 DA 032943 01
Project Dates and Amount of Award: 02/01/12-01/31/15; $2,001,204

PI: *White,Eric
Co-I: Martinez, Fernando (Int Med-Pulm./Critical Care)
Title: Matrix and Bioreactors for Human Lung Regeneration
Sponsor: NIH - Subcontracts TO Yale University  U01 HL 111016
Project Dates and Amount of Award: 01/01/12-12/31/12; $349,297

PI: *Wicha,Max
Awardee / Fellow: Hassan, Khaled
Title: Blocking the Notch Pathway Inhibits the Epithelial-Mesenchymal Transition Status in Lung Cancer.
Sponsor: NLCP
Project Dates and Amount of Award: 01/01/12-12/31/13; $108,000

PI: *Wrobel,James
Title: A Randomized Controlled Trial of Custom Foot Orthoses for the Treatment of Plantar Heel Pain
Sponsor: American Podiatric Med. Assoc. TO Rosalind Franklin University of Medicine and Sciences
Project Dates and Amount of Award: 08/01/11-03/31/12; $11,055

Medical Education

PI: *Piatt,Gretchen
Title: REACT:  Rethinking Eating and ACTivity
Sponsor: Defense, Department of-Air Force, Department of the-Subcontracts TO University of Pittsburgh
Project Dates and Amount of Award: 08/01/11-05/30/12; $44,447

PI: *Raoof,Ameed
Co-I: Stein, Tamara (Division of Anatomical Science) / Sullivan, Kelli (Division of Anatomical Science)
Title: Assessing the Effectiveness of New Embalming Fluid Used for Preservation and Presentation of Specimens for Anatomical Education
Sponsor: Greenblendz, Inc
Project Dates and Amount of Award: 12/01/11-05/31/12; $55,000

Microbiology and Immunology

PI: *Schloss,Patrick
Co-I: Marino, Simeone (Microbiology and Immunology)
Title: Diversity and Stability Relationships in the Murine Microbiome
Sponsor: NIH  1 R01 GM 099514 01
Project Dates and Amount of Award: 02/01/12-01/31/16; $1,406,160


PI: *Feldman,Eva
Title: Effect of Anti MASP-2 Treatment on the Development of Diabetic Neuropathy
Sponsor: Omeros Corporation
Project Dates and Amount of Award: 01/01/12-12/31/12; $32,554

PI: *Feldman,Eva
Title: Establishment of Clinical Trial Infrastructure
Sponsor: Neuralstem, Inc
Project Dates and Amount of Award: 02/01/12-07/31/12; $54,925

PI: *Paulson,Henry
Title: Novel Cell-Based Screens for Therapeutic Compounds in SCA3
Sponsor: National Ataxia Foundation
Project Dates and Amount of Award: 01/01/12-12/31/12; $70,000

Obstetrics & Gynecology

PI: *Andreatta,Pamela
Co-I: Dooley-Hash, Suzanne (Emergency Medicine UM Adult) / House, Joseph (Emergency Medicine UM CES) / Vahratian, Anjel (Obstetrics and Gynecology Dept)
Title: Critical Analyses and Development of Training Mechanisms: Cholinergic Crisis and Pediatric/Neonatal Intubation
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 11/04/11-09/29/14; $3,377,701

PI: *DeLancey,John
Co-I: Ashton-Miller, James (Mechanical Engineering)
Title: Urethral Mobility by MR
Sponsor: American Medical Systems
Project Dates and Amount of Award: 11/01/11-01/31/12; $27,837

Ophthalmology & Visual Sciences

PI: *Heckenlively,John
Title: Ocusciences Photography Project
Sponsor: Ocuscience
Project Dates and Amount of Award: 07/01/11-06/30/12; $4,000

Orthopaedic Surgery

PI: *Caird,Michelle
Co-I: Kozloff, Kenneth (Orthopaedic Surgery)
Title: Treatment of the Growing Spine with Bisphosphonates: Mechanical Properties and Healing
Sponsor: Scoliosis Research Society
Project Dates and Amount of Award: 03/01/12-02/28/13; $10,000

PI: *Jepsen,Karl
Title: Functionality and Fracture Susceptibility of Corticocancellous Structures
Sponsor: NIH  7 R01 AR 056639 03
Project Dates and Amount of Award: 09/15/11-07/31/12; $13,331

PI: *Mendias,Christopher
Co-I: Bedi, Asheesh (Orthopaedic Surgery) / Roessler, Blake (Int Med-Rheumatology)
Title: Treatment of Rotator Cuff Tears by Adipose-Derived Stem Cell Therapy
Sponsor: Defense, Department of-Army, Department of the-Subcontracts TO Tissue Genesis, Inc.
Project Dates and Amount of Award: 09/01/11-02/28/13; $329,935

PI: *Miller,Bruce
Title: Impact of Postoperative Management on Outcomes and healing of Rotator Cuff Repairs
Sponsor: Vanderbilt University  UL1 RR 024975
Project Dates and Amount of Award: 09/01/11-05/31/12; $10,000


PI: *Shore,Susan
Co-I: Bledsoe Jr, Sanford (Kresge Hearing Research Inst) / Umemori, Hisashi (Molecular & Behav Neurosc Inst)
Title: Function of Somatosensory Pathways to Cochlear Nucleus
Sponsor: NIH  2 R01 DC 004825 11
Project Dates and Amount of Award: 03/01/12-02/28/17; $2,525,967


PI: *Bachman,Michael
Title: The Host Mucosal Response to Microbial Iron Metabolism
Sponsor: NIH  7 K08 GM 085612 04
Project Dates and Amount of Award: 08/01/11-04/30/14; $344,417

PI: *Miller,Richard
Co-I: Galecki, Andrzej (Int Med-Geriatric Medicine) / Harper, James (Pathology Department)
Title: Consortium to Study the Genetics of Longevity
Sponsor: NIH - Subcontracts TO California Pacific Medical Center  U19 AG 023122
Project Dates and Amount of Award: 09/30/11-08/31/21; $427,570

PI: *Newton,Duane
Title: IMDX Flu A/B and RSV Assay for Abbott m2000 Assay FOR USE ON THE ABBOTT m2000 SYSTEM
Sponsor: Intelligent Medical Devices, Inc. (IMDx) TO MDC Associates, LLC
Project Dates and Amount of Award: 07/18/11-06/30/13; $80,000

PI: *Newton,Duane
Title: IntelligentMDx Vancomycin Resistance Screening Real-Time PCR assay
Sponsor: MDC Associates, LLC
Project Dates and Amount of Award: 07/18/11-06/30/13; $278,000

Pediatrics & Communicable Diseases

PI: *Barks,John
Title: Hydrocortisone and Extubation - SubProject Under Neonatal Research Network Umbrella Project
Sponsor: NIH - Subcontracts TO Wayne State University  U01 HD 036790
Project Dates and Amount of Award: 04/01/11-03/31/12; $3,822

PI: *Bocks,Martin
Co-I: Cook, Keith (GSA - Administration (GSA/ADM)) / Devaney, Eric (Cardiac Surgery Section) / Gurney, James (Pediatrics-Cardiology) / Owens, Sonal (Pediatrics-Cardiology)
Title: Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
Sponsor: NIH - Subcontracts TO Integrated Sensing Systems (ISSYS)
Project Dates and Amount of Award: 12/16/11-02/28/12; $57,260

PI: *Gipson,Debbie
Awardee / Fellow: Selewski, David
Title: Acute Kidney Injury in the Pediatric ICU
Sponsor: Renal Research Institute, LLC
Project Dates and Amount of Award: 01/01/12-12/31/12; $35,000

PI: *Levine,John
Awardee / Fellow: Harris, Andrew
Title: CIBMTR Protocol #09 The Role of Minimal Residual Disease Testing before and after Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia
Sponsor: National Marrow Donor Program (NMDP)
Project Dates and Amount of Award: 12/09/11-12/08/13; $8,000

PI: *Levine,John
Awardee / Fellow: Connelly, James
Co-I: Goldstein, Steven (Int Med-Hematology/Oncology)
Title: CIBMTR RDSafe A Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life
Sponsor: Center for International Blood and Marrow Transplant Research (CIBMTR) TO National Marrow Donor Program (NMDP)
Project Dates and Amount of Award: 02/01/12-09/30/13; $25,000

PI: *Mohr,Bethany
Co-I: Markman, Lisa (Pediatric Hospitalists) / Strouse, Peter (Department of Radiology)
Title: Medical Resources System (MRS)
Sponsor: Michigan, State of, Human Services, Department of
Project Dates and Amount of Award: 01/01/12-09/30/13; $201,368

PI: *Yanik,Gregory
Title: Data and Evaluation Agreement Jubilant Draximage Inc.
Sponsor: Jubilant DraxImage Inc
Project Dates and Amount of Award: 09/23/11-09/22/12; $1,000


PI: *Isom,Lori
Awardee / Fellow: Calhoun, Jeffrey
Title: Role of SCN1B in Pediatric Epilepsy
Sponsor: Epilepsy Foundation of America
Project Dates and Amount of Award: 01/02/12-12/31/12; $20,000


PI: *Conroy,Deirdre
Co-I: Armitage, Roseanne (Psychiatry Department) / Arnedt, J Todd (Psychiatry Department)
Title: Development of an Insomnia Treatment for Adolescents with Depression
Sponsor: Flinn, Ethel and James, Foundation
Project Dates and Amount of Award: 01/01/12-12/31/13; $170,000

PI: *Evans,Simon
Title: Nutritional Components of Psychiatric Disease and Treatment Response
Sponsor: NIH  1 K01 MH 093708 01 A1
Project Dates and Amount of Award: 01/09/12-12/31/15; $599,032

PI: *Mickey,Brian
Title: Functional Neuroimaging of Individual Differences in Affect and Motivation in Major Depression
Sponsor: NIH  1 K23 MH 092648 01 A1
Project Dates and Amount of Award: 02/01/12-01/31/16; $729,216

PI: *Sripada,Sekhar
Title: Neural and Pharmacological Issociation of Prefrontal Regulation in ADHD and Alcohol Dependence
Sponsor: NIH  1 K23 AA 020297 01 A1
Project Dates and Amount of Award: 02/05/12-01/31/17; $690,890

Radiation Oncology

PI: *Hamstra,Daniel
Title: A Phase I and Biomarker Study of Everolimus Added to Combined Hormonal and Radiation Therapy for High Risk Prostate Cancer
Sponsor: Novartis
Project Dates and Amount of Award: 10/01/11-12/31/14; $100,000


PI: *Dillman,Jonathan
Title: Siemens Funding/Supplemental to RSNA: Comparative Effectiveness of MR Enterography, Enteric Ultrasound and Ultrasound Elastography Imaging in the Evaluation of Pediatric Small Bowel Crohn Disease
Sponsor: Siemens Medical Solutions USA, Inc
Project Dates and Amount of Award: 02/02/12-02/01/14; $26,000


PI: *Beer,David
Title: Stem Cells and the Origin of Barrett's Esophagus
Sponsor: NIH - Subcontracts TO Columbia University  U54 CA 126513
Project Dates and Amount of Award: 09/26/11-08/31/12; $12,084

PI: *Chen,Guoan
Title: Discovery and Validation of Serum Micro-RNAs for Lung Cancer Diagnosis and Prognosis
Sponsor: Bonnie J. Addario Lung Cancer Foundation (BJALCF)
Project Dates and Amount of Award: 01/01/12-12/31/12; $50,000

PI: *Kunisaki,Shaun
Title: Fetal Derived Induced Pluripotent Stem Cells and Neural Progenitors for Spinal Cord Regeneration in Myelomeningocele
Sponsor: Johnson, Robert Wood, Fdn.
Project Dates and Amount of Award: 01/01/12-12/31/15; $420,000

PI: *Liu,Yang
Awardee / Fellow: Brown, Nicholas
Title: The Promotion of Inflammation by Bacterial Sialidases After Influenza Infection
Sponsor: NIH  1 F32 AI 096730 01 A1
Project Dates and Amount of Award: 02/02/12-02/01/14; $113,494

PI: *Pagani,Francis
Title: REduce Driveline Trauma through StabIlization and Exit Site (RESIST)
Sponsor: Thoratec Corporation
Project Dates and Amount of Award: 12/20/11-07/14/13; $9,300

PI: *Rectenwald,John
Title: Zenith Fenestrated AAA Endovascular Graft
Sponsor: Cook Incorporated
Project Dates and Amount of Award: 01/16/12-11/30/16; $58,200

PI: *Wang,Stewart
Title: Motor Vehicle Crash Investigation Study
Sponsor: Nissan Motor Company
Project Dates and Amount of Award: 01/01/12-03/31/12; $150,058

Unit for Laboratory Animal Medicine

PI: *Dysko,Robert
Title: ULAM Services at NCRC for Phrixus Pharmaceuticals- Non Federal Sources
Sponsor: Phrixus Pharmaceuticals, Inc
Project Dates and Amount of Award: 09/01/11-08/31/12; $10,498


The list of research publications will continue in the next issue of UMMS Research News.


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