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NOVEMBER 2011, Vol. 29

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HEADLINES

Learn About Research Strategic Plan at Nov. 30 Research Town Hall

The Office of Research will discuss recent improvements to clinical research resources and a new research strategic plan for the health system at a Town Hall:

Research Town Hall
Wednesday, November 30, 2011
1:00 - 2:00 PM
Ford Auditorium, Main Hospital

Steve Kunkel, Ph.D., Senior Associate Dean for Research and Tom Shanley, M.D., Associate Dean for Clinical & Translational Research and Director, Michigan Institute for Clinical & Health Research (MICHR) will speak at the event, which has been well attended in the past. In April, a Town Hall was held to introduce REDCap, a new data capture and management tool for researchers. And a year ago, MICHR presented the Strategic Assessment of the Clinical Research Enterprise (SACRE), where Ken Pienta, M.D., outlined plans for improvements in eight key areas of concern to investigators. Dr. Shanley will report on progress in these areas and more.

Dr. Kunkel will then present future plans for the research arm of the health system and ways we are meeting the health concerns of our local communities and beyond.

A light lunch will be available beforehand outside the auditorium.

Attend the Open House for the Biomedical Research Store and Microscopy & Image Analysis Laboratory!

The Biomedical Research Core Facilities are growing, with new Biomedical Research Store and Microscopy & Image Analysis Laboratory locations at the North Campus Research Complex.

Biomedical Research Store

Attend the Biomedical Research Store Open House!
Explore their new space at the open house on Tuesday, December 6, 2011 from 1:00 - 5:00 PM while enjoying cookies and punch:

North Campus Research Complex
Building 14, Room 179
2800 Plymouth Road
Phone: 734-615-2601

Due to increased demand, this newest Biomedical Research Store location will expand it hours. Beginning December 5, 2011, the new hours at this location will be:

  • Mondays and Tuesdays: 8:00 AM - 12:15 PM and 1:15 - 5:00 PM
  • Wednesdays and Thursdays: 1:00 - 5:00 PM

The Biomedical Research Store provides University of Michigan research investigators with easy, on-site procurement of enzymes, reagents, and kits used in molecular, cell biology, and protein chemistry. For more information or to schedule an appointment outside of regular business hours, contact Chris Stilson at 734-936-2870 or cyost@med.umich.edu.

Microscopy & Image Analysis Laboratory (MIL) also opened a new location in Fall 2011.

Microscopy & Image Analysis Laboratory

Attend the MIL Open House on Tuesday, December 6, 2011 from 1:00 - 5:00 PM featuring fresh fruit and snacks:

North Campus Research Complex
Building 20, Room 53S
2800 Plymouth Road
Phone: 734-763-0702

The MIL is a centralized facility focusing on studies of cell and tissue morphology and ultrastructure. It offers state-of-the-art equipment for microscopic imaging, including fluorescence microscopy, as well as scanning and transmission electron microscopy. For information on the MIL NCRC services and hours, please contact Chris Edwards at 734-763-1170 or fishon@umich.edu.

MICHR Workshops for Fellows and Junior Faculty

Several MICHR research education programs are upcoming that scholars and junior faculty may want to know about.  All are described on the MICHR Education Events webpage.

  1. K Writing Workshop begins at 5:00 PM November 30, 2011 in the BSRB conference rooms off the lobby.  Three sessions open to those currently writing a K23 or other career development award.  Register for this workshop.
  1. RCR4K:  MICHR is piloting a project-based approach to help K23, K08, K01, etc. awardees meet their NIH training requirement in RCR (responsible conduct of research). This is a 4-session seminar.  It starts December 8, 2011.  Register for this seminar.  Five trainees who complete the seminar (funded by a CTSA supplement) will be eligible for conference travel funds to speak about their RCR project (before 4/20/12).
  1. The revamped Introduction to Clinical and Health Research is an orientation for fellows and junior faculty interested in careers in translational research. Although the sessions build upon each other, people can pick and choose what they want to take.   Begins January 18, 2012, 4:30 - 6:30 PM in the BSRB conference rooms.

    Please register for each of the Intro course sessions separately:
    Session 1: Study Design and Development
      – Register for this session.
    Session 2: Getting Started with a Research Project
      – Register for this session.
    Session 3: Avoiding Pitfalls in Clinical & Health Research
      – Register for this session.
    Session 4: Research Funding and Budgeting
      – Register for this session.
    Session 5: Next Steps in Your Research Career
      – Register for this session.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Human Research

IRBMED Holiday Season Schedule

As the weather grows colder and the holiday season approaches, the IRBMED Office would like to remind you that:

  • IRBMED review boards do not meet on Thursday, November 24, 2011, Thanksgiving Day, nor on Friday, November 25, 2011, the day following Thanksgiving.
  • IRBMED review boards do not meet during the holiday closure (12/24/11 to 1/3/12).  The last meetings of 2011 are Thursday, December 22, 2011, and Friday, December 23, 2011.  The first meeting of 2011 will be Thursday, January 5, 2012 (Boards B1 and B2).
  • The IRBMED Office is not open for regular business during the holiday closure beginning the afternoon of December 23.  The office will reopen on Tuesday, January 3, 2012, at 8:30 AM.  The drop-box outside our offices at 2800 Plymouth Road will remain open to receive submissions, though mail will not be opened until January 3, 2012.  In addition, campus mail will not be delivered during the holiday closure.

Happy Holidays!

IRBMED – FINAL NOTICE – End of the Legacy (Paper) System

IRBMED is ending all support for studies managed through the Legacy (paper) application system as of December 23, 2011.  All active Legacy projects must complete “Migration” to eResearch Regulatory Management (eRM).  Any studies that do not complete Migration will be Administratively Terminated December 23, 2011.  

Contact IRBMED Regulatory Staff (734-763-4768) for help with Migration. Migration involves a new eRM application with special “pointers” to alert the IRBMED Board that the new application is not a new project, but a Migration of a former Legacy project.  

If a study is administratively terminated, no research activities (e.g. enrollment, data collection or analysis) may take place until the study is re-submitted in eRM and approved as if a brand-new project.

 

Animal Research

The “Cost” of Non-Compliance

The use of animals for research and teaching at the University of Michigan is a privilege, and with that privilege comes responsibility.  As a Principal Investigator (PI), you are responsible for ensuring that all work performed under a UCUCA-approved protocol remains compliant.  During a busy day, it is easy for distractions to allow errors to happen.  It is often too easy for laboratory staff and scientists who are in a hurry to make mistakes.  However, it is in your best interest as PI to make sure that you and all your laboratory staff are operating within the confines of your UCUCA-approved protocol and the policies and guidelines set forth by the Unit for Laboratory Animal Medicine (ULAM) and UCUCA.

Conducting any animal work not covered by an approved UCUCA protocol or failure to adhere to ULAM or UCUCA policies and guidelines can result in protocol non-compliance.  Such non-compliance can result in temporary revocation of privileges to work with animals for some of your staff or, in extreme cases, suspension of approval for one or more of the PI’s protocols.  In addition, the non-compliance may be reported to your department chair or dean, the Office of Laboratory Animal Welfare (OLAW; a division of NIH), and external funding sources.  In addition, PHS (Public Health Service) Policy requires that in cases of serious non-compliance any costs associated with that non-compliance must be removed from the NIH grant.  This can include costs related to animals, supplies, and personnel effort.

The animal use protocol is not only a concise description of an animal research project.  It is also a contractual agreement between the Principal Investigator and the UCUCA that ensures that animals receive the highest standard of care within both the contexts of research and daily care.  If you have any questions regarding UCUCA or ULAM policies, SOPs, and guidelines, please contact us at 734-763-8028 or (ucuca.office@umich.edu).


SHARPENING THE FOCUS:

Tips on Grant Proposal Preparation

The NIH Biosketch – Use Like Windex – Make Multiple Surfaces Shine!

By Christine Black, Assistant Director for Research Services, Office of Research
(This is one in a series of tips published in UMMS Research News about writing proposals.)

NIH Biosketch (4pp) Follow outline explicitly.

Personal Statement: Spiff it up….especially if you are a new investigator.

  • Content contributes to PI’s rating on the Investigator review criterion.
  • Can be more than one paragraph.
  • The statement explains how your experience qualifies you for your role on your project. Show you have track record and ability to perform the proposed work.
  • Imminent promotion? Are you slated for an important promotion, e.g., to assistant professor? Include the date it is scheduled to happen in the personal statement. While NIH does not require any particular title, your status may affect how reviewers view your qualifications. After submitting, you can inform the Scientific Review Officer that the promotion took place up to 30 days before the meeting.
  • If you have space, end with summary sentence, e.g., To conclude, my strong computational experience in combination with well-established interdisciplinary collaborations provide a basis for successful project leadership.

Are awards/honors transparent? If implication of some named awards is not clear to reviewer, include brief explanation.

Publications reflect proposed methods through shining examples of prior work and data.

  • Present 15, and state “these are selected from a total of X number.”
  • Can separate into: “Recent pubs most relevant to the application” and “Additional recent pubs important to the field.”
  • You can annotate (make crystal clear), e.g., elaborate details of experimentation or data relevant to the proposed work.
  • Other Key Personnel: To facilitate good statements from your busy collaborators, consider drafting a personal statement for each that he or she can modify.
  • Do not include pubs that are submitted but not yet accepted to a journal.

Techniques:

  • Use gapping (incomplete sentences) in order to present your information concisely and save space, e.g., "Instructor (2007-2010). Planned course activities. Graded all assignments. Held regular conferences with students."
  • Use parallelism – keep the structure of your phrases and/or sentences consistent (as above example where each phrase starts with verb).

Some exemplars:


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Edward Mallinckrodt, Jr. Foundation Grant Program
Internal Deadline: December 1, 2011

The basic aim of the Edward Mallinckrodt, Jr. Foundation is to advance knowledge in the various fields of medical and health research. It is further the general aims to (1) confine contributions to those worthy projects that are in need of initial start-up funding to move the projects forward to the point of other independent support or (2) support highly promising young investigators (e.g. have not been a PI on an R01) at the time when start-up funds are limited and initial progress is dependent on additional funding. The Foundation is most interested in basic research with upstream potential for impacting disease.  For this reason, we encourage only projects involving basic science.

Eligibility:
The applicant must have a permanent appointment in the Medical School. For example: Those with titles of Clinical Lecturer or Clinical Instructor would not qualify for this funding program, as these are not permanent appointments. Those with titles of Research Investigators  and Research Assistant Professor are eligible for this award, as these are permanent positions.

It is not the intent to support projects that are already under way and are already receiving significant grant support to provide long-range funding beyond an initial three-year period of support. The Foundation will not fund overhead, and grants will be made and restricted to domestic institutions.

Grants are made in the amount of $50,000 - $75,000 per year for a period of one to three years and are contingent upon a yearly progress report by the applicant. The Foundation reviews applications three times a year. The next Foundation deadline is February 1, 2012. The University of Michigan may submit a maximum of two proposals.

For consideration as an institutional nominee, submit the items below electronically by December 1, 2011 following the instructions listed on the cover sheetDownload the cover sheet, see FAQs, and view complete Foundation guidelines.

  • Cover sheet
  • Nominating letter from the department chair
  • 3-page research plan
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions.

Mary Kay Foundation Grants for Innovative Translational Cancer Research
Internal Deadline: December 6, 2011

The Mary Kay Foundation is accepting grant applications for innovative translational research in ovarian, uterine, breast or cervical cancer. Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately such research would lead to improvements in diagnosis, prognosis, prevention, or treatment of cancer. The award will be up to $100,000 (combined direct and indirect costs) for a two-year period. The University of Michigan may submit TWO applications: one through the Medical School and one through the School of Public Health. Deadline for submission of an application to the Foundation is February 3, 2012.

For consideration as an institutional nominee, submit the following electronically in a single PDF document - in the order listed – by December 6, 2011:

We acknowledge receipt of all electronic submissions.

For applications through the Medical School: send to (limitedsubmissions@umich.edu).
For applications through the School of Public Health: send to (afranz@umich.edu).

Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. Visit the foundation website for complete information.

Damon Runyon Clinical Investigator Award
Internal Deadline: December 15, 2011

The Damon Runyon Cancer Research Foundation’s Clinical Investigator Award supports early career physician-scientists conducting patient-oriented cancer research. The goal of this innovative program is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient’s bedside in search of breakthrough treatments. The Foundation is seeking investigators demonstrating innovation and creativity and gives preference to those whose research adheres to the “Handshake Rule,” meaning that the physician will conduct research studies that directly involve patients.

This program is specifically intended to provide outstanding young physicians with the resources and training structure essential to becoming successful clinical investigators. Damon Runyon has a novel partnership with the National Institutes of Health (NIH) and the National Cancer Institute (NCI), which uniquely opens access to the NIH Clinical Center (CC) to Damon Runyon Clinical Investigators.

The $450,000 award will be for a period of three years. Funding in the amount of $150,000 will be allocated to the awardee’s institution each year for the support of the Clinical Investigator.  Funds are intended to be flexible and can be used for a variety of scientific needs including the Investigator’s stipend and/or fringe benefits (up to $100,000), salaries for professional and technical personnel, special equipment, supplies, and other miscellaneous items required to conduct the proposed research. No part of this grant can be used for indirect costs or institutional overhead. The Foundation will also retire up to $100,000 of any qualifying medical school debt still owed by the awardee.

Eligibility Criteria:

  • Applicants must be U.S. citizens or permanent legal residents.
  • Applicants must have a M.D. or M.D./Ph.D. degree from an accredited institution and be board-eligible.
  • The applicant may apply within the first four years of his/her initial full faculty appointment after the final year of his/her subspecialty training (adjunct or acting positions are not eligible). Candidates may apply up to three times during this eligibility period. Candidates holding or awarded R01s at the time of application are not eligible to apply.
  • The applicant must commit to spending 80% of their time conducting research.
  • The applicant is required to apply in conjunction with a mentor who is established in the field of clinical translational cancer research, cancer prevention and/or epidemiology and can provide the critical guidance needed during the period of the award. No more than two Damon Runyon Clinical Investigators will be funded to work with the same mentor at any given time.
  • Investigators may receive funding from other sources to support their research. However, no other physician-scientist career development award from a private source (non-federal government) may be held concurrently with the Clinical Investigator Award.
  • Scientific or budgetary overlap with other funded projects is not allowed.

NOTE: Not all eligibility criteria may be listed in this abstract. Before submitting an application for this internal competition, it is the applicant’s responsibility to visit the foundation website and verify that BOTH the applicant AND their project meet ALL eligibility criteria.

UM may nominate three candidates. Deadline for submission of an application to Damon Runyon is February 15, 2012.

For consideration as an institutional nominee, submit the items below electronically by December 15, 2011 following the instructions listed on the cover sheetDownload the cover sheet and see an FAQ document.

  • Cover sheet
  • Nominating letter from the department chair
  • 3-page research plan
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions.

Camille Dreyfus Teacher-Scholar Awards Program
Internal Deadline: December 16, 2011
Foundation Deadline: February 9, 2012

The Camille Dreyfus Teacher-Scholar Awards Program supports the research and teaching careers of talented faculty in the chemical sciences.  Criteria for selection includes an independent body of scholarship attained within the first five years of appointment as an independent researcher and a demonstrated commitment to education, signaling the promise of continuing outstanding contributions to both research and teaching.

Nominations must provide compelling evidence of the advancement of important knowledge in the chemical sciences by the nominee.  Further, the nomination should describe dedication and contributions to education in the chemical sciences, particularly with respect to undergraduates.  The award provides a $75,000 research grant normally expended over a period of five years.

Nominees must hold a full-time tenure-track academic appointment to have been appointed no earlier than mid-year 2006.  The University of Michigan is allowed to nominate one faculty member for this award.

For internal review and consideration as a UM nominee, please submit the following in a single, electronic PDF file to (OVPRlimitedsubmissions@umich.edu) by December 16, 2011:

  1. Online nomination form (not yet available as of 11/18/11)
  2. Nomination letter from the department chair. This letter should explicitly detail the impact that the award would have on nominee’s career; highlight the nominee’s achievements and the basis for selection (3 p. limit).
  3. A summary description, with references, of the nominee’s research accomplishments as an independent faculty member, and a description of research plan (3 p. limit).
  4. A statement intended to convince the reviewers of the nominee’s dedication to education in the chemical sciences (3 p. limit).
  5. CV (7 p. limit) to include a list of publications in which independent contributions and undergraduate co-authors are clearly identified, and indicating research support.
  6. A budget (less than one page) to describe how award funds will be used.

In addition to the electronic version, please forward a complete original paper nomination and one additional copy, printed single-sided, on 8 ½ x 11 inch paper, 12 point font, and assembled (no staples, paper clips, folders, colored paper or bond paper) by December 16, 2011 to:

The Office of the Vice President for Research (OVPR)
c/o Lisa Turek
4080 Fleming 1340

The selected nominee (OVPR to notify when review is complete) must provide three letters of support, printed single-sided, on 8 1/2 x11-inch paper, 12pt. font, mailed directly to the Foundation from individuals who know the nominee’s capabilities and accomplishments. The letters cannot be accepted via electronic mail, fax, or if received with the nomination package. The three letters of support should be sent to:

Dr. Mark Cardillo, Executive Director
The Camille and Henry Dreyfus Foundation, Inc.
555 Madison Ave., 20th Floor
New York, NY  10022-3301

The foundation recommends using a delivery service that provides proof of delivery due to the volume of mail received near the program deadline. Additional details are available at the Dreyfus website.


UMMS AWARDED GRANTS

External Awarded Grants

An asterisk next to a name means that they are the Contact PI for the program, since some projects are awarded with multiple PIs.

Click here to view.

Anesthesiology

PI: *Booth,Victoria
Co-I: Diniz Behn, Cecilia (LSA Mathematics)
Title: Dynamics of Sleep-Wake Regulation
Sponsor: NSF
Project Dates and Amount of Award: 10/01/11-09/30/14; $299,998

Biological Chemistry

PI: *Saper,Mark
Title: Crystallization of Outer Membrane Proteins for Export of Polysaccharide Capsule
Sponsor: NIH  1 R21 AI 088543 01 A1
Project Dates and Amount of Award: 09/30/11-08/31/13; $412,640

Cell & Developmental Biology

PI: *Giger,Roman
Co-I: Segal, Benjamin (Neurology Department)
Title: Immune-Mediated Axonal Repair in the Injured Adult Mammalian CNS
Sponsor: Dana, Charles A. Foundation
Project Dates and Amount of Award: 10/01/11-09/30/14; $200,000

PI: *Gumucio,Deborah
Co-I: Margolis, Benjamin (Int Med-Nephrology) / Schnell, Santiago (Molec & Integrative Physiology)
Title: Morphogenesis of the Fetal Intestinal Epithelium
Sponsor: NIH  1 R01 DK 089933 01
Project Dates and Amount of Award: 09/21/11-05/31/16; $2,119,214

Comprehensive Cancer Center

PI: *Wicha,Max
Title: NCI-Centers of Quantitative Imaging Excellence
Sponsor: American College of Radiology TO NIH - Subcontracts
Project Dates and Amount of Award: 01/01/11-12/31/11; $9,000

Dermatology

PI: *Fisher,Gary
Title: Non-invasive Assessment of Skin Molecular Structure
Sponsor: Access Business Group
Project Dates and Amount of Award: 07/01/11-02/28/12; $44,905

PI: *Gudjonsson,Johann
Title: A Phase II Open-Label Study of the Safety, Pharmacokinetics, and Efficacy of a True Human Anti-Inflammatory Therapeutic Antibody (RA-18C3) in Subjects with Moderate to Severe Plaque Psoriasis (Derm 641)
Sponsor: XBiotech
Project Dates and Amount of Award: 09/08/11-08/11/13; $116,080

PI: *Helfrich,Yolanda
Title: A Multicenter, Observational, Non-interventional, Narrative Study to Evaluate Patient-Reported Experiences of Living with Moderate-to-Severe Plaque Psoriasis
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 09/19/11-12/31/12; $35,970

Emergency Medicine

PI: *Meurer,William
Title: Mechanical Retrieval and Recanalization of Stroke Clots using Embolectomy
Sponsor: NIH - Subcontracts TO Univ Of California Los Angeles  P50 NS 044378
Project Dates and Amount of Award: 05/01/11-04/30/13; $45,847

PI: *Scott,Phillip
Title: Cardio Vascular Heart Grant Year 5
Sponsor: CDC-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $5,760

PI: *Stanley,Rachel
Co-I: Moler, Frank (Pediatrics-Intensive Care) / Rogers, Alexander (Emergency Medicine UM CES)
Title: Great Lakes Emergency Medical Services for Children Research Network (GLEMSCRN)
Sponsor: NIH  2 U03 MC 000003 11
Project Dates and Amount of Award: 09/01/11-08/31/12; $630,000

Human Genetics

PI: *Kalantry,Sundeep
Title: Initiation of Epigenetic Transcriptional Regulation
Sponsor: NIH  1 DP2 OD 008646 01
Project Dates and Amount of Award: 09/30/11-08/31/16; $2,332,500

Internal Medicine

PI: *Baker,Laurence
Co-I: Erba, Harry (Int Med-Hematology/Oncology) / Hoban, Carolyn (Int Med-Hematology/Oncology) / Redman, Bruce (Int Med-Hematology/Oncology) / Schott, Anne (Int Med-Hematology/Oncology)
Title: Southwest Oncology Group Biorepository
Sponsor: NIH  2 U24 CA 114748 06
Project Dates and Amount of Award: 09/26/11-03/31/14; $3,251,932

PI: *Baptist,Alan
Title: A Prospective Observational Study to Assess the Role of Selected Biomarkers in Subjects Requiring Daily Medium- to High-dose Inhaled Corticosteroids for Persistent Asthma
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 09/06/11-08/31/12; $50,451

PI: *Brosius III,Frank
Co-I: Abcouwer, Steven (Ophthalmology & Visual Science) / Feldman, Eva (Neurology Department) / Kretzler, Matthias (Int Med-Nephrology)
Title: Post-Mortem Gene Expression Changes in a Murine Model of Diabetic Complications
Sponsor: NIH - Subcontracts TO Georgia Health Sciences University  U24 DL 076169
Project Dates and Amount of Award: 10/01/11-09/30/12; $196,529

PI: *Brosius III,Frank / Burant,Charles / Feldman,Eva / Gardner,Thomas / Pennathur,Subramaniam
Co-I: Abcouwer, Steven (Ophthalmology & Visual Science) / Antonetti, David (Ophthalmology & Visual Science) / Jagadish, Hosagrahar (COE EECS - CSE Division) / Kretzler, Matthias (Int Med-Nephrology) / Lombard, David (Pathology Department) / Pop-Busui, Rodica (Metabolism, Endo & Diabetes) / Qi, Nathan (Metabolism, Endo & Diabetes) / Shedden, Kerby (LSA Statistics)
Title: Metabolic Reprogramming in Diabetic Complications
Sponsor: NIH  1 DP3 DK 094292 01
Project Dates and Amount of Award: 09/30/11-08/31/16; $5,514,789

PI: *Carethers,John
Co-I: Tseng-Rogenski, Stephanie (Int Med-Gastroenterology)
Title: Microsatellite Instability and the DNA Mismatch Repair System
Sponsor: NIH  2 R01 DK 067287 07 A1
Project Dates and Amount of Award: 09/16/11-08/31/16; $1,691,065

PI: *Chey,William
Title: DEVELOPMENT AND VALIDATION OF THE AUTOMATED EVALUATION OF GASTROINTESTINAL SYMPTOMS (AEGIS) PLATFORM
Sponsor: Ironwood Pharmaceuticals
Project Dates and Amount of Award: 10/27/11-10/26/14; $930,365

PI: *Chugh,Aman
Title: TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation
Sponsor: Endosense TO Premier Research
Project Dates and Amount of Award: 10/18/11-09/30/12; $87,180

PI: *Cibrik,Diane
Title: Everolimus Assay Development and Validation Study
Sponsor: University of Colorado
Project Dates and Amount of Award: 05/01/11-06/14/12; $13,780

PI: *Couriel,Daniel
Title: Data Transmission Agreement-Medical College of Wisconsin Center for International Blood and Marrow Transplant Research(CIBMTR)
Sponsor: Medical College of Wisconsin TO National Marrow Donor Program (NMDP)
Project Dates and Amount of Award: 12/02/07-12/31/17; $314,500

PI: *Flaherty,Kevin
Title: A Randomized, Double-Blind, Placebo Controlled, Phase 3 Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Sponsor: InterMune Pharmaceuticals
Project Dates and Amount of Award: 10/25/11-12/31/13; $234,090

PI: *Galecki,Andrzej
Title: Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
Sponsor: NIH - Subcontracts TO Joslin Diabetes Center  R03 DK 094484
Project Dates and Amount of Award: 09/15/11-08/31/12; $11,663

PI: *Good,Eric
Title: Prospective Randomized EVAluation of the WATCHMAN LAA Closure Device In Patients with Atrial Fibrillation Versus Long Term Warfarin Therapy (PREVAIL)
Sponsor: Atritech, Inc
Project Dates and Amount of Award: 03/17/11-02/28/16; $141,125

PI: *Hussain,Maha
Co-I: Al-Hawary, Mahmoud (Department of Radiology)
Title: 2011.016:  A Phase II Study of Single-Agent Tesetaxel in Chemotherapy-Naive and Chemotherapy-Exposed Patients who have Progressive, Castration-Resistant Prostate Cancer
Sponsor: Genta, Inc.
Project Dates and Amount of Award: 09/09/11-09/08/15; $611,133

PI: *James,Mary
Co-I: Fries, Brant (Health Management and Policy)
Title: University of Michigan Long Term Care Data Archive 2011-2012
Sponsor: Health and Human Services, Department of-Office of the Secretary-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $300,000

PI: *Kalemkerian,Gregory
Title: 2011.060:  An Open Label, Multi-Center, IRESSA Clinical Access Program of Gefitinib 250 mg (IRESSA) for the Continued Treatment of Patients in the United States who are Currently Benefiting or Have Benefited from Gefitinib Treatment
Sponsor: AstraZeneca plc TO United BioSource Corporation
Project Dates and Amount of Award: 09/16/11-07/19/16; $10,300

PI: *Kaplan,Mariana
Title: Neutrophils in the Pathogenesis of Lupus
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 03/24/11-08/01/12; $229,320

PI: *Kretzler,Matthias
Title: Cross-Species Systems Biology of Diabetic Nephropathy
Sponsor: NIH - Subcontracts TO Georgia Health Sciences University  U24 DK 076169
Project Dates and Amount of Award: 09/01/11-08/31/12; $100,000

PI: *Liu,Suling
Co-I: Guan, Jun-Lin (Int Med-Molecular Med&Genetics) / Wicha, Max (Int Med-Hematology/Oncology)
Title: A Novel Strategy to Target Breast Cancer Stem Cells Utilizing MicroRNA100
Sponsor: Susan G. Komen for the Cure
Project Dates and Amount of Award: 11/01/11-10/31/14; $450,000

PI: *Marrero,Jorge
Title: A Multicenter, Global, Randomized, Doubleblind Study of AxitPatients With Advanced Hepatocellular Carcinoma Following Failure of One Prior Antiangiogenic Therapy
Sponsor: Pfizer Incorporated TO INC Research
Project Dates and Amount of Award: 05/19/11-12/31/13; $124,469

PI: *Miller,David
Co-I: Sherman, David (PHARMACY Medicinal Chemistry)
Title: Marine Microbial Products as Novel Agents Against Neurotropic Arboviruses
Sponsor: NIH  1 R21 AI 093642 01
Project Dates and Amount of Award: 09/30/11-08/31/13; $427,625

PI: *Mineishi,Shin
Co-I: Braun, Thomas (Biostatistics Department)
Title: Multi-Center Single Arm Phase II Study of Myeloablative Allogeneic Stem Cell Transplantation for Non-Remission Acute Myeloblastic Leukemia (AML) using Clofarabine and Busulfan x 4 (CloBu4) Regimen - OTSUKA
Sponsor: Otsuka America Pharm, Inc.
Project Dates and Amount of Award: 10/05/11-02/29/16; $515,799

PI: *Mineishi,Shin
Co-I: Braun, Thomas (Biostatistics Department)
Title: Multi-Center Single Arm Phase II Study of Myeloablative Allogeneic Stem Cell Transplantation for Non-Remission Acute Myeloblastic Leukemia (AML) using Clofarabine and Busulfan x 4 (CloBu4) Regimen - GENZYME
Sponsor: Genzyme Corporation
Project Dates and Amount of Award: 10/05/11-02/29/16; $515,800

PI: *Myers Jr,Martin
Title: Molecular and Neural Mechanisms of Leptin Action
Sponsor: American Diabetes Assoc, Inc.
Project Dates and Amount of Award: 01/01/12-12/31/12; $42,750

PI: *Ojo,Akinlolu
Title: Cognitive Decline In Chronic Renal Insufficiency
Sponsor: NIH - Subcontracts TO Northern California Institute for Research & Education, Inc. (NCIRE)  R01 DK 069406
Project Dates and Amount of Award: 08/01/11-05/31/12; $11,756

PI: *Ojo,Akinlolu
Co-I: Herman, William (Metabolism, Endo & Diabetes) / Luan, Fu-Lung (Int Med-Nephrology) / Song, Peter (Biostatistics Department)
Title: A Clinical Trial to Prevent New Onset Diabetes After Transplantation
Sponsor: NIH  1 R01 DK 092475 01
Project Dates and Amount of Award: 09/09/11-05/31/15; $1,946,718

PI: *Pelosi Jr,Frank
Title: Medtronic 2011 EP Fellowship Program
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 07/01/11-06/30/12; $40,000

PI: *Piette,John
Co-I: Bernstein, Steven (Int Med-General Medicine) / Blaum, Caroline (Int Med-Geriatric Medicine) / Kerr, Eve (Int Med-General Medicine) / Kim, Christopher (Int Med-General Medicine) / Williams, Brent (Int Med-General Medicine)
Title: Improving Transition Outcomes through Accessible Health IT and Caregiver Support
Sponsor: NIH  1 R01 AG 039474 01
Project Dates and Amount of Award: 09/01/11-08/31/16; $2,884,761

PI: *Pitt,Bertram
Co-I: Day, Sharlene (Int Med-Cardiology) / Mueller, Gisela (Department of Radiology)
Title: The Role of Exercise as a Preemptive Strategy in Preclinical Hypertrophic Cardiomyopathy
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/11-06/30/13; $110,000

PI: *Pop-Busui,Rodica
Title: Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
Sponsor: NIH - Subcontracts TO Joslin Diabetes Center  R03 DK 194494
Project Dates and Amount of Award: 09/15/11-08/31/12; $7,755

PI: *Raskin,Leonid
Title: Genetic Basis of Familial Colorectal Cancer Type X
Sponsor: NIH  1 K99 CA 158141 01 A1
Project Dates and Amount of Award: 09/20/11-08/31/13; $242,991

PI: *Redman,Bruce
Title: 2011.061:  An Exploratory Study to Investigate the Immunomodulatory Activity of Various Dose Levels of Anti Programmed-Death-1 Receptor (PD-1) Antibody (BMS-936558) in Subjects with Metastatic Clear-cell Renal Cell Carcinoma (RCC)
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 10/07/11-04/06/14; $215,970

PI: *Saint,Sanjay
Co-I: Flanders, Scott (Int Med-General Medicine) / Krein, Sarah (Int Med-General Medicine) / Manojlovich, Milisa (School of Nursing) / Rogers, Mary (Int Med-General Medicine)
Title: Expansion of the National Implementation of Comprehensive Unit-Based Safety Program (CUSP) to reduce CAUTI
Sponsor: Health Research and Educational Trust TO American Hospital Association
Project Dates and Amount of Award: 08/15/11-08/14/12; $377,477

PI: *Saran,Rajiv
Title: Establishing a Surveillance System for Chronic Kidney Disease - Component 2
Sponsor: CDC 1 U58 DP 003835 01
Project Dates and Amount of Award: 09/30/11-09/29/16; $1,707,540

PI: *Saran,Rajiv
Co-I: Gillespie, Brenda (Ctr Statistical Consul & Res) / Herman, William (Metabolism, Endo & Diabetes) / Heung, Michael (Int Med-Nephrology) / Morgenstern, Hal (Epidemiology Department) / Shahinian, Vahakn (Int Med-Nephrology) / Young, Eric (Int Med-Nephrology)
Title: Establishing a Surveillance System for Chronic Kidney Disease - Component 1
Sponsor: CDC 1 U58 DP 003836 01
Project Dates and Amount of Award: 09/30/11-09/29/16; $2,750,000

PI: *Schuetze,Scott
Title: 2011.033:  A Randomized Controlled Study of Yondelis (trabectedin) or Dacarbazine for the Treatment of Advanced Liposarcoma or Leiomyosarcoma Previously Treated with an Anthracycline and Ifosfamide
Sponsor: Johnson & Johnson Pharmaceutical Research & Development L.L.C. (J&JPRD)
Project Dates and Amount of Award: 10/06/11-05/30/15; $426,800

PI: *Sisson,Thomas
Co-I: Christensen, Paul (Int Med-Pulm./Critical Care)
Title: Effects of Oral Piclamilast on Murine Pulmonary Fibrosis
Sponsor: NYCOMED GmbH TO Michigan State University
Project Dates and Amount of Award: 09/15/11-09/14/12; $36,000

PI: *Sitrin,Robert
Co-I: Bauman, Kristy (Int Med-Pulm./Critical Care) / Chiodo, Anthony (Physical Medicine & Rehab Dept) / Rodriguez, Gianna (Physical Medicine & Rehab Dept)
Title: Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/30/11-10/29/15; $1,248,585

PI: *Talpaz,Moshe
Co-I: Bixby, Dale (Int Med-Hematology/Oncology)
Title: 2011.050:  An Open Label Assessment of Safety and Efficacy of Ruxolitinib (Incb018424) in Subjects with Primary Myelofibrosis, Post Essential Thrombocythemiamyelofibrosis and Post Polycythemia Veramyelofibrosis Who Have Platelet Counts Of 50 X109/L to 100 X109/L
Sponsor: Incyte Pharmaceuticals, Inc. TO PPD, Inc.
Project Dates and Amount of Award: 08/23/11-09/22/16; $821,094

PI: *Wang,Shaomeng
Co-I: Lu, Jianfeng (Int Med-Hematology/Oncology) / Mceachern, Donna (Int Med-Hematology/Oncology) / Sun, Haiying (Int Med-Hematology/Oncology)
Title: Design and Development of New Therapy for the Treatment of Human Breast Vancer by Overcoming Apoptosis Resistance of Breast Cancer Cells
Sponsor: Breast Cancer Research Fdn
Project Dates and Amount of Award: 10/01/11-09/30/12; $225,000

PI: *Wang,Shaomeng
Co-I: Dou, Yali (Pathology Department)
Title: Targeting MLL1 Activity for New Leukemia Therapy
Sponsor: Leukemia and Lymphoma Society
Project Dates and Amount of Award: 10/01/11-09/30/14; $600,000

PI: *Weitzel III,William
Co-I: Kruger, Grant (Mechanical Engineering)
Title: A Commercially-Viable MEMS-based Ultrasonic Volume Flow Sensor
Sponsor: NIH - Subcontracts TO Sonetics Ultrasound, Inc.
Project Dates and Amount of Award: 09/15/10-12/31/11; $45,000

PI: *Wicha,Max
Co-I: Korkaya, Hasan (Int Med-Hematology/Oncology)
Title: Her-2 Regulation of Breast Cancer Stem Cells in Her 2 Negative (Non-Amplified) Tumors
Sponsor: Breast Cancer Research Fdn
Project Dates and Amount of Award: 10/01/11-09/30/12; $225,000

PI: *Wicha,Max
Title: Assessing the Notch Pathway as a Therapeutic Target in Lung Cancer Adenocarcinoma.
Sponsor: NIH  1 K08 CA 158425 01 A1
Project Dates and Amount of Award: 09/22/11-08/31/16; $874,320

PI: *Wiggins,Jocelyn
Co-I: Nyquist, Linda (Institute of Gerontology)
Title: ASPREE - Aspirin in Reducing Events in the Elderly
Sponsor: NIH - Subcontracts TO Minneapolis Medical Research Foundation (MMRF)  U01 AG 029824
Project Dates and Amount of Award: 09/30/11-01/31/17; $408,000

PI: *Wiggins,Roger
Co-I: Inoki, Ken (Life Sciences Institute-Admin)
Title: Podocyte Hypertrophy, Stress and Urine
Sponsor: NIH  2 R01 DK 046073 17 A1
Project Dates and Amount of Award: 09/20/11-08/31/16; $1,691,065

PI: *Worden,Francis
Title: Phase II Trial Evaluating Axitinib In Patients with Unresectable, Recurrent Or Metastatic Head And Neck Cancer
Sponsor: Pfizer Incorporated TO National Comprehensive Cancer Network (NCCN)
Project Dates and Amount of Award: 05/06/11-05/06/15; $322,830

PI: *Zikmund-Fisher,Brian
Title: Identifying and Reducing Cognitive Biases Created by Decision Aids - U/M Subcontract
Sponsor: NIH - Subcontracts TO Duke University  R01 CA 087595
Project Dates and Amount of Award: 07/01/10-07/31/12; $330,429

Michigan Institute for Clinical and Health Research

PI: *Shanley,Thomas
Title: SARC 016-MICHR Data Management Service
Sponsor: SARC
Project Dates and Amount of Award: 05/01/11-04/30/15; $46,751

Microbiology and Immunology

PI: *Martens,Eric
Title: Host Responses to Mucus Layer Colonization by Commensal Microbiota Species
Sponsor: GPC
Project Dates and Amount of Award: 07/01/11-06/30/12; $50,000

Molecular & Integrative Physiology

PI: *Claflin,Dennis
Title: Acute Administration of CK-2127107 in an In-Vitro Permeabilized Muscle Fiber Analysis System Using Human Tissue
Sponsor: Cytokinetics
Project Dates and Amount of Award: 10/10/11-12/09/12; $78,471

PI: *Lehman,Michael
Title: Opioid Regulation of GnRH Pulses
Sponsor: NIH  7 R01 HD 039916 10
Project Dates and Amount of Award: 06/15/11-07/31/12; $284,322

PI: *MacDougald,Ormond
Co-I: Evans, Charles (Metabolism, Endo & Diabetes)
Title: Marrow Adiposity and Skeletal Hhomeostasis
Sponsor: NIH - Subcontracts TO Maine Medical Center  R24 DK 092759
Project Dates and Amount of Award: 09/30/11-06/30/12; $242,765

PI: *Schnell,Santiago
Title: Amgen Support for Systems Biology Symposium
Sponsor: Amgen, Inc.
Project Dates and Amount of Award: 03/01/11-08/31/11; $5,000

PI: *Stuenkel,Edward
Title: Spatiotemporal Activation and Actions of Munc13 in Neurotransmitter Release
Sponsor: NIH  1 F31 NS 077810 01
Project Dates and Amount of Award: 09/05/11-09/04/15; $130,985

Neurology

PI: *Irani,David
Title: Astrocyte Dysfunction in EAE
Sponsor: NIH  1 R21 NS 074008 01 A1
Project Dates and Amount of Award: 09/15/11-08/31/13; $427,625

PI: *Kutcher,Jeffrey
Co-I: Broglio, Steven (School of Kinesiology) / Eckner, James (Physical Medicine & Rehab Dept)
Title: Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Sport Concussion Assessment
Sponsor: ElMindA
Project Dates and Amount of Award: 10/11/11-10/13/13; $677,523

PI: *Parent,Jack
Title: Cardiac Mechanisms of SUDEP in Dravet Syndrome
Sponsor: Citizens United for Research in Epilepsy (CURE)
Project Dates and Amount of Award: 09/01/11-08/31/12; $100,000

PI: *Parent,Jack
Title: Predictive Genes, Mechanisms, and Clinical Biomarkers of SUDEP
Sponsor: NIH - Subcontracts TO Baylor College of Medicine  P20 NS 076916
Project Dates and Amount of Award: 09/26/11-08/31/12; $101,075

PI: *Paulson,Henry
Title: AIM 2012 Conference
Sponsor: NIH  1 R13 NS 077698 01
Project Dates and Amount of Award: 09/30/11-09/29/12; $20,000

Neurosurgery

PI: *Castro,Maria
Co-I: Lowenstein, Pedro (Neurosurgery)
Title: Gutless Adenovirus Mediated Gene Therapy for Glioma
Sponsor: NIH  7 U01 NS 052465 05
Project Dates and Amount of Award: 09/01/11-08/31/12; $633,279

PI: *Castro,Maria
Co-I: Lowenstein, Pedro (Neurosurgery)
Title: Engineering the Brain Immune System for Tumor Therapy
Sponsor: NIH  7 R01 NS 057711 04
Project Dates and Amount of Award: 07/01/11-12/31/13; $1,110,978

PI: *Castro,Maria
Co-I: Lowenstein, Pedro (Neurosurgery)
Title: Crosstalk between Glioma Cells & Immune Cells in the Tumor Microenvironment: Therapeutic Implications
Sponsor: NIH  7 R01 NS 074387 02
Project Dates and Amount of Award: 07/01/11-02/29/16; $1,921,884

PI: *Lowenstein,Pedro
Co-I: Castro, Maria (Neurosurgery)
Title: Brain Immune Response: Cellular & Molecular Mechanisms
Sponsor: NIH  7 R01 NS 061107 04
Project Dates and Amount of Award: 07/01/11-07/31/13; $807,636

PI: *Pandey,Aditya
Title: Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm
Sponsor: Micro Therapeutics, Inc TO University Of Florida
Project Dates and Amount of Award: 10/07/11-08/31/12; $24,500

Obstetrics & Gynecology

PI: *DeLancey,John
Title: Clinical Evaluation, Ultrasound, and MRI of Women Who Experience Tampon Slippage
Sponsor: Johnson & Johnson
Project Dates and Amount of Award: 11/01/10-07/31/12; $106,271

Ophthalmology & Visual Sciences

PI: *Antonetti,David
Title: Supplemental Funds for ERC Equipment Purchase on PAF-11-01376/N013178 Antonetti RPB Professorship
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 08/15/11-08/15/12; $150,000

PI: *Mian,Shahzad
Title: Loteprednol 0.5% for Management of Ocular GVHD
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/11-06/30/12; $2,500

PI: *Petty,Howard
Title: Pilot Studies on the Anti-Tumor Capacity of Novel Catalytic Nanoparticles
Sponsor: Pardee, Elsa U., Foundation
Project Dates and Amount of Award: 09/01/11-08/31/12; $137,376

Orthopaedic Surgery

PI: *Miller,Bruce
Title: University of Michigan Sports Medicine and Shoulder Surgery Fellowship
Sponsor: DePuy Mitek, Inc
Project Dates and Amount of Award: 08/01/11-07/31/12; $25,000

Otolaryngology

PI: *Kileny,Paul
Title: The Impact of Floating Linear Gain (FLG) on Speech Understanding in Children with Hearing Loss
Sponsor: Oticon, Inc
Project Dates and Amount of Award: 06/01/11-06/30/12; $12,905

PI: *Kileny,Paul
Co-I: Singer, David (Naval Arch & Marine Dept)
Title: Physiology Driven Ship Design of Advanced Naval Vessels for Mitigation of Noise-induced Hearing Loss
Sponsor: US DOD-Navy, Department of the TO Michigan Engineering Services
Project Dates and Amount of Award: 10/19/11-08/31/14; $499,589

PI: *Schacht,Jochen
Title: Fabrication of Noise Exposure Cages
Sponsor: Medical Univ of South Carolina
Project Dates and Amount of Award: 09/28/11-04/30/12; $659

PI: *Zwolan,Teresa / Lesperance,Marci
Co-I: Thorne, Marc (Otorhinolaryngology Department)
Title: Sound Support Program 2011/12
Sponsor: Health and Human Services, Department of-Centers for Medicare and Medicaid Services-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $269,846

Pathology

PI: *Chinnaiyan,Arul
Title: Reconstructing Targetable Pathways in Lung Cancer using a Bioinformatics Approach
Sponsor: NIH  1 F31 CA 165866 01
Project Dates and Amount of Award: 01/01/12-12/31/13; $63,974

PI: *Giacherio,Donald
Title: Validation of the Advia Centaur Tacrolimus Assay
Sponsor: Siemens Health Care Diagnostics, Inc
Project Dates and Amount of Award: 09/30/11-03/29/13; $37,846

PI: *Grembecka,Jolanta
Co-I: Cierpicki, Tomasz (Pathology Department) / Hess, Jay (Pathology Department) / Sun, Duxin (PHARMACY Pharmaceutical Sci)
Title: Development of Novel Anti-Leukemia Agents Targeting the Menin-MLL Interaction
Sponsor: NIH  1 R01 CA 160467 01
Project Dates and Amount of Award: 09/01/11-07/31/16; $1,679,150

PI: *Hogaboam,Cory
Title: Novel Immunologic Effects of Semaphorin 7a in IPF
Sponsor: NIH - Subcontracts TO Yale University  R01 HL 109233
Project Dates and Amount of Award: 08/03/11-06/30/12; $16,791

PI: *Lieberman,Andrew
Title: Defining theRole of SUMOylation in Spinobulbar Muscular Atrophy
Sponsor: NIH  1 F31 NS 076189 01
Project Dates and Amount of Award: 01/01/12-12/31/13; $91,450

Pediatrics & Communicable Diseases

PI: *Dombkowski,Kevin
Title: Enhancing Interoperability of Electronic Data Exchange
Sponsor: CDC TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-08/31/12; $56,296

PI: *Freed,Gary
Co-I: Clark, Sarah (Pediatrics-Ambulatory Care Pgm) / Dombkowski, Kevin (Pediatrics-Ambulatory Care Pgm)
Title: Pediatric and Managed Care Issues - Medicaid
Sponsor: Health and Human Services, Department of-Centers for Medicare and Medicaid Services-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $251,449

PI: *Innis,Jeffrey
Title: Pediatric Genetics Outreach Clinic 2011-2012
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $44,750

PI: *Levine,John
Title: Primary Immune Deficiency Treatment Consortium
Sponsor: NIH - Subcontracts TO National Childhood Cancer Foundation  U54 AI 082973
Project Dates and Amount of Award: 09/01/10-08/31/11; $27,840

PI: *Menon,Ram
Co-I: Chen, Ming (Pediatrics-Endocrinology) / Filbrun, Amy (Pediatrics-Pulmonary Medicine) / Nasr, Samya (Pediatrics-Pulmonary Medicine) / Sandberg, David (Child Behavioral Health)
Title: Newborn Screening - Pediatric Endocrine
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $530,155

PI: *Prosser,Lisa
Co-I: Tarini, Beth (Pediatrics-Ambulatory Care Pgm) / Ye, Wen (Biostatistics Department)
Title: Health and Economic Outcomes for Newborn Screening
Sponsor: AHRQ 1 R01 HS 020644 01
Project Dates and Amount of Award: 09/30/11-09/29/16; $2,450,154

PI: *Russell,Mark
Title: Pediatric Heart Network: Single Ventricle Reconstruction Extension Study Biologic Specimen Repository for Hypoplastic left Heart Syndrome and other Single Ventricle Anomalies
Sponsor: NIH - Subcontracts TO New England Research Institute  U10 HL 068270
Project Dates and Amount of Award: 09/01/11-06/30/12; $23,648

PI: *Shah,Prachi
Title: Fetal Alcohol Syndrome Diagnostic Clinic
Sponsor: HRSA TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $15,000

Pharmacology

PI: *Iniguez-Lluhi,Jorge
Title: Chemical probes targeting the SUMO protease SENP1 in Prostate Cancer
Sponsor: NIH  1 R03 MH 095586 01
Project Dates and Amount of Award: 09/19/11-08/31/13; $77,750

Physical Medicine & Rehabilitation

PI: *Kaufman,Jacqueline
Co-I: Reuter-Lorenz, Patricia (LSA Psychology) / Warschausky, Seth (Physical Medicine & Rehab Dept)
Title: Auditory and Visual Working Memory in Children with Cerebral Palsy
Sponsor: U.S. Department Of Education
Project Dates and Amount of Award: 10/11/11-09/30/14; $599,278

PI: *Tate,Denise
Co-I: Chiodo, Anthony (Physical Medicine & Rehab Dept) / Kalpakjian, Claire (Physical Medicine & Rehab Dept) / Meade, Michelle (Physical Medicine & Rehab Dept) / Pelletier Cameron, Anne (Urology Surgery) / Rodriguez, Gianna (Physical Medicine & Rehab Dept)
Title: The University of Michigan Model Spinal Cord Injury Care System
Sponsor: U.S. Department Of Education
Project Dates and Amount of Award: 10/01/11-09/30/16; $2,283,809

Psychiatry

PI: *Flynn,Heather
Title: Predictors of Response to Perinatal Depression Treatment: Establishing Processes and Infrastructure for Multisite Effectiveness Research
Sponsor: AHRQ 1 R03 HS 020987 01
Project Dates and Amount of Award: 09/30/11-09/29/13; $99,998

PI: *Kerber,Kevin
Title: Methodology for Comparative Effectiveness Research in Mental Health
Sponsor: NIH - Subcontracts TO Michigan State University  RC4 MH 092737
Project Dates and Amount of Award: 09/30/10-08/31/13; $97,965

PI: *Muzik,Maria
Co-I: Rosenblum, Katherine (Psychiatry Department)
Title: Community-Participatory Teen Parenting Project in Western Wayne County
Sponsor: Starfish Family Services
Project Dates and Amount of Award: 10/01/11-09/30/12; $40,732

PI: *Zubieta,Jon
Title: Role of the Dopaminergic Reward System in Substance Abuse Risk (Weiland K Award)
Sponsor: NIH  1 K01 DA 031755 01
Project Dates and Amount of Award: 09/15/11-08/31/16; $789,321

Radiation Oncology

PI: *Morgan,Meredith
Title: Radiosensitization of Pancreatic Tumor Xenografts by LB100
Sponsor: Lixte Biotechnology Holdings, Inc (Lixte)
Project Dates and Amount of Award: 10/01/11-09/30/12; $5,000

Radiology

PI: *Chan,Heang-Ping
Title: Improving Microcalcification Reconstruction in Digital Tomosynthesis Mammography for Early Detection of Breast Cancer
Sponsor: Susan G. Komen for the Cure
Project Dates and Amount of Award: 11/01/11-10/31/14; $180,000

PI: *Kilbourn,Michael
Title: Development of the PET Radiopharmaceutical [18F]Fluoroestradiol (FES)
Sponsor: JUAMA
Project Dates and Amount of Award: 09/15/11-09/14/12; $10,500

PI: *Mukherji,Suresh
Co-I: Galban, Craig (Department of Radiology)
Title: Early Prediction of Treatment Efficacy in Head and Neck Cancer: Parametric Response Map Application to Magnetic Resonance Perfusion Data.
Sponsor: American Society of Head and Neck Radiology (ASHNR)
Project Dates and Amount of Award: 01/01/12-12/31/12; $15,000

PI: *Wang,Xueding
Co-I: Fowlkes, J (Department of Radiology) / Jiang, John (Department of Radiology) / Kaplan, Mariana (Int Med-Rheumatology) / Myles, James (Mich Inst for Clin & Hlth Resr)
Title: Physiology of Inflammatory Arthritis in High Resolution
Sponsor: NIH  1 R01 AR 060350 01
Project Dates and Amount of Award: 09/06/11-06/30/16; $2,627,703

Surgery

PI: *Bolling,Steven
Co-I: Pagani, Francis (Cardiac Surgery Section)
Title: Surgical Ablation vs. No Surgical Ablation for Patients with Persistent or Longstanding Persistent Atrial Fibrillation Undergoing Mitral Valve Surgery
Sponsor: NIH - Subcontracts TO Mount Sinai Medical Center, The  U01 HL 088942
Project Dates and Amount of Award: 07/01/11-06/30/13; $52,140

PI: *Geiger,James
Co-I: Annich, Gail (Pediatrics-Intensive Care) / Balis, Ulysses (Pathology Department) / Bartlett, Robert (GSA - Administration (GSA/ADM)) / Blaauw, David (COE EECS - CSE Division) / Gianchandani, Yogesh (COE EECS - ECE Division) / Kapila, Sunil (DENT Ortho/Peds Dentistry) / Kinnear, Thomas (Ross School of Business) / Kipke, Daryl (Biomedical Engineering) / Middleton, Leonard (Ross School of Business) / Myers, Jeffrey (Pathology Department) / Nervina, Jeanne (DENT Ortho/Peds Dentistry) / Roessler, Blake (Int Med-Rheumatology) / Shih, Albert (Mechanical Engineering) / Teitelbaum, Daniel (Pediatric Surgery Section) / Wan, Julian (Urology Surgery)
Title: University of Michigan MPED & PMDI Pediatric Medical Device Consortium
Sponsor: FDA 2 P50 FD 003787 03
Project Dates and Amount of Award: 09/15/11-08/31/13; $2,200,000

PI: *Li,Qiao
Title: Immunotherapy of Melanoma Utilizing Cancer Stem Cell-based Vaccines
Sponsor: Pardee, Elsa U., Foundation
Project Dates and Amount of Award: 10/01/11-09/30/12; $123,346

PI: *Pagani,Francis
Co-I: Aaronson, Keith (Int Med-Cardiology)
Title: REcovery of Cardiac Function On VEntriculaR Assist Device
Sponsor: NIH - Subcontracts TO University of Pittsburgh  R01 HL 086918
Project Dates and Amount of Award: 07/01/11-06/30/12; $38,875

PI: *Simeone,Diane
Co-I: Kwon, Richard (Int Med-Gastroenterology)
Title: Early Detection of Pancreatic Cystic Malignancy Using Protein and Glycan Biomarkers
Sponsor: NIH - Subcontracts TO Van Andel Research Institute  U01 CA 152653
Project Dates and Amount of Award: 08/17/10-06/30/15; $214,310

PI: *Teitelbaum,Daniel
Co-I: Feng, Yong (Pediatric Surgery Section)
Title: TPN-Associated Intestinal Atrophy:  Addressing the Modulation of Intestinal Taste Receptor Abundance in its Pathogenesis
Sponsor: Ajinomoto Company, Inc.
Project Dates and Amount of Award: 08/01/11-10/31/12; $150,414

PI: *Wang,Stewart
Title: Sean's Story: A National Youth Firesetting Prevention and Intervention Toolkit
Sponsor: Homeland Security, Department of
Project Dates and Amount of Award: 05/20/11-05/19/12; $298,656

PI: *Wang,Stewart
Title: State Burn Coordinating Center
Sponsor: Health and Human Services, Department of-Office of the Secretary-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/11-09/30/12; $375,000

PI: *Zou,Weiping
Title: B7-H4 and Tumor
Sponsor: Amplimmune
Project Dates and Amount of Award: 09/21/11-09/20/14; $83,712

Unit for Laboratory Animal Medicine

PI: *Dysko,Robert
Title: ULAM Services at NCRC for Lycera
Sponsor: Lycera Inc
Project Dates and Amount of Award: 08/01/11-07/31/12; $115,175

Urology

PI: *Keller,Evan
Title: Inflammatory Cytokines in Men with Lower Urinary Tract Symptoms (LUTS)
Sponsor: NIH - Subcontracts TO Mayo Clinic  R01 DK 058859
Project Dates and Amount of Award: 09/01/11-10/31/11; $18,600

PI: *Weizer,Alon
Title: Prospective Randomized Trial of NMP22 Bladder Check Versus Cytology for the Surveillance of Patients with Low Grade Non Muscle Invasive Urothelial Carcinoma of the Bladder
Sponsor: Alere, LLC
Project Dates and Amount of Award: 02/01/22-02/02/22; $25,198


UMMS RESEARCH PUBLICATIONS

The list of research publications will continue in the next issue of UMMS Research News.

 


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